The synthesis of Benzhydryl 6a-Bromopenicillanic acid -1-oxide with air catalyzed by Fe(NO3)3-FeBr3 using Benzhydryl 6a-Bromopenicillanic acid as starting material was reported. The oxidation was selective and no sulf...The synthesis of Benzhydryl 6a-Bromopenicillanic acid -1-oxide with air catalyzed by Fe(NO3)3-FeBr3 using Benzhydryl 6a-Bromopenicillanic acid as starting material was reported. The oxidation was selective and no sulfone was formed. Compared with conventional method, using the Fe(NO3)3-FeBr3 as catalyst, the reaction time was reduced from 4 h to 1 h and the yield was enhanced from 65.0% to 93.5%.展开更多
The title compound, 4β,6α,9α-trimethy-2-carboxyltricyclo[6.3.0.0^（4,5）]undec-2-ene, is a sesquiterpene which was first isolated from Ligularia caloxantha and characterized by MS and NMR. In addition, the structur...The title compound, 4β,6α,9α-trimethy-2-carboxyltricyclo[6.3.0.0^（4,5）]undec-2-ene, is a sesquiterpene which was first isolated from Ligularia caloxantha and characterized by MS and NMR. In addition, the structure was determined by X-ray single-crystal diffraction. It crystallizes in orthorhombie, space group P212121 with a = 8.197（2）, b = 14.876（3）, c = 22.281（6） A, α = β = γ = 90°, V = 2716.9（11） ]A^3, Z = 8, C15H22O2, Mr = 234.34, Dc = 1.146 g/cm^3, μ（MoKa） = 0.074 mm^-1, F（000） = 1024, the final R = 0.0384 and wR = 0.0856 for 6200 independent reflections （Rint = 0.066） and 2538 observed ones （I 〉 2σ（I））. In the molecule, there are three fused five-membered rings; while in this crystal form, the asymmetric unit contains two molecules of the same hand and they are linked together by two intermolecular O-H...O hydrogen bonds to form a dimer.展开更多
文摘The synthesis of Benzhydryl 6a-Bromopenicillanic acid -1-oxide with air catalyzed by Fe(NO3)3-FeBr3 using Benzhydryl 6a-Bromopenicillanic acid as starting material was reported. The oxidation was selective and no sulfone was formed. Compared with conventional method, using the Fe(NO3)3-FeBr3 as catalyst, the reaction time was reduced from 4 h to 1 h and the yield was enhanced from 65.0% to 93.5%.
文摘The title compound, 4β,6α,9α-trimethy-2-carboxyltricyclo[6.3.0.0^（4,5）]undec-2-ene, is a sesquiterpene which was first isolated from Ligularia caloxantha and characterized by MS and NMR. In addition, the structure was determined by X-ray single-crystal diffraction. It crystallizes in orthorhombie, space group P212121 with a = 8.197（2）, b = 14.876（3）, c = 22.281（6） A, α = β = γ = 90°, V = 2716.9（11） ]A^3, Z = 8, C15H22O2, Mr = 234.34, Dc = 1.146 g/cm^3, μ（MoKa） = 0.074 mm^-1, F（000） = 1024, the final R = 0.0384 and wR = 0.0856 for 6200 independent reflections （Rint = 0.066） and 2538 observed ones （I 〉 2σ（I））. In the molecule, there are three fused five-membered rings; while in this crystal form, the asymmetric unit contains two molecules of the same hand and they are linked together by two intermolecular O-H...O hydrogen bonds to form a dimer.
