Synthesis of the disaccharide [3-D-Glup-（1→3）-6-deoxy-α-L-Talp Ⅱ, and its dimer Ⅲ from the O-antigenic polysaccharide of Burkholderia pseudomallei strain 304b, were achieved through assembly of suitably synthesi...Synthesis of the disaccharide [3-D-Glup-（1→3）-6-deoxy-α-L-Talp Ⅱ, and its dimer Ⅲ from the O-antigenic polysaccharide of Burkholderia pseudomallei strain 304b, were achieved through assembly of suitably synthesized building blocks, 4-methox- ylphenyl 6-deoxy-2,4-di-O-benzoyl-α-L-talopyranoside （7）, 3-O-allyl-2,4,6-tri-O-benzoyl-α,β-D-glucopyranosyl trichloroacetimi- date （8） and 2,3,4,6-tetra-O-benzoyl-α,β-D-glucopyranosyl trichloroacetimidate （11）. The total yield of Ⅲ from 4-methoxylphenyl 2.3-O-isopropvlidene-α-L-rhamnoovranoside （1） was 18%.展开更多
基金supported by the Doctoral Program Foundation of Institutions of Higher Education of China(No:20070019072).
文摘Synthesis of the disaccharide [3-D-Glup-（1→3）-6-deoxy-α-L-Talp Ⅱ, and its dimer Ⅲ from the O-antigenic polysaccharide of Burkholderia pseudomallei strain 304b, were achieved through assembly of suitably synthesized building blocks, 4-methox- ylphenyl 6-deoxy-2,4-di-O-benzoyl-α-L-talopyranoside （7）, 3-O-allyl-2,4,6-tri-O-benzoyl-α,β-D-glucopyranosyl trichloroacetimi- date （8） and 2,3,4,6-tetra-O-benzoyl-α,β-D-glucopyranosyl trichloroacetimidate （11）. The total yield of Ⅲ from 4-methoxylphenyl 2.3-O-isopropvlidene-α-L-rhamnoovranoside （1） was 18%.
