期刊文献+
共找到653篇文章
< 1 2 33 >
每页显示 20 50 100
2-氨基-4-乙酰基嘧啶的合成研究
1
作者 刘杨 包安丽 +1 位作者 黄爱玲 张兴 《四川化工》 CAS 2024年第1期13-15,44,共4页
2-氨基-4-乙酰基嘧啶是乙酰基嘧啶类具有较好生物活性的一种杂环化合物,是制备含嘧啶环的磺胺类药物和磺酰脲类除草剂的重要中间体。研究了2-氨基-4-乙酰基嘧啶的合成途径和合成方法,阐述了用2,3-丁二酮合成2-氨基-4-乙酰基嘧啶的操作... 2-氨基-4-乙酰基嘧啶是乙酰基嘧啶类具有较好生物活性的一种杂环化合物,是制备含嘧啶环的磺胺类药物和磺酰脲类除草剂的重要中间体。研究了2-氨基-4-乙酰基嘧啶的合成途径和合成方法,阐述了用2,3-丁二酮合成2-氨基-4-乙酰基嘧啶的操作步骤和过程,对过程中遇到的问题及解决方法进行了说明,并通过新路径下的操作过程优化确定了最优反应参数和最终路线,为2,3-丁二酮合成2-氨基-4-乙酰基嘧啶探索出了一条安全、高效、高产的合成途径。 展开更多
关键词 2-氨基-4-乙酰基嘧啶 合成路线 3 3-二乙氧基-2-丁酮 烯胺酮 2-氨基-4-(1 1-二乙氧基乙基)嘧啶 最优反应参数
下载PDF
基于2-氨基-4-乙酰氨基苯甲醚的AMA高效合成路线研究
2
作者 韩兆林 蒙晓龙 +3 位作者 杜国峰 郑萌乐 余敦江 李荣刚 《山西化工》 CAS 2024年第10期40-41,61,共3页
传统的氨基丙二酸合成复杂耗时,因此,本文采用高纯度试剂和关键仪器,研究聚焦于高效合成氨基丙二酸。通过优化Ni/SiO_(2)催化剂的制备和加氢反应条件,在定制的反应装置中实现了高纯度AMA的合成,并通过HPLC验证产物纯度。研究结果显示,当... 传统的氨基丙二酸合成复杂耗时,因此,本文采用高纯度试剂和关键仪器,研究聚焦于高效合成氨基丙二酸。通过优化Ni/SiO_(2)催化剂的制备和加氢反应条件,在定制的反应装置中实现了高纯度AMA的合成,并通过HPLC验证产物纯度。研究结果显示,当Ni/SiO_(2)催化剂中镍质量分数为30%、反应温度为100℃、压力为1.8 MPa时,2-NMA加氢合成AMA的效率最优,获得高于99%的转化率和选择性。催化剂最佳用量为2-NMA质量的5%。产物结构通过谱图分析得到验证,证实了AMA的成功合成。 展开更多
关键词 氨基丙二酸 2-氨基-4-乙酰氨基苯甲醚 加氢工艺
下载PDF
New 4-imino-4H-Chromeno[2,3-d]Pyrimidin-3(5H)-Amine: Synthesis, Cytotoxic Effects on Tumoral Cell Lines and in Silico ADMET Properties
3
作者 Marwa Dhiabi Sirine Karoui +7 位作者 Mehdi Fakhfakh Souhir Abid Emmanuelle Limanton Rémy Le Guével Thierry Charlier Ludovic Paquin Jean-Pierre Bazureau Houcine Ammar 《International Journal of Organic Chemistry》 2024年第3期107-122,共16页
The synthesis of new 4-imino-4H-chromeno[2,3-d]pyrimidin-3(5H)-amine in four steps including one step under microwave dielectric heating is reported. The structural identity of the synthesized compounds was establishe... The synthesis of new 4-imino-4H-chromeno[2,3-d]pyrimidin-3(5H)-amine in four steps including one step under microwave dielectric heating is reported. The structural identity of the synthesized compounds was established according to their spectroscopic analysis, such as FT-IR, NMR and mass spectroscopy. These new compounds were tested for their antiproliferative activities on seven representative human tumoral cell lines (Huh7 D12, Caco2, MDA-MB231, MDA-MB468, HCT116, PC3 and MCF7) and also on fibroblasts. Among them, only the compounds 6c showed micromolar cytotoxic activity on tumor cell lines (1.8 50 50 > 25 μM). Finally, in silico ADMET studies ware performed to investigate the possibility of using of the identified compound 6c as potential anti-tumor compound. 展开更多
关键词 2-amino-4H-Chromene 4H-Chromeno[2 3-d]Pyrimidin-3(5H)-Amine Microwave Irradiation Tumoral Cell Line in Silico ADMET
下载PDF
新型2-氨基-4-苯基-3-氰基-4H-吡喃并熊果酸衍生物的设计合成及活性研究
4
作者 杨俊 黄蕊 +2 位作者 杨显娟 舒海霞 梁光平 《精细化工中间体》 CAS 2024年第5期10-14,共5页
以熊果酸为原料,经过氧化、缩合、取代、环化四步反应得到2-氨基-4-苯基-3-氰基-4H-吡喃并熊果酸衍生物4a、4b和4c,其结构经过^(1)H NMR、^(13)C NMR、HRMS确证。采用CCK-8法评价化合物4a~4c对人非小细胞肺癌细胞株(A549)、人肺腺癌耐... 以熊果酸为原料,经过氧化、缩合、取代、环化四步反应得到2-氨基-4-苯基-3-氰基-4H-吡喃并熊果酸衍生物4a、4b和4c,其结构经过^(1)H NMR、^(13)C NMR、HRMS确证。采用CCK-8法评价化合物4a~4c对人非小细胞肺癌细胞株(A549)、人肺腺癌耐顺铂细胞株(A549/DDP)的抗增殖活性,化合物4a~4c对A549及A549/DDP细胞的抑制活性都优于阳性对照药物顺铂,其中化合物4b对A549/DDP细胞表现出良好的体外抑制活性[IC_(50)=(0.087±0.003)μmol/L]及选择性。 展开更多
关键词 熊果酸 2-氨基-4-苯基-3-氰基-4H-吡喃 色烯 人肺腺癌耐顺铂细胞株A549/DDP
下载PDF
基于微通道技术合成2-氨基-5-氟-3',4'-二氯联苯
5
作者 严泽华 何星帅 +1 位作者 吴浩 尹凯 《世界农药》 CAS 2024年第5期54-60,共7页
2-氨基-5-氟-3',4'-二氯联苯是琥珀酸脱氢酶抑制剂(SDHI)类杀菌剂—联苯吡菌胺的重要中间体。基于微通道技术,以3,4-二氯苯胺为原料,经重氮化、中和、与对氟苯胺偶联得到2-氨基-5-氟-3',4'-二氯联苯。系统考察了影响重... 2-氨基-5-氟-3',4'-二氯联苯是琥珀酸脱氢酶抑制剂(SDHI)类杀菌剂—联苯吡菌胺的重要中间体。基于微通道技术,以3,4-二氯苯胺为原料,经重氮化、中和、与对氟苯胺偶联得到2-氨基-5-氟-3',4'-二氯联苯。系统考察了影响重氮化、中和、偶联3步对反应的影响,并得出优化条件:盐酸与3,4-二氯苯胺当量6:1,亚硝酸钠与3,4-二氯苯胺当量1.1︰1,成盐反应温度60℃,重氮反应温度25℃,氢氧化钠当量6.5︰1,中和温度25℃,偶联最佳温度120℃,对氟苯胺当量10︰1。在此优化条件下合成2-氨基-5-氟-3',4'-二氯联苯粗品含量85%,精制后含量可以达到98.5%,2步总收率65%。 展开更多
关键词 2-氨基-5-氟-3' 4'-二氯联苯 联苯吡菌胺 微通道技术
下载PDF
Effects of 4-amino-2-methyl-cantharidinimide on GABA_C receptors 被引量:1
6
作者 张艳欣 廖玉芳 +3 位作者 王明正 古艳婷 肖奕 王新风 《Journal of Chinese Pharmaceutical Sciences》 CAS 2012年第3期251-258,共8页
The antiepileptic effect of 4-amino-2-methyl-cantharidinimide(AMC) was reported,but its mechanism remains unknown.In this study,we investigated the effects of AMC on a rat model of penicillin-induced epilepsy.The do... The antiepileptic effect of 4-amino-2-methyl-cantharidinimide(AMC) was reported,but its mechanism remains unknown.In this study,we investigated the effects of AMC on a rat model of penicillin-induced epilepsy.The doses of 88 and 22 mg/kg AMC and the dose of 154 mg/kg sodium valproate(VPA) were administered intragastrically(i.g.) 30 min before penicillin injection,respectively.The epileptiform activity was verified by electrocorticographic(ECoG) recordings.The levels of GABA and GABAC receptors in hippocampus were determined by immunohistochemistry,and real-time polymerase chain reaction(RT-PCR) technique was used to detect the mRNA expression of GABAC receptor ρ2.The mean frequency and amplification of spike epileptiform activity were significantly decreased in AMC and VPA-pretreated rats compared with those of non-pretreated penicillin-induced epilepsy(PIE) group.The levels of GABA,GABAC receptors and the mRNA expression of GABAC receptors ρ2 in AMC and VPA-pretreated rats were significantly increased as compared with PIE group.These findings indicate that AMC and VPA have an antiepileptic effect on PIE in rats,and the antiepileptic effect of AMC may be mediated by the GABAC receptors and GABA. 展开更多
关键词 4-amino-2-methyl-cantharidinimide Antiepileptic effect GABAc receptors IMMUNOHISTOCHEMISTRY RT-PCR
原文传递
Ni/SiO_(2)催化剂催化2-硝基-4-乙酰胺基苯甲醚加氢性能研究
7
作者 丁军委 王树森 +3 位作者 徐广文 唐培龙 尚鸿瑞 赵石磊 《青岛科技大学学报(自然科学版)》 CAS 2023年第1期27-34,共8页
Ni系催化剂具有原料丰富,价格低的优点,本研究将Ni负载在SiO_(2)表面,用于2-硝基-4-乙酰胺基苯甲醚(NMA)加氢反应。Ni/SiO_(2)催化剂采用溶胶-凝胶法制备,用BET、XRD、SEM、TEM、NH_(3)-TPD、H_(2)-TPR等表征技术对催化剂结构进行表征,... Ni系催化剂具有原料丰富,价格低的优点,本研究将Ni负载在SiO_(2)表面,用于2-硝基-4-乙酰胺基苯甲醚(NMA)加氢反应。Ni/SiO_(2)催化剂采用溶胶-凝胶法制备,用BET、XRD、SEM、TEM、NH_(3)-TPD、H_(2)-TPR等表征技术对催化剂结构进行表征,考察了加氢反应性能随催化剂结构、反应温度和压力变化规律。以商用雷尼镍催化剂作为对照,考察催化剂催化NMA加氢反应性能。研究结果表明:Ni负载量为30%时,Ni/SiO_(2)催化剂适量的酸性和Ni纳米粒子之间的协同作用使得Ni/SiO_(2)表现出最高的催化活性;在100℃、加氢压力1.8 MPa条件下反应2 h, NMA转化率达到100%,目标产物2-氨基-4-乙酰氨基苯甲醚(AMA)选择性超过99.3%。 展开更多
关键词 2-氨基-4-乙酰氨基苯甲醚 催化加氢 2-硝基-4-乙酰胺基苯甲醚
下载PDF
Structure identification of 4-amino-2-(arylamino)thiazole-5-carboxylic esters
8
作者 Hai-Long Zhao Hua-Long Chen +1 位作者 Jie Zhou Bai-Ling Xu 《Chinese Chemical Letters》 SCIE CAS CSCD 2016年第2期302-304,共3页
In our previous work,we found a new method by chance for the synthesis of thiazole derivatives with diversified substitutes on 2-and 5-positions of the thiazole scaffold which was published in Chinese Chemical Letters... In our previous work,we found a new method by chance for the synthesis of thiazole derivatives with diversified substitutes on 2-and 5-positions of the thiazole scaffold which was published in Chinese Chemical Letters[2014,Vol.25 p.411].The structures were identified by ~1H NMR,^(13)C NMR and HRMS as 2-alkoxy-4-amino-Narylthiazole-5-carboxamides. 展开更多
关键词 In PPM Structure identification of 4-amino-2 arylamino)thiazole-5-carboxylic esters HRMS
原文传递
4-氨基-1-羟基-2-氧-1,8-萘啶-3-甲酰胺类化合物抑制HIV整合酶链转移活性的主要微观结构因素探究
9
作者 康家雄 李爱秀 +1 位作者 靳玉瑞 肖泽云 《化学与生物工程》 CAS 2023年第6期16-21,34,共7页
以25个4-氨基-1-羟基-2-氧-1,8-萘啶-3-甲酰胺类化合物为研究对象,利用遗传函数逼近法(GFA)构建了10个二维定量构效关系(2D-QSAR)模型,从中选取最优模型并检验其预测可靠性,并分析4-氨基-1-羟基-2-氧-1,8-萘啶-3-甲酰胺类化合物抑制HIV... 以25个4-氨基-1-羟基-2-氧-1,8-萘啶-3-甲酰胺类化合物为研究对象,利用遗传函数逼近法(GFA)构建了10个二维定量构效关系(2D-QSAR)模型,从中选取最优模型并检验其预测可靠性,并分析4-氨基-1-羟基-2-氧-1,8-萘啶-3-甲酰胺类化合物抑制HIV整合酶链转移活性的主要微观结构因素。结果表明,最优2D-QSAR模型的R^(2)=0.7776、Q^(2)=0.6421、r^(2)=0.87、(r^(2)-r′02)/r^(2)=0.01、k′=0.97、r^(2)_(m)=0.58,具有较高的稳定性和外部预测能力;热力学描述符AlogP、电拓扑状态描述符ES_Sum_sssN、ES_Sum_ssCH 2和空间描述符Shadow_nu是影响4-氨基-1-羟基-2-氧-1,8-萘啶-3-甲酰胺类化合物抑制HIV整合酶链转移活性的主要微观结构因素,其中Shadow_nu是最重要的微观结构因素。 展开更多
关键词 4-氨基-1-羟基-2-氧-1 8-萘啶-3-甲酰胺 整合酶链转移 抑制剂 遗传函数逼近法 二维定量构效关系
下载PDF
Removal of 5-Amino-2-chlorotoluene-4-sulfonic and Chlorhydric Acids from Wastewater by Weakly Basic Resin 被引量:3
10
作者 李长海 许振良 李春平 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2006年第5期696-699,共4页
This research deals with an investigation of the adsorption of two acids, namely, 5-amino- 2-chlorotoluene-4-sulfonic and chlorhydric acids from their solution onto weakly basic resin. The screening of res-ins, kineti... This research deals with an investigation of the adsorption of two acids, namely, 5-amino- 2-chlorotoluene-4-sulfonic and chlorhydric acids from their solution onto weakly basic resin. The screening of res-ins, kinetics, and isotherm were studied. The results indicate that the D301R is more appropriate for the removal of acids from solution. The adsorption of acids obeys Langmuir isotherm and the first-order kinetics model. Sorptive affinity of the two acids on D301R was found to be in the order of 5-amino-2-chlorotoluene-4-sulfonic acid> chlorhydric acid. Thermodynamic parameters for the adsorption of acids were calculated and discussed. The maxi-mum removal of acids was observed around 97% and 76% at 25℃ for 5-amino-2-chlorotoluene-4-sulfonic acid and chlorhydric acid , respectively. 展开更多
关键词 5-amino-2-chlorotoluene-4-sulfonic acid chlorhydric acid ADSORPTION weakly basic resin
下载PDF
An Efficient and Rapid Synthesis of 2-amino-4-arylthiazoles Employing Microwave Irradiation in Water 被引量:1
11
作者 Kishor S. Jain Jitender B. Bariwal +4 位作者 Muthu K. Kathiravan Vikas K. Raskar Gajanan S. Wankhede Nitin A. Londhe Satish N. Dighe 《Green and Sustainable Chemistry》 2011年第2期35-38,共4页
A facile, high yielding green chemical synthetic protocol adaptable to the parallel synthesis of a library of potentially bioactive 2-amino-4-arylthiazoles is reported herein. The methodology involves the condensation... A facile, high yielding green chemical synthetic protocol adaptable to the parallel synthesis of a library of potentially bioactive 2-amino-4-arylthiazoles is reported herein. The methodology involves the condensation of various aracyl bromides with N-arylthioureas under MWI using water as solvent, to yield pure products (81%-97%) in very short reaction times (1-20 min). 展开更多
关键词 Green CHEMICAL Synthesis MWI WATER 2-amino-4-arylthiazoles
下载PDF
Microwave promoted one-pot synthesis of 3-(2′-amino-3′-cyano-4′-arylpyrid-6′-yl)coumarins 被引量:1
12
作者 Jian Feng Zhou Gui Xia Gong +1 位作者 Feng Xia Zhu San Jun Zhi 《Chinese Chemical Letters》 SCIE CAS CSCD 2009年第1期37-39,共3页
A facile procedure for the synthesis of 3-(2′-amino-3′-cyano-4′-arylpyrid-6′-yl) coumarins are being reported starting from 3- acetylcoumarin, aromatic aldehydes and malononitrile. The reactions were carried out... A facile procedure for the synthesis of 3-(2′-amino-3′-cyano-4′-arylpyrid-6′-yl) coumarins are being reported starting from 3- acetylcoumarin, aromatic aldehydes and malononitrile. The reactions were carried out on microwave irradiation in good yield with short time and easy work-up. The structures of all the compounds have been confirmed on the basis of their analytical, IR, ^1H NMR, and mass spectral data. 展开更多
关键词 3-(2-amino-3′-cyano-4′arylpyrid-6′-yl) coumarin Aromatic aldehyde 3-Acetylcoumarin Microwave irradiation
下载PDF
1,6-二氢-4-甲基-6-氧代-3-吡啶磺酰氯的合成工艺研究
13
作者 周瑞 周志旭 +5 位作者 岳朝晨 张娅 李磊 高笛 鹿田 柴慧芳 《广东化工》 CAS 2024年第3期1-3,共3页
1,6-二氢-4-甲基-6-氧代-3-吡啶磺酰氯是一种重要医药化工中间体。本文以4-甲基-5-硝基吡啶-2-醇为原料,经两步反应得到目标化合物。该合成方法操作简便、后处理操作简便,花费时间少且产物纯度高,产品收率为33.51%;此方法为1,6-二氢-4-... 1,6-二氢-4-甲基-6-氧代-3-吡啶磺酰氯是一种重要医药化工中间体。本文以4-甲基-5-硝基吡啶-2-醇为原料,经两步反应得到目标化合物。该合成方法操作简便、后处理操作简便,花费时间少且产物纯度高,产品收率为33.51%;此方法为1,6-二氢-4-甲基-6-氧代-3-吡啶磺酰氯的合成提供了合成路线,也为进一步相关类似的合成研究奠定基础。 展开更多
关键词 4-甲基-5-硝基吡啶-2-醇 5-氨基-4-甲基吡啶-2-醇 合成 工艺 医药
下载PDF
Removal of 5-Amino-2-chlorotoluene-4-sulfonic and Chlorhydric Acids From Wastewater by Weakly Basic Resin: Equilibrium and Kinetics
14
作者 CHANG-HAI LI 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2007年第5期392-397,共6页
Objective To study the adsorption of 5-Amino-2-chlorotoluene-4-sulfonic (CLT) and chlorhydric (HCl) acids from wastewater by weakly basic resin. Methods The kinetics and isotherm were studied. Thermodynamic parameters... Objective To study the adsorption of 5-Amino-2-chlorotoluene-4-sulfonic (CLT) and chlorhydric (HCl) acids from wastewater by weakly basic resin. Methods The kinetics and isotherm were studied. Thermodynamic parameters for the adsorption of acids were calculated and discussed. Results The adsorption of CLT and HCl acids followed Langmuir isotherm and the first-order kinetics model. Conclusion The adsorptive affinity of the two acids on D301R is in the order of CLT acid 〉 HCl acid. CLT and HCl acids can be separated. 展开更多
关键词 5-amino-2-chlorotoluene-4-sulfonic acid Chlorhydric acid ADSORPTION Weakly basic resin
下载PDF
Synthesis and Evaluation of 2-Amino-4H-Pyran-3-Carbonitrile Derivatives as Antitubercular Agents
15
作者 Chunxia Chen Minghui Lu +4 位作者 Zhihui Liu Junting Wan Zhengchao Tu Tianyu Zhang Ming Yan 《Open Journal of Medicinal Chemistry》 2013年第4期128-135,共8页
A series of 2-amino-4H-pyran-3-carbonitrile derivatives were designed and synthesized. Their antitubercular activities were evaluated against autoluminescent M. tuberculosis H37Ra and standard strain M. tuberculosis H... A series of 2-amino-4H-pyran-3-carbonitrile derivatives were designed and synthesized. Their antitubercular activities were evaluated against autoluminescent M. tuberculosis H37Ra and standard strain M. tuberculosis H37Rv. No obvious antitubercular activities could be observed (MIC > 10 ug/mL). The results are in sharp contrast with the previously reported data. 展开更多
关键词 2-amino-4H-Pyran-3-Carbonitrile SYNTHESIS ANTITUBERCULAR Activity
下载PDF
Spectroscopic Characterization, Molecular Modeling and DFT/TD-DFT/PCM Calculations of Novel Hydrogen-Bonded Charge Transfer Complex between Chloranilic Acid and 2-Amino-4,6-Dimethylpyridine
16
作者 Khairia M. Al-Ahmary Fatimah A. Alshehri +1 位作者 Faten M. Atlam Mohamed K. Awad 《Open Journal of Physical Chemistry》 2020年第1期1-32,共32页
A charge transfer hydrogen bonded complex between the electron donor (proton acceptor) 2-amino-4,6-dimethylpyridine with the electron acceptor (proton donor) chloranilic acid has been synthesized and studied experimen... A charge transfer hydrogen bonded complex between the electron donor (proton acceptor) 2-amino-4,6-dimethylpyridine with the electron acceptor (proton donor) chloranilic acid has been synthesized and studied experimentally and theoretically. The stability constant recorded high values indicating the high stability of the formed complex. In chloroform, ethanol, methanol and acetonitrile were found the stoichiometric ratio 1:1. The solid complex was prepared and characterized by different spectroscopy techniques. FTIR, 1H and 13C NMR studies supported the presence of proton and charge transfers in the formed complex. Complemented with experimental results, molecular modelling using the density functional theory (DFT) calculations was carried out in the gas, chloroform and methanol phases where the existence of charge and hydrogen transfers. Finally, a good consistency between experimental and theoretical calculations was found confirming that the applied basis set is the suitable one for the system under investigation. 展开更多
关键词 2-amino-4 6-Dimethylpyridine Charge Transfer DFT Hydrogen BOND Molecular Modelling COMPUTATIONS and Spectroscopy
下载PDF
Theoretical Study on the Reaction Mechanism of 2-Methoxybenzaldehyde,4-Bromo-indanone,Malononitrile and Ammonium Acetate One-pot to Form 6-(2-Methoxyphenyl)-2-amino-6-bromo-5H-indeno[1,2-b]pyridine-3-carbonitrile
17
作者 张福兰 黄辉胜 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2017年第10期1685-1696,共12页
The reaction mechanism of 2-methoxybenzaldehyde, 4-bromo-indanone, malononitrile and ammonium acetate one-pot to form 6-(2-methoxyphenyl)-2-amino-6-bromo-5 Hindeno[1,2-b]pyridine-3-carbonitrile was studied by densit... The reaction mechanism of 2-methoxybenzaldehyde, 4-bromo-indanone, malononitrile and ammonium acetate one-pot to form 6-(2-methoxyphenyl)-2-amino-6-bromo-5 Hindeno[1,2-b]pyridine-3-carbonitrile was studied by density functional theory. The geometries of the reactants, transition states, intermediates and products were optimized at the PW91/DNP level. Vibration analysis was carried out to confirm the transition state structure. Reaction pathways were investigated in this study. The result indicates that the reaction Re→ TSB1→IMB1→ TSB2→ IMB2→TSB3→IMB3→TSB4→IMB4→TSB5→IMB5→TSB6→IMB6→TSB7→IMB7→ TSB8→IMB8→TSB9→IMB9→P2 is the main pathway, the activation energy of which is the lowest. The dominant product predicted theoretically is in agreement with the experiment results. 展开更多
关键词 2-methoxybenzaldehyde 4-bromo-indanone 6-(2-methoxyphenyl)-2-amino-6-bromo-5H-indeno[1 2-b]pyridine-3-carbonitrile density functional reaction mechanism
下载PDF
Syntheses and Characterization of Two New Alkaline Earth Metal-organic Topological Frameworks with 3-Amino-1H-1,2,4-triazole-5-carboxylate
18
作者 陈友存 许军军 +1 位作者 汪快兵 王彦 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2011年第6期799-804,共6页
Two new alkaline earth metal coordination polymers constructed from the deriva-tive of 1,2,4-triazole are presented herein,namely,{[Sr(AmTAZAc)2(H2O)]}(1) and {[Ba(AmTAZAc)2(H2O)]}(2)(AmTAZAc = 3-amino-1H... Two new alkaline earth metal coordination polymers constructed from the deriva-tive of 1,2,4-triazole are presented herein,namely,{[Sr(AmTAZAc)2(H2O)]}(1) and {[Ba(AmTAZAc)2(H2O)]}(2)(AmTAZAc = 3-amino-1H-1,2,4-triazole-5-carboxylate),which have been synthesized by using the layering method and structurally characterized by elemental analysis,IR,and single-crystal X-ray diffraction.Complexes 1 and 2 are isostructural,and both crystallize in the orthorhombic system,space group Fdd2.X-ray structural analysis shows that 1 or 2 has an intriguing 3-D infinite network of(318.438.510) topology based on a 2-D sheet structure of(4,4) net.The result shows that noncovalent interactions play an important role in strengthening the whole structures of the compounds. 展开更多
关键词 coordination polymer alkaline earth metal complex topological frameworks 3-amino-1H-1 2 4-triazole-5-carboxylate
下载PDF
4-氨基-2-三氟甲基苯基维甲酸酯对MCF-7细胞增殖和分化的影响及其机制研究 被引量:10
19
作者 汪楠 陈飞虎 +3 位作者 葛金芳 潘春晓 彭晓清 居靖 《中国药理学通报》 CAS CSCD 北大核心 2013年第6期767-772,共6页
目的研究4-氨基-2-三氟甲基苯基维甲酸酯(4-ami-no-2-trifluoromethyl-phenyl retinate,ATPR)对人乳腺癌MCF-7细胞增殖和分化的作用及其可能机制。方法不同浓度的ATPR作用MCF-7细胞后,绘制细胞生长曲线,分析细胞增殖情况;瑞氏-吉姆萨染... 目的研究4-氨基-2-三氟甲基苯基维甲酸酯(4-ami-no-2-trifluoromethyl-phenyl retinate,ATPR)对人乳腺癌MCF-7细胞增殖和分化的作用及其可能机制。方法不同浓度的ATPR作用MCF-7细胞后,绘制细胞生长曲线,分析细胞增殖情况;瑞氏-吉姆萨染色法观察细胞形态学改变;酶联免疫法(ELISA法)检测粘蛋白(mucin 1,MUC-1)活性;RT-PCR法检测维甲酸受体(RARα、RARβ、RARγ)、维甲酸受体诱导基因1(RRIG1)、雌激素受体(ERα、ERβ)mRNA的表达;Western blot法检测RARα、RARβ、RARγ蛋白的表达。结果 ATPR明显抑制MCF-7细胞增殖,且随浓度和时间增加而逐渐增强;镜下观察ATPR作用72 h后MCF-7细胞形态趋向正常细胞分化;ELISA结果显示ATPR明显降低MCF-7细胞培养上清MUC-1浓度(P<0.05);ATPR作用MCF-7细胞72 h后,RARβ、RRIG1、ERβ表达增强(P<0.05),RARγ表达下调(P<0.05),RARα和ERα表达则无明显变化。结论 ATPR可明显抑制MCF-7细胞增殖并诱导其分化程度增高,其机制可能与调节维甲酸受体和雌激素受体平衡,并上调RRIG1表达有关。 展开更多
关键词 4-氨基-2-三氟甲基苯基维甲酸酯 乳腺癌 细胞增殖 细胞分化 MCF-7细胞 维甲酸衍生物
下载PDF
4-氨基-2-三氟甲基苯基维甲酸酯通过PTEN/PI3K/Akt抑制YAC-1细胞增殖和诱导其分化 被引量:6
20
作者 彭晓清 陈飞虎 +3 位作者 葛金芳 汪楠 潘春晓 雷静 《中国药理学通报》 CAS CSCD 北大核心 2014年第1期60-65,共6页
目的研究新型维甲酸衍生物4-氨基-2-三氟甲基苯基维甲酸酯(4-amino-2-trifluoromethyl—phenylretinate,ATPR)对鼠淋巴瘤YAC-1细胞增殖和分化的作用及其可能机制。方法不同浓度的ATPR作用鼠淋巴瘤YAC-1细胞后,MTT检测细胞生长抑制率... 目的研究新型维甲酸衍生物4-氨基-2-三氟甲基苯基维甲酸酯(4-amino-2-trifluoromethyl—phenylretinate,ATPR)对鼠淋巴瘤YAC-1细胞增殖和分化的作用及其可能机制。方法不同浓度的ATPR作用鼠淋巴瘤YAC-1细胞后,MTT检测细胞生长抑制率;LDH法检测细胞毒性;瑞氏-吉姆萨染色法检测细胞形态;NBT检测细胞分化阳性率;RT—PCR和Westernblot法检测维甲酸受体mRNA和蛋白表达变化;Westernblot法检测FFEN/P13K/Akt和cyclinD的蛋白表达。结果ATPR(10^-5、10^-6、10^-7、10^-8、10^-9mol·L^-1)用药后72h明显抑制YAC-1细胞增殖,其抑制作用随浓度和时间增加而逐渐增强;随着药物浓度升高,ATPR对YAC-1细胞毒性增强;ATPR(10^-5~10^-9mol·L^-1)作用72h后可诱导YAC-1细胞形态呈现高分化趋势,且NBT阳性率升高;ATPR(10^-5mol·L^-1)体外用药72h可诱导RARα的mR—NA和蛋白表达升高,但RARβ和RARγ表达无明显变化;而且可诱导PTEN表达升高并下调p-Akt和cyclinD的蛋白表达。结论ATPR可明显抑制YAC-1细胞增殖并诱导其分化,其机制可能是与RARα结合后参与调节PTEN/P13K/Akt信号通路,从而抑制cyclinD的过表达。 展开更多
关键词 4-氨基-2-三氟甲基苯基维甲酸酯 淋巴瘤 细胞增 细胞分化 YAC-1细胞 维甲酸衍生物 PTEN P13K AKT
下载PDF
上一页 1 2 33 下一页 到第
使用帮助 返回顶部