Research progress on the mechanism of exercise against depression

The substantial global health burden of depression encourages the development of innovative and broadly effective interventions.This paper aimed to examine recent advancements by which exercise works as an antidepressant and recommends optimal types and quantity of exercise as supplemental therapies in treating depression.Sedentary behavior and low physical activity significantly influence the onset of depression.Being an effective treatment option,exercise can significantly reduce depression risk.Exercise exerts antidepressant effects as it modulates neurotransmitters,neuroplasticity,the immune system,and hormone levels.Effective exercise forms include yoga,strength training,and walking/jogging.Tailored exercise regimens that consider individual preferences and tolerability can improve outcomes.Regular exercise enhances general well-being and reduces depressive symptoms.Additional research is needed to understand the complex basis of exercise's effects on depression.Exercise is a cost-effective and accessible intervention for depression management that needs additional exploration.Thus,customized exercise programs,as per each patient’s needs,are essential for their successful implementation clinically.

一株吡虫啉羟基化菌株及其转化产物的鉴定

从南京地区的土壤中筛选出一株命名为NJ2的菌株,该菌株的静息细胞可催化杀虫剂吡虫啉为一种极性更大的化合物。经BioMerieux Vitek自动微生物分析系统仪和16S rDNA序列分析,NJ2菌株鉴定为嗜麦芽寡养单胞菌(Stenotrophomonas maltophilia)。采用有机溶剂萃取和重结晶可得到转化产物晶体,质谱分析结果显示转化产物分子离子峰为272,而底物分子离子峰为256,表明转化产物为吡虫啉的羟基化产物。核磁共振分析进一步表明羟基位于吡虫啉咪唑烷环上的5′碳原子上。转化动力学测试结果表明,转化10d后,吡虫啉的含量减少了1.15mmol/L,转化产物的含量达到1.10mmol/L,摩尔转化系数为95.9%。S.maltophiliaNJ2持续转化能力强和高摩尔转换系数的特点,可用于工业生产羟基吡虫啉并进一步合成更高杀虫活性的烯式吡虫啉。