异甘草酸镁注射液与5%葡萄糖注射液、10%果糖注射液配伍的稳定性

目的:考察异甘草酸镁注射液与5%葡萄糖注射液、10%果糖注射液2种输液配伍的稳定性。方法:将异甘草酸镁注射液与5%葡萄糖注射液、10%果糖注射液按临床常用的浓度配伍,室温下放置8 h,分别于0、2、4、6、8 h取样,用高效液相色谱法测定异甘草酸镁的含量,用酸度计测定pH值,用光阻法测定其不溶性微粒。结果:异甘草酸镁注射液与上述2种注射液配伍后,8 h内的pH值、含量两项指标的变化在《中华人民共和国药典》(2010年版)规定的范围之内,但不溶性微粒指标较大,不符合相关规定。结论:异甘草酸镁注射液与5%葡萄糖注射液、10%果糖注射液配伍后,含量与pH值符合《中华人民共和国药典》(2010年版)规定,但不溶性微粒指标不符合规定,建议临床不配伍使用。

Dextrose in the banked blood products does not seem to affect the blood glucose levels in patients undergoing liver transplantation

AIM: Hyperglycemia commonly seen in liver transplantation (LT) has often been attributed to the dextrose in the storage solution of blood transfusion products. The purpose of the study is to compare the changes of the blood glucose levels in transfused and non-transfused patients during LT. METHODS: A retrospective study on 60 biliary pediatric patients and 16 adult patients undergoing LT was carried out. Transfused pediatric patients were included in Group Ⅰ (GⅠ), those not transfused in Group Ⅱ (GⅡ). Twelve adult patients were not given transfusion and assigned to Group Ⅲ(GⅢ); whereas, four adult patients who received massive transfusion were assigned to Group Ⅳ (GⅣ). The blood glucose levels, volume of blood transfused, and the volume of crystalloid infused were recorded, compared and analyzed. RESULTS: Results showed that the changes in blood glucose levels during LT for both non-transfused and minimally transfused pediatric groups and non-transfused and massively-transfused adult groups were almost the same. CONCLUSION: We conclude that blood transfusion does not cause significant changes in the blood glucose levels in this study.