目的探讨(1-3)-β-D葡聚糖联合降钙素原(procalcitonin,PCT)、CD4^(+)T淋巴细胞多指标在艾滋病患者马尔尼菲篮状菌感染早期诊断临床研究。方法回顾性选取我院2020年1月—2022年6月住院的120例艾滋病患者为研究对象。依据实验室结果,将...目的探讨(1-3)-β-D葡聚糖联合降钙素原(procalcitonin,PCT)、CD4^(+)T淋巴细胞多指标在艾滋病患者马尔尼菲篮状菌感染早期诊断临床研究。方法回顾性选取我院2020年1月—2022年6月住院的120例艾滋病患者为研究对象。依据实验室结果,将其分为马尔尼菲篮状菌感染确诊组(血或组织液培育养出马尔尼菲篮状菌),简称A组(62例),及马尔尼菲篮状菌感染临床诊断组[根据临床症状、体征、血常规及(1-3)-β-D葡聚糖、PCT、CD4^(+)T淋巴细胞多指标诊断],简称B组(58例)。检测患者(1-3)-β-D葡聚糖、PCT、CD4^(+)T淋巴细胞的表达水平,采用受试者工作特征(receiver-operating characteristic,ROC)曲线下面积(area under the curve,AUC)评估上述指标联合检测对艾滋病患者感染马尔尼菲篮状菌的诊断效能。结果A组的(1-3)-β-D葡聚糖和PCT水平均高于B组,CD4^(+)T淋巴细胞个数低于B组(P<0.05);(1-3)-β-D葡聚糖、PCT、CD4^(+)T淋巴细胞联合检测的AUC为0.933,(1-3)-β-D葡聚糖单独检测的AUC是0.812,PCT单独检测的AUC为0.883,CD4^(+)T淋巴细胞单独检测的AUC是0.810,(1-3)-β-D葡聚糖、PCT和CD4^(+)T淋巴细胞联合检测的AUC皆优于三项单独检测,表明(1-3)-β-D葡聚糖、PCT和CD4^(+)T淋巴细胞联合检测的诊断价值皆优于单一指标诊断,且联合检测的特异度、约登指数分别为92.43%和0.580,均高于三项单独检测。结论(1-3)-β-D葡聚糖联合PCT和CD4^(+)T淋巴细胞多指标对艾滋病马尔尼菲篮状菌感染具有非常高的临床诊断价值,能够帮助医生分析出高危风险患者,及时制定治疗方案,同时也承担预后效果的判断依据,对治疗艾滋病马尔尼菲篮状菌感染具有非常重要的研究价值。展开更多
The implementation of the South-to-North Water Diversion Project (SNWDP) has alleviated groundwater resource pressure in North China to some extent, resulting in a gradual deceleration of land subsidence and even rebo...The implementation of the South-to-North Water Diversion Project (SNWDP) has alleviated groundwater resource pressure in North China to some extent, resulting in a gradual deceleration of land subsidence and even rebound in some areas. To investigate the spatiotemporal evolution characteristics of land subsidence in the eastern plain of Beijing following the SNWDP, this study employs Ascending (ASC) and Descending (DES) InSAR data combined with a Strain Model (SM) to obtain a Three-Dimensional (3-D) deformation field from 2016 to 2018. Through analysis of the 3-D deformation characteristics and spatiotemporal evolution of land subsidence in this region from 2016 to 2018, the results reveal a shift in the distribution of subsiding areas after the South-to-North Water Diversion, with a marked decrease in subsidence rates in certain areas. The maximum subsidence rate in the Beijing area has decreased to 110 mm/yr, accompanied by horizontal deformation at a rate of 12 mm/yr. Additionally, by examining the spatial relationship between major active faults and subsidence deformation in this region, the study further elucidates the influence of fault activity on the spatial distribution of subsidence deformation.展开更多
The synthesis of new 4-imino-4H-chromeno[2,3-d]pyrimidin-3(5H)-amine in four steps including one step under microwave dielectric heating is reported. The structural identity of the synthesized compounds was establishe...The synthesis of new 4-imino-4H-chromeno[2,3-d]pyrimidin-3(5H)-amine in four steps including one step under microwave dielectric heating is reported. The structural identity of the synthesized compounds was established according to their spectroscopic analysis, such as FT-IR, NMR and mass spectroscopy. These new compounds were tested for their antiproliferative activities on seven representative human tumoral cell lines (Huh7 D12, Caco2, MDA-MB231, MDA-MB468, HCT116, PC3 and MCF7) and also on fibroblasts. Among them, only the compounds 6c showed micromolar cytotoxic activity on tumor cell lines (1.8 50 50 > 25 μM). Finally, in silico ADMET studies ware performed to investigate the possibility of using of the identified compound 6c as potential anti-tumor compound.展开更多
Coverage control for each sensor is based on a 2D directional sensing model in directional sensor networks conventionally. But the 2D model cannot accurately characterize the real environment. In order to solve this p...Coverage control for each sensor is based on a 2D directional sensing model in directional sensor networks conventionally. But the 2D model cannot accurately characterize the real environment. In order to solve this problem,a new 3D directional sensor model and coverage enhancement algorithm is proposed. We can adjust the pitch angle and deviation angle to enhance the coverage rate. And the coverage enhancement algorithm is based on an improved gravitational search algorithm. In this paper the two improved strategies of GSA are directional mutation strategy and individual evolution strategy. A set of simulations show that our coverage enhancement algorithm has a good performance to improve the coverage rate of the wireless directional sensor network on different number of nodes,different virtual angles and different sensing radius.展开更多
This paper shows the procedure to obtain a continuous coverage map based on a collection of power meas- urements using a Geographic Information System, through satellite photographs of the Professional Unit Adolfo Lop...This paper shows the procedure to obtain a continuous coverage map based on a collection of power meas- urements using a Geographic Information System, through satellite photographs of the Professional Unit Adolfo Lopez Mateos, and a group of punctual samples of the power of the Common Pilot Channel (CPICH);which is used to estimate the radio communications channel conditions, taken at different positions and dis- tances. These samples were taken using specialized equipment to obtain georeferenced measurements, and by a technique of statistical prediction, as the Krige Method, generate continuous coverage maps, making it possible to know the distribution of power, and therefore understanding the behavior and configuration of a Base Station, which in third generation cellular systems is also called Node B.展开更多
文摘目的探讨(1-3)-β-D葡聚糖联合降钙素原(procalcitonin,PCT)、CD4^(+)T淋巴细胞多指标在艾滋病患者马尔尼菲篮状菌感染早期诊断临床研究。方法回顾性选取我院2020年1月—2022年6月住院的120例艾滋病患者为研究对象。依据实验室结果,将其分为马尔尼菲篮状菌感染确诊组(血或组织液培育养出马尔尼菲篮状菌),简称A组(62例),及马尔尼菲篮状菌感染临床诊断组[根据临床症状、体征、血常规及(1-3)-β-D葡聚糖、PCT、CD4^(+)T淋巴细胞多指标诊断],简称B组(58例)。检测患者(1-3)-β-D葡聚糖、PCT、CD4^(+)T淋巴细胞的表达水平,采用受试者工作特征(receiver-operating characteristic,ROC)曲线下面积(area under the curve,AUC)评估上述指标联合检测对艾滋病患者感染马尔尼菲篮状菌的诊断效能。结果A组的(1-3)-β-D葡聚糖和PCT水平均高于B组,CD4^(+)T淋巴细胞个数低于B组(P<0.05);(1-3)-β-D葡聚糖、PCT、CD4^(+)T淋巴细胞联合检测的AUC为0.933,(1-3)-β-D葡聚糖单独检测的AUC是0.812,PCT单独检测的AUC为0.883,CD4^(+)T淋巴细胞单独检测的AUC是0.810,(1-3)-β-D葡聚糖、PCT和CD4^(+)T淋巴细胞联合检测的AUC皆优于三项单独检测,表明(1-3)-β-D葡聚糖、PCT和CD4^(+)T淋巴细胞联合检测的诊断价值皆优于单一指标诊断,且联合检测的特异度、约登指数分别为92.43%和0.580,均高于三项单独检测。结论(1-3)-β-D葡聚糖联合PCT和CD4^(+)T淋巴细胞多指标对艾滋病马尔尼菲篮状菌感染具有非常高的临床诊断价值,能够帮助医生分析出高危风险患者,及时制定治疗方案,同时也承担预后效果的判断依据,对治疗艾滋病马尔尼菲篮状菌感染具有非常重要的研究价值。
文摘The implementation of the South-to-North Water Diversion Project (SNWDP) has alleviated groundwater resource pressure in North China to some extent, resulting in a gradual deceleration of land subsidence and even rebound in some areas. To investigate the spatiotemporal evolution characteristics of land subsidence in the eastern plain of Beijing following the SNWDP, this study employs Ascending (ASC) and Descending (DES) InSAR data combined with a Strain Model (SM) to obtain a Three-Dimensional (3-D) deformation field from 2016 to 2018. Through analysis of the 3-D deformation characteristics and spatiotemporal evolution of land subsidence in this region from 2016 to 2018, the results reveal a shift in the distribution of subsiding areas after the South-to-North Water Diversion, with a marked decrease in subsidence rates in certain areas. The maximum subsidence rate in the Beijing area has decreased to 110 mm/yr, accompanied by horizontal deformation at a rate of 12 mm/yr. Additionally, by examining the spatial relationship between major active faults and subsidence deformation in this region, the study further elucidates the influence of fault activity on the spatial distribution of subsidence deformation.
文摘The synthesis of new 4-imino-4H-chromeno[2,3-d]pyrimidin-3(5H)-amine in four steps including one step under microwave dielectric heating is reported. The structural identity of the synthesized compounds was established according to their spectroscopic analysis, such as FT-IR, NMR and mass spectroscopy. These new compounds were tested for their antiproliferative activities on seven representative human tumoral cell lines (Huh7 D12, Caco2, MDA-MB231, MDA-MB468, HCT116, PC3 and MCF7) and also on fibroblasts. Among them, only the compounds 6c showed micromolar cytotoxic activity on tumor cell lines (1.8 50 50 > 25 μM). Finally, in silico ADMET studies ware performed to investigate the possibility of using of the identified compound 6c as potential anti-tumor compound.
基金Sponsored by the National Natural Science Foundation of China(Grant No.61175126)National Research Foundation for the Doctoral Program of Higher Education of China(Grant No.20112304110009)the Fundamental Research Funds for the Central Universities of China(Grant No.HEUCFZ1209)
文摘Coverage control for each sensor is based on a 2D directional sensing model in directional sensor networks conventionally. But the 2D model cannot accurately characterize the real environment. In order to solve this problem,a new 3D directional sensor model and coverage enhancement algorithm is proposed. We can adjust the pitch angle and deviation angle to enhance the coverage rate. And the coverage enhancement algorithm is based on an improved gravitational search algorithm. In this paper the two improved strategies of GSA are directional mutation strategy and individual evolution strategy. A set of simulations show that our coverage enhancement algorithm has a good performance to improve the coverage rate of the wireless directional sensor network on different number of nodes,different virtual angles and different sensing radius.
文摘This paper shows the procedure to obtain a continuous coverage map based on a collection of power meas- urements using a Geographic Information System, through satellite photographs of the Professional Unit Adolfo Lopez Mateos, and a group of punctual samples of the power of the Common Pilot Channel (CPICH);which is used to estimate the radio communications channel conditions, taken at different positions and dis- tances. These samples were taken using specialized equipment to obtain georeferenced measurements, and by a technique of statistical prediction, as the Krige Method, generate continuous coverage maps, making it possible to know the distribution of power, and therefore understanding the behavior and configuration of a Base Station, which in third generation cellular systems is also called Node B.
