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Effects of 6-minute walk test on the QT dispersion in patients with congestive heart failure
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作者 惠海鹏 许顶立 李琦 《Journal of Medical Colleges of PLA(China)》 CAS 2003年第1期42-44,共3页
Objective: To investigate the clinical value of QT dispersion (QTd) and the effects of 6-minute walk test (6-MWT) mimicking the patients' daily activities on QTd in patients with congestive heart failure (CHF).Met... Objective: To investigate the clinical value of QT dispersion (QTd) and the effects of 6-minute walk test (6-MWT) mimicking the patients' daily activities on QTd in patients with congestive heart failure (CHF).Methods: Twenty-eight CHF patients and 22 normal subjects participated these study, who all completed 6-MWT without developing severe arrhythmias.Before and after 6-MWT, standardized 12-lead surface ECGs were obtained to measure QTd and corrected QTd (QTcd).Results: Both before and after 6-MWT, the QTd and QTcd in CHF patients were longer than those in the controls (P<0.001), and QTd and QTcd after 6-MWT were significantly shorter than those before 6-MWT in CHF patients (P=0.007, and 0.018).There was no significant difference in the measurement in the control group.Conclusion: QTd and QTcd are longer in CHF patients than in normal subjects.Moderate exercise may improve the inhomogeneity of ventricular repolarization dispersion in CHF patients. 展开更多
关键词 congestive heart failure QT dispersion 6-minute walk test
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An Assessment of Cardiovascular Functional Capacity of a Group of Chronic Heart Failure Patients Using the 6-Minute Walk Test in a Cameroonian Urban Setting
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作者 Félicité Kamdem Chris Nadège Nganou-Gnindjio +10 位作者 Dieudonné Danwe Franc Christ-Roi Soemessabot Elysée Claude Bika Léle Ba Hamadou Sidick Mouliom Lade Viché Henri Ngoté Caroline Kenmegne Marie Solange Ndom Ebongue Siddikatou Djibrilla William Ngatchou 《World Journal of Cardiovascular Diseases》 2023年第6期275-282,共8页
Background: Chronic heart failure is a public health problem worldwide. It has a high mortality rate and is accompanied by a decreased functional capacity and alteration of the quality of life. Objective: This st... Background: Chronic heart failure is a public health problem worldwide. It has a high mortality rate and is accompanied by a decreased functional capacity and alteration of the quality of life. Objective: This study aimed to assess the cardiovascular functional capacity of a group of patients suffering from heart failure using the 6-minute walk test (6 MWT). Methods: This was a cross-sectional study carried out in the cardiology unit of Douala’s general hospital for 4 months. We included all eligible patients aged 18 years or more who had stable chronic heart failure and gave informed consent. Those who had an acute coronary syndrome (≤1 month), tachycardia (HR ≥ 120 bpm), high blood pressure (SBP ≥ 180 mmHg and/or DBP ≥ 100 mmHg) and reduced mobility due to orthopaedic reasons were excluded. A 6 MWT was done according to the American Thoracic Society guidelines. The 6 MWT result was considered poor for - 450 m and good for >450 m. Results: We recruited a total of 81 patients (61.7% women) with a mean age of 65.9 ± 10.6 years. The most frequent risk factor for heart failure was high blood pressure (77.8%), alcohol consumption(69.1%) and a sedentary lifestyle (53.1%). The left ventricular ejection fraction was mostly preserved (42.0%) or mildly altered (46.9). The 6 MWT results were poor in 55.6% of cases, average in 19.8% of cases and good in only 24.7% of cases. More than half (59.3%) of the participants perceived the effort as being difficult. The cardiovascular functional capacity was significantly associated with age, heart failure stage and physical activity (p Conclusion: Most patients suffering from chronic stable heart failure in the general hospital of Douala have poor cardiovascular functional capacity. 展开更多
关键词 Cardiovascular Functional Capacity Chronic Heart Failure 6-minute walk Test Cameroon
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Six-Minute Walk Test in Patients with Rheumatoid Arthritis
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作者 Sandor Balsamo Ana Paula Monteiro Gomides +5 位作者 Licia Maria Henrique da Mota Frederico Santos de Santana Raphaela Franco Miranda Talita Yokoy Luciana Muniz Leopoldo Luiz Santos-Neto 《Open Journal of Rheumatology and Autoimmune Diseases》 2019年第1期14-24,共11页
Background: The 6-minute walk test (6TC) was initially used as an instrument for assessing physical and cardiorespiratory capacity, but is currently being used to monitor treatments, and compare physical interventions... Background: The 6-minute walk test (6TC) was initially used as an instrument for assessing physical and cardiorespiratory capacity, but is currently being used to monitor treatments, and compare physical interventions and prognostic evaluation. Although already recognized as a research method in several specialties, 6TC has not been used in rheumatology. Patients with rheumatoid arthritis (RA) may have impaired functional capacity as well as increased cardiovascular mortality. An adequate functional evaluation of these patients is necessary and the 6TC may be useful in this sense. Objective: The aim of this study was to perform the 6-minute walk test in RA patients and to compare the performance with a control group. Method: A cross-sectional study was carried out in which the sample consisted of 85 women, 46 patients with rheumatoid arthritis and 39 healthy controls. A descriptive analysis of the data was performed. One-Way ANOVA methodology was used to compare the patient and control groups followed by the graphic analysis. Results: The distance walked on the 6TC by RA patients was on average 522.2 meters. In the distance control group found in the 6TC was on average 628.8 meters, the difference being statistically significant. Conclusion: In this study the distance covered in 6TC by women with RA was lower than that of healthy women of the same age. 展开更多
关键词 6-minute walk Test RHEUMATOID ARTHRITIS Functional Capacity Physical Capacity CARDIORESPIRATORY Capacity PERSON Performed
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Relationship between 6-minute walk test and pulmonary function test in stable chronic obstructive pulmonary disease with different severities 被引量:5
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作者 CHEN Hong LIANG Bin-miao +5 位作者 TANG Yong-jiang XU Zhi-bo WANG Ke YI Qun OU Xue-mei FENG Yu-lin 《Chinese Medical Journal》 SCIE CAS CSCD 2012年第17期3053-3058,共6页
Background The relationship between the 6-minute walk test (6MWT) and pulmonary function test in stable chronic obstructive pulmonary disease (COPD) remains unclear. We evaluate the correlation of 6MWT and spirome... Background The relationship between the 6-minute walk test (6MWT) and pulmonary function test in stable chronic obstructive pulmonary disease (COPD) remains unclear. We evaluate the correlation of 6MWT and spirometric parameters in stable COPD with different severities. 6MWT data assessed included three variables: the 6-minute walk distance (6MWD), 6-minute walk work (6MWORK), and pulse oxygen desaturation rate (SPO2%). Methods 6MWT and pulmonary function test were assessed for 150 stable COPD patients with different severities. Means and standard deviations were calculated for the variables of interest. Analysis of variance was performed to compare means. Correlation coefficients were calculated for 6MWT data with the spirometric parameters and dyspnea Borg scale. Multiple stepwise regression analysis was used to screen pulmonary function-related predictors of 6MWT data. Results The three variables of 6MWT all varied as the severities of the disease. The 6MWD and 6MWORK both correlated with some spirometric parameters (positive or negative correlation; the absolute value of r ranging from 0.34 to 0.67; P 〈0.05) in severe and very severe patients, and the SPO2% correlated with the dyspnea Borg scale in four severities (t= -0.33, -0.34, -0.39, -0.53 respectively; P 〈0.05). The 6MWD was correlated with the 6MWORK in four severities (r=0.56, 0.57, 0.72, 0.81 respectively, P 〈0.05), and neither of them correlated with the SPO2%. The percent of predicted forced expiratory volume in 1 second (FEV1% predicted) and residual volume to total lung capacity ratio (RV/TLC) were predictors of the 6MWD, and the maximum voluntary ventilation (MW) was the predictor of the 6MWORK. Conclusions 6MWT correlated with the spirometric parameters in severe and very severe COPD patients. 6MWT may be used to monitor changes of pulmonary function in these patients. 展开更多
关键词 pulmonary disease chronic obstructive 6-minute walk test pulmonary function test correlation analysis
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延续护理对老年慢性心衰患者6min步行试验及再住院率的影响研究 被引量:6
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作者 王延华 《中医临床研究》 2017年第36期108-109,共2页
目的:探讨延续护理对老年慢性心衰患者6min步行试验及再住院率的影响,并进行研究。方法:选取我院2015年2月-2017年2月收治的老年慢性心衰患者142例作为研究对象,随机分为两组。对照组患者应用常规护理方法,研究组患者在常规护理基础上... 目的:探讨延续护理对老年慢性心衰患者6min步行试验及再住院率的影响,并进行研究。方法:选取我院2015年2月-2017年2月收治的老年慢性心衰患者142例作为研究对象,随机分为两组。对照组患者应用常规护理方法,研究组患者在常规护理基础上联合延续护理干预,两组患者护理时间均为3个月,出院时均进行6min步行试验及3个月内再住院率比较。结果:研究组患者出院6min步行试验检测结果显著优于对照组患者(P<0.05),再住院率方面显著低于对照组患者(P<0.05)。结论:老年慢性心衰患者在常规护理基础上联合出院后延续护理干预,在改善患者心功能情况的同时提升患者6min步行试验成绩,并将再住院率有效降低。 展开更多
关键词 延续护理 老年慢性心衰患者 6min步行试验 再住院率 影响
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丹蒌通痹汤对冠心病心绞痛痰瘀阻络证临床疗效、心绞痛发作情况、脑钠肽及6 min步行实验的影响
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作者 倪飞珍 《安徽医药》 2025年第2期395-399,共5页
目的探究丹蒌通痹汤对冠心病心绞痛痰瘀阻络证病人临床疗效、心绞痛发作情况、脑钠肽(BNP)及6 min步行实验(6MWT)的影响。方法选取2020年6月至2022年6月永康市中医院收治的94例冠心病心绞痛痰瘀阻络证病人。采用随机数字表法分为两组,... 目的探究丹蒌通痹汤对冠心病心绞痛痰瘀阻络证病人临床疗效、心绞痛发作情况、脑钠肽(BNP)及6 min步行实验(6MWT)的影响。方法选取2020年6月至2022年6月永康市中医院收治的94例冠心病心绞痛痰瘀阻络证病人。采用随机数字表法分为两组,对照组(47例)进行常规的西药治疗,观察组(47例)在对照组的基础上服用丹蒌通痹汤,4周为1个疗程,连续治疗1个疗程。评估两组中医症状评分及临床疗效,统计心绞痛发作情况。检测两组治疗前后血清BNP水平,比较两组6MWT结果,并观察治疗方案的安全性。结果两组病人治疗后中医症状主症、次症及总评分均降低(P<0.05),且观察组中医症状主症、次症及总评分均低于对照组(P<0.05);观察组治疗总有效率为91.47%,高于对照组的74.47%(P<0.05);两组病人心绞痛发作次数、持续时间、硝酸甘油用量及疼痛程度均降低(P<0.05),且观察组心绞痛发作次数、持续时间、硝酸甘油用量及疼痛程度均低于对照组(P<0.05);两组治疗后BNP水平降低、6MWT水平升高(P<0.05),且观察组BNP水平低于对照组,6MWT水平高于对照组(P<0.05);对照组、观察组不良反应率分别为12.77%、17.02%,差异无统计学意义(P>0.05)。结论丹蒌通痹汤能够提高冠心病心绞痛痰瘀阻络证病人的临床疗效,改善临床症状和病人心功能,有效减少心绞痛的发作,安全性较高。 展开更多
关键词 冠心病 心绞痛 丹蒌通痹汤 痰瘀阻络证 脑钠肽 6 min步行实验
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太极拳运动对COPD患者康复效果的影响 被引量:1
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作者 董理 马志君 《当代体育科技》 2015年第34期17-18,共2页
慢性阻塞性肺疾病(COPD)是当前世界各国积极防治但治疗效果不佳的一种疾病。该论文内容即是探讨配合太极拳运动的综合干预方案在此疾病防治中的积极作用,研究多途径、多手段、多学科干预对慢性阻塞性肺疾病的防治作用。通过太极拳运动... 慢性阻塞性肺疾病(COPD)是当前世界各国积极防治但治疗效果不佳的一种疾病。该论文内容即是探讨配合太极拳运动的综合干预方案在此疾病防治中的积极作用,研究多途径、多手段、多学科干预对慢性阻塞性肺疾病的防治作用。通过太极拳运动对慢性阻塞性肺疾病患者进行适当干预,观察康复组和对照组的康复效果差别。目的:探讨太极拳运动对慢性阻塞性肺疾病患者的治疗效果。实验方法:选取牡丹江红旗医院已诊断COPD患者49名。随机分为康复组和对照组,康复组对其进行药物治疗同时也进行太极拳运动的指导训练,对照组仅进行药物治疗。两组均坚持为期六个月的治疗锻炼。两组患者年龄、性别、病理统计学分析无显著差异,具有可比性。测试方法:分析治疗前后6 min步行实验结果与肺活量、心率、血压、身高体重指标的相关性,并通过相关文献调查法和spss软件进行数据分析来研究太极拳运动对此病的干预情况。结论:太极拳运动对慢性阻塞性肺疾病的治疗具有明显意义。 展开更多
关键词 慢性阻塞性肺疾病 太极拳 六分钟步行实验 身体机能
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中西医结合治疗慢性心力衰竭疗效观察 被引量:5
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作者 田才林 罗俊 +2 位作者 孙佳浩 刘中民 范慧敏 《浙江临床医学》 2019年第1期39-40,共2页
目的 探讨中西医结合治疗慢性心力衰竭的临床疗效.方法 根据2014?年中国心衰指南临床心衰标准,纳入慢性心衰患者50例,采用随机数字表法分为两组,对照组25例,采用常规西医治疗;干预组25例,采用常规西医治疗+中药辨证论治.检测6分钟步行... 目的 探讨中西医结合治疗慢性心力衰竭的临床疗效.方法 根据2014?年中国心衰指南临床心衰标准,纳入慢性心衰患者50例,采用随机数字表法分为两组,对照组25例,采用常规西医治疗;干预组25例,采用常规西医治疗+中药辨证论治.检测6分钟步行距离实验、明尼苏达心衰生活质量生活评分、心超测定左室射血分数(LVEF)及血浆脑钠肽(NT-proBNP)相关指标.结果 (1)6分钟步行距离实验:治疗后干预组6分钟步行距离显著高于治疗前和对照组,差异有统计学意义(P<0.05).(2)明尼苏达生活质量问卷(MLHFQ):治疗后干预组评分显著低于对照组,差异有统计学意义(P<0.05).(3)心脏超声:两组LVEF较治疗前均显著提高(P<0.05).(4)血浆NT-proBNP比较:两组治疗后均较治疗前显著降低(P<0.05),干预组较对照组显著下降(P<0.05).结论 中西医结合治疗可明显改善心力衰竭患者的临床症状及心功能. 展开更多
关键词 中西医结合治疗 慢性心力衰竭 6分钟步行距离实验 心脏超声 血浆脑钠肽 明尼苏达生活质量问卷
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Effect of Tongxinluo Capsule on Patients with Syndrome X and Affective Disorder 被引量:4
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作者 Xiaolei Lv Zhiqiang Zhao +1 位作者 Jieyuan Feng Jianzhong Zhu 《Chinese Medicine》 2018年第2期55-62,共8页
Background: To explore the therapeutic effect of Tongxinluo capsule (Tongxinluo) on patients with Syndrome X and Affective Disorder. Methods: Fifty-six patients with Syndrome X and Affective Disorder were randomly div... Background: To explore the therapeutic effect of Tongxinluo capsule (Tongxinluo) on patients with Syndrome X and Affective Disorder. Methods: Fifty-six patients with Syndrome X and Affective Disorder were randomly divided into a Tongxinluo capsule group and a placebo control group. The duration of treatment was 12 weeks. A 6-minute walking test, exercise load electrocardiogram and clinical symptom assessment were performed before and after treatment. After 12 weeks of treatment, the scores of the Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) were repeated. The levels of serum endothelin-1 (ET-1) and nitric oxide (NO) were measured before and after treatment. Results: Compared with the placebo control group, the Tongxinluo group SAS and SDS scores were lower than those before treatment (all P < 0.01), and the 6-minute walking distance increased significantly (P < 0.01). Clinical symptoms were significantly improved. The exercise test results suggested that, while improved, there was no significant difference (P > 0.05) when compared to before treatment. In the Tongxinluo treatment group, the levels of plasma endothelin-1 decreased significantly (P < 0.01) and nitric oxide levels were significantly increased (P < 0.01), with a significant difference when compared to the control group (P Conclusions: The Tongxinluo capsule can improve the Affective Disorder of Syndrome X, reduce the degree of anxiety and depression, increase exercise tolerance, reduce clinical symptoms, and improve vascular endothelial function. 展开更多
关键词 SYNDROME X AFFECTIVE DISORDER 6-minute walkING TEST
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Meta-analysis on Efficacy of Yiqi Huoxue Chinese Drugs in the Treatment of Coronary Heart Disease after Coronary Revascularization
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作者 Yaonan DU Chenwei SONG +1 位作者 Areyi JIAERKEN Xiaofeng WANG 《Medicinal Plant》 CAS 2019年第3期69-76,共8页
[Objectives] To make a systematic evaluation on the therapeutic efficacy and safety of Yiqi Huoxue traditional Chinese drugs combined with western medicine in treatment of coronary heart disease( CHD) after coronary r... [Objectives] To make a systematic evaluation on the therapeutic efficacy and safety of Yiqi Huoxue traditional Chinese drugs combined with western medicine in treatment of coronary heart disease( CHD) after coronary revascularization. [Methods] The literatures were retrieved from China Knowledge Infrastructure( CNKI),Chinese science and technology journal full-text database( VIP database,VIP),Wanfang Data,the Chinese biomedical Database,Pub Med,Embase,and the Cochrane Library. The retrieval time was set to the creation of the database to January 2017. The randomized controlled trial( RCT) was conducted on the comparison between Yiqi Huoxue Chinese drugs combined with western medicine and the western medicine alone in the treatment of CHD after coronary revascularization. The literature information was extracted and the methodological quality of the included literature was evaluated according to the bias risk assessment tool developed by the Cochrane Collaboration. Meta-analysis was performed with the aid of Rev Man 5. 3 software. Coronary artery restenosis rate,angina pectoris treatment efficiency,left ventricular ejection fraction( LVEF),left ventricular end-diastolic volume( LVEDV),B-type natriuretic peptide( BNP),6-minute walk test( 6 MWT),and adverse reactions were analyzed. [Results] A total of 29 articles were included,a total of2 518 patients,the literature quality was low. Meta-analysis results showed that compared with the treatment by western medicine alone,Yiqi Huoxue Chinese drugs combined with western medicine could further reduce coronary restenosis rate[RR = 0. 45,95% CI( 0. 34,0. 60),P <0. 000 01],improve the angina pectoris treatment efficiency[RR = 1. 13,95% CI( 1. 05,1. 21),P = 0. 000 5],raise LVEF[WMD = 4. 25,95% CI( 3. 46,5. 04),P < 0. 000 01],reduce LVEDV[WMD =-10. 41,95% CI(-17. 88,-2. 95),P = 0. 006],decrease the plasma BNP level[WMD =-32. 32,95% CI(-44. 92,-19. 72),P < 0. 000 01],and increase 6 MWT distance(WMD = 62. 25,95% CI( 21. 71,102. 78),P = 0. 003)[Conclusions]Yiqi Huoxue Chinese drugs combined with western medicine can alleviate the symptoms of angina pectoris,reduce the rate of coronary restenosis,improve heart function and improve exercise capacity,thereby improving clinical efficacy in patients with CHD after coronary revascularization. 展开更多
关键词 CORONARY heart disease Yiqi Huoxue CHINESE DRUGS CORONARY revascularization META-ANALYSIS LEFT VENTRICULAR end fraction LEFT VENTRICULAR end-diastolic volume B-type natriuretic peptide 6-minute walk test Adverse reactions
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Normative Values of Cardio-Respiratory Endurance in Adults in Benin
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作者 H. Etienne Alagnide D. Didier Niama Natta +4 位作者 Emmanuel Sogbossi Wilfried Dahoueto Eric Dossa M. Antonin Agbogbo G. Toussaint Kpadonou 《Open Journal of Therapy and Rehabilitation》 2021年第4期143-153,共11页
<span style="font-family:Verdana;">Cardiorespiratory endurance is a determining factor in the assessment of the state of health of a person. Objective: To determine the reference values for cardiorespi... <span style="font-family:Verdana;">Cardiorespiratory endurance is a determining factor in the assessment of the state of health of a person. Objective: To determine the reference values for cardiorespiratory endurance in Beninese adults. Methods: Prospective trans</span><span style="font-family:Verdana;">versal study, with a descriptive and analytical aim. It was carried out on h</span><span style="font-family:Verdana;">ealthy adult subjects (18 to 50 years old), of Cotonou and Abomey cities, from October 2017 to May 2018, without clinically identifiable orthopedic, cardiorespiratory, osteoarticular or neuromotor impairment. These subjects performed three different cardio-respiratory endurance tests: The six-minute walk test (WT6), cycloergometer test (CT) and the step test (ST). Data processing and analysis were done using SPSS version 22 software. A linear regression model was used to establish the prediction equation of maximal oxygen uptake (VO</span><sub><span style="font-family:Verdana;">2</span></sub><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">max) with the WT6 data. The significance level chosen was 5%. Results: Subjects average age was 30.0 ± 9.8 years. It was especially men (54.20%), students (42.13%), with a normal corpulence (69.91%). At WT6, they walked 365 m to 798 m (557.1 ± 93.6 m) with extreme heart rates (EHR) of 67 to 189 (136.7 ± 19.0) beats per minute. At ST, the extreme powers developed were 2.7 watts/kg and 11.8 watts/kg (6.4 ± 1.8 watts/kg), with EHR of 99 to 204 (168.4 ± 15.4) beats per minute. The predictor equation of VO</span><sub><span style="font-family:Verdana;">2</span></sub></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">max by WT6 was function of the subject’s weight, age and sex (R = 0.73). Conclusion-</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">Discussion: These normative values of cardio-respiratory endurance of Beninese subjects seem to be specific to them. An extension of the present study to a larger sample nevertheless seems desirable.</span> 展开更多
关键词 Cardio-Respiratory Endurance 6-minute walk Test Step Test VO2 Max BENIN
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Comparative breakthrough: Umbilical cord mesenchymal stem cells vs bone marrow mesenchymal stem cells in heart failure treatment
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作者 Peng Li 《World Journal of Cardiology》 2024年第12期776-780,共5页
In this article,we evaluate the comparative efficacy and safety of mesenchymal stem cells(MSCs)derived from bone marrow(BM-MSCs)and umbilical cord(UC-MSCs)in the treatment of heart failure and myocardial infarction.MS... In this article,we evaluate the comparative efficacy and safety of mesenchymal stem cells(MSCs)derived from bone marrow(BM-MSCs)and umbilical cord(UC-MSCs)in the treatment of heart failure and myocardial infarction.MSCs have gained importance as living bio drug due to their regenerative potential,with BM-MSCs being the most extensively studied.However,UC-MSCs offer unique advantages,such as noninvasive collection and fewer ethical concerns.This systematic review and meta-analysis summarizes data from 13 randomized controlled trials,which included a total of 693 patients.Their study shows that UC-MSCs significantly improved left ventricular ejection fraction by 5.08%at 6 months and 2.78%at 12 months compared with controls,while BM-MSCs showed no significant effect.Neither cell type showed significant changes in 6-minute walk distance.In addition,UC-MSCs and BM-MSCs had comparable safety profiles,with no significant differences in major adverse cardiac events,except for a lower rehospitalization rate observed with BM-MSCs.These results position UC-MSCs as a promising alternative in MSC-based therapies for cardiac disease,offering potential improvements in cardiac function while maintaining a favorable safety profile.Future research should focus on optimizing adminis-tration protocols and further exploring the long-term benefits and mechanisms of UC-MSCs in cardiac repair. 展开更多
关键词 Mesenchymal stem cells Heart failure Umbilical cord-derived mesenchymal stem cells Bone marrow-derived mesenchymal stem cells Left ventricular ejection fraction 6-minute walking distance Cardiac regeneration therapy
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Cardiac catheterization and comprehensive clinical evaluation after bidirectional Glenn shunt surgery in 60 patients with complex congenital heart disease
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作者 汤尚秋 李一凡 张智伟 《South China Journal of Cardiology》 CAS 2018年第2期89-96,共8页
Background The bidirectional Glenn shunt surgery is a palliative procedure for patients with complex congenital heart disease(CHD) who are not suitable for biventricular repair in early life. There is limited eviden... Background The bidirectional Glenn shunt surgery is a palliative procedure for patients with complex congenital heart disease(CHD) who are not suitable for biventricular repair in early life. There is limited evidence of successful strategies for long-term hemodynamic stabilization. Furthermore, there have been no data on optimal hemodynamics that could be used as a reference for patients' follow-on management. Methods Sixty CHD patients, 44 male and 16 female, with bidirectional Glenn shunt surgery and cardiac catheterization were enrolled at our hospital between January 2014 and December 2016. Pre-and post Glenn shunt percutaneous oxygen saturation(SpO_2), 6-minute walk test(6 MWT), superior vena cava pressure(SVCP), pulmonary arterial pressure(PAP), pulmonary capillary wedge pressure(PCWP), pulmonary vascular resistance(PVR), small pulmonary vascular resistance(s PVR) were measured. Pre-and post-total cavopulmonary connection(TCPC) SpO_2, and in-hospital complications were monitored. The optimal hemodynamic cutoff values for TCPC patient selection were estimated by receive operating characteristic(ROC) curve analysis. Results SpO_2 was significantly increased by bidirectional Glenn shunt surgery(75.42 ± 9.62% to 86.98 ± 7.63%, P 〈 0.001) from 82.70 ± 5.99% to 95.00 ±4.07% in the 47 patients with TCPC. Forty-two patients completed the 6 MWT with a mean distance of 362.7 ±75.0 m and a SpO_2 decrease from 81.80 ± 7.84% to 67.59 ± 1.82%(P 〈 0.001). The △SpO_2 and 6-minute walk distance(6 MWD) in the 32 who underwent TCPC and ten of them did not reach statistical significance(17.22 ±13.82% vs. 13.87 ± 8.74%, P = 0.08 and 358.88 ± 78.97 m vs. 374.80 ± 62.55 m, P = 0.564]. After cardiac catheterization, 47 patients were selected for TCPC. The right pulmonary artery systolic pressure(s RPAP), mean right pulmonary artery pressure(m RPAP), mean left pulmonary artery pressure(m LPAP), PVR, and s PVR were significantly lower in the TCPC group than in the non-TCPC group. The differences in superior vena cava systolic blood pressure(s SVCP), mean superior vena cava pressure(m SVCP), and left pulmonary artery systolic pressure(s LPAP) were not significant. The optimal cutoff values for TCPC were s SVCP ≤ 20 mm Hg(P = 0.025),s RPAP ≤ 22 mm Hg(P = 0.0001, mRPAP ≤ 13 mm Hg(P =0.003), s LPAP ≤ 27 mm Hg(P =0.03), m LPAP ≤ 11 mm Hg(P = 0.01), PVR ≤ 4.3 Wood U/m^2(P 〈0.0001) and were significantly associated with TCPC selection,except for m SVCP ≤ 19 mm Hg(P = 0.06) and s PVR ≤ 2.0 wood U/m^2(P = 0.0531). One patient died because of low cardiac output after TCPC. In-hospital mortality was 2.1%. Conclusion The SpO_2 can be significantly improved after bidirectional Glenn shunt and TCPC surgery. The 6 MWT is an index of activity tolerance prior toTCPC. Hemodynamic values of s SVCP ≤ 20 mm Hg, s RPAP ≤ 22 mm Hg, m RPAP ≤ 13 mm Hg, s LPAP ≤ 27 mm Hg, m LPAP ≤ 11 mm Hg, and PVR ≤ 4.3 Wood U/m^2 can help identify post Glenn-shunt patients indicated for TCPC. 展开更多
关键词 bidirectional Glenn shunt 6-minute walk test cardiac catheterization study total cavopulmonary connection
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Long-term Efficacy of Pulmonary Artery Desnervation Treatment in Heart Failure With Preserved Ejection Fraction:A Subgroup Analysis of 3-year Results From the PADN-5 Study
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作者 Hang Zhang Wande Yu +5 位作者 Mengyu Zhang Wei Li Jing Kan Dujiang Xie Juan Zhang Shaoliang Chen 《Cardiology Discovery》 2024年第3期206-212,共7页
Objective:The Pulmonary Arterial Denervation in Patients With Pulmonary Hypertension Associated With the Left Heart Failure(PADN-5)study proved that pulmonary artery denervation(PADN)is associated with significant imp... Objective:The Pulmonary Arterial Denervation in Patients With Pulmonary Hypertension Associated With the Left Heart Failure(PADN-5)study proved that pulmonary artery denervation(PADN)is associated with significant improvements in hemodynamic and clinical outcomes in patients with combined pre-and post-capillary pulmonary hypertension(CpcPH).This study aimed to assess the 3-year clinical results of PADN in patients who had heart failure with preserved ejection fraction(HFpEF)developing into CpcPH(HFpEF-CpcPH).Methods:In this post hoc analysis of the PADN-5 trial,38 patients with HFpEF were included in screening out of 98 patients with CpcPH who were randomly assigned to treatment with sildenafil and sham PADN(sham PADN(plus sildenafil)group,abbreviated as sham group)or PADN(PADN group).HFpEF in the PADN-5 trial was defined as a left ventricular ejection fraction≥50%,and CpcPH was defined as a mean pulmonary arterial pressure≥25 mmHg,a pulmonary arterial wedge pressure>15 mmHg,and a pulmonary vascular resistance>3.0 WU.The changes in the 6-minute walk distance(6-MWD)and the plasma concentration of N-terminal pro-brain natriuretic peptide(NT-proBNP)at 6-month and 3-year follow-up,as well as the clinical endpoint of the occurrence of clinical worsening,defined as cardiopulmonary-related death,rehospitalization,or heart or lung transplantation at 3-year follow-up were examined.Results:Thirty-eight patients with HFpEF-CpcPH were assigned to the PADN group(n=19)or the sham group(n=19).At the 6-month follow-up,6-MWD(433(275,580)m vs.342(161,552)m),and reductions in NT-proBNP(−47%(−99%,331%)vs.−12%(−82%,54%))were significantly improved in the PADN group(all P<0.05).Over the 3-year follow-up period,PADN treatment resulted in marked increases in 6-MWD(450(186,510)m vs.348(135,435)m)and reductions in NT-proBNP(−55%(−99%,38%)vs.−10%(−80%,95%))(all P<0.05).Clinical worsening was experienced by 12 patients(63%)in the sham group,but by only 5 patients(26%)in the PADN group(hazard ratio=0.149,95%confidence interval:0.038–0.584,P=0.006).The 6-MWD and PADN treatments were independent predictors of clinical deterioration in patients with HFpEF-CpcPH.Conclusions:PADN therapy is associated with improvements in exercise capacity and clinical outcomes.PADN therapy may have a potential role in patients with HFpEF-CpcPH for whom current treatment options are limited. 展开更多
关键词 Heart failure Combined pre-and post-capillary pulmonary hypertension Pulmonary artery denervation 6-minute walk distance Clinical worsening
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冠状动脉介入治疗对急性心肌梗死患者心功能的影响
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作者 曾晖 刘俊敏 张良民 《透析与人工器官》 2024年第1期54-57,共4页
目的探究冠状动脉介入治疗对急性心肌梗死患者心功能的影响。方法选取2020年7月-2023年6月我院收治的86例急性心肌梗死患者,根据不同治疗方式分成对照组和观察组,每组各43例。对照组接受常规治疗,观察组接受冠状动脉介入,对比两组治疗... 目的探究冠状动脉介入治疗对急性心肌梗死患者心功能的影响。方法选取2020年7月-2023年6月我院收治的86例急性心肌梗死患者,根据不同治疗方式分成对照组和观察组,每组各43例。对照组接受常规治疗,观察组接受冠状动脉介入,对比两组治疗前后心功能指标[左室舒张末期容积指数(LVEDVI)、左室收缩末期容积指数(LVESVI)、左心室射血分数(LVEF)]、6 min步行试验(6-minute walk test,6MWT)以及心脏不良事件发生率。结果治疗前,两组心功能标对比(P>0.05),治疗4周后,观察组LVEDVI、LVESVI下降较对照组明显,LVEF提升较对照组明显,具有显著差异(P<0.05);治疗1周后,两组6MWT对比无统计学意义(P>0.05),治疗2周、治疗4周后,两组6MWT逐渐提升,观察组较对照组提升明显,具有统计学意义(P<0.05);两组心脏不良事件发生率对比,观察组更低(P<0.05)。结论急性心肌梗死患者行冠状动脉介入治疗,能改善患者心功能,提高患者6MWT距,改善运动耐力,对于心脏不良事件发生率的降低有积极作用。 展开更多
关键词 急性心肌梗死 冠状动脉介入 常规治疗 心功能指标 6 min步行试验(6-minute walk test 6MWT) 心脏不良事件
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芪苈强心胶囊对慢性心力衰竭的影响 被引量:3
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作者 李如意 范亚坤 +1 位作者 李英肖 齐晓勇 《国际中医中药杂志》 2010年第5期409-410,共2页
目的 观察芪苈强心胶囊对慢性心力衰竭患者运动耐量的影响.方法 将入选的86例慢性心力衰竭患者,随机分为治疗组和对照组,均给与血管紧张素转化酶抑制剂(ACEI)类、利尿剂、卡维地洛或倍他乐克和地戈辛等常规治疗,治疗组在常规治疗基础... 目的 观察芪苈强心胶囊对慢性心力衰竭患者运动耐量的影响.方法 将入选的86例慢性心力衰竭患者,随机分为治疗组和对照组,均给与血管紧张素转化酶抑制剂(ACEI)类、利尿剂、卡维地洛或倍他乐克和地戈辛等常规治疗,治疗组在常规治疗基础上加服芪苈强心胶囊4粒,3次/d.观察4周后患者运动耐量及左室射血分数(LVEF)的变化.结果 治疗后两组6min步行试验距离增加(P均<0.05),且治疗组增加明显(P<0.05).治疗后两组LVEF均提高(P均<0.05).治疗组显效率、总有效率均高于对照组(P均<0.05).结论 芪苈强心胶囊联合常规西药,可有效增加患者的运动耐量、改善心功能. 展开更多
关键词 芪苈强心胶囊 慢性心力衰竭 6分钟步行试验
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速尿联合多巴胺在慢性心力衰竭治疗中的临床分析
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作者 林海亮 《实用心脑肺血管病杂志》 2009年第11期966-967,共2页
目的观察速尿联合多巴胺在慢性心力衰竭治疗中的作用。方法将84例慢性心力衰竭患者,随机分成治疗组(n=42)和对照组(n=42)分别进行心功能分级和6min步行试验。对照组采用基础治疗(吸氧,半坐卧位,卡托普利、β-受体阻滞剂、螺内酯、... 目的观察速尿联合多巴胺在慢性心力衰竭治疗中的作用。方法将84例慢性心力衰竭患者,随机分成治疗组(n=42)和对照组(n=42)分别进行心功能分级和6min步行试验。对照组采用基础治疗(吸氧,半坐卧位,卡托普利、β-受体阻滞剂、螺内酯、地高辛),治疗组在此之上加用速尿和多巴胺,每天给予多巴胺20-40 mg、速尿20-100 mg加入5%葡萄糖100-250 ml静脉滴注,两组均治疗1个疗程,观察两组治疗后的疗效(心功能改善和6min试验变化情况)。结果与对照组比较,治疗组心功能和6min试验有明显改善,差异有统计学意义(P〈0.01)。结论速尿加多巴胺在慢性心力衰竭治疗中有明显治疗作用。 展开更多
关键词 慢性心力衰竭 速尿 多巴胺 6min步行试验
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