99m Tc-HL91显像与分化型甲状腺癌清甲后复发的关系研究

目的:研究99m Tc-HL91显像与分化型甲状腺癌清甲后复发的关系研究。方法:临床纳入2014-06-2016-06我院收治的86例分化型甲状腺癌患者进行研究,患者均采用99m Tc-HL91双时相甲状腺局部静态显像进行检查,利用感兴趣区技术,计算99m Tc-HL91早期和延迟T/N比。根据术后清甲治疗后结果将患者分为复发组(n=14)和无复发组(n=72),观察两组患者99m Tc-HL91显像T/N比值情况。结果:乳头状癌、滤泡状癌患者早期T/N值、延迟期T/N值对比差异无统计学意义(P>0.05)。随访患者两年,乳头状癌患者复发率为16.07%,滤泡状癌患者复复发率为16.67%,不同病理类型患者甲状腺癌复发率差异无统计学意义(P>0.05)。乳头状癌、滤泡状癌患者复发组早期和延迟期T/N值均大于非复发组,均(P<0.05)。结论:99m Tc-HL91显像能准确扫描出分化型甲状腺癌病灶的乏氧组织及乏氧程度,同时99m Tc-HL91的早期和延迟T/N比值与分化型甲状腺癌术后清甲治疗成功后的复发有密切关系。

(99)~Tc HL91“hotspot”imaging of mice bearing human carcinoma by gamma camera and the effects of tumor necrosis on imaging

To evaluate the hypoxia avid agent 99m Tc HL91 ( 99m Tc labeled 4, 9 diaza 3, 3, 10, 10 tetramethyldodecan 2, 11 dione dioxime) as the tracer of tumor “hot spot' imaging and the influence of tumor necrosis on the image Methods After injection of 99m Tc HL91, 6 nude mice bearing human breast cancer MCF 7 and 18 nude mice bearing human pancreatic adenocarcinoma were subjected to gamma camera imaging, postmortem analysis, and autoradiography and imaging of tumor sections Results The image of tumor was identified 1 hour after injection of 99m Tc HL91 Images demonstrated gradually increased 99m Tc HL91 uptake in the tumor 1-12 hours after injection ( P <0 05-0 001) Six hours after injection, the radioactivity ratios of tumor to thorax and tumor to head were higher than 2 1 Six hours after injection, the radioactivity ratios of tumor to brain, muscle, blood, heart, lung and kidney in pancreatic adenocarcinoma bearing nude mice were 101 0±114 7, 30 0±30 3, 19 9±21 9, 14 4±15 1, 3 71±2 41 and 0 46±0 26, respectively, and the radioactivity ratios in breast cancer MCF 7 bearing nude mice were close to these figures The radioactivity of non necrotic tumor was 3 77 times that of necrotic tumor However, the radioactivity ratios of tumor to liver, intestine and stomach were lower than 1 3 Autoradiographs and images of tumor sections showed that the radioactivity was higher in the region of solid tumor than in the necrotic region Conclusion 99m Tc HL91 via gamma camera positively identifies regional tumor in nude mice bearing human cancer 99m Tc HL91 retention is lower in necrotic tumor than in non necrotic tumor The low radioactivity ratio of tumor to abdominal organs limits the application of 99m Tc HL91 in detecting abdominal tumors

脑梗死患者的^99m Tc-HL91 SPECT乏氧显像

目的^99m Tc-HL91 SPECT检测不同亚型脑梗死患者的乏氧组织，探讨乏氧组织能否代表缺血半暗带。方法：对57例发病14d内的脑梗死患者和9例无脑病的对照者行辨^99m Tc-HL91 SPECT脑乏氧显像，显示乏氧组织。其中5例患者同时进行^99m Tc-HL91 SPECT脑血流灌注显像，1例患者行”F-FDG葡萄糖代谢显像。结果：对照组乏氧显像全部为阴性，30例脑梗死患者呈阳性，均为完全或部分前循环梗死，乏氧组织位于梗死灶外周。10例复查乏氧显像的患者乏氧组织均缩小或消失，其中1例乏氧组织持续存在至发病后第44天。脑血流显像提示，梗死侧大脑半球血流下降，其中2例乏氧显像呈阳性。葡萄糖显像提示，患者在发病后17d时梗死灶仍存在葡萄糖代谢，乏氧显像仍呈阳性。结论：一部分完全或部分前循环梗死患者存在乏氧组织，该组织代表可逆性损伤组织，可持续存在至亚急性期和慢性期。

^(99m)Tc-MIBI联合^(99m)Tc-HL91乏氧显像对60例原发性肺癌的诊断评价

目的探讨^(99m)Tc-甲氧基异丁基异腈(^(99m)Tc-MIBI)肺亲肿瘤显像联合^(99m)Tc-4,9-二氮- 3,3,10,10-四甲基十二烷-2,11-二酮肟(^(99m)Tc-HL91)乏氧显像对原发性肺癌的诊断效能。方法对60例拟诊断原发性肺癌患者,术前进行^(99m)Tc-MIBI及^(99m)Tc-HL91显像,以病理结果为金标准,分析^(99m)Tc-MIBI联合^(99m)Tc-HL91显像对原发性肺癌的诊断价值。结果病理结果证实原发性肺癌48例,良性病变12例。^(99m)Tc-MIBI、^(99m)Tc-HL91和^(99m)Tc-MIBI+^(99m)Tc-HL91显像对原发性肺癌诊断的灵敏度、特异度和准确率分别为89．6%(43/48)、77．1%(37/48)、95．8%(46/48),75．0%(9/12)、91．7%(11/12)、83．3%(10/12)和86．7%(52/60)、80．0%(48/60)、93．3%(56/60)。结论^(99m)Tc-MIBI肺亲肿瘤显像联合^(99m)Tc-HL91乏氧显像有助于提高对原发性肺癌的诊断效能。