Based on the analysis of nonlinear geometric characteristics of the suspension systems and tires, a 3D nonlinear dynamic model of a typical heavy truck is established. The impact factors of dynamic tire loads, includi...Based on the analysis of nonlinear geometric characteristics of the suspension systems and tires, a 3D nonlinear dynamic model of a typical heavy truck is established. The impact factors of dynamic tire loads, including the dynamic load stress factors, and the maximal and the minimal vertical dynamic load factors, are used to evaluate the dynamic interaction between heavy vehicles and roads under the condition of random road surface roughness. Matlab/Simulink is used to simulate the nonlinear dynamic system and calculate the impact factors. The effects of different road surface conditions on the safety of vehicle movement and the durability of parts of a vehicle are analyzed, as well as the effects of different structural parameters and different vehicle speeds on road surfaces. The study results provide both the warning limits of road surface roughness and the limits of corresponding dynamic parameters for the 5-axle heavy truck.展开更多
BACKGROUND The prognosis of gastric cancer in an advanced stage remains poor. The exact efficacy of the use of intraoperative sustained-release chemotherapy with 5-fluorouracil(5-FU) in advanced-stage gastric cancer i...BACKGROUND The prognosis of gastric cancer in an advanced stage remains poor. The exact efficacy of the use of intraoperative sustained-release chemotherapy with 5-fluorouracil(5-FU) in advanced-stage gastric cancer is still unelucidated.AIM To explore the long-term survival benefit of using sustained-release 5-FU implants in stage Ⅱ and stage Ⅲ gastric cancer patients.METHODS Patients with gastric cancer in a locally advanced stage and who underwent an R0 radical resection between Jan 2014, to Dec 2016, in this single institution were included. Patients with pathological diagnoses other than adenocarcinoma were excluded. All included patients were grouped according to whether intraoperative sustained-release(SR) chemotherapy with 5-FU was used or not(NSR). The primary end-point was 5-year overall survival. Kaplan–Meier method with logrank test was used to analyze the overall survival of patients and Cox analysis was used to analyze prognosis factors of these patients.RESULTS In total, there were 563 patients with gastric cancer with locally advanced stage, who underwent an R0 radical resection. 309 patients were included in the final analysis. 219(70.9%) were men, with an average age of 58.25 years. Furthermore, 56(18.1%) received neoadjuvant chemotherapy, and 191(61.8%) were in TNM stage Ⅲ. In addition, 158 patients received intraoperative sustainedrelease chemotherapy with 5-FU and were included in the SR group, while the other 161 patients were included in the NSR group. The overall complication rate was 12.94% in the whole group and 10.81%, 16.46% in SR and NSR groups, respectively. There were no significant differences between the two groups in overall survival and complication rate(P > 0.05). The multivariate cox analysis indicated that only N Stage and neoadjuvant therapy were independent influencing factors of survival.CONCLUSION Intraoperative sustained-release chemotherapy usage with 5-FU, did not improve the survival of patients who underwent an R0 radical resection in locally advanced stage of gastric cancer.展开更多
In this study, we aimed to investigate the influencing factors of postoperative 5-year survival rate in non small-cell lung cancer（NSCLC） patients with stage I–III. We enrolled 220 patients who underwent surgical o...In this study, we aimed to investigate the influencing factors of postoperative 5-year survival rate in non small-cell lung cancer（NSCLC） patients with stage I–III. We enrolled 220 patients who underwent surgical operation and survived longer than 3 months, with histologically confirmed adenocarcinoma or squamous cell carcinoma from Jan. 2009 to Dec. 2009. Multiple variables, like age, gender, smoking, alcohol, obesity, family history of cancer, diabetes, hypertension, antidiabetic drugs, tumor staging, pathology, treatments, surgical side as well as lipid levels, were selected. We found that tumor staging was associated with 5-year survival rate of stage I–III NSCLC patients by univariate analysis. Furthermore, diabetes mellitus, hypertension and surgical side were associated with the overall survival of NSCLC patients with stage I, stageⅡand stage III, respectively. In conclusion, the status of chronic disease had potential effect on the postoperative 5-year survival rate of lung cancer patients.展开更多
目的对比分析CiteScore(CS)与影响因子(IF)、5年影响因子(5IF)在社会科学引文索引(SSCI)信息科学与图书馆学期刊中对期刊评价效果的异同。方法在Web of Science数据库(WoS)期刊引证报告(JCR)内获得2016年信息科学与图书馆学各期刊IF、5I...目的对比分析CiteScore(CS)与影响因子(IF)、5年影响因子(5IF)在社会科学引文索引(SSCI)信息科学与图书馆学期刊中对期刊评价效果的异同。方法在Web of Science数据库(WoS)期刊引证报告(JCR)内获得2016年信息科学与图书馆学各期刊IF、5IF及其他相关指标,在Scopus数据库获得2016年收录的信息科学与图书馆学各期刊的CS及其相关指标,选取两种数据库中共同收录的53种期刊为研究对象,将数据整理到Excel 2007表格,并采用SPSS 17.0软件对IF、5IF和CS进行相关性分析。结果⑴53种期刊IF和CS均值分别为1.282和1.616,二者差异有统计学意义(Z=4.546,P=0.000),5IF均值(1.588)和CS均值差异无统计学意义(Z=1.138,P=0.255)。⑵53种期刊中IF>CS的有12种(22.6%),其余41种(77.4%)期刊均是IF<CS。5IF>CS的有25种(47.2%),5IF<CS的有27种(50.9%)。⑶IF、5IF和CS的排序并不完全一致,有的甚至相差较大。⑷48种期刊(90.6%)在Scopus数据库中的分区均优于SSCI内的分区。⑸CS与IF、5IF大小具有显著正相关(r=0.789,0.842,均P=0.000),排序具有高度正相关(r=0.936,0.956,均P=0.000)。结论 IF、5IF和CS指标对期刊影响力评价具有一致性,但CS和5IF的相关性更强。展开更多
以Web of Science和JCR为数据来源,借助于h-index、五年期影响因子(IF5)和某一期刊的hindex所涵盖的所有论文的被引频次密度中位数hTci-median 3个指标,通过对物理、生命医学基础、财经和社会科学领域在JCR2010年引证报告中IF5排名前50...以Web of Science和JCR为数据来源,借助于h-index、五年期影响因子(IF5)和某一期刊的hindex所涵盖的所有论文的被引频次密度中位数hTci-median 3个指标,通过对物理、生命医学基础、财经和社会科学领域在JCR2010年引证报告中IF5排名前50的期刊的统计分析,确认它们在各自学科期刊中的核心地位,提出对个刊进行三段式评估的途径。此外,用大量的数据深入揭示h-index和IF5及新指标hTci-median在期刊评价中的内涵和属性区别,表明hTci-median成为一个新的期刊评价指标的科学性。展开更多
基金The Science and Technology Support Program of Jiangsu Province(No.BE201047)
文摘Based on the analysis of nonlinear geometric characteristics of the suspension systems and tires, a 3D nonlinear dynamic model of a typical heavy truck is established. The impact factors of dynamic tire loads, including the dynamic load stress factors, and the maximal and the minimal vertical dynamic load factors, are used to evaluate the dynamic interaction between heavy vehicles and roads under the condition of random road surface roughness. Matlab/Simulink is used to simulate the nonlinear dynamic system and calculate the impact factors. The effects of different road surface conditions on the safety of vehicle movement and the durability of parts of a vehicle are analyzed, as well as the effects of different structural parameters and different vehicle speeds on road surfaces. The study results provide both the warning limits of road surface roughness and the limits of corresponding dynamic parameters for the 5-axle heavy truck.
基金the CAMS Initiative for Innovative Medicine,No.2016-I2M-1-007。
文摘BACKGROUND The prognosis of gastric cancer in an advanced stage remains poor. The exact efficacy of the use of intraoperative sustained-release chemotherapy with 5-fluorouracil(5-FU) in advanced-stage gastric cancer is still unelucidated.AIM To explore the long-term survival benefit of using sustained-release 5-FU implants in stage Ⅱ and stage Ⅲ gastric cancer patients.METHODS Patients with gastric cancer in a locally advanced stage and who underwent an R0 radical resection between Jan 2014, to Dec 2016, in this single institution were included. Patients with pathological diagnoses other than adenocarcinoma were excluded. All included patients were grouped according to whether intraoperative sustained-release(SR) chemotherapy with 5-FU was used or not(NSR). The primary end-point was 5-year overall survival. Kaplan–Meier method with logrank test was used to analyze the overall survival of patients and Cox analysis was used to analyze prognosis factors of these patients.RESULTS In total, there were 563 patients with gastric cancer with locally advanced stage, who underwent an R0 radical resection. 309 patients were included in the final analysis. 219(70.9%) were men, with an average age of 58.25 years. Furthermore, 56(18.1%) received neoadjuvant chemotherapy, and 191(61.8%) were in TNM stage Ⅲ. In addition, 158 patients received intraoperative sustainedrelease chemotherapy with 5-FU and were included in the SR group, while the other 161 patients were included in the NSR group. The overall complication rate was 12.94% in the whole group and 10.81%, 16.46% in SR and NSR groups, respectively. There were no significant differences between the two groups in overall survival and complication rate(P > 0.05). The multivariate cox analysis indicated that only N Stage and neoadjuvant therapy were independent influencing factors of survival.CONCLUSION Intraoperative sustained-release chemotherapy usage with 5-FU, did not improve the survival of patients who underwent an R0 radical resection in locally advanced stage of gastric cancer.
基金General Research Program of Medical Health in Zhejiang Province(Grant No.2014KYB039)Zhejiang Provincial Program for the Zhejiang Medical and Health Science and Technology Program(Grant No.2015KYB071)+2 种基金Scientific Research Fund Project of Integrated Chinese and Western Medicine Institute in Zhejiang Province(Grant No.2014LYK021)Science and Technology in Zhejiang Province Chinese Medicine Program(Grant No.2016ZA038)1022 Talent Training Program of Zhejiang Cancer Hospital
文摘In this study, we aimed to investigate the influencing factors of postoperative 5-year survival rate in non small-cell lung cancer（NSCLC） patients with stage I–III. We enrolled 220 patients who underwent surgical operation and survived longer than 3 months, with histologically confirmed adenocarcinoma or squamous cell carcinoma from Jan. 2009 to Dec. 2009. Multiple variables, like age, gender, smoking, alcohol, obesity, family history of cancer, diabetes, hypertension, antidiabetic drugs, tumor staging, pathology, treatments, surgical side as well as lipid levels, were selected. We found that tumor staging was associated with 5-year survival rate of stage I–III NSCLC patients by univariate analysis. Furthermore, diabetes mellitus, hypertension and surgical side were associated with the overall survival of NSCLC patients with stage I, stageⅡand stage III, respectively. In conclusion, the status of chronic disease had potential effect on the postoperative 5-year survival rate of lung cancer patients.
文摘以Web of Science和JCR为数据来源,借助于h-index、五年期影响因子(IF5)和某一期刊的hindex所涵盖的所有论文的被引频次密度中位数hTci-median 3个指标,通过对物理、生命医学基础、财经和社会科学领域在JCR2010年引证报告中IF5排名前50的期刊的统计分析,确认它们在各自学科期刊中的核心地位,提出对个刊进行三段式评估的途径。此外,用大量的数据深入揭示h-index和IF5及新指标hTci-median在期刊评价中的内涵和属性区别,表明hTci-median成为一个新的期刊评价指标的科学性。
