In order to Isolate anti-human Immunodeflclency virus (HIV) agents from natural products, 97 ethanollc extracts of 90 fungi were tested for their Inhibitory activity on HIV-1. Most of the extracts tested were relati...In order to Isolate anti-human Immunodeflclency virus (HIV) agents from natural products, 97 ethanollc extracts of 90 fungi were tested for their Inhibitory activity on HIV-1. Most of the extracts tested were relatively non-toxic to human lymphocytic MT-4 cells, but extracts of some fungi exhibited potent antl-HIV activity In an in vitro 3-(4, 5-dlmethyl-2 thlazoyl)-2,5-dlphenyl-2H-tetrazollum bromide assay with a selectivity Index greater than 3. Most fungi were Isolated from Dendrobium sp. and Taxus sp.展开更多
基金National Medicine Science Foundation during the 10th Five-Year Plan Period (2001BA705B01) and the National Science Fund for Distinguished Young Scholars (30325047).
文摘In order to Isolate anti-human Immunodeflclency virus (HIV) agents from natural products, 97 ethanollc extracts of 90 fungi were tested for their Inhibitory activity on HIV-1. Most of the extracts tested were relatively non-toxic to human lymphocytic MT-4 cells, but extracts of some fungi exhibited potent antl-HIV activity In an in vitro 3-(4, 5-dlmethyl-2 thlazoyl)-2,5-dlphenyl-2H-tetrazollum bromide assay with a selectivity Index greater than 3. Most fungi were Isolated from Dendrobium sp. and Taxus sp.