EFFECT OF ACUPUNCTURE-MOXIBUSTION PLUS CHINESE MEDICINAL HERBS ON PLASMA TXB_2, 6-Keto-PGF1α IN PATIENTS WITH VASCULAR DEMENTIA

In the present paper, changes of TXB2, 6-Keto-PGF1α contents before and after treatment by using acupuncture, moxibustion and Chinese medicinal herbs and in comparison with the normal values of healthy people were observed in 30 vascular dementia (VD) patients. Results showed that in VD patients, the content of serum TXB2 increased significantly and that of 6-Keto-PG1α decreased markedly in comparison with control group (P<0. 01), suggesting a significant imbalance between plasma TXB2 and 6-Keto-PG1α; after combined treatment with acupuncture, moxibustion and Chinese herbs, the content of plasma 6-Keto-PG1α raised remarkably and that of TXBα lowered,which had a positive correlation with clinical therapeutic effect. The fact indicates that this combined treatment is capable of regulating the balance between plasma TXB2 and 6-Keto-PG1α, increasing cerebral blood flow, raising the metabolic rate of the brain tissues and improving functions of the brain.

儿茶酚胺对大鼠血管内皮功能的影响

目的探讨儿茶酚胺对大鼠血管内皮分泌功能的影响。方法利用大鼠异丙肾上腺素(ISP)心肌损伤模型,采用放免的方法测定血中内皮素(ET-1),前列腺素代谢产物6-酮前列腺素F1α(6-keto-PG1α)和血栓素B2(TXB2)的含量。结果试验组ISP导致血浆中ET-1明显增高;6-keto-PG1α含量明显降低而TXB2的含量明显增高。结论异丙肾上腺素损伤血管内皮分泌功能,从而可能影响血管的舒缩功能、血小板的凝血与止血的平衡状态,进一步导致心肌损伤及其他脏器的损伤。

五福饮颗粒剂对大鼠实验性膝骨关节炎预防作用的实验研究

目的:探讨五福饮颗粒剂(WFYG)对膝骨关节炎预防作用机制。方法:将30只大鼠随机分为假手术组、模型组和中药预防组,每组各10只;模型组和预防组均采用Hulth法建立大鼠KOA模型;预防组大鼠造模当天即灌胃WFYG,假手术组和模型组灌胃等量生理盐水,共10周。采用ELISA测定大鼠血清及关节液白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)的含量,采用IHC法检测大鼠软骨骨形态发生蛋白-2(BMP-2)的表达,采用PAS法检测大鼠软骨蛋白多糖(PG)的表达。结果:与模型组相比,WFYG可以显著降低血清及关节液中IL-1β、IL-6含量(P<0.01),上调软骨组织BMP-2的表达(P<0.01),延缓软骨中PG的丢失(P<0.01)。结论:WFYG预防KOA作用机制可能与其降低KOA大鼠血清和关节液中炎IL-1β和IL-6含量,减少炎性反应,提高软骨细胞分泌BMP-2,促进关节软骨合成蛋白多糖PG有关。