24-Methylenecholest-5-ene-7-oxo-3β,19-diacetate 5 was synthesized starting from stigmasterol via twelve step reactions in 4.1% overall yield. It can be served as a key intermediate for the synthesis of 24-methylenech...24-Methylenecholest-5-ene-7-oxo-3β,19-diacetate 5 was synthesized starting from stigmasterol via twelve step reactions in 4.1% overall yield. It can be served as a key intermediate for the synthesis of 24-methylenecholest-5-ene-3β,7β,19-triol 1, a naturally occuring polyhydroxylated sterol with potential biological activity.展开更多
Five compounds were isolated from mycelia of A.awamori ,and identified as ergosta 5,7,22 trien 3 β ol(Ⅰ),hexadecanoic acid(Ⅱ),ergosta 7,22 diene 3 β,5α,6β triol(Ⅲ), 5α,8α epidioxyergosta 6,22 diene 3 β ol(Ⅳ...Five compounds were isolated from mycelia of A.awamori ,and identified as ergosta 5,7,22 trien 3 β ol(Ⅰ),hexadecanoic acid(Ⅱ),ergosta 7,22 diene 3 β,5α,6β triol(Ⅲ), 5α,8α epidioxyergosta 6,22 diene 3 β ol(Ⅳ)and ergosta 7,22 diene 3,6 dione(Ⅴ)on the basis of spectral data and physical and chemical identification respectively.Among them,compound V was obtained from this genus for the first time.展开更多
Two new spirostanol saponins, (25S)-spirostane-1β,3β,5β-triol 3-O-β-D-glucopyrano- side 1 and rhodeasapogenin 3-O-β-D-glucopyranosyl-(1 → 4)-β-D-glucopyranoside 2, together with a known saponin, rhodeasapogenin...Two new spirostanol saponins, (25S)-spirostane-1β,3β,5β-triol 3-O-β-D-glucopyrano- side 1 and rhodeasapogenin 3-O-β-D-glucopyranosyl-(1 → 4)-β-D-glucopyranoside 2, together with a known saponin, rhodeasapogenin 3-O-β-D-glucopyranoside 3, were isolated from the underground parts of Tupistra chinensis Bak.. Their structures were determined by spectroscopic analysis.展开更多
A new degraded sesquiterpene was isolated from the marine actinomycete Streptomyces sp. 0616208. Its structure was elucidated as （1α; 4aα; 5α, 7β, 8aβ）-5, 8a-dimethyl-decahydrona- phthalene-1, 4a, 7-triol on th...A new degraded sesquiterpene was isolated from the marine actinomycete Streptomyces sp. 0616208. Its structure was elucidated as （1α; 4aα; 5α, 7β, 8aβ）-5, 8a-dimethyl-decahydrona- phthalene-1, 4a, 7-triol on the basis of spectroscopic data.展开更多
Microbial transformation of diosgenin(1) was carried out with the white-rot fungus,Coriolus versicolor.A new polyhydroxyl metabolite,(25R)-spirost-5-ene-3β,7β,21-triol(2),was obtained as a result of hydroxylation.It...Microbial transformation of diosgenin(1) was carried out with the white-rot fungus,Coriolus versicolor.A new polyhydroxyl metabolite,(25R)-spirost-5-ene-3β,7β,21-triol(2),was obtained as a result of hydroxylation.Its structure was elucidated on the basis of 1D and 2D NMR as well as HR-ESI-MS spectroscopic analysis.展开更多
基金We are grateful to the National Natural Science Foundation of China (No. 29932030)the NationalHigh Technology Development Project (No. 2001AA624030)the Natural Science Foundationof Guangdong Province (No. 04300569) for financial support for this work.
文摘24-Methylenecholest-5-ene-7-oxo-3β,19-diacetate 5 was synthesized starting from stigmasterol via twelve step reactions in 4.1% overall yield. It can be served as a key intermediate for the synthesis of 24-methylenecholest-5-ene-3β,7β,19-triol 1, a naturally occuring polyhydroxylated sterol with potential biological activity.
文摘Five compounds were isolated from mycelia of A.awamori ,and identified as ergosta 5,7,22 trien 3 β ol(Ⅰ),hexadecanoic acid(Ⅱ),ergosta 7,22 diene 3 β,5α,6β triol(Ⅲ), 5α,8α epidioxyergosta 6,22 diene 3 β ol(Ⅳ)and ergosta 7,22 diene 3,6 dione(Ⅴ)on the basis of spectral data and physical and chemical identification respectively.Among them,compound V was obtained from this genus for the first time.
文摘Two new spirostanol saponins, (25S)-spirostane-1β,3β,5β-triol 3-O-β-D-glucopyrano- side 1 and rhodeasapogenin 3-O-β-D-glucopyranosyl-(1 → 4)-β-D-glucopyranoside 2, together with a known saponin, rhodeasapogenin 3-O-β-D-glucopyranoside 3, were isolated from the underground parts of Tupistra chinensis Bak.. Their structures were determined by spectroscopic analysis.
文摘A new degraded sesquiterpene was isolated from the marine actinomycete Streptomyces sp. 0616208. Its structure was elucidated as （1α; 4aα; 5α, 7β, 8aβ）-5, 8a-dimethyl-decahydrona- phthalene-1, 4a, 7-triol on the basis of spectroscopic data.
基金supported by the National Natural Science Foundation of China(No.30770237)the Program for New Century Excellent Talents in University(No.NCET-05-0852)
文摘Microbial transformation of diosgenin(1) was carried out with the white-rot fungus,Coriolus versicolor.A new polyhydroxyl metabolite,(25R)-spirost-5-ene-3β,7β,21-triol(2),was obtained as a result of hydroxylation.Its structure was elucidated on the basis of 1D and 2D NMR as well as HR-ESI-MS spectroscopic analysis.
