Oxidation of 2,2'-Dihydroxy-3,3'-di-tert-buty-5,5'-dimethoxyl-biphenyl to 3,3'-Di-tert-butylbiphenyl-2,5,2',5'-diquinone with Copper(Ⅱ)Chloride as Catalyst:Synthesis,Structure and Spectral Properties of Diquinone

Use of free air as oxidant and copper（II）chloride as catalyst,3,3＇-di-tert-butylbi-phenyl-2,5,2＇,5＇-diquinone（BBDQ）was prepared via catalytic oxidation of 2,2＇-dihydroxy-3,3＇-di-tert-butyl-5,5＇-dimethoxy-biphenyl（di-BHA）.The yield of reaction attained 95% and the selectivity for BBDQ was 100%.The single-crystal X-ray diffraction analysis reveals that the dihedral angle between two rings（benzene rings for di-BHA and quinone rings for BBDQ）changes from 89.8 to 45.3o,indicating the steric hindrance effects of methyl disappear in the oxidation process.The crystal structures of di-BHA and BBDQ are further confirmed by their spectral characterizations.The probable mechanism for this oxidation process is also discussed.

吉祥草的化学成分研究

目的：对吉祥草的化学成分进行研究。方法：利用萃取，硅胶、凝胶和反相硅胶柱色谱以及高效液相色谱法进行分离和纯化，采用谱学技术（1D和2D NMR谱，MS，IR等）进行结构鉴定。结果：从吉祥草中分离鉴定了6个化合物，分别是1α，3β-dihydroxy-5β-pregn-16-en-20-one 3-O-β-D-glucopyranoside（1），syringaresinol-β-D-gluco-side（2），sophoraflavoneB（3），stigmast-5，22-dien-3-O-β-D-glucopyranoside（4），胡萝卜苷（5），α-D-glucose（6）。结论：化合物1为新化合物，化合物2～6为首次从该植物中分离得到。

苏木心材中一个新黄酮类化合物

目的:从苏木Caesalpinia sappan中寻找新的活性成分。方法:用溶剂萃取及硅胶正相色谱进行活性成分的分离纯化,根据理化性质、光谱数据进行结构鉴定。结果:从苏木95%乙醇提取物中分离得到了9个化合物:3,8-dihydroxy-4,10-dimethoxy-7-oxo-[2]benzopyrano[4,3-b][1]benzopyran-7-(5H)-one(1),3-deoxysappanchal-cone(2),sappanchalcone(3),3-deoxysappanone B(4),鼠李素(rhamnetin,5),原苏木素C(protosappanin C,6),3,7-di-hydroxy-chroman-4-one(7),己二酸二甲酯(8),胡萝卜苷(daucosterin,9)。结论:化合物1为新化合物,化合物7,8为首次从该植物中分离得到。药理筛选结果表明,化合物3对多种癌细胞株具有一定的抑制活性。

A New Chromone Derivative from Stellera chamaejasme L

A new chromone derivative, 3-[1- (2, 4, 6-trihydroxyphenyl) 3-di-(4-hydroxyphenyl) 1-propanone-2-yl] 5,7-dihydroxy-8-di(4-hydroxyphenyl)methyl-4H-1-benzopyran-4-one, named as isomohsenone was isolated from the roots of Stellera chamaejasme L. together with known chamaechromone. Its structure was determined by the analysis of MS and NMR data, especially 2D NMR spectra.

New Flavonoid Glycoside from Thalictrum przewalskii

A new flavonoid glycoside, 5, 7-dihydroxy-4'-methoxyflavonoid 7-Q-[6-O-(4-O-acetyl-alpha-L-rhamnosyl)-3-O-beta-D-glucosyl]-6-O-acetyl-beta-D-glucoside was isolated from Thalictrum przewalskii. Its structure was determined on basis of spectroscopic evidences.

Syntheses and Crystal Structures of [Na(H_2O)](C_(17)H_(13)O_6SO_3)·2H_2O and [Ni(H_2O)_6](C_(17)H_(13)O_6SO_3)_2·4H_2O

Two hydrates of sodium 5,7-dihydroxy-6,4'-dimethoxyisoflavone-3'-sulfonate ([Na(H2O)](C17H13O6SO3)2H2O, 1) and nickel 5,7-dihydroxy-6,4'-dimethoxyisoflavone-3'-sulfonate ([Ni(H2O)6](C17H13O6SO3)24H2O, 2) were syn-thesized and characterized by IR, 1H NMR and X-ray diffraction analyses. The hydrate 1 crystallizes in the mono-clinic system, space group P2(1) with a=0.8201(9) nm, b=0.8030(8) nm, c=1.5361(16) nm, =102.052(12), V=0.9893(18) nm3, Dc=1.579 g/cm3, Z=2, =0.252 nm-1, F(000)=488, R=0.0353, wR=0.0873. The hydrate 2 belongs to triclinic system, space group P-1 with a=0.7411(3) nm, b=0.8333(3) nm, c=1.7448(7) nm, a=86.361(6), 撸?6.389(5), ?=88.999(3), V=1.0731(7) nm3, Dc=1.587 g/cm3, Z=1, =0.649 mm-1, F(000)=534. In the structure of 1, the sodium cation is coordinated by six oxygen atoms and two adjacent ones are bridged by three oxygen atoms to form an octahedron chain. The C—H…p hydrogen bonds exist between two isoflavone molecules in the structure of 2. Meanwhile, hydrogen bonds in two compounds, link themselves to assemble two three-dimensional network structures, respectively.

神香草倍半萜类化学成分研究

目的研究神香草Hyssopus cuspidatus干燥地上部分的倍半萜类化学成分。方法采用D101大孔吸附树脂、硅胶柱色谱、ODS、Toyopearl HW-40C、Sephadex LH-20以及半制备HPLC等方法进行分离纯化,根据理化性质以及波谱数据对化合物进行结构鉴定。结果从神香草95%乙醇提取物中分离得到15个化合物,分别鉴定为3-eudesmene-1β-11-diol(1)、4-eudesmene-1β,11-diol(2)、1β,11-dihydroxy-5-eudesmene(3)、ent-4(15)-eudesmen-1α,11-diol(4)、7α,11-dihydroxy-cadin-10(14)-ene(5)、eudesmane-1β,5α,11-triol(6)、5-epi-eudesma-4(15)-ene-1β,6β-diol(7)、4(15)-eudesmene-1β,6α-diol(8)、(7R*)-opposit-4(15)-ene-1β,11-diol(9)、cryptomeridiol(10)、octahydro-4-hydroxy-3α-methyl-7-methylene-α-(1-methylethyl)-1H-indene-1-methanol(11)、caryolane-1,9β-diol(12)、(3S,5R,6S,7E)-3,5,6-trihydroxy-7-megastigmen-9-one(13)、spathulenol(14)、4β,10α-aromadendranediol(15)。结论化合物1～15均为首次从该属植物中分离得到。