Plants respond to drought stress with different physical manners, such as morphology and color of leaves. Thus, plants can be considered as a sort of living-sensors for monitoring dynamic of soil water content or the ...Plants respond to drought stress with different physical manners, such as morphology and color of leaves. Thus, plants can be considered as a sort of living-sensors for monitoring dynamic of soil water content or the stored water in plant body. Because of difficulty to identify the early wilting symptom of plants from the results in 2D （two-dimension） space, this paper presented a preliminary study with 3D （three-dimension）-based image, in which a laser scanner was used for achieving the morphological information of zucchini （Cucurbita pepo） leaves. Moreover, a leaf wilting index （DLWIF） was defined by fractal dimension. The experiment consisted of phase-1 for observing the temporal variation of DLWIF and phase-2 for the validation of this index. During the experiment, air temperature, luminous intensity, and volumetric soil water contents （VSWC） were simultaneously recorded over time. The results of both phases fitted the bisector （line： 1：1） with R2=0.903 and REMS=0.155. More significantly, the influence of VSWC with three levels （0.22, 0.30, and 0.36 cm3 cm-3） on the response of plant samples to drought stress was observed from separated traces of DLWIF. In brief, two conclusions have been made： （i） the laser scanner is an effective tool for the non-contact detection of morphological wilting of plants, and （ii） defined DLWIF can be a promising indicator for a category of plants like zucchini.展开更多
Inhibition of Notch1 signaling has been shown to promote astrocyte-derived neurogenesis after stroke.To investigate the regulatory role of Notch1 signaling in this process,in this study,we used a rat model of stroke b...Inhibition of Notch1 signaling has been shown to promote astrocyte-derived neurogenesis after stroke.To investigate the regulatory role of Notch1 signaling in this process,in this study,we used a rat model of stroke based on middle cerebral artery occlusion and assessed the behavior of reactive astrocytes post-stroke.We used theγ-secretase inhibitor N-[N-(3,5-diuorophenacetyl)-1-alanyl]-S-phenylglycine t-butylester(DAPT)to block Notch1 signaling at 1,4,and 7 days after injury.Our results showed that only administration of DAPT at 4 days after stroke promoted astrocyte-derived neurogenesis,as manifested by recovery of white matter fiber bundle integrity on magnetic resonance imaging,which is consistent with recovery of neurologic function.These findings suggest that inhibition of Notch1 signaling at the subacute stage post-stroke mediates neural repair by promoting astrocyte-derived neurogenesis.展开更多
We present a method for computed tomography(CT)image processing and modeling for tibia microstructure,achieved by using computer graphics and fractal theory.Given the large-scale image data of tibia species with DICOM...We present a method for computed tomography(CT)image processing and modeling for tibia microstructure,achieved by using computer graphics and fractal theory.Given the large-scale image data of tibia species with DICOM standard for clinical applications,we take advantage of algorithms such as image binarization,hot pixel removing and close operation to obtain visually clear image for tibia microstructure.All of these images are based on 20 CT scanning images with 30μm slice thickness and 30μm interval and continuous changes in pores.For each pore,we determine its profile by using an improved algorithm for edge detection.Then,to calculate its three-dimensional fractal dimension,we measure the circumference perimeter and area of the pores of bone microstructure using a line fitting method based on the least squares.Subsequently,we put forward an algorithm for the pore profiles through ellipse fitting.The results show that the pores have significant fractal characteristics because of the good linear correlation between the perimeter and the area parameters in log–log scale coordinates system,and the ratio of the elliptical short axis to the long axis through ellipse fitting tends to 0.6501.Based on support vector machine and structural risk minimization principle,we put forward a mapping database theory of structure parameters among the pores of CT images and fractal dimension,Poisson’s ratios,porosity and equivalent aperture.On this basis,we put forward a new concept for 3D modeling called precision-measuring digital expressing to reconstruct tibia microstructure for human hard tissue.展开更多
基金the Chinese-German Center for Scientific Promotion (Chinesisch-Deutsches Zentrum für Wissenschaftsfrderung) under the Project of Sino-German Research Group (GZ494)the Beijing Municipal Education Commission for Building Scientific Research and Scientific Research Base (2008BJKY01)+1 种基金the German Academic Exchange Service (DAAD),and China Scholarship Council (CSC) for enhancing our cooperationthe International Cooperation Fund of Ministry of Science and Technology, China (2010DFA34670)
文摘Plants respond to drought stress with different physical manners, such as morphology and color of leaves. Thus, plants can be considered as a sort of living-sensors for monitoring dynamic of soil water content or the stored water in plant body. Because of difficulty to identify the early wilting symptom of plants from the results in 2D （two-dimension） space, this paper presented a preliminary study with 3D （three-dimension）-based image, in which a laser scanner was used for achieving the morphological information of zucchini （Cucurbita pepo） leaves. Moreover, a leaf wilting index （DLWIF） was defined by fractal dimension. The experiment consisted of phase-1 for observing the temporal variation of DLWIF and phase-2 for the validation of this index. During the experiment, air temperature, luminous intensity, and volumetric soil water contents （VSWC） were simultaneously recorded over time. The results of both phases fitted the bisector （line： 1：1） with R2=0.903 and REMS=0.155. More significantly, the influence of VSWC with three levels （0.22, 0.30, and 0.36 cm3 cm-3） on the response of plant samples to drought stress was observed from separated traces of DLWIF. In brief, two conclusions have been made： （i） the laser scanner is an effective tool for the non-contact detection of morphological wilting of plants, and （ii） defined DLWIF can be a promising indicator for a category of plants like zucchini.
基金supported by the National Natural Science Foundation of China,Nos.81801660(to XZH)and 81771788(to YMY)。
文摘Inhibition of Notch1 signaling has been shown to promote astrocyte-derived neurogenesis after stroke.To investigate the regulatory role of Notch1 signaling in this process,in this study,we used a rat model of stroke based on middle cerebral artery occlusion and assessed the behavior of reactive astrocytes post-stroke.We used theγ-secretase inhibitor N-[N-(3,5-diuorophenacetyl)-1-alanyl]-S-phenylglycine t-butylester(DAPT)to block Notch1 signaling at 1,4,and 7 days after injury.Our results showed that only administration of DAPT at 4 days after stroke promoted astrocyte-derived neurogenesis,as manifested by recovery of white matter fiber bundle integrity on magnetic resonance imaging,which is consistent with recovery of neurologic function.These findings suggest that inhibition of Notch1 signaling at the subacute stage post-stroke mediates neural repair by promoting astrocyte-derived neurogenesis.
基金supported by the National Key Research and Development Program of China(No.2016YFC1100600)the National Nature Science Foundation of China(Nos.61540006,61672363).
文摘We present a method for computed tomography(CT)image processing and modeling for tibia microstructure,achieved by using computer graphics and fractal theory.Given the large-scale image data of tibia species with DICOM standard for clinical applications,we take advantage of algorithms such as image binarization,hot pixel removing and close operation to obtain visually clear image for tibia microstructure.All of these images are based on 20 CT scanning images with 30μm slice thickness and 30μm interval and continuous changes in pores.For each pore,we determine its profile by using an improved algorithm for edge detection.Then,to calculate its three-dimensional fractal dimension,we measure the circumference perimeter and area of the pores of bone microstructure using a line fitting method based on the least squares.Subsequently,we put forward an algorithm for the pore profiles through ellipse fitting.The results show that the pores have significant fractal characteristics because of the good linear correlation between the perimeter and the area parameters in log–log scale coordinates system,and the ratio of the elliptical short axis to the long axis through ellipse fitting tends to 0.6501.Based on support vector machine and structural risk minimization principle,we put forward a mapping database theory of structure parameters among the pores of CT images and fractal dimension,Poisson’s ratios,porosity and equivalent aperture.On this basis,we put forward a new concept for 3D modeling called precision-measuring digital expressing to reconstruct tibia microstructure for human hard tissue.
