Effect of MTECl on the functional expression of TCRαβ^+3G11^-6C10^-CD4^+CD8^- thymocyte subset

A murine CD4+ thymocyte subset with phenotype of TCRαβ + 3G11- 6C10- CD4 + CD8- CD69 + /- HSAmed/lo contains the cells in relatively functional matured status. The functional property of the cells in this subset is characterized by the unique pattern of cytokine production at transitional stage from ThO to Th2 type with the latter being the dominant type. After being co-cultured with murine thymic medullary epithelial cell line (MTEC1) cells, a murine

SCN5A基因多态性与早期复极改变关系的研究

目的探讨心脏钠离子通α亚单位(SCN5A)基因的遗传多态性与早期复极改变(ERV)的关系。方法采用PCR产物直接测序技术,对来自2009～2010年的84例研究对象进行SCN5A的2个单核苷酸多态位点(SNP)1673A>G,3666+69G>C的基因检测,其中ERV患者54例,健康对照组30例,分析比较其基因型及等位基因频率分布。结果在33例ERV患者中,1673A>G位点未发现明显基因突变,未再进一步检测;3666+69G>C位点ERV组与健康对照组比较基因型及等位基因频率分布差异有统计学意义(p<0.05);ERV组内,男女性别比较,晕厥与非晕厥组比较及J波抬高幅度>0.1mV与≤0.1mV的组间比较3666+69G>C基因型及等位基因频率分布差异无统计学意义(p>0.05)。结论3666+69G基因多态性(G→C)可能与ERV相关。