以"28 d龄期同强度等级"为目标优选配合比,开展了C50机制砂与河砂混凝土30 m T梁足尺模型试验,对比研究机制砂与河砂混凝土的力学性能、耐久性能、实体结构的抗裂性能。研究结果表明:机制砂混凝土通过优选配合比,具备不劣于...以"28 d龄期同强度等级"为目标优选配合比,开展了C50机制砂与河砂混凝土30 m T梁足尺模型试验,对比研究机制砂与河砂混凝土的力学性能、耐久性能、实体结构的抗裂性能。研究结果表明:机制砂混凝土通过优选配合比,具备不劣于河砂的良好的施工性能;机制砂混凝土比河砂混凝土在力学性能方面优势明显;机制砂混凝土的抗氯离子渗透性能及实体梁的抗裂性能与河砂混凝土相近;用机制砂配制的海工混凝土用于实体结构是可行性的。展开更多
Phosphatidylserine(PS)is distributed asymmetrically in the plasma membrane of eukaryotic cells.Phosphatidylserine flippase(P4-ATPase)transports PS from the outer leaflet of the lipid bilayer to the inner leaflet of th...Phosphatidylserine(PS)is distributed asymmetrically in the plasma membrane of eukaryotic cells.Phosphatidylserine flippase(P4-ATPase)transports PS from the outer leaflet of the lipid bilayer to the inner leaflet of the membrane to maintain PS asymmetry.TheβsubunitTMEM30 Ais indispensable for transport and proper function of P4-ATPase.Previous studies have shown that the ATP11 A and TMEM30 A complex is the molecular switch for myotube formation.However,the role of Tmem30 a in skeletal muscle regeneration remains elusive.In the current study,Tmem30 a was highly expressed in the tibialis anterior(TA)muscles of dystrophin-null(mdx)mice and BaCl2-induced muscle injury model mice.We generated a satellite cell(SC)-specific Tmem30 a conditional knockout(cKO)mouse model to investigate the role of Tmem30 a in skeletal muscle regeneration.The regenerative ability of cKO mice was evaluated by analyzing the number and diameter of regenerated SCs after the TA muscles were injured by BaCl2-injection.Compared to the control mice,the cKO mice showed decreased Pax7+and MYH3+SCs,indicating diminished SC proliferation,and decreased expression of muscular regulatory factors(MYOD and MYOG),suggesting impaired myoblast proliferation in skeletal muscle regeneration.Taken together,these results demonstrate the essential role of Tmem30 a in skeletal muscle regeneration.展开更多
This research investigates the appropriateness of the linear specification of the market model for modeling and forecasting the cryptocurrency prices during the pre-COVID-19 and COVID-19 periods.Two extensions are off...This research investigates the appropriateness of the linear specification of the market model for modeling and forecasting the cryptocurrency prices during the pre-COVID-19 and COVID-19 periods.Two extensions are offered to compare the performance of the linear specification of the market model(LMM),which allows for the measurement of the cryptocurrency price beta risk.The first is the generalized additive model,which permits flexibility in the rigid shape of the linearity of the LMM.The second is the time-varying linearity specification of the LMM(Tv-LMM),which is based on the state space model form via the Kalman filter,allowing for the measurement of the time-varying beta risk of the cryptocurrency price.The analysis is performed using daily data from both time periods on the top 10 cryptocurrencies by adjusted market capitalization,using the Crypto Currency Index 30(CCI30)as a market proxy and 1-day and 7-day forward predictions.Such a comparison of cryptocurrency prices has yet to be undertaken in the literature.The empirical findings favor the Tv-LMM,which outperforms the others in terms of modeling and forecasting performance.This result suggests that the relationship between each cryptocurrency price and the CCI30 index should be locally instead of globally linear,especially during the COVID-19 period.展开更多
文摘以"28 d龄期同强度等级"为目标优选配合比,开展了C50机制砂与河砂混凝土30 m T梁足尺模型试验,对比研究机制砂与河砂混凝土的力学性能、耐久性能、实体结构的抗裂性能。研究结果表明:机制砂混凝土通过优选配合比,具备不劣于河砂的良好的施工性能;机制砂混凝土比河砂混凝土在力学性能方面优势明显;机制砂混凝土的抗氯离子渗透性能及实体梁的抗裂性能与河砂混凝土相近;用机制砂配制的海工混凝土用于实体结构是可行性的。
基金supported by the National Natural Science Foundation of China(81770950,81970841)Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(2019-12M-5-032)Department of Science and Technology of Sichuan Province(21ZDYF4279,2020JDZH0026,2021JDZH0022)。
文摘Phosphatidylserine(PS)is distributed asymmetrically in the plasma membrane of eukaryotic cells.Phosphatidylserine flippase(P4-ATPase)transports PS from the outer leaflet of the lipid bilayer to the inner leaflet of the membrane to maintain PS asymmetry.TheβsubunitTMEM30 Ais indispensable for transport and proper function of P4-ATPase.Previous studies have shown that the ATP11 A and TMEM30 A complex is the molecular switch for myotube formation.However,the role of Tmem30 a in skeletal muscle regeneration remains elusive.In the current study,Tmem30 a was highly expressed in the tibialis anterior(TA)muscles of dystrophin-null(mdx)mice and BaCl2-induced muscle injury model mice.We generated a satellite cell(SC)-specific Tmem30 a conditional knockout(cKO)mouse model to investigate the role of Tmem30 a in skeletal muscle regeneration.The regenerative ability of cKO mice was evaluated by analyzing the number and diameter of regenerated SCs after the TA muscles were injured by BaCl2-injection.Compared to the control mice,the cKO mice showed decreased Pax7+and MYH3+SCs,indicating diminished SC proliferation,and decreased expression of muscular regulatory factors(MYOD and MYOG),suggesting impaired myoblast proliferation in skeletal muscle regeneration.Taken together,these results demonstrate the essential role of Tmem30 a in skeletal muscle regeneration.
文摘This research investigates the appropriateness of the linear specification of the market model for modeling and forecasting the cryptocurrency prices during the pre-COVID-19 and COVID-19 periods.Two extensions are offered to compare the performance of the linear specification of the market model(LMM),which allows for the measurement of the cryptocurrency price beta risk.The first is the generalized additive model,which permits flexibility in the rigid shape of the linearity of the LMM.The second is the time-varying linearity specification of the LMM(Tv-LMM),which is based on the state space model form via the Kalman filter,allowing for the measurement of the time-varying beta risk of the cryptocurrency price.The analysis is performed using daily data from both time periods on the top 10 cryptocurrencies by adjusted market capitalization,using the Crypto Currency Index 30(CCI30)as a market proxy and 1-day and 7-day forward predictions.Such a comparison of cryptocurrency prices has yet to be undertaken in the literature.The empirical findings favor the Tv-LMM,which outperforms the others in terms of modeling and forecasting performance.This result suggests that the relationship between each cryptocurrency price and the CCI30 index should be locally instead of globally linear,especially during the COVID-19 period.
