3-D seismic interpretation of stratigraphic and structural features in the Upper Jurassic to Lower Cretaceous sequence of the Gullfaks Field,Norwegian North Sea:A case study of reservoir development

The 3-D seismic dataset is a key tool to analyze and understand the mechanism of structural and stratigraphic hydrocarbon(HC)trapping in the subsurface.Conventionally used subsurface seismic characterization methods for fractures are based on the theory of effective anisotropy medium.The aim of this work is to improve the structural images with dense sampling of 3-D survey to evaluate structural and stratigraphic models for reservoir development to predict reservoir quality.The present study of the Gullfaks Field,located in the Norwegian North Sea Gullfaks sector,identifies the shallowest structural elements.The steepness of westward structural dip decreases eastward during the Upper Jurassic to Lower Cretaceous deposition.Reservoir sands consist of the Middle Jurassic deltaic deposits and Lower Jurassic fluvial channel and delta plain deposits.Sediment supply steadily prevails on sea-level rise and the succession displays a regressive trend indicated by a good continuous stacking pattern.The key factor for the development of reservoirs in the Gullfaks Field is fault transmissibility with spatially distributed pressure.The majority of mapped faults with sand-to-sand contacts are non-sealing,which provide restriction for the HC flow between the fault blocks.The traps for HC accumulation occur between the post-rift and syn-rift strata,i.e.antiform set by extensional system,unconformity trap at the top of syndeposition,and structural trap due to normal faults.Overall reservoir quality in the studied area is generally excellent with average 35%porosity and permeability in the Darcy range.Our findings are useful to better understand the development of siliciclastic reservoirs in similar geological settings worldwide.

Research on the 3-D Seismic Structures in Qinghai-Xizang Plateau

Based on the recording data from the analogue and broadband digital seismic stations in and around Qinghai-Xizang (Tibet) Plateau, the three dimensional (3-D) seismic velocity structures in Qinghai-Xizang Plateau were obtained by using the regional body wave tomography and surface wave tomography. The results from these two tomography methods have similar characteristics for P- and S-wave velocity structures in crust and upper mantle. They show that there are remarkable low velocity zones in the upper crust of Lhasa block in the southern Qinghai-Xizang Plateau and the lower crust and upper mantle of Qiangtang block in the northern Qinghai-Xizang Plateau. These phenomena may be related to the different steps of collision process in southern and northern Qinghai-Xizang Plateau.

3-D Seismic Identification and Characterization of Ancient Channel Morphology

It is easy to identify ancient fluvial morphologic types by the outcrop,log and core data.However,the horizontal distribution and geometry of the channels can only be identified and predicted by relying on the 3-D seismic data.The 3-D seismic horizon slices,especially,can play an important role in the sandstone prediction of meandering rivers,distributary channels and low-sinuosity channels.Every microfacies unit,including main channels,such as sinuous or branching channels,levee,crevasse channels,ligule crevasse splay and floodplain etc.can be identified.Braided channel sandstones are planar tabular lateral-connected sandbodies and the distribution of thick main channel belts can only be identified from 3-D seismic data.As the braided sandstones are ubiquitous,their occurrence and distribution do not need to be predicted.Generally,the coal velocity is so low that it can create a strong amplitude reflection in coal strata.It consequently conceals the amplitude respondence to anastomosing channel sandstone which could be identified from 3-D seismic inversion data sometimes.Case studies of mud-rich low-sinuosity rivers identified with 3-D seismic data indicate that the scales and width-to-thickness ratio of such sandbodies are small,laterally unconnected,and generally occurred on distant or further parts of an alluvial fan under dry climate conditions.Sometimes extraction of seismic attributes of every reflection event along horizons is expected to maximize expression of the spatial evolutions of ancient channels.

(1-3)-β-D葡聚糖联合降钙素原、CD4^(+)T淋巴细胞多指标在艾滋病患者马尔尼菲篮状菌感染早期诊断临床研究

目的探讨(1-3)-β-D葡聚糖联合降钙素原(procalcitonin,PCT)、CD4^(+)T淋巴细胞多指标在艾滋病患者马尔尼菲篮状菌感染早期诊断临床研究。方法回顾性选取我院2020年1月—2022年6月住院的120例艾滋病患者为研究对象。依据实验室结果,将其分为马尔尼菲篮状菌感染确诊组(血或组织液培育养出马尔尼菲篮状菌),简称A组(62例),及马尔尼菲篮状菌感染临床诊断组[根据临床症状、体征、血常规及(1-3)-β-D葡聚糖、PCT、CD4^(+)T淋巴细胞多指标诊断],简称B组(58例)。检测患者(1-3)-β-D葡聚糖、PCT、CD4^(+)T淋巴细胞的表达水平,采用受试者工作特征(receiver-operating characteristic,ROC)曲线下面积(area under the curve,AUC)评估上述指标联合检测对艾滋病患者感染马尔尼菲篮状菌的诊断效能。结果A组的(1-3)-β-D葡聚糖和PCT水平均高于B组,CD4^(+)T淋巴细胞个数低于B组(P<0.05);(1-3)-β-D葡聚糖、PCT、CD4^(+)T淋巴细胞联合检测的AUC为0.933,(1-3)-β-D葡聚糖单独检测的AUC是0.812,PCT单独检测的AUC为0.883,CD4^(+)T淋巴细胞单独检测的AUC是0.810,(1-3)-β-D葡聚糖、PCT和CD4^(+)T淋巴细胞联合检测的AUC皆优于三项单独检测,表明(1-3)-β-D葡聚糖、PCT和CD4^(+)T淋巴细胞联合检测的诊断价值皆优于单一指标诊断,且联合检测的特异度、约登指数分别为92.43%和0.580,均高于三项单独检测。结论(1-3)-β-D葡聚糖联合PCT和CD4^(+)T淋巴细胞多指标对艾滋病马尔尼菲篮状菌感染具有非常高的临床诊断价值,能够帮助医生分析出高危风险患者,及时制定治疗方案,同时也承担预后效果的判断依据,对治疗艾滋病马尔尼菲篮状菌感染具有非常重要的研究价值。

老年COPD继发肺部真菌感染患者外周血(1-3)-β-D葡聚糖、淋巴细胞水平变化的临床意义

目的分析老年慢性阻塞性肺疾病(COPD)继发肺部真菌感染(PFI)患者外周血(1-3)-β-D葡聚糖、淋巴细胞水平变化的临床意义。方法选取老年COPD继发PFI患者108例(PFI组)和老年COPD未继发PFI患者80例(非PFI组)。分析PFI组痰液病原菌分布情况;比较两组临床资料、外周血(1-3)-β-D葡聚糖、淋巴细胞亚群水平。分析COPD继发PFI的影响因素及(1-3)-β-D葡聚糖与淋巴细胞水平的相关性。结果PFI组患者痰液病原菌主要为曲霉菌、假丝酵母菌和白念珠菌。PFI组(1-3)-β-D葡聚糖、CD3^(+)CD8^(+)高于非PFI组,CD3^(+)CD4^(+)、CD3^(+)CD4^(+)/CD3^(+)CD8^(+)低于非PFI组(P<0.05)。外周血(1-3)-β-D葡聚糖与CD3^(+)CD4^(+)、CD3^(+)CD4^(+)/CD3^(+)CD8^(+)呈负相关,与CD3^(+)CD8^(+)呈正相关(P<0.001);(1-3)-β-D葡聚糖、CD3^(+)CD4^(+)、CD3^(+)CD4^(+)/CD3^(+)CD8^(+)均为老年COPD患者继发PFI的独立影响因素(P<0.05)。结论(1-3)-β-D葡聚糖、CD3^(+)CD4^(+)、CD3^(+)CD4^(+)/CD3^(+)CD8^(+)是老年COPD患者继发PFI的影响因素,可为其临床治疗提供参考。

1例RHD-CE(3-7)-D基因重组与RHCE变异型患者的血清学与分子生物学分析

目的 研究分析1例Rh血型弱D、弱cE患者的血清学与分子生物学特征,为该类患者的临床安全输血提供实验依据。方法 采用微柱凝胶卡法对患者红细胞进行ABO、RhDCcEe抗原的鉴定,同时采用试管法进行血型复核,抗人球蛋白卡法筛查不规则抗体;采用PCR-SSP法对RhDCcEe(RhD、RhC、Rhc、RhE、Rhe)基因型进行检测;三代全长测序技术对RHD/RHCE基因序列进行测序分析。结果 微柱凝胶卡法鉴定ABO、RhD、RhCcEe血型抗原的结果为:A抗原(-)、B抗原(-)、RhD(1+)、RhC(4+)、Rhc(1+)、RhE(1+)、Rhe(4+)、对照孔(-);试管法ABO、RhD、RhCcEe抗原鉴定该患者表型为:A抗原(-)、B抗原(-)、RhD(w+)、RhC(4+)、Rhc(w+)、RhE(w+)、Rhe(4+),对照管(-);抗人球蛋白卡法筛查患者不规则抗体阴性;PCR-SSP法血型基因分型RhDCcEe结果:RhD(+)、RhC(+)、Rhc(+)、RhE(+)、Rhe(+);RHD/RHCE基因结果:RHD单倍体1为外显子1-10全缺失,而单倍体2为外显子RHD-CE基因重组融合,且确认其重组类型为RHD-CE(3-7)-D,起点在外显子2(g.20238-20312之间),终点在外显子8(g49184-50480之间),同时RHCE基因第6外显子存在新碱基点突变RHCE*cE(827C>A)。结论RHD-CE(3-7)-D基因重组融合与RHCE*cE(827C>A)新等位基因突变可能引起D、cE血型抗原弱表达,为临床安全输血提供了重要的实验数据支持。

Application of 9-component S-wave 3D seismic data to study sedimentary facies and reservoirs in a biogasbearing area:A case study on the Pleistocene Qigequan Formation in Taidong area,Sanhu Depression,Qaidam Basin,NW China

To solve the problems in restoring sedimentary facies and predicting reservoirs in loose gas-bearing sediment,based on seismic sedimentologic analysis of the first 9-component S-wave 3D seismic dataset of China,a fourth-order isochronous stratigraphic framework was set up and then sedimentary facies and reservoirs in the Pleistocene Qigequan Formation in Taidong area of Qaidam Basin were studied by seismic geomorphology and seismic lithology.The study method and thought are as following.Firstly,techniques of phase rotation,frequency decomposition and fusion,and stratal slicing were applied to the 9-component S-wave seismic data to restore sedimentary facies of major marker beds based on sedimentary models reflected by satellite images.Then,techniques of seismic attribute extraction,principal component analysis,and random fitting were applied to calculate the reservoir thickness and physical parameters of a key sandbody,and the results are satisfactory and confirmed by blind testing wells.Study results reveal that the dominant sedimentary facies in the Qigequan Formation within the study area are delta front and shallow lake.The RGB fused slices indicate that there are two cycles with three sets of underwater distributary channel systems in one period.Among them,sandstones in the distributary channels of middle-low Qigequan Formation are thick and broad with superior physical properties,which are favorable reservoirs.The reservoir permeability is also affected by diagenesis.Distributary channel sandstone reservoirs extend further to the west of Sebei-1 gas field,which provides a basis to expand exploration to the western peripheral area.

Gravity tectonics controls on reservoir-scale sandbodies:Insights from 3D seismic geomorphology of the canyons buried in the upper slope of the Eastern Niger delta basin

High-resolution 3D seismic data analysis was integrated with a calibrated well and biostratigraphy data to present the first overview of a buried Pleistocene canyon system on the upper slope of the eastern Niger Delta,the Galabor Canyon.Attribute maps of specific horizons allow documenting the changing morphologies and infill lithologies of two main branches of the canyon through two stages of activity separated by a reference horizon dated at 0.99 Ma based on well calibration.At the upper slope,growth faults dissect the canyon heads,the catchment of which encroaches a network of valleys incised on the outer shelf.The canyon fill is composed of muddy channels and mass-transport deposits,largely derived from the collapse of canyon walls and sand-rich bodies forming a tract sourced by shelf-edge deltas at the outlet of the incised valleys.High-density turbiditic processes likely control the distribution of sand bodies along the canyon,ranging from tributary fans on the upper slope to 6 km-wide meander belts on the middle slope.The sandy deposits accumulate in minibasins formed along the canyon path,downstream of the subsiding hanging wall of the growth faults and upstream of shale ridges that damp the flow in the canyon.These results show that canyons can be major targets for sand reservoir exploration on the upper slope of large muddy deltas.

Three-Dimensional Density Distribution and Seismic Activity along the Guxiang–Tongmai Segment of the Jiali Fault,Tibet

The Guxiang-Tongmai segment of the Jiali fault is situated northeast of the Namche Barwa Syntaxis in northeastern Tibet.It is one of the most active strike-slip faults near the syntaxis and plays a pivotal role in the examination of seismic activity within the eastern Himalayan Syntaxis.New study in the research region has yielded a 1:200000 gravity dataset covering an area 1500 km^(2).Using wavelet transform multiscale decomposition,scratch analysis techniques,and 3D gravity inversion methods,gravity anomalies,fault distributions,and density structures were determined across various scales.Through the integration of our new gravity data with other geophysical and geological information,our findings demonstrate substantial variations in the overall crustal density within the region,with the fault distribution closely linked to these density fluctuations.Disparities in stratigraphic density are important causes of variations in the capacity of geological formations to endure regional tectonic stress.Earthquakes are predominantly concentrated within the density transition zone and are primarily situated in regions of elevated density.The hanging wall stress within the Guxiang-Tongmai segment of the Jiali fault exhibits a notable concentration,marked by pronounced anisotropy,and is positioned within the density differential zone,which is prone to earthquakes.

Spatiotemporal Evolution Analysis of the 3-D Deformation Field of Land Subsidence in Beijing after the South-to-North Water Diversion Project

The implementation of the South-to-North Water Diversion Project (SNWDP) has alleviated groundwater resource pressure in North China to some extent, resulting in a gradual deceleration of land subsidence and even rebound in some areas. To investigate the spatiotemporal evolution characteristics of land subsidence in the eastern plain of Beijing following the SNWDP, this study employs Ascending (ASC) and Descending (DES) InSAR data combined with a Strain Model (SM) to obtain a Three-Dimensional (3-D) deformation field from 2016 to 2018. Through analysis of the 3-D deformation characteristics and spatiotemporal evolution of land subsidence in this region from 2016 to 2018, the results reveal a shift in the distribution of subsiding areas after the South-to-North Water Diversion, with a marked decrease in subsidence rates in certain areas. The maximum subsidence rate in the Beijing area has decreased to 110 mm/yr, accompanied by horizontal deformation at a rate of 12 mm/yr. Additionally, by examining the spatial relationship between major active faults and subsidence deformation in this region, the study further elucidates the influence of fault activity on the spatial distribution of subsidence deformation.

基于二萘并[2,3-B∶2′,3′-D]呋喃基团的高效窄发射蓝光OLED器件

高效率窄光谱蓝色有机电致发光器件(OLED)是柔性显示领域的研究重点之一。本文以二萘并[2,3-B∶2′,3′-D]呋喃为弱电子受体、N-(4-联苯基)-1-萘胺作为电子给体设计合成了一种D-A-D型蓝光分子DPF-NA,其在正己烷溶液中的发射峰位于441 nm。理论计算与光物理测试结果显示DPF-NA具有杂化局域电荷转移激发态(HLCT)特性,兼具局域态(LE)高发光效率与电荷转移态(CT)高激子利用率特征,在二氯甲烷溶液中的光致发光量子效率(PLQY)为81.2%。基于质量分数3%DPF-NA掺杂浓度的OLED器件电致发光(EL)峰位于455 nm,半峰宽(FWHM)仅为26 nm,CIE(x,y)坐标为(0.14,0.08),最大外量子效率(EQEmax)为6.76%。

New 4-imino-4H-Chromeno[2,3-d]Pyrimidin-3(5H)-Amine: Synthesis, Cytotoxic Effects on Tumoral Cell Lines and in Silico ADMET Properties

The synthesis of new 4-imino-4H-chromeno[2,3-d]pyrimidin-3(5H)-amine in four steps including one step under microwave dielectric heating is reported. The structural identity of the synthesized compounds was established according to their spectroscopic analysis, such as FT-IR, NMR and mass spectroscopy. These new compounds were tested for their antiproliferative activities on seven representative human tumoral cell lines (Huh7 D12, Caco2, MDA-MB231, MDA-MB468, HCT116, PC3 and MCF7) and also on fibroblasts. Among them, only the compounds 6c showed micromolar cytotoxic activity on tumor cell lines (1.8 50 50 > 25 μM). Finally, in silico ADMET studies ware performed to investigate the possibility of using of the identified compound 6c as potential anti-tumor compound.

血浆(1-3)-β-D葡聚糖诊断新生儿侵袭性真菌感染的价值

探讨在针对新生儿侵袭性真菌感染的诊断中使用血浆(1-3)-β-D葡聚糖能够产生的诊断效能。方法 选取2021年1月到2022年2月因为侵袭性真菌感染于医院寻求医疗干预的新生儿总共60例作为本次研究的一部分研究对象记为1组;另外选取60例健康婴儿作为2组;统计、对比两组患者的血浆(1-3)-β-D葡聚糖水平、CD4+T淋巴细胞数水平;整理PCR技术针对1组患者诊断结果,将其与血浆(1-3)-β-D葡聚糖诊断侵袭性真菌感染的诊断效能进行对比。结果 研究结果显示1组患者的血浆(1-3)-β-D葡聚糖水平、CD4+T淋巴细胞数水平较之于2组患者存在明显差异,1组患者血浆(1-3)-β-D葡聚糖水平更高,而CD4+T淋巴细胞数水平明显更低;P<0.05。在针对诊断效能的考察上,血浆(1-3)-β-D葡聚糖诊断效能和PCR诊断结果之间在灵敏度、特异度方面差异不大,P>0.05。结论 针对罹患侵袭性真菌感染的新生儿使用血浆(1-3)-β-D葡聚糖进行检查,一定程度上能够确保诊断结果的严谨程度,可使用。

血浆(1,3)-β-D葡聚糖检测在侵袭性真菌感染诊断中的价值分析

研究血浆(1,3)-β-D葡聚糖检测技术(G实验)应用于侵袭性真菌感染(IFI)诊断中的应用价值。方法 选择我院在2023年1月至2024年1月期间收治的100例高危型侵袭型真菌感染患者,应用MB-80微生物快速检测动态系统以及对应的试剂对患者的血浆(1,3)-β-D葡聚糖进行检测,分析真菌培养、G实验和联合检测结果;三种方法的诊断效能;三种方法的ROC曲线。结果 确诊IFI阳性共28例,阴性共72例;联合检测的诊断效能高于真菌培养或者G实验。联合检测面积高于单一检测。结论 在侵袭性真菌感染的诊断中,应用血浆(1,3)-β-D葡聚糖检测,诊断效能良好,在和传统真菌培养技术联合检测下,可进一步提升诊断效能。

3-D seismic tomography for velocity and interface structure of the crust and upper mantle(theoreticalpart)

A method of three dimensional (3-D) model parameterization is presented that makes forward and inverse problems become easy. The velocity and interface structure of crust and upper mantle are described by a set of highly smoothed functions. Shooting ray tracing method is chosen to calculate the ray paths for both forward and inverse problems. The partial derivatives of traveltime with respect to parameters of the model grids are calculated analytically while rays are being traced. Because velocity and interface functions have second-order continuous partial derivatives, the geometrical shadow zones at the surface caused by scattering and focusing of ray paths can be prevented. After ray tracing, an equation consisting of matrix and vectors for inverse problem is obtained. We use singular value decomposition method with damped factor to solve the equation. A synthetic data set which consists of several in-line profiles is used to test the methods. The results show that the methods are robust. Compared with the two dimensional method, the 3-D inversion method can give the right position of interfaces and the velocity structure when the crustal model is complicated.

3-D Simulation Study on Seismic Response of Bridge Piles in Landslide

The anti-slide support structure is widely used in the anti-seismic reinforcement of bridge foundations,but related experimental research was processing slowly. Based on the prototype of the Jiuzhaigou bridge at the Chengdu-Lanzhou Railway,a 3-D simulation model was established on the basis of the shaking table model test,and the rationality of the dynamic analysis model was verified by indicators such as the bending moment of the bridge piles,peak soil pressure,and PGA amplification factors. The results show that the inertia force of the bridge pier has an important influence on the deformation of the pile foundation. The bending moment and shearing force are larger in lateral bridge piles,and the maximum value is near the pile top. The PGA amplification factor is stronger in the back of the rear anti-slide piles and so is it in front of the bridge pier,and the soil is prone to slip and damage. The bedrock is rigid and the dynamic response is maintained at a low level. The anti-slide piles in the rear row play a major role in the anti-seismic reinforcement design,and the anti-slide piles in the front row can be used as an auxiliary support structure.

深部真菌感染患者血浆1-3-β-D葡聚糖检测的临床意义

目的探讨深部真菌感染患者血浆1-3-β-D葡聚糖检测的临床意义。方法 应用ME-80微生物动态快速 检测系统,及GKT-5M Set动态真菌检测试剂盒定量检测血浆中1-3-β-D葡聚糖的含量。结果正常对照组血浆 1-3-β-D葡聚糖含量为(2.83士2.57)μg／L;深部真菌感染组为(54.06士36.13)μg／L,经t检验分析,对照组与深部 真菌感染组1-3-β-D葡聚糖平均值差异非常显著(t=7.741,P<0.001)。结论 血浆葡聚糖检测可在拟诊早期为 临床医生提供机体是否感染真菌的可靠信息,是一种实用的真菌感染早期诊断方法。

三乙基苄基氯化铵催化下水介质中吡喃并[2，3-d]嘧啶衍生物的一步合成

以芳亚甲基丙二腈、1,3-二甲基巴比妥酸为原料,以水为溶剂,在100℃以三乙基苄基氯化铵(TEBAC)为催化剂合成了一系列的吡喃并[2,3-d]嘧啶衍生物,该方法具有反应条件温和,产率良好(78%～90%)和环境友好等优点.产物的结构通过IR,1H NMR和元素分析表征,并进一步通过X射线衍射分析确证.

基于小波变换的显微图像清晰度评价函数及3-D自动调焦技术

提出了基于小波变换的图像清晰度评价函数。采用大NA(数值孔径)和小NA的显微图像序列,比较分析了本文提出的评价函数和经典的归一化方差函数、熵函数、能量拉普拉斯函数以及另外两种基于小波变换评价函数的清晰度评价性能。同时采用带有标准偏差为25的高斯噪声显微图像序列,比较了这五种评价函数的抗噪能力。实验结果表明:提出的评价函数具有最高的聚焦精度和聚焦分辨率,且具有与抗噪能力最强的归一化方差函数相当的抗噪能力。提出了基于区域选择的自动聚焦方法,实现了处于不同深度的微操作对象的3-D自动聚焦。该评价函数和区域选择聚焦技术可以用于高精度的自动微操作作业中。进一步说明自动调焦是实现自动化微操作的关键技术,而其核心是清晰度评价函数的选取或构建。

3-D颞骨模型的制作与应用

目的探讨利用粉末堆积打印技术制作的高仿真3-D颞骨模型在解剖技能训练及模拟手术中的应用。方法利用高分辨率CT获取活体颞骨断层图像(正常人2例,慢性中耳炎患者2例),数据导入Mimics软件行图像分割及颞骨三维重建,以石膏粉末为原料,利用粉末堆积快速成型技术打印出颞骨模型,重要解剖结构与组织(听骨链、面神经、位听器、炎性渗出及胆脂瘤等)以不同颜色打印,并在显微镜下进行手术演练。结果颞骨模型的硬度与人骨相近,模型表面及内部骨性标志明显,解剖精确度高,钻磨触感接近真实,满足颞骨解剖技能训练及模拟手术的要求。结论利用粉末堆积打印技术能制作出仿真度更高、更接近实际人体解剖结构的颞骨模型,帮助临床医生在术前全面了解患者的颞骨及周围组织解剖结构与病变情况,制定和优化手术方案,减少并发症。