3D printing is widely adopted to quickly produce rock mass models with complex structures in batches,improving the consistency and repeatability of physical modeling.It is necessary to regulate the mechanical properti...3D printing is widely adopted to quickly produce rock mass models with complex structures in batches,improving the consistency and repeatability of physical modeling.It is necessary to regulate the mechanical properties of 3D-printed specimens to make them proportionally similar to natural rocks.This study investigates mechanical properties of 3D-printed rock analogues prepared by furan resin-bonded silica sand particles.The mechanical property regulation of 3D-printed specimens is realized through quantifying its similarity to sandstone,so that analogous deformation characteristics and failure mode are acquired.Considering similarity conversion,uniaxial compressive strength,cohesion and stress–strain relationship curve of 3D-printed specimen are similar to those of sandstone.In the study ranges,the strength of 3D-printed specimen is positively correlated with the additive content,negatively correlated with the sand particle size,and first increases then decreases with the increase of curing temperature.The regulation scheme with optimal similarity quantification index,that is the sand type of 70/140,additive content of 2.5‰and curing temperature of 81.6℃,is determined for preparing 3D-printed sandstone analogues and models.The effectiveness of mechanical property regulation is proved through uniaxial compression contrast tests.This study provides a reference for preparing rock-like specimens and engineering models using 3D printing technology.展开更多
Three-dimensional(3D)printing technology has been widely used to create artificial rock samples in rock mechanics.While 3D printing can create complex fractures,the material still lacks sufficient similarity to natura...Three-dimensional(3D)printing technology has been widely used to create artificial rock samples in rock mechanics.While 3D printing can create complex fractures,the material still lacks sufficient similarity to natural rock.Extrusion free forming(EFF)is a 3D printing technique that uses clay as the printing material and cures the specimens through high-temperature sintering.In this study,we attempted to use the EFF technology to fabricate artificial rock specimens.The results show the physico-mechanical properties of the specimens are significantly affected by the sintering temperature,while the nozzle diameter and layer thickness also have a certain impact.The specimens are primarily composed of SiO_(2),with mineral compositions similar to that of natural rocks.The density,uniaxial compressive strength(UCS),elastic modulus,and tensile strength of the printed specimens fall in the range of 1.65–2.54 g/cm3,16.46–50.49 MPa,2.17–13.35 GPa,and 0.82–17.18 MPa,respectively.It is capable of simulating different types of rocks,especially mudstone,sandstone,limestone,and gneiss.However,the simulation of hard rocks with UCS exceeding 50 MPa still requires validation.展开更多
3D printing stands at the forefront of transforming space exploration,offering unprecedented on-demand and rapid manufacturing capabilities.It adeptly addresses challenges such as mass reduction,intricate component fa...3D printing stands at the forefront of transforming space exploration,offering unprecedented on-demand and rapid manufacturing capabilities.It adeptly addresses challenges such as mass reduction,intricate component fabrication,and resource constraints.Despite the obstacles posed by microgravity and extreme environments,continual advancements underscore the pivotal role of 3D printing in aerospace science.Beyond its primary function of producing space structures,3D printing contributes significantly to progress in electronics,biomedicine,and resource optimization.This perspective delves into the technological advantages,environmental challenges,development status,and opportunities of 3D printing in space.Envisioning its crucial impact,we anticipate that 3D printing will unlock innovative solutions,reshape manufacturing practices,and foster self-sufficiency in future space endeavors.展开更多
In order to obtain better quality cookies, food 3D printing technology was employed to prepare cookies. The texture, color, deformation, moisture content, and temperature of the cookie as evaluation indicators, the in...In order to obtain better quality cookies, food 3D printing technology was employed to prepare cookies. The texture, color, deformation, moisture content, and temperature of the cookie as evaluation indicators, the influences of baking process parameters, such as baking time, surface heating temperature and bottom heating temperature, on the quality of the cookie were studied to optimize the baking process parameters. The results showed that the baking process parameters had obvious effects on the texture, color, deformation, moisture content, and temperature of the cookie. All of the roasting surface heating temperature, bottom heating temperature and baking time had positive influences on the hardness, crunchiness, crispiness, and the total color difference(ΔE) of the cookie. When the heating temperatures of the surfac and bottom increased, the diameter and thickness deformation rate of the cookie increased. However,with the extension of baking time, the diameter and thickness deformation rate of the cookie first increased and then decreased. With the surface heating temperature of 180 ℃, the bottom heating temperature of 150 ℃, and baking time of 15 min, the cookie was crisp and moderate with moderate deformation and uniform color. There was no burnt phenomenon with the desired quality. Research results provided a theoretical basis for cookie manufactory based on food 3D printing technology.展开更多
The existence of joints or other kinds of discontinuities has a dramatic efect on the stability of rock excavations and engineering.As a result,a great challenge in rock mass mechanics testing is to prepare rock or ro...The existence of joints or other kinds of discontinuities has a dramatic efect on the stability of rock excavations and engineering.As a result,a great challenge in rock mass mechanics testing is to prepare rock or rock-like samples with defects.In recent years,3D printing technology has become a promising tool in the feld of rock mass mechanics and engineering.This study frst reviews and discusses the research status of traditional test methods in rock mass mechanics tests of making rock samples with defects.Then,based on the comprehensive analysis of previous research,the application of 3D printing technology in rock mass mechanics is expounded from the following three aspects.The frst is the printing material.Although there are many materials for 3D printing,it has been found that 3D printing materials that can be used for rock mass mechanics research are very limited.After research,we summarize and evaluate printing material that can be used for rock mass mechanics studies.The second is the printing methodology,which mainly introduces the current application forms of 3D printing technology in rock mass mechanics.This includes printed precise casting molds and one-time printed samples.The last one is the printing model,which includes small-scale samples for mechanical tests and large-scale physical models.Then,the benefts and drawbacks of using 3D printing samples in mechanical tests and the validity of their simulation of real rock are discussed.Compared with traditional rock samples collected in nature or synthetic rock-like samples,the samples made by 3D printing technology have unique advantages,such as higher test repeatability,visualization of rock internal structure and stress distribution.There is thus great potential for the use of 3D printing in the feld of rock mass mechanics.However,3D printing materials also have shortcomings,such as insufcient material strength and accuracy at this stage.Finally,the application prospect of 3D printing technology in rock mass mechanics research is proposed.展开更多
Three-dimensional(3D)printing technology has opened a new paradigm to controllably and reproducibly fabricate bioengineered neural constructs for potential applications in repairing injured nervous tissues or producin...Three-dimensional(3D)printing technology has opened a new paradigm to controllably and reproducibly fabricate bioengineered neural constructs for potential applications in repairing injured nervous tissues or producing in vitro nervous tissue models.However,the complexity of nervous tissues poses great challenges to 3D-printed bioengineered analogues,which should possess diverse architectural/chemical/electrical functionalities to resemble the native growth microenvironments for functional neural regeneration.In this work,we provide a state-of-the-art review of the latest development of 3D printing for bioengineered neural constructs.Various 3D printing techniques for neural tissue-engineered scaffolds or living cell-laden constructs are summarized and compared in terms of their unique advantages.We highlight the advanced strategies by integrating topographical,biochemical and electroactive cues inside 3D-printed neural constructs to replicate in vivo-like microenvironment for functional neural regeneration.The typical applications of 3D-printed bioengineered constructs for in vivo repair of injured nervous tissues,bio-electronics interfacing with native nervous system,neural-on-chips as well as brain-like tissue models are demonstrated.The challenges and future outlook associated with 3D printing for functional neural constructs in various categories are discussed.展开更多
This study aims to investigate the benefcial efects of surface retaining elements (SREs) on the mechanical behaviors of bolted rock and roadway stability. 3D printing (3DP) technology is utilized to create rock analog...This study aims to investigate the benefcial efects of surface retaining elements (SREs) on the mechanical behaviors of bolted rock and roadway stability. 3D printing (3DP) technology is utilized to create rock analogue prismatic specimens for conducting this investigation. Uniaxial compression tests with acoustic emission (AE) and digital image correlation techniques have been conducted on 3DP specimens bolted with diferent SREs. The results demonstrate that the strength and modulus of elasticity of the bolted specimens show a positive correlation with the area of the SRE;the AE characteristics of the bolted specimens are higher than those of the unbolted specimen, but they decrease with an increase in SRE area, thus further improving the integrity of the bolted specimens. The reinforcement efect of SREs on the surrounding rock of roadways is further analyzed using numerical modelling and feld test. The results provide a better understanding of the role of SREs in rock bolting and the optimization of rock bolting design. Furthermore, they verify the feasibility of 3DP for rock analogues in rock mechanics tests.展开更多
Three-dimensional-structured metal oxides have myriad applications for optoelectronic devices.Comparing to conventional lithography-based manufacturing methods which face significant challenges for 3D device architect...Three-dimensional-structured metal oxides have myriad applications for optoelectronic devices.Comparing to conventional lithography-based manufacturing methods which face significant challenges for 3D device architectures,additive manufacturing approaches such as direct ink writing offer convenient,on-demand manufacturing of 3D oxides with high resolutions down to sub-micrometer scales.However,the lack of a universal ink design strategy greatly limits the choices of printable oxides.Here,a universal,facile synthetic strategy is developed for direct ink writable polymer precursor inks based on metal-polymer coordination effect.Specifically,polyethyleneimine functionalized by ethylenediaminetetraacetic acid is employed as the polymer matrix for adsorbing targeted metal ions.Next,glucose is introduced as a crosslinker for endowing the polymer precursor inks with a thermosetting property required for 3D printing via the Maillard reaction.For demonstrations,binary(i.e.,ZnO,CuO,In_(2)O_(3),Ga_(2)O_(3),TiO_(2),and Y_(2)O_(3)) and ternary metal oxides(i.e.,BaTiO_(3) and SrTiO_(3)) are printed into 3D architectures with sub-micrometer resolution by extruding the inks through ultrafine nozzles.Upon thermal crosslinking and pyrolysis,the 3D microarchitectures with woodpile geometries exhibit strong light-matter coupling in the mid-infrared region.The design strategy for printable inks opens a new pathway toward 3D-printed optoelectronic devices based on functional oxides.展开更多
Three-dimensional(3D)printing technology is increasingly used in experimental research of geotechnical engineering.Compared to other materials,3D layer-by-layer printing specimens are extremely similar to the inherent...Three-dimensional(3D)printing technology is increasingly used in experimental research of geotechnical engineering.Compared to other materials,3D layer-by-layer printing specimens are extremely similar to the inherent properties of natural layered rock masses.In this paper,soft-hard interbedded rock masses with different dip angles were prepared based on 3D printing(3DP)sand core technology.Uniaxial compression creep tests were conducted to investigate its anisotropic creep behavior based on digital imaging correlation(DIC)technology.The results show that the anisotropic creep behavior of the 3DP soft-hard interbedded rock mass is mainly affected by the dip angles of the weak interlayer when the stress is at low levels.As the stress level increases,the effect of creep stress on its creep anisotropy increases significantly,and the dip angle is no longer the main factor.The minimum value of the long-term strength and creep failure strength always appears in the weak interlayer within 30°–60°,which explains why the failure of the layered rock mass is controlled by the weak interlayer and generally emerges at 45°.The tests results are verified by comparing with theoretical and other published studies.The feasibility of the 3DP soft-hard interbedded rock mass provides broad prospects and application values for 3DP technology in future experimental research.展开更多
Three-dimensional(3D)printing,an additive manufacturing technique,is widely employed for the fabrication of various electrochemical energy storage devices(EESDs),such as batteries and supercapacitors,ranging from nano...Three-dimensional(3D)printing,an additive manufacturing technique,is widely employed for the fabrication of various electrochemical energy storage devices(EESDs),such as batteries and supercapacitors,ranging from nanoscale to macroscale.This technique offers excellent manufacturing flexibility,geometric designability,cost-effectiveness,and eco-friendliness.Recent studies have focused on the utilization of 3D-printed critical materials for EESDs,which have demonstrated remarkable electrochemical performances,including high energy densities and rate capabilities,attributed to improved ion/electron transport abilities and fast kinetics.However,there is a lack of comprehensive reviews summarizing and discussing the recent advancements in the structural design and application of 3D-printed critical materials for EESDs,particularly rechargeable batteries.In this review,we primarily concentrate on the current progress in 3D printing(3DP)critical materials for emerging batteries.We commence by outlining the key characteristics of major 3DP methods employed for fabricating EESDs,encompassing design principles,materials selection,and optimization strategies.Subsequently,we summarize the recent advancements in 3D-printed critical materials(anode,cathode,electrolyte,separator,and current collector)for secondary batteries,including conventional Li-ion(LIBs),Na-ion(SIBs),K-ion(KIBs)batteries,as well as Li/Na/K/Zn metal batteries,Zn-air batteries,and Ni–Fe batteries.Within these sections,we discuss the 3DP precursor,design principles of 3D structures,and working mechanisms of the electrodes.Finally,we address the major challenges and potential applications in the development of 3D-printed critical materials for rechargeable batteries.展开更多
Ceramic cores are the key intermediate components of hollow blades for aero-engine.Conventional processes,such as hot-press molding and gel film casting,face difficulties in fabricating complex-structured ceramic core...Ceramic cores are the key intermediate components of hollow blades for aero-engine.Conventional processes,such as hot-press molding and gel film casting,face difficulties in fabricating complex-structured ceramic cores due to the complexity of moulds and long process cycles.Stereolithography 3D printing provides a new idea for the fabrication of complex-structured ceramic cores.The effect of sintering temperature on open porosity,bulk density,weight loss rate,shrinkage rate,flexural strength and microstructure of the Al_(2)O_(3)-based ceramic core doped with 10vol.%polysilazane(PSZ)was studied.The sintering mechanism of PSZ-reinforced ceramic cores was analyzed.Results show that the optimum sintering temperature of PSZ-reinforced ceramic cores is 1,450°C.At this temperature,the open porosity of the ceramic core is 36.60%,bulk density is 2.33 g·cm^(-3),weight loss rate is 22.11%,shrinkage rate along the X,Y,Z directions is 5.72%,5.01%,9.61%,respectively;the flexural strength is 28.794 MPa at 25°C and 13.649 MPa at 1,500°C.Properties of 3D printing PSZ-reinforced ceramic cores can meet the casting requirement of superalloy hollow blades,which is expected to promote the industrial application of 3D printing complex structure ceramic cores.展开更多
Because of the complex nerve anatomy and limited regeneration ability of natural tissue,the current treatment effect for long-distance peripheral nerve regeneration and spinal cord injury(SCI)repair is not satisfactor...Because of the complex nerve anatomy and limited regeneration ability of natural tissue,the current treatment effect for long-distance peripheral nerve regeneration and spinal cord injury(SCI)repair is not satisfactory.As an alternative method,tissue engineering is a promising method to regenerate peripheral nerve and spinal cord,and can provide structures and functions similar to natural tissues through scaffold materials and seed cells.Recently,the rapid development of 3D printing technology enables researchers to create novel 3D constructs with sophisticated structures and diverse functions to achieve high bionics of structures and functions.In this review,we first outlined the anatomy of peripheral nerve and spinal cord,as well as the current treatment strategies for the peripheral nerve injury and SCI in clinical.After that,the design considerations of peripheral nerve and spinal cord tissue engineering were discussed,and various 3D printing technologies applicable to neural tissue engineering were elaborated,including inkjet,extrusion-based,stereolithography,projection-based,and emerging printing technologies.Finally,we focused on the application of 3D printing technology in peripheral nerve regeneration and spinal cord repair,as well as the challenges and prospects in this research field.展开更多
At present,the clinical reconstruction of the auricle usually adopts the strategy of taking autologous costal cartilage.This method has great trauma to patients,poor plasticity and inaccurate shaping.Three-dimensional...At present,the clinical reconstruction of the auricle usually adopts the strategy of taking autologous costal cartilage.This method has great trauma to patients,poor plasticity and inaccurate shaping.Three-dimensional(3D)printing technology has made a great breakthrough in the clinical application of orthopedic implants.This study explored the combination of 3D printing and tissue engineering to precisely reconstruct the auricle.First,a polylactic acid(PLA)polymer scaffold with a precisely customized patient appearance was fabricated,and then auricle cartilage fragments were loaded into the 3D-printed porous PLA scaffold to promote auricle reconstruction.In vitro,gelatin methacrylamide(GelMA)hydrogels loaded with different sizes of rabbit ear cartilage fragments were studied to assess the regenerative activity of various autologous cartilage fragments.In vivo,rat ear cartilage fragments were placed in an accurately designed porous PLA polymer ear scaffold to promote auricle reconstruction.The results indicated that the chondrocytes in the cartilage fragments could maintain the morphological phenotype in vitro.After three months of implantation observation,it was conducive to promoting the subsequent regeneration of cartilage in vivo.The autologous cartilage fragments combined with 3D printing technology show promising potential in auricle reconstruction.展开更多
The development of projection-based stereolithography additive manufacturing techniques and magnetic photosensitive resins has provided a powerful approach to fabricate miniaturized magnetic functional devices with co...The development of projection-based stereolithography additive manufacturing techniques and magnetic photosensitive resins has provided a powerful approach to fabricate miniaturized magnetic functional devices with complex three-dimensional spatial structures.However,the present magnetic photosensitive resins face great challenges in the trade-off between high ferromagnetism and excellent printing quality.To address these challenges,we develop a novel NdFeB-Fe_(3)O_(4) magnetic photosensitive resin comprising 20 wt.%solid loading of magnetic particles,which can be used to fabricate high-precision and ferromagnetic functional devices via micro-continuous liquid interface production process.This resin combining ferromagnetic NdFeB microparticles and strongly absorbing Fe_(3)O_(4) nanoparticles is able to provide ferromagnetic capabilities and excellent printing quality simultaneously compared to both existing soft and hard magnetic photosensitive resins.The established penetration depth model reveals the effect of particle size,solid loading,and absorbance on the curing characteristics of magnetic photosensitive resin.A high-precision forming and ferromagnetic capability of the NdFeB-Fe_(3)O_(4) magnetic photosensitive resin are comprehensively demonstrated.It is found that the photosensitive resin(NdFeB:Fe_(3)O_(4)=1:1)can print samples with sub-40μm fine features,reduced by 87%compared to existing hard magnetic photosensitive resin,and exhibits significantly enhanced coercivity and remanence in comparison with existing soft magnetic photosensitive resins,showing by an increase of 24 times and 6 times,respectively.The reported NdFeB-Fe_(3)O_(4) magnetic photosensitive resin is anticipated to provide a new functional material for the design and manufacture of next-generation micro-robotics,electromagnetic sensor,and magneto-thermal devices.展开更多
In recent years, additive manufacturing (AM), known as “3D printing”, has experienced exceptional growth thanks to the development of mechatronics and materials science. Fused filament deposition (FDM) manufacturing...In recent years, additive manufacturing (AM), known as “3D printing”, has experienced exceptional growth thanks to the development of mechatronics and materials science. Fused filament deposition (FDM) manufacturing is the most widely used technique in the field of AM, due to low operating and material costs. However, the materials commonly used for this technology are virgin thermoplastics. It is worth noting a considerable amount of waste exists due to failed print and disposable prototypes. In this regard, using green and sustainable materials is essential to limit the impact on the environment. The recycled, bio-based, and blended recycled materials are therefore a potential approach for 3D printing. In contrast, the lack of understanding of the mechanism of interlayer adhesion and the degradation of materials for FDM printing has posed a major challenge for these green materials. This paper provides an overview of the FDM technique and material requirements for 3D printing filaments. The main objective is to highlight the advantages and disadvantages of using recycled, bio-based, and blended materials based on thermoplastics for 3D printing filaments. In this work, solutions to improve the mechanical properties of 3D printing parts before, during, and after the printing process are pointed out. This paper provides an overview on choosing which materials and solutions depend on the specific application purposes. Moreover, research gaps and opportunities are mentioned in the discussion and conclusions sections of this study.展开更多
This paper takes the fuselage bracket of the quadrotor UAV as the object,combined with the characteristics of less constraints in the 3D printing process,achieves the optimal structure of the UAV body structure design...This paper takes the fuselage bracket of the quadrotor UAV as the object,combined with the characteristics of less constraints in the 3D printing process,achieves the optimal structure of the UAV body structure design form,using the inspire topology optimization analysis,with the optimization goal of maximizing the overall stiffness and the optimized structure was checked for strength and verified by 3D printing prototype.The results show that under the premise of meeting the design strength and stiffness requirements,the mass is reduced by 53.29%compared with the original design.The research shows that the application of topology optimization and 3D printing technology to the structural design of UAVs will achieve significant weight reduction effects,providing a feasible way to realize lightweight,complex and integrated design and manufacturing of components.展开更多
Projection micro stereolithography(PμSL)is a high-resolution(up to 0.6μm)3D printing technology based on area projection triggered photopolymerization,and capable of fabricating complex 3D architectures covering mul...Projection micro stereolithography(PμSL)is a high-resolution(up to 0.6μm)3D printing technology based on area projection triggered photopolymerization,and capable of fabricating complex 3D architectures covering multiple scales and with multiple materials.This paper reviews the recent development of the PμSL based 3D printing technologies,together with the related applications.It introduces the working principle,the commercialized products,and the recent multiscale,multimaterial printing capability of PμSL as well as some functional photopolymers that are suitable to PμSL.This review paper also summarizes a few typical applications of PμSL including mechanical metamaterials,optical components,4D printing,bioinspired materials and biomedical applications,and offers perspectives on the directions of the further development of PμSL based 3D printing technology.展开更多
The insulation effect of the air cavity surrounding the riser in a 3D printed sand mold was studied. The influence of the air cavity on heat flux was theoretically analyzed. The results demonstrated that the heat flux...The insulation effect of the air cavity surrounding the riser in a 3D printed sand mold was studied. The influence of the air cavity on heat flux was theoretically analyzed. The results demonstrated that the heat flux of the air cavity in the 3D printed sand mold was significantly less than that of resin-bonded sand. The insulation effect of the air cavity in sand molds for a cylinder casting and a stress-frame casting were simulated using software COMSOL. The results illustrated that the air cavity could be used to insulate the riser and it was more suitable for a lower melting point metal casting. An air cavity with 10-15 mm width and 5-10 mm away from the riser can significantly prolong the solidification of the riser by over 10%. Meanwhile, the sand mold for the stressframe was made by 3D printing technology and poured with aluminum alloy A356 melt. The experiment results showed that the presence of the air cavity led to a 12.5% increase of the solidification time of its riser.展开更多
The major drawback associated with PEEK implants is their biologically inert surface,which caused unsatisfactory cellular response and poor adhesion between the implants and surrounding soft tissues against proper bon...The major drawback associated with PEEK implants is their biologically inert surface,which caused unsatisfactory cellular response and poor adhesion between the implants and surrounding soft tissues against proper bone growth.In this study,polyetheretherketone(PEEK)was incorporated with calcium hydroxyapatite(cHAp)to fabricate a PEEK-cHAp biocomposite,using the fused deposition modeling(FDM)method and a surface treatment strategy to create microporous architectures onto the filaments of PEEK lattice scaffold.Also,nanostructure and morphological tests of the PEEK-cHAp biocomposite were modeled and analyzed on the FDM-printed PEEK-cHAp biocomposite sample to evaluate its mechanical and thermal strengths as well as in vitro cytotoxicity via a scanning electron microscope(SEM).A technique was used innovatively to create and investigate the porous nanostructure of the PEEK with controlled pore size and distribution to promote cell penetration and biological integration of the PEEK-cHAp into the tissue.In vivo tests demonstrated that the surface-treated micropores facilitated the adhesion of newly regenerated soft tissues to form tight implant-tissue interfacial bonding between the cHAp and PEEK.The results of the cell culture depicted that PEEK-cHAp exhibited better cell proliferation attachment spreading and higher alkaline phosphatase activity than PEEK alone.Apatite islands formed on the PEEK-cHAp composite after immersion in simulated body fluid of Dulbecco’s modified Eagle medium(DMEM)for 14 days and grew continuously with more or extended periods.The microstructure treatment of the crystallinity of PEEK was comparatively and significantly different from the PEEK-cHAp sample,indicating a better treatment of PEEK-cHAp.The in vitro results obtained from the PEEK-cHAp biocomposite material showed its biodegradability and performance suitability for bone implants.This study has potential applications in the field of biomedical engineering to strengthen the conceptual knowledge of FDM and medical implants fabricated from PEEK-cHAp biocomposite materials.展开更多
Tissue engineering is an emerging means for resolving the problems of tissue repair and organ replacement in regenerative medicine.Insufficient supply of nutrients and oxygen to cells in large-scale tissues has led to...Tissue engineering is an emerging means for resolving the problems of tissue repair and organ replacement in regenerative medicine.Insufficient supply of nutrients and oxygen to cells in large-scale tissues has led to the demand to prepare blood vessels.Scaffold-based tissue engineering approaches are effective methods to form new blood vessel tissues.The demand for blood vessels prompts systematic research on fabrication strategies of vascular scaffolds for tissue engineering.Recent advances in 3D printing have facilitated fabrication of vascular scaffolds,contributing to broad prospects for tissue vascularization.This review presents state of the art on modeling methods,print materials and preparation processes for fabrication of vascular scaffolds,and discusses the advantages and application fields of each method.Specially,significance and importance of scaffold-based tissue engineering for vascular regeneration are emphasized.Print materials and preparation processes are discussed in detail.And a focus is placed on preparation processes based on 3D printing technologies and traditional manufacturing technologies including casting,electrospinning,and Lego-like construction.And related studies are exemplified.Transformation of vascular scaffolds to clinical application is discussed.Also,four trends of 3D printing of tissue engineering vascular scaffolds are presented,including machine learning,near-infrared photopolymerization,4D printing,and combination of self-assembly and 3D printing-based methods.展开更多
基金the National Natural Science Foundation of China(Nos.51988101 and 42007262).
文摘3D printing is widely adopted to quickly produce rock mass models with complex structures in batches,improving the consistency and repeatability of physical modeling.It is necessary to regulate the mechanical properties of 3D-printed specimens to make them proportionally similar to natural rocks.This study investigates mechanical properties of 3D-printed rock analogues prepared by furan resin-bonded silica sand particles.The mechanical property regulation of 3D-printed specimens is realized through quantifying its similarity to sandstone,so that analogous deformation characteristics and failure mode are acquired.Considering similarity conversion,uniaxial compressive strength,cohesion and stress–strain relationship curve of 3D-printed specimen are similar to those of sandstone.In the study ranges,the strength of 3D-printed specimen is positively correlated with the additive content,negatively correlated with the sand particle size,and first increases then decreases with the increase of curing temperature.The regulation scheme with optimal similarity quantification index,that is the sand type of 70/140,additive content of 2.5‰and curing temperature of 81.6℃,is determined for preparing 3D-printed sandstone analogues and models.The effectiveness of mechanical property regulation is proved through uniaxial compression contrast tests.This study provides a reference for preparing rock-like specimens and engineering models using 3D printing technology.
基金financially supported by the Beijing Natural Science Foundation for Young Scientists(Grant No.8214052)the Talent Fund of Beijing Jiaotong University(Grant No.2021RC226)the State Key Laboratory for GeoMechanics and Deep Underground Engineering,China University of Mining and Technology(Grant No.SKLGDUEK2115).
文摘Three-dimensional(3D)printing technology has been widely used to create artificial rock samples in rock mechanics.While 3D printing can create complex fractures,the material still lacks sufficient similarity to natural rock.Extrusion free forming(EFF)is a 3D printing technique that uses clay as the printing material and cures the specimens through high-temperature sintering.In this study,we attempted to use the EFF technology to fabricate artificial rock specimens.The results show the physico-mechanical properties of the specimens are significantly affected by the sintering temperature,while the nozzle diameter and layer thickness also have a certain impact.The specimens are primarily composed of SiO_(2),with mineral compositions similar to that of natural rocks.The density,uniaxial compressive strength(UCS),elastic modulus,and tensile strength of the printed specimens fall in the range of 1.65–2.54 g/cm3,16.46–50.49 MPa,2.17–13.35 GPa,and 0.82–17.18 MPa,respectively.It is capable of simulating different types of rocks,especially mudstone,sandstone,limestone,and gneiss.However,the simulation of hard rocks with UCS exceeding 50 MPa still requires validation.
基金supported by the National Natural Science Foundation of China(52125501 and 52205317)the Key Research Project of Shaanxi Province(2021LLRH-08)+4 种基金the Program for Innovation Team of Shaanxi Province(2023-CX-TD-17)the Natural Science Basis Research Plan in Shaanxi Province of China(2022JQ-523)the High-Level Talent Recruitment Program of Shaanxi Provincethe Fundamental Research Funds for the Central UniversitiesChina Postdoctoral Science Foundation。
文摘3D printing stands at the forefront of transforming space exploration,offering unprecedented on-demand and rapid manufacturing capabilities.It adeptly addresses challenges such as mass reduction,intricate component fabrication,and resource constraints.Despite the obstacles posed by microgravity and extreme environments,continual advancements underscore the pivotal role of 3D printing in aerospace science.Beyond its primary function of producing space structures,3D printing contributes significantly to progress in electronics,biomedicine,and resource optimization.This perspective delves into the technological advantages,environmental challenges,development status,and opportunities of 3D printing in space.Envisioning its crucial impact,we anticipate that 3D printing will unlock innovative solutions,reshape manufacturing practices,and foster self-sufficiency in future space endeavors.
基金Supported by Heilongjiang Provincial Fruit Tree Modernization Agro-industrial Technology Collaborative Innovation and Promotion System Project(2019-13)。
文摘In order to obtain better quality cookies, food 3D printing technology was employed to prepare cookies. The texture, color, deformation, moisture content, and temperature of the cookie as evaluation indicators, the influences of baking process parameters, such as baking time, surface heating temperature and bottom heating temperature, on the quality of the cookie were studied to optimize the baking process parameters. The results showed that the baking process parameters had obvious effects on the texture, color, deformation, moisture content, and temperature of the cookie. All of the roasting surface heating temperature, bottom heating temperature and baking time had positive influences on the hardness, crunchiness, crispiness, and the total color difference(ΔE) of the cookie. When the heating temperatures of the surfac and bottom increased, the diameter and thickness deformation rate of the cookie increased. However,with the extension of baking time, the diameter and thickness deformation rate of the cookie first increased and then decreased. With the surface heating temperature of 180 ℃, the bottom heating temperature of 150 ℃, and baking time of 15 min, the cookie was crisp and moderate with moderate deformation and uniform color. There was no burnt phenomenon with the desired quality. Research results provided a theoretical basis for cookie manufactory based on food 3D printing technology.
基金the National Natural Science Foundation of China(52074166)Shandong Province(ZR2021YQ38)the Open Grant of State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines(SKLMRDPC20KF02).
文摘The existence of joints or other kinds of discontinuities has a dramatic efect on the stability of rock excavations and engineering.As a result,a great challenge in rock mass mechanics testing is to prepare rock or rock-like samples with defects.In recent years,3D printing technology has become a promising tool in the feld of rock mass mechanics and engineering.This study frst reviews and discusses the research status of traditional test methods in rock mass mechanics tests of making rock samples with defects.Then,based on the comprehensive analysis of previous research,the application of 3D printing technology in rock mass mechanics is expounded from the following three aspects.The frst is the printing material.Although there are many materials for 3D printing,it has been found that 3D printing materials that can be used for rock mass mechanics research are very limited.After research,we summarize and evaluate printing material that can be used for rock mass mechanics studies.The second is the printing methodology,which mainly introduces the current application forms of 3D printing technology in rock mass mechanics.This includes printed precise casting molds and one-time printed samples.The last one is the printing model,which includes small-scale samples for mechanical tests and large-scale physical models.Then,the benefts and drawbacks of using 3D printing samples in mechanical tests and the validity of their simulation of real rock are discussed.Compared with traditional rock samples collected in nature or synthetic rock-like samples,the samples made by 3D printing technology have unique advantages,such as higher test repeatability,visualization of rock internal structure and stress distribution.There is thus great potential for the use of 3D printing in the feld of rock mass mechanics.However,3D printing materials also have shortcomings,such as insufcient material strength and accuracy at this stage.Finally,the application prospect of 3D printing technology in rock mass mechanics research is proposed.
基金financially supported by the National Natural Science Foundation of China (52125501)OPEN Project (BHJ17C019)+4 种基金the Key Research Project of Shaanxi Province (2021LLRH-08)the Program for Innovation Team of Shaanxi Province (2023-CX-TD-17)the Natural Science Basic Research Program of Shaanxi Province (2023-JCQN-0543)the China Postdoctoral Science Foundation (2021M702597)the Fundamental Research Funds for the Central Universities
文摘Three-dimensional(3D)printing technology has opened a new paradigm to controllably and reproducibly fabricate bioengineered neural constructs for potential applications in repairing injured nervous tissues or producing in vitro nervous tissue models.However,the complexity of nervous tissues poses great challenges to 3D-printed bioengineered analogues,which should possess diverse architectural/chemical/electrical functionalities to resemble the native growth microenvironments for functional neural regeneration.In this work,we provide a state-of-the-art review of the latest development of 3D printing for bioengineered neural constructs.Various 3D printing techniques for neural tissue-engineered scaffolds or living cell-laden constructs are summarized and compared in terms of their unique advantages.We highlight the advanced strategies by integrating topographical,biochemical and electroactive cues inside 3D-printed neural constructs to replicate in vivo-like microenvironment for functional neural regeneration.The typical applications of 3D-printed bioengineered constructs for in vivo repair of injured nervous tissues,bio-electronics interfacing with native nervous system,neural-on-chips as well as brain-like tissue models are demonstrated.The challenges and future outlook associated with 3D printing for functional neural constructs in various categories are discussed.
基金supported by the Young Scientist Project of National Key Research and Development Program of China(2021YFC2900600)the National Natural Science Foundation of China(52074166)Shandong Province(ZR2021YQ38).
文摘This study aims to investigate the benefcial efects of surface retaining elements (SREs) on the mechanical behaviors of bolted rock and roadway stability. 3D printing (3DP) technology is utilized to create rock analogue prismatic specimens for conducting this investigation. Uniaxial compression tests with acoustic emission (AE) and digital image correlation techniques have been conducted on 3DP specimens bolted with diferent SREs. The results demonstrate that the strength and modulus of elasticity of the bolted specimens show a positive correlation with the area of the SRE;the AE characteristics of the bolted specimens are higher than those of the unbolted specimen, but they decrease with an increase in SRE area, thus further improving the integrity of the bolted specimens. The reinforcement efect of SREs on the surrounding rock of roadways is further analyzed using numerical modelling and feld test. The results provide a better understanding of the role of SREs in rock bolting and the optimization of rock bolting design. Furthermore, they verify the feasibility of 3DP for rock analogues in rock mechanics tests.
基金financial support of this research by the National Natural Science Foundation of China (No. 51905446)the Research Center for Industries of the Future (RCIF) at Westlake University for partially supporting this work。
文摘Three-dimensional-structured metal oxides have myriad applications for optoelectronic devices.Comparing to conventional lithography-based manufacturing methods which face significant challenges for 3D device architectures,additive manufacturing approaches such as direct ink writing offer convenient,on-demand manufacturing of 3D oxides with high resolutions down to sub-micrometer scales.However,the lack of a universal ink design strategy greatly limits the choices of printable oxides.Here,a universal,facile synthetic strategy is developed for direct ink writable polymer precursor inks based on metal-polymer coordination effect.Specifically,polyethyleneimine functionalized by ethylenediaminetetraacetic acid is employed as the polymer matrix for adsorbing targeted metal ions.Next,glucose is introduced as a crosslinker for endowing the polymer precursor inks with a thermosetting property required for 3D printing via the Maillard reaction.For demonstrations,binary(i.e.,ZnO,CuO,In_(2)O_(3),Ga_(2)O_(3),TiO_(2),and Y_(2)O_(3)) and ternary metal oxides(i.e.,BaTiO_(3) and SrTiO_(3)) are printed into 3D architectures with sub-micrometer resolution by extruding the inks through ultrafine nozzles.Upon thermal crosslinking and pyrolysis,the 3D microarchitectures with woodpile geometries exhibit strong light-matter coupling in the mid-infrared region.The design strategy for printable inks opens a new pathway toward 3D-printed optoelectronic devices based on functional oxides.
基金the support of the National Natural Science Foundation of China(Grant Nos.42207199,52179113,42272333)Zhejiang Postdoctoral Scientific Research Project(Grant Nos.ZJ2022155,ZJ2022156)。
文摘Three-dimensional(3D)printing technology is increasingly used in experimental research of geotechnical engineering.Compared to other materials,3D layer-by-layer printing specimens are extremely similar to the inherent properties of natural layered rock masses.In this paper,soft-hard interbedded rock masses with different dip angles were prepared based on 3D printing(3DP)sand core technology.Uniaxial compression creep tests were conducted to investigate its anisotropic creep behavior based on digital imaging correlation(DIC)technology.The results show that the anisotropic creep behavior of the 3DP soft-hard interbedded rock mass is mainly affected by the dip angles of the weak interlayer when the stress is at low levels.As the stress level increases,the effect of creep stress on its creep anisotropy increases significantly,and the dip angle is no longer the main factor.The minimum value of the long-term strength and creep failure strength always appears in the weak interlayer within 30°–60°,which explains why the failure of the layered rock mass is controlled by the weak interlayer and generally emerges at 45°.The tests results are verified by comparing with theoretical and other published studies.The feasibility of the 3DP soft-hard interbedded rock mass provides broad prospects and application values for 3DP technology in future experimental research.
基金supported by Stable Support Plan Program for Higher Education Institutions(20220815094504001)Shenzhen Key Laboratory of Advanced Energy Storage(No.ZDSYS20220401141000001).
文摘Three-dimensional(3D)printing,an additive manufacturing technique,is widely employed for the fabrication of various electrochemical energy storage devices(EESDs),such as batteries and supercapacitors,ranging from nanoscale to macroscale.This technique offers excellent manufacturing flexibility,geometric designability,cost-effectiveness,and eco-friendliness.Recent studies have focused on the utilization of 3D-printed critical materials for EESDs,which have demonstrated remarkable electrochemical performances,including high energy densities and rate capabilities,attributed to improved ion/electron transport abilities and fast kinetics.However,there is a lack of comprehensive reviews summarizing and discussing the recent advancements in the structural design and application of 3D-printed critical materials for EESDs,particularly rechargeable batteries.In this review,we primarily concentrate on the current progress in 3D printing(3DP)critical materials for emerging batteries.We commence by outlining the key characteristics of major 3DP methods employed for fabricating EESDs,encompassing design principles,materials selection,and optimization strategies.Subsequently,we summarize the recent advancements in 3D-printed critical materials(anode,cathode,electrolyte,separator,and current collector)for secondary batteries,including conventional Li-ion(LIBs),Na-ion(SIBs),K-ion(KIBs)batteries,as well as Li/Na/K/Zn metal batteries,Zn-air batteries,and Ni–Fe batteries.Within these sections,we discuss the 3DP precursor,design principles of 3D structures,and working mechanisms of the electrodes.Finally,we address the major challenges and potential applications in the development of 3D-printed critical materials for rechargeable batteries.
基金This work was financially supported by the National Natural Science Foundation of China(No.U22A20129)National Science and Technology Major Project(No.2017-VI-0002-0072)+2 种基金National Key Research and Development Program of China(No.2018YFB1106600)Fundamental Research Funds for the Central Universities(WK5290000003)Students'Innovation and Entrepreneurship Foundation of USTC(Nos.CY2022G10 and CY2022C24).
文摘Ceramic cores are the key intermediate components of hollow blades for aero-engine.Conventional processes,such as hot-press molding and gel film casting,face difficulties in fabricating complex-structured ceramic cores due to the complexity of moulds and long process cycles.Stereolithography 3D printing provides a new idea for the fabrication of complex-structured ceramic cores.The effect of sintering temperature on open porosity,bulk density,weight loss rate,shrinkage rate,flexural strength and microstructure of the Al_(2)O_(3)-based ceramic core doped with 10vol.%polysilazane(PSZ)was studied.The sintering mechanism of PSZ-reinforced ceramic cores was analyzed.Results show that the optimum sintering temperature of PSZ-reinforced ceramic cores is 1,450°C.At this temperature,the open porosity of the ceramic core is 36.60%,bulk density is 2.33 g·cm^(-3),weight loss rate is 22.11%,shrinkage rate along the X,Y,Z directions is 5.72%,5.01%,9.61%,respectively;the flexural strength is 28.794 MPa at 25°C and 13.649 MPa at 1,500°C.Properties of 3D printing PSZ-reinforced ceramic cores can meet the casting requirement of superalloy hollow blades,which is expected to promote the industrial application of 3D printing complex structure ceramic cores.
基金financially sponsored by the National Key Research and Development Program of China(2018YFA0703000)the National Natural Science Foundation of China(No.U1909218)+2 种基金the Joint Funds of Guangdong Basic and Applied Basic Research Foundation(2019A1515110261)the Special Projects in Key Fields from the Department of Education of Guangdong Province(2022ZDZX2059)the Dongguan Science and Technology of Social Development Program(20221800905072)。
文摘Because of the complex nerve anatomy and limited regeneration ability of natural tissue,the current treatment effect for long-distance peripheral nerve regeneration and spinal cord injury(SCI)repair is not satisfactory.As an alternative method,tissue engineering is a promising method to regenerate peripheral nerve and spinal cord,and can provide structures and functions similar to natural tissues through scaffold materials and seed cells.Recently,the rapid development of 3D printing technology enables researchers to create novel 3D constructs with sophisticated structures and diverse functions to achieve high bionics of structures and functions.In this review,we first outlined the anatomy of peripheral nerve and spinal cord,as well as the current treatment strategies for the peripheral nerve injury and SCI in clinical.After that,the design considerations of peripheral nerve and spinal cord tissue engineering were discussed,and various 3D printing technologies applicable to neural tissue engineering were elaborated,including inkjet,extrusion-based,stereolithography,projection-based,and emerging printing technologies.Finally,we focused on the application of 3D printing technology in peripheral nerve regeneration and spinal cord repair,as well as the challenges and prospects in this research field.
基金supported by the National Natural Science Foundation of China(No.81171731)the Project of Chengdu Science and Technology Bureau(Nos.2021-YF05-01619-SN and 2021-RC05-00022-CG)+2 种基金the Science and Technology Project of Tibet Autonomous Region(Nos.XZ202202YD0013C and XZ201901-GB-08)the Sichuan Science and Technology Program(No.2022YFG0066)the 1·3·5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(Nos.ZYJC21026,ZYGD21001 and ZYJC21077).
文摘At present,the clinical reconstruction of the auricle usually adopts the strategy of taking autologous costal cartilage.This method has great trauma to patients,poor plasticity and inaccurate shaping.Three-dimensional(3D)printing technology has made a great breakthrough in the clinical application of orthopedic implants.This study explored the combination of 3D printing and tissue engineering to precisely reconstruct the auricle.First,a polylactic acid(PLA)polymer scaffold with a precisely customized patient appearance was fabricated,and then auricle cartilage fragments were loaded into the 3D-printed porous PLA scaffold to promote auricle reconstruction.In vitro,gelatin methacrylamide(GelMA)hydrogels loaded with different sizes of rabbit ear cartilage fragments were studied to assess the regenerative activity of various autologous cartilage fragments.In vivo,rat ear cartilage fragments were placed in an accurately designed porous PLA polymer ear scaffold to promote auricle reconstruction.The results indicated that the chondrocytes in the cartilage fragments could maintain the morphological phenotype in vitro.After three months of implantation observation,it was conducive to promoting the subsequent regeneration of cartilage in vivo.The autologous cartilage fragments combined with 3D printing technology show promising potential in auricle reconstruction.
基金supported by the National Key Research and Development Program of China(Grant Number2022YFB460001602)National Natural Science Foundation of China(Grant Numbers 52125505,U20A20297)the Key-area Research and Development Program of Guangdong Province(Grant Number 2020B090923003)。
文摘The development of projection-based stereolithography additive manufacturing techniques and magnetic photosensitive resins has provided a powerful approach to fabricate miniaturized magnetic functional devices with complex three-dimensional spatial structures.However,the present magnetic photosensitive resins face great challenges in the trade-off between high ferromagnetism and excellent printing quality.To address these challenges,we develop a novel NdFeB-Fe_(3)O_(4) magnetic photosensitive resin comprising 20 wt.%solid loading of magnetic particles,which can be used to fabricate high-precision and ferromagnetic functional devices via micro-continuous liquid interface production process.This resin combining ferromagnetic NdFeB microparticles and strongly absorbing Fe_(3)O_(4) nanoparticles is able to provide ferromagnetic capabilities and excellent printing quality simultaneously compared to both existing soft and hard magnetic photosensitive resins.The established penetration depth model reveals the effect of particle size,solid loading,and absorbance on the curing characteristics of magnetic photosensitive resin.A high-precision forming and ferromagnetic capability of the NdFeB-Fe_(3)O_(4) magnetic photosensitive resin are comprehensively demonstrated.It is found that the photosensitive resin(NdFeB:Fe_(3)O_(4)=1:1)can print samples with sub-40μm fine features,reduced by 87%compared to existing hard magnetic photosensitive resin,and exhibits significantly enhanced coercivity and remanence in comparison with existing soft magnetic photosensitive resins,showing by an increase of 24 times and 6 times,respectively.The reported NdFeB-Fe_(3)O_(4) magnetic photosensitive resin is anticipated to provide a new functional material for the design and manufacture of next-generation micro-robotics,electromagnetic sensor,and magneto-thermal devices.
文摘In recent years, additive manufacturing (AM), known as “3D printing”, has experienced exceptional growth thanks to the development of mechatronics and materials science. Fused filament deposition (FDM) manufacturing is the most widely used technique in the field of AM, due to low operating and material costs. However, the materials commonly used for this technology are virgin thermoplastics. It is worth noting a considerable amount of waste exists due to failed print and disposable prototypes. In this regard, using green and sustainable materials is essential to limit the impact on the environment. The recycled, bio-based, and blended recycled materials are therefore a potential approach for 3D printing. In contrast, the lack of understanding of the mechanism of interlayer adhesion and the degradation of materials for FDM printing has posed a major challenge for these green materials. This paper provides an overview of the FDM technique and material requirements for 3D printing filaments. The main objective is to highlight the advantages and disadvantages of using recycled, bio-based, and blended materials based on thermoplastics for 3D printing filaments. In this work, solutions to improve the mechanical properties of 3D printing parts before, during, and after the printing process are pointed out. This paper provides an overview on choosing which materials and solutions depend on the specific application purposes. Moreover, research gaps and opportunities are mentioned in the discussion and conclusions sections of this study.
文摘This paper takes the fuselage bracket of the quadrotor UAV as the object,combined with the characteristics of less constraints in the 3D printing process,achieves the optimal structure of the UAV body structure design form,using the inspire topology optimization analysis,with the optimization goal of maximizing the overall stiffness and the optimized structure was checked for strength and verified by 3D printing prototype.The results show that under the premise of meeting the design strength and stiffness requirements,the mass is reduced by 53.29%compared with the original design.The research shows that the application of topology optimization and 3D printing technology to the structural design of UAVs will achieve significant weight reduction effects,providing a feasible way to realize lightweight,complex and integrated design and manufacturing of components.
基金the National Natural Science Foundation of China(51420105009).
文摘Projection micro stereolithography(PμSL)is a high-resolution(up to 0.6μm)3D printing technology based on area projection triggered photopolymerization,and capable of fabricating complex 3D architectures covering multiple scales and with multiple materials.This paper reviews the recent development of the PμSL based 3D printing technologies,together with the related applications.It introduces the working principle,the commercialized products,and the recent multiscale,multimaterial printing capability of PμSL as well as some functional photopolymers that are suitable to PμSL.This review paper also summarizes a few typical applications of PμSL including mechanical metamaterials,optical components,4D printing,bioinspired materials and biomedical applications,and offers perspectives on the directions of the further development of PμSL based 3D printing technology.
基金funded by the National Science and Technology Major Project of the Ministry of Science and Technology of China under Project No.2016YFB1100703
文摘The insulation effect of the air cavity surrounding the riser in a 3D printed sand mold was studied. The influence of the air cavity on heat flux was theoretically analyzed. The results demonstrated that the heat flux of the air cavity in the 3D printed sand mold was significantly less than that of resin-bonded sand. The insulation effect of the air cavity in sand molds for a cylinder casting and a stress-frame casting were simulated using software COMSOL. The results illustrated that the air cavity could be used to insulate the riser and it was more suitable for a lower melting point metal casting. An air cavity with 10-15 mm width and 5-10 mm away from the riser can significantly prolong the solidification of the riser by over 10%. Meanwhile, the sand mold for the stressframe was made by 3D printing technology and poured with aluminum alloy A356 melt. The experiment results showed that the presence of the air cavity led to a 12.5% increase of the solidification time of its riser.
基金We appreciate the funding/financial support received from the Higher Education Innovation Fund(HEIF)of De Montfort University,Leicester,UK,under Research Project No.0043.06.
文摘The major drawback associated with PEEK implants is their biologically inert surface,which caused unsatisfactory cellular response and poor adhesion between the implants and surrounding soft tissues against proper bone growth.In this study,polyetheretherketone(PEEK)was incorporated with calcium hydroxyapatite(cHAp)to fabricate a PEEK-cHAp biocomposite,using the fused deposition modeling(FDM)method and a surface treatment strategy to create microporous architectures onto the filaments of PEEK lattice scaffold.Also,nanostructure and morphological tests of the PEEK-cHAp biocomposite were modeled and analyzed on the FDM-printed PEEK-cHAp biocomposite sample to evaluate its mechanical and thermal strengths as well as in vitro cytotoxicity via a scanning electron microscope(SEM).A technique was used innovatively to create and investigate the porous nanostructure of the PEEK with controlled pore size and distribution to promote cell penetration and biological integration of the PEEK-cHAp into the tissue.In vivo tests demonstrated that the surface-treated micropores facilitated the adhesion of newly regenerated soft tissues to form tight implant-tissue interfacial bonding between the cHAp and PEEK.The results of the cell culture depicted that PEEK-cHAp exhibited better cell proliferation attachment spreading and higher alkaline phosphatase activity than PEEK alone.Apatite islands formed on the PEEK-cHAp composite after immersion in simulated body fluid of Dulbecco’s modified Eagle medium(DMEM)for 14 days and grew continuously with more or extended periods.The microstructure treatment of the crystallinity of PEEK was comparatively and significantly different from the PEEK-cHAp sample,indicating a better treatment of PEEK-cHAp.The in vitro results obtained from the PEEK-cHAp biocomposite material showed its biodegradability and performance suitability for bone implants.This study has potential applications in the field of biomedical engineering to strengthen the conceptual knowledge of FDM and medical implants fabricated from PEEK-cHAp biocomposite materials.
文摘Tissue engineering is an emerging means for resolving the problems of tissue repair and organ replacement in regenerative medicine.Insufficient supply of nutrients and oxygen to cells in large-scale tissues has led to the demand to prepare blood vessels.Scaffold-based tissue engineering approaches are effective methods to form new blood vessel tissues.The demand for blood vessels prompts systematic research on fabrication strategies of vascular scaffolds for tissue engineering.Recent advances in 3D printing have facilitated fabrication of vascular scaffolds,contributing to broad prospects for tissue vascularization.This review presents state of the art on modeling methods,print materials and preparation processes for fabrication of vascular scaffolds,and discusses the advantages and application fields of each method.Specially,significance and importance of scaffold-based tissue engineering for vascular regeneration are emphasized.Print materials and preparation processes are discussed in detail.And a focus is placed on preparation processes based on 3D printing technologies and traditional manufacturing technologies including casting,electrospinning,and Lego-like construction.And related studies are exemplified.Transformation of vascular scaffolds to clinical application is discussed.Also,four trends of 3D printing of tissue engineering vascular scaffolds are presented,including machine learning,near-infrared photopolymerization,4D printing,and combination of self-assembly and 3D printing-based methods.