Four new indole alkaloids from Plantago asiatica

Four new indole alkaloids,plasiaticines A-D(1-4),together with two known ones,were isolated from the seeds of Plantago asiatica.The structures of the new compounds were elucidated on the basis of comprehensive analysis of spectroscopic data.All compounds were tested for their cytotoxic activity,and all compounds except 4 were tested for their acetylcholinesterase(AChE)inhibitory activities.

New Lycopodium alkaloids from Lycopodium obscurum

Three new Lycopodium alkaloids,obscurumines C-E(1-3),along with nine known compounds,were isolated from the club moss Lycopodium obscurum L.Structures of the new compounds were determined on the basis of their spectroscopic analysis and the relative configurations of 1 were established by X-ray crystallographic analysis.All the new isolates were tested for the acetylcholinesterase(AChE)inhibitory activity.

Carinatines A and B,Lycopodium Alkaloids from Phlegmariurus carinatus

Carinatine A(1),a C16N2-type Lycopodium alkaloid possessing a 5/6/6/6 ring system formed by a new C-4/C-12 bond,and carinatine B(2),the first derivative of lycojaponicumin C,along 16 known compounds,were isolated from the whole plant of Phlegmariurus carinatus.Their structures were elucidated based on the spectroscopic data.The two new isolates were no inhibitory activity for the acetylcholinesterase(AChE).

A new flavonol C-glycoside and a rare bioactive lignanamide from Piper wallichii Miq. Hand.-Mazz

This study was conducted to investigate the chemical constituents of Piper wallichii （Miq.） Hand.-Mazz. and evaluate their biological activity. Compounds were isolated by various column chromatographic methods, and their structures were elucidated on the basis of physical characteristics and spectral data. The 1, 1-diphenyl-2-picrylhydrazyl （DPPH）-scavenging activity and acetylcholinesterase （AChE）-inhibitory activity of the compounds were evaluated. Five compounds were obtained and identified as 8-C-β-D-glucopyranosylkaempferol-3-O-β-D-glucopyranoside （1）, 1, 2-dihydro-6,8-dimethoxy-7-hydroxy-l-（3, 5-dimethoxy-4-hydroxyphenyl）-N^1, N^2-bis-[2-（4-hydroxyphenyl）ethyl]-2, 3-naphthalene dicarboxamide （2）, goniothalactam （3）, aristololactam A IIla （4） and piperlonguminine （5）. Compound 1 was a new flavonol C-glycoside, 2 was a rare lignanamide, which was isolated from the family Piperaceae for the first time, and compound 3 was isolated from this plant for the first time. Among them, 2 showed potent DPPH-scavenging activity, with IC50 of 31.38 ± 0.97 μmol·L^-1; Compounds 2, 3, and 4 showed AChE inhibitory activity at 100 μmol·L^-1, with inhibition rates of 28.57% ± 1.47%, 18.48% ± 2.41% and 17.4% ±3.03%, respectively.

A pair of new tirucallane triterpenoid epimers from the stems of Picrasma quassioides

A pair of new tirucallane triterpenoid epimers,picraquassins M and N(1 and 2),were isolated from the stems of Picrasma quassioides(D.Don)Benn.Their structures were determined based on comprehensive spectroscopic and X-ray crystallographic analyses.In addition,their ACh E inhibitory activity,cytotoxicity against five human tumour cell lines(SW480,MCF-7,HepG2,Hela,and PANC-1),and antimicrobial activity against two bacteria(Staphylococcus.aureus 209 P and Escherichia coli ATCC0111)and two fungi(Candida albicans FIM709 and Aspergillus niger R330)were evaluated.