Purpose:.To investigate the clinical significance of 24-hour monitoring of intraocular pressure(IOP).Methods: A total of 571 cases(1055 eyes) undergoing 24-hour monitoring of IOP in the Second People's Hospital of...Purpose:.To investigate the clinical significance of 24-hour monitoring of intraocular pressure(IOP).Methods: A total of 571 cases(1055 eyes) undergoing 24-hour monitoring of IOP in the Second People's Hospital of Zhengzhou between June 2012 and March 2013 were retrospectively analyzed.Results: Among all 1055 eyes,.298 had suspected glaucoma(28.2%); 390(37.0%) were diagnosed with glaucoma but received no treatment(312 with primary open angle glaucoma(POAG).and 78 with primary angle closure glaucoma(PACG));215(20.4%) were diagnosed with glaucoma and received medical treatment;. 132( 12. 5 %). underwent glaucoma filtration surgery;.and there were 20 others..Through 24-hour IOP monitoring,.104 among 298 cases with suspected glaucoma were diagnosed with normal tension glaucoma(NTG),.110 with POAG,.and 28 with the secondary glaucoma..Condition assessment and treatment plans were presented for 390 glaucoma cases receiving no treatment..Adjustment was made in the medical treatment of 138 eyes..Following glaucoma filtration surgery,.52 eyes received clinical advice on subsequent treatment.Conclusion: The simplified 24-hour IOP monitoring method is readily accepted by patients,.which is of great significance for providing guidance on the diagnosis of glaucoma and the assessment of the efficacy of glaucoma surgery..However,one-time 24-hour IOP monitoring is not sufficiently efficacious to make a definite diagnosis of NTG..Therefore,.long-term follow-up and repeated 24-hour IOP monitoring are required to diagnose NTG,.along with a variety of related examinations.展开更多
Introduction: Delayed gastric emptying (DGE) often occurs in patients with gastroesophageal reflux (GER) due to neurological impairment (NI). 13C has been used as an alternative tool for measuring the gastric emptying...Introduction: Delayed gastric emptying (DGE) often occurs in patients with gastroesophageal reflux (GER) due to neurological impairment (NI). 13C has been used as an alternative tool for measuring the gastric emptying rates. The aim of this study was to predict gastric emptying in children with GER using 13C-acetate breath test (ABT) by 24-hour pH monitoring. Methods: Nineteen patients were divided into 2 groups: a DGE group with NI (14 patients), and normal-emptying group without NI (5 patients). The liquid test meal consisted of RacolTM (5 ml/kg) mixed with 13C-acetate (50 mg for infants, 100 mg for children, and 150 mg for adolescents). 13CO2 was measured using a gas chromatograph-isotope ratio mass spectrometer. The results are expressed as the % of 13C expired per hour and cumulative 13C excretion over a 3-hour periods including the parameters of half excretion and lag time. Results: The mean half excretion time was 1.762 hour in the DGE group and 1.095 hour in the normal-emptying group (P = 0.0196). The mean lag time was 0.971 hour in the DGE group and 0.666 hour in the normal-emptying group (P = 0.0196). Therefore, DGE was significantly more prevalent in the DGE compared to the normal-emptying group. The percentage of the time when the pH was less than 4 on 24-hour esophageal pH monitoring was 21.6% ± 9.2% in the DGE group and 28.5% ± 11.6% in the normal-emptying group (P = 0.4634). Conclusion: The percentage of time when the pH is less than 4 on 24-hour pH monitoring cannot predict DGE measured by the 13C-ABT in GER.展开更多
目的应用24 h食管多通道腔内阻抗-pH监测(multichannel intraluminal esophageal impedance and pH monitoring,MII-pH)探讨胃食管反流性咳嗽(gastroesophageal reflux cough,GERC)的反流特点。方法方便收集2016年3月—2018年5月就诊福...目的应用24 h食管多通道腔内阻抗-pH监测(multichannel intraluminal esophageal impedance and pH monitoring,MII-pH)探讨胃食管反流性咳嗽(gastroesophageal reflux cough,GERC)的反流特点。方法方便收集2016年3月—2018年5月就诊福建省立医院的GERC患者46例,典型GERD组32例,健康对照组30名,所有患者经过高分辨测压及MII-pH监测,比较DeMeester积分、酸、弱酸、非酸、液体、混合、气体及近端反流次数不同。结果 GERC组与健康对照组相比,DeMeester积分[13.2(2.6～260.03) vs 0.97(0.2-9.78)]、酸[40.9(0～190.2) vs 4.5(0～22.6)]、弱酸[65.0(4.4～197.0) vs 29.6(0～97.0)]、液体[53.7(13.2～181.2) vs 17.8(3.4～100.4)]、混合[64.1(14.6～203.2) vs 20.6(0～85.7)]、非酸[6.5(0～227.0) vs 2.2(0～88)]、气体[37.0(5.4-416.3) vs 20.3(3.5～32.7)]、近端反流[13.5(0～79.8) vs 1.6(0～11.5)]结果均明显升高(P<0.05);与典型GERD组相比,GERC组De Meester积分[13.2(2.6～260.03)vs 18.6(3.21～276.77)]、酸反流次数[40.9(0～190.2) vs 63.5(31.9～172.4)]均明显减低(P<0.05),气体反流[37.0(5.4～416.3)vs 22.9(3.3～98.7)]、近端反流次数[13.5(0～79.8) vs 4.7(0～33.5)]明显升高(P<0.05)。非酸、弱酸、混合反流次数与典型GERD组相仿(P>0.05)。结论GERC患者存在异常反流,气体反流及近端反流异常可能是GERD患者导致GERC的原因。展开更多
文摘Purpose:.To investigate the clinical significance of 24-hour monitoring of intraocular pressure(IOP).Methods: A total of 571 cases(1055 eyes) undergoing 24-hour monitoring of IOP in the Second People's Hospital of Zhengzhou between June 2012 and March 2013 were retrospectively analyzed.Results: Among all 1055 eyes,.298 had suspected glaucoma(28.2%); 390(37.0%) were diagnosed with glaucoma but received no treatment(312 with primary open angle glaucoma(POAG).and 78 with primary angle closure glaucoma(PACG));215(20.4%) were diagnosed with glaucoma and received medical treatment;. 132( 12. 5 %). underwent glaucoma filtration surgery;.and there were 20 others..Through 24-hour IOP monitoring,.104 among 298 cases with suspected glaucoma were diagnosed with normal tension glaucoma(NTG),.110 with POAG,.and 28 with the secondary glaucoma..Condition assessment and treatment plans were presented for 390 glaucoma cases receiving no treatment..Adjustment was made in the medical treatment of 138 eyes..Following glaucoma filtration surgery,.52 eyes received clinical advice on subsequent treatment.Conclusion: The simplified 24-hour IOP monitoring method is readily accepted by patients,.which is of great significance for providing guidance on the diagnosis of glaucoma and the assessment of the efficacy of glaucoma surgery..However,one-time 24-hour IOP monitoring is not sufficiently efficacious to make a definite diagnosis of NTG..Therefore,.long-term follow-up and repeated 24-hour IOP monitoring are required to diagnose NTG,.along with a variety of related examinations.
文摘Introduction: Delayed gastric emptying (DGE) often occurs in patients with gastroesophageal reflux (GER) due to neurological impairment (NI). 13C has been used as an alternative tool for measuring the gastric emptying rates. The aim of this study was to predict gastric emptying in children with GER using 13C-acetate breath test (ABT) by 24-hour pH monitoring. Methods: Nineteen patients were divided into 2 groups: a DGE group with NI (14 patients), and normal-emptying group without NI (5 patients). The liquid test meal consisted of RacolTM (5 ml/kg) mixed with 13C-acetate (50 mg for infants, 100 mg for children, and 150 mg for adolescents). 13CO2 was measured using a gas chromatograph-isotope ratio mass spectrometer. The results are expressed as the % of 13C expired per hour and cumulative 13C excretion over a 3-hour periods including the parameters of half excretion and lag time. Results: The mean half excretion time was 1.762 hour in the DGE group and 1.095 hour in the normal-emptying group (P = 0.0196). The mean lag time was 0.971 hour in the DGE group and 0.666 hour in the normal-emptying group (P = 0.0196). Therefore, DGE was significantly more prevalent in the DGE compared to the normal-emptying group. The percentage of the time when the pH was less than 4 on 24-hour esophageal pH monitoring was 21.6% ± 9.2% in the DGE group and 28.5% ± 11.6% in the normal-emptying group (P = 0.4634). Conclusion: The percentage of time when the pH is less than 4 on 24-hour pH monitoring cannot predict DGE measured by the 13C-ABT in GER.
文摘目的应用24 h食管多通道腔内阻抗-pH监测(multichannel intraluminal esophageal impedance and pH monitoring,MII-pH)探讨胃食管反流性咳嗽(gastroesophageal reflux cough,GERC)的反流特点。方法方便收集2016年3月—2018年5月就诊福建省立医院的GERC患者46例,典型GERD组32例,健康对照组30名,所有患者经过高分辨测压及MII-pH监测,比较DeMeester积分、酸、弱酸、非酸、液体、混合、气体及近端反流次数不同。结果 GERC组与健康对照组相比,DeMeester积分[13.2(2.6～260.03) vs 0.97(0.2-9.78)]、酸[40.9(0～190.2) vs 4.5(0～22.6)]、弱酸[65.0(4.4～197.0) vs 29.6(0～97.0)]、液体[53.7(13.2～181.2) vs 17.8(3.4～100.4)]、混合[64.1(14.6～203.2) vs 20.6(0～85.7)]、非酸[6.5(0～227.0) vs 2.2(0～88)]、气体[37.0(5.4-416.3) vs 20.3(3.5～32.7)]、近端反流[13.5(0～79.8) vs 1.6(0～11.5)]结果均明显升高(P<0.05);与典型GERD组相比,GERC组De Meester积分[13.2(2.6～260.03)vs 18.6(3.21～276.77)]、酸反流次数[40.9(0～190.2) vs 63.5(31.9～172.4)]均明显减低(P<0.05),气体反流[37.0(5.4～416.3)vs 22.9(3.3～98.7)]、近端反流次数[13.5(0～79.8) vs 4.7(0～33.5)]明显升高(P<0.05)。非酸、弱酸、混合反流次数与典型GERD组相仿(P>0.05)。结论GERC患者存在异常反流,气体反流及近端反流异常可能是GERD患者导致GERC的原因。
