AIM： To observe the prevalence of hepatitis B virus （HBV） infection in maintenance hemodialysis patients. METHODS： Eighty-eight hemodialysis patients who had been receiving hemodialysis regularly for an average of...AIM： To observe the prevalence of hepatitis B virus （HBV） infection in maintenance hemodialysis patients. METHODS： Eighty-eight hemodialysis patients who had been receiving hemodialysis regularly for an average of 39.45 ± 7.57 （range from 36 to 49） rno were enrolled in this study. HBV markers were measured in these patients before hemodialysis and in 100 healthy controls by the chemiluminescent microparticle immunoassay （CMI） method in order to compare the incidence of HBV infection in hemodialysis patients versus normal healthy people. All patients were then divided into two groups： patients positive for HBV markers （i.e. those positive for HBsAg, anti-HBc, HBeAg, anti-HBe, with or without positive anti-HBs） （n = 33）, and patients negative for HBV markers （including those only positive anti-HBs） （n = 55）. The following information was obtained for all patients： socio-demographic data, number of blood transfusions and some laboratory investigations. After 39.45 ± 7.57 mo follow-up, HBV markers were measured in these patients by CMI. RESULTS： The incidence of HBV infection in maintenance hemodialysis patients was 37.5%, which was higher than in controls （9%）. In the patients positive for HBV markers, there were 13 patients （39.4%） who had a history of blood transfusion, which was more than the number [12 （21.8%）, P = 0.04] of patients negative for HBV markers. Eight of the 88 patients negative for HBV markers turned out to be positive, while three of the 33 patients positive for HBV markers turned out to be negative. There was no cirrhosis of the liver or hepatoma occurring in these patients. CONCLUSION： Maintenance hemodialysis patientshave a higher risk of HBV infection than the average population. The number of blood transfusions is associated with an increased prevalence of HBV. While it is hard for hemodialysis patients to eliminate HBV, the prognosis of patients with positive HBV markers is good.展开更多
Patients of end stage renal disease on maintenance hemodialysis were enrolled to study the prevalence of occult and dual hepatitis B virus (HBV) and hepatitis C virus (HCV) infection and non-occult hepatitis B and C v...Patients of end stage renal disease on maintenance hemodialysis were enrolled to study the prevalence of occult and dual hepatitis B virus (HBV) and hepatitis C virus (HCV) infection and non-occult hepatitis B and C virus infection. One hundred and two patients were enrolled. Thirty patients had HCV infection, three of them were positive in anti-HCV. So, 27 (90%) of HCV-positive patients had occult HCV infection. Eleven (11%) patients had HBV infection. Five patients were positive in anti-HBc or HBV-DNA, but negative in HBsAg (occult HBV infection). Three (3%) patients had dual HBV and HCV infection. None of the patients showed changes in viral markers during the follow-up of 8 mo on average (1-12 mo).展开更多
Wise maintenance-procedures are essential for achieving high industrial productivities and low energy expenditure. A major part of the energy used in any production process is expended during the maintenance of the em...Wise maintenance-procedures are essential for achieving high industrial productivities and low energy expenditure. A major part of the energy used in any production process is expended during the maintenance of the employed equipment. To ensure plant reliability and equipment availability, a condition-based maintenance policy has been developed in this investigation. In particular, this project explored the use of vibration parameters in the diagnosis of equipment failure. A computer-based diagnostic tool employing an artificial neural-network (ANN) was developed to analyse the ensuing machinery faults, their causes and consequences. For various categories of this type of machinery, a vibration-severity chart (ISO 12372 / BS 4675: 1971) appropriately colour coded according to defined mechanical faults, was used in training of the ANN. The model was validated using data obtained from a centrifugal pump on full load and fed into the program written in Visual Basic. The results revealed that, for centrifugal pumps within 15 to 300kw power range, vibration-velocity amplitude of between 0.9 and 2.7mm/s was within acceptable limits. When the values rose to between 2.8 and 7.0mm/s, closer monitoring and improved understanding of the equipment condition was needed. The evolved diagnostic and prognostic model is applicable for other rotary equipment that is used within the same power limits.展开更多
The main sea water pump is the key equipment for the floating production storage and offloading （FPSO）. Affected by some factors such as hull deformation, sea water corrosion, rigid base and pipeline stress, the vib...The main sea water pump is the key equipment for the floating production storage and offloading （FPSO）. Affected by some factors such as hull deformation, sea water corrosion, rigid base and pipeline stress, the vibration value of main sea water pump in the horizontal direction is abnormally high and malfunctions usually happen. Therefore, it is essential to make fault diagnosis of main sea water pump, By conventional off-line monitoring and vibration amplitude spectrum analysis, the fault cycle is found and the alarm value and stop value of equipment are set, which is helpful to equipment maintenance and accident prevention.展开更多
The work aims to investigate the in vitro release,pharmacokinetics(PK),pharmacodynamics(PD)and PK-PD relationships of Salvianolic Acid B micro-porous osmotic pump pellets(SalB-MPOPs)in angina pectoris New Zealand Whit...The work aims to investigate the in vitro release,pharmacokinetics(PK),pharmacodynamics(PD)and PK-PD relationships of Salvianolic Acid B micro-porous osmotic pump pellets(SalB-MPOPs)in angina pectoris New Zealand White(NZW)rabbits,compared with those of SalB immediate-release pellets(SalB-IRPs).The SalB plasma concentrations and Superoxide dismutase levels(PD index)were recorded continuously at predetermined time interval after administration,and the related parameters were calculated by using Win-Nonlin software.The release profile of MPOPs was more sustained than that of IRPs.PK results indicated that the mean C_(max) was significantly lower,the SalB plasma concentrations were steadier,both area under concentration-time curve from 0 to 24 h(AUC_(0-24 h))and from 0 to infinity(AUC_(0-∞))were presented larger,and both the peak concentration time(T_(max))and mean residence time(MRT)were prolonged for MPOPs,as compared with those of IRPs.PD results suggested that peak drug effect(E_(max))was lower and the equilibration rate constant(k_(e0))between the central compartment and the effect compartment was higher of MPOPs vs.those of IRPs.PKePD relationships demonstrated that the effectconcentration-time(ECT)course of MPOPs was clockwise hysteresis loop,and that of IRPs was counter-clockwise hysteresis loop.Collectively,those results demonstrated that MPOPs were potential formulations in treating angina pectoris induced by atherosclerosis.展开更多
Condition based maintenance(CBM) is one of the solutions to machinery maintenance requirements. Latest approaches to CBM aim at reducing human engagement in the real-time fault detection and decision making. Machine l...Condition based maintenance(CBM) is one of the solutions to machinery maintenance requirements. Latest approaches to CBM aim at reducing human engagement in the real-time fault detection and decision making. Machine learning techniques like fuzzy-logic-based systems, neural networks, and support vector machines help to reduce human involvement. Most of these techniques provide fault information with 100% confidence. It is undeniably apparent that this area has a vast application scope. To facilitate future exploration, this review is presented describing the centrifugal pump faults, the signals they generate, their CBM based diagnostic schemes, and case studies for blockage and cavitation fault detection in centrifugal pump(CP) by performing the experiment on test rig. The classification accuracy is above 98% for fault detection. This review gives a head-start to new researchers in this field and identifies the un-touched areas pertaining to CP fault diagnosis.展开更多
目的:建立完善而健全的设备维修保养监管系统。方法:利用面向服务的体系结构(service-oriented architecture,SOA)作为主体架构,并利用互联网信息服务(internet information service,IIS)管理器作为发布工具。结果 :规范和优化了维修保...目的:建立完善而健全的设备维修保养监管系统。方法:利用面向服务的体系结构(service-oriented architecture,SOA)作为主体架构,并利用互联网信息服务(internet information service,IIS)管理器作为发布工具。结果 :规范和优化了维修保养监管流程,建立的信息化维修保养监管系统操作简单、查询方便、统计便捷,促进了医疗设备维修管理的规范化、合理化。结论:该系统的实现对于提高维修效率及设备使用时间、保障设备的使用价值具有良好的促进作用,进一步达到了节约成本的目的。展开更多
文摘AIM： To observe the prevalence of hepatitis B virus （HBV） infection in maintenance hemodialysis patients. METHODS： Eighty-eight hemodialysis patients who had been receiving hemodialysis regularly for an average of 39.45 ± 7.57 （range from 36 to 49） rno were enrolled in this study. HBV markers were measured in these patients before hemodialysis and in 100 healthy controls by the chemiluminescent microparticle immunoassay （CMI） method in order to compare the incidence of HBV infection in hemodialysis patients versus normal healthy people. All patients were then divided into two groups： patients positive for HBV markers （i.e. those positive for HBsAg, anti-HBc, HBeAg, anti-HBe, with or without positive anti-HBs） （n = 33）, and patients negative for HBV markers （including those only positive anti-HBs） （n = 55）. The following information was obtained for all patients： socio-demographic data, number of blood transfusions and some laboratory investigations. After 39.45 ± 7.57 mo follow-up, HBV markers were measured in these patients by CMI. RESULTS： The incidence of HBV infection in maintenance hemodialysis patients was 37.5%, which was higher than in controls （9%）. In the patients positive for HBV markers, there were 13 patients （39.4%） who had a history of blood transfusion, which was more than the number [12 （21.8%）, P = 0.04] of patients negative for HBV markers. Eight of the 88 patients negative for HBV markers turned out to be positive, while three of the 33 patients positive for HBV markers turned out to be negative. There was no cirrhosis of the liver or hepatoma occurring in these patients. CONCLUSION： Maintenance hemodialysis patientshave a higher risk of HBV infection than the average population. The number of blood transfusions is associated with an increased prevalence of HBV. While it is hard for hemodialysis patients to eliminate HBV, the prognosis of patients with positive HBV markers is good.
文摘Patients of end stage renal disease on maintenance hemodialysis were enrolled to study the prevalence of occult and dual hepatitis B virus (HBV) and hepatitis C virus (HCV) infection and non-occult hepatitis B and C virus infection. One hundred and two patients were enrolled. Thirty patients had HCV infection, three of them were positive in anti-HCV. So, 27 (90%) of HCV-positive patients had occult HCV infection. Eleven (11%) patients had HBV infection. Five patients were positive in anti-HBc or HBV-DNA, but negative in HBsAg (occult HBV infection). Three (3%) patients had dual HBV and HCV infection. None of the patients showed changes in viral markers during the follow-up of 8 mo on average (1-12 mo).
文摘Wise maintenance-procedures are essential for achieving high industrial productivities and low energy expenditure. A major part of the energy used in any production process is expended during the maintenance of the employed equipment. To ensure plant reliability and equipment availability, a condition-based maintenance policy has been developed in this investigation. In particular, this project explored the use of vibration parameters in the diagnosis of equipment failure. A computer-based diagnostic tool employing an artificial neural-network (ANN) was developed to analyse the ensuing machinery faults, their causes and consequences. For various categories of this type of machinery, a vibration-severity chart (ISO 12372 / BS 4675: 1971) appropriately colour coded according to defined mechanical faults, was used in training of the ANN. The model was validated using data obtained from a centrifugal pump on full load and fed into the program written in Visual Basic. The results revealed that, for centrifugal pumps within 15 to 300kw power range, vibration-velocity amplitude of between 0.9 and 2.7mm/s was within acceptable limits. When the values rose to between 2.8 and 7.0mm/s, closer monitoring and improved understanding of the equipment condition was needed. The evolved diagnostic and prognostic model is applicable for other rotary equipment that is used within the same power limits.
文摘The main sea water pump is the key equipment for the floating production storage and offloading （FPSO）. Affected by some factors such as hull deformation, sea water corrosion, rigid base and pipeline stress, the vibration value of main sea water pump in the horizontal direction is abnormally high and malfunctions usually happen. Therefore, it is essential to make fault diagnosis of main sea water pump, By conventional off-line monitoring and vibration amplitude spectrum analysis, the fault cycle is found and the alarm value and stop value of equipment are set, which is helpful to equipment maintenance and accident prevention.
基金This study is financially supported by the major project of National Science and Technology of China for new drugs development(No.2009ZX09310-004)Jiangsu Province Ordinary College and University innovative research programs(No.CX10B-374Z).
文摘The work aims to investigate the in vitro release,pharmacokinetics(PK),pharmacodynamics(PD)and PK-PD relationships of Salvianolic Acid B micro-porous osmotic pump pellets(SalB-MPOPs)in angina pectoris New Zealand White(NZW)rabbits,compared with those of SalB immediate-release pellets(SalB-IRPs).The SalB plasma concentrations and Superoxide dismutase levels(PD index)were recorded continuously at predetermined time interval after administration,and the related parameters were calculated by using Win-Nonlin software.The release profile of MPOPs was more sustained than that of IRPs.PK results indicated that the mean C_(max) was significantly lower,the SalB plasma concentrations were steadier,both area under concentration-time curve from 0 to 24 h(AUC_(0-24 h))and from 0 to infinity(AUC_(0-∞))were presented larger,and both the peak concentration time(T_(max))and mean residence time(MRT)were prolonged for MPOPs,as compared with those of IRPs.PD results suggested that peak drug effect(E_(max))was lower and the equilibration rate constant(k_(e0))between the central compartment and the effect compartment was higher of MPOPs vs.those of IRPs.PKePD relationships demonstrated that the effectconcentration-time(ECT)course of MPOPs was clockwise hysteresis loop,and that of IRPs was counter-clockwise hysteresis loop.Collectively,those results demonstrated that MPOPs were potential formulations in treating angina pectoris induced by atherosclerosis.
文摘Condition based maintenance(CBM) is one of the solutions to machinery maintenance requirements. Latest approaches to CBM aim at reducing human engagement in the real-time fault detection and decision making. Machine learning techniques like fuzzy-logic-based systems, neural networks, and support vector machines help to reduce human involvement. Most of these techniques provide fault information with 100% confidence. It is undeniably apparent that this area has a vast application scope. To facilitate future exploration, this review is presented describing the centrifugal pump faults, the signals they generate, their CBM based diagnostic schemes, and case studies for blockage and cavitation fault detection in centrifugal pump(CP) by performing the experiment on test rig. The classification accuracy is above 98% for fault detection. This review gives a head-start to new researchers in this field and identifies the un-touched areas pertaining to CP fault diagnosis.
文摘目的:建立完善而健全的设备维修保养监管系统。方法:利用面向服务的体系结构(service-oriented architecture,SOA)作为主体架构,并利用互联网信息服务(internet information service,IIS)管理器作为发布工具。结果 :规范和优化了维修保养监管流程,建立的信息化维修保养监管系统操作简单、查询方便、统计便捷,促进了医疗设备维修管理的规范化、合理化。结论:该系统的实现对于提高维修效率及设备使用时间、保障设备的使用价值具有良好的促进作用,进一步达到了节约成本的目的。
