[Objectives]To investigate the clinical effect of different doses of Xuesaitong combined with autologous platelet-rich gel(APG)on patients with diabetic foot(DF).[Methods]90 patients with diabetic foot admitted to our...[Objectives]To investigate the clinical effect of different doses of Xuesaitong combined with autologous platelet-rich gel(APG)on patients with diabetic foot(DF).[Methods]90 patients with diabetic foot admitted to our hospital from February 2017 to February 2019 were enrolled in the study.According to the random number table method,the subjects were divided into study group A and B and control group C.Group A was given a low dose of Xuesaitong combined with APG,while group B was given high-dose Xuesaitong combined with APG and group C was treated only with APG.Patients in the three groups were observed and the changes of related indexes were detected.[Results]After treatment,with regard to the three groups,the fasting blood glucose,2-h postprandial blood glucose level,HbA1c,TNF-α,Hcy,blood urea nitrogen(BUN),creatinine(Cr)and 24-h urine protein levels were all decreased,yet AT-III level was increased,and granulation tissue coverage and thickness,wound clearance rate were increased,while the repair time of ulcer surface was significantly reduced.The above indexes were all significantly different(P<0.05).Compared with the control group C,the changes of the indexes in the study group A and B were the same as above,and the difference was significant(P<0.05).Compared with the study group A,the level of AT-III in group B was significantly increased(P<0.05),while TNF-α,Hcy,BUN,Cr and 24-h urine protein levels were significantly decreased(P<0.05).There was no significant difference in the other indexes between groups A and B(P>0.05).[Conclusions]Xuesaitong combined with APG could effectively reduce the blood sugar level of DF patients,improve the clinical indexes,promote wound healing,and the high-dose group had more significant advantages and was worthy of promotion.展开更多
目的观察前列地尔脂微球载体制剂治疗糖尿病肾病(DN)的疗效,并探讨其对血清β2微球蛋白(β2-MG)、血栓素B2(TXB2)水平的影响。方法 82例DN患者随机分为观察组42例和对照组40例,2组均给予低脂、低钠饮食,对照组给予常规治疗,观察组在此...目的观察前列地尔脂微球载体制剂治疗糖尿病肾病(DN)的疗效,并探讨其对血清β2微球蛋白(β2-MG)、血栓素B2(TXB2)水平的影响。方法 82例DN患者随机分为观察组42例和对照组40例,2组均给予低脂、低钠饮食,对照组给予常规治疗,观察组在此基础上加用前列地尔脂微球制剂,10μg加入20 m L生理盐水,静脉推注,1次/d,2组疗程均为4周。结果观察组总有效率显著高于对照组(P<0.05)。观察组治疗后肾功能相关指标及血清β2-MG、TXB2水平均较对照组下降显著(P<0.05或P<0.01)。结论在常规治疗基础上加用前列地尔脂微球载体制剂,可有效提高DN临床疗效,显著改善肾功能,降低血清β2-MG、TXB2水平,安全性较高。展开更多
基金Applied Basic Research Program of Yunnan Province(2017FH001-081).
文摘[Objectives]To investigate the clinical effect of different doses of Xuesaitong combined with autologous platelet-rich gel(APG)on patients with diabetic foot(DF).[Methods]90 patients with diabetic foot admitted to our hospital from February 2017 to February 2019 were enrolled in the study.According to the random number table method,the subjects were divided into study group A and B and control group C.Group A was given a low dose of Xuesaitong combined with APG,while group B was given high-dose Xuesaitong combined with APG and group C was treated only with APG.Patients in the three groups were observed and the changes of related indexes were detected.[Results]After treatment,with regard to the three groups,the fasting blood glucose,2-h postprandial blood glucose level,HbA1c,TNF-α,Hcy,blood urea nitrogen(BUN),creatinine(Cr)and 24-h urine protein levels were all decreased,yet AT-III level was increased,and granulation tissue coverage and thickness,wound clearance rate were increased,while the repair time of ulcer surface was significantly reduced.The above indexes were all significantly different(P<0.05).Compared with the control group C,the changes of the indexes in the study group A and B were the same as above,and the difference was significant(P<0.05).Compared with the study group A,the level of AT-III in group B was significantly increased(P<0.05),while TNF-α,Hcy,BUN,Cr and 24-h urine protein levels were significantly decreased(P<0.05).There was no significant difference in the other indexes between groups A and B(P>0.05).[Conclusions]Xuesaitong combined with APG could effectively reduce the blood sugar level of DF patients,improve the clinical indexes,promote wound healing,and the high-dose group had more significant advantages and was worthy of promotion.
文摘目的观察前列地尔脂微球载体制剂治疗糖尿病肾病(DN)的疗效,并探讨其对血清β2微球蛋白(β2-MG)、血栓素B2(TXB2)水平的影响。方法 82例DN患者随机分为观察组42例和对照组40例,2组均给予低脂、低钠饮食,对照组给予常规治疗,观察组在此基础上加用前列地尔脂微球制剂,10μg加入20 m L生理盐水,静脉推注,1次/d,2组疗程均为4周。结果观察组总有效率显著高于对照组(P<0.05)。观察组治疗后肾功能相关指标及血清β2-MG、TXB2水平均较对照组下降显著(P<0.05或P<0.01)。结论在常规治疗基础上加用前列地尔脂微球载体制剂,可有效提高DN临床疗效,显著改善肾功能,降低血清β2-MG、TXB2水平,安全性较高。
