目的 系统评价ADD1基因Gly460Trp多态性与原发性高血压发病风险的相关性。方法 查计算机检索PubMed、Embase、CBM、VIP、Wanfang Data和CNKI，查找关于ADD1基因Gly460Trp多态性与原发性高血压发病相关性的病例对照研究，检索时限均为各...目的 系统评价ADD1基因Gly460Trp多态性与原发性高血压发病风险的相关性。方法 查计算机检索PubMed、Embase、CBM、VIP、Wanfang Data和CNKI，查找关于ADD1基因Gly460Trp多态性与原发性高血压发病相关性的病例对照研究，检索时限均为各数据库建库至2015年8月。由两名评价员同时进行文献筛选及资料提取，采用Stata 12.0软件进行Meta分析。结果 共纳入文献43篇，包括12 309例原发性高血压患者，13 833例对照。Meta分析结果显示，ADD1基因Gly460Trp多态性与原发性高血压之间的相关性在等位基因模型（T vs. G：OR=1.10，95%CI：1.03～1.17）、显性基因模型（TT+GT vs. GG：OR=1.10，95%CI：1.00～1.20)、隐性基因模型（TT vs. GG+GT：OR=1.17，95%CI：1.07～1.29）和纯合子模型（TT vs. GG：OR=1.20，95%CI：1.06～1.35）中有统计学意义，尤其是在亚洲人群中。结论 本Meta分析表明，ADD1基因Gly460Trp位点多态性与原发性高血压发病风险有相关性，尤其是亚洲人群。展开更多
Dietary potassium-supplementation has been associated with a decreased risk of hypertension and other cardiovascular outcomes.However,blood pressure(BP)responses to potassium supplementation vary among individuals.Thi...Dietary potassium-supplementation has been associated with a decreased risk of hypertension and other cardiovascular outcomes.However,blood pressure(BP)responses to potassium supplementation vary among individuals.This study was designed to examine the association between 12 single nucleotide polymorphisms(SNPs)in the adducin 1 alpha(ADD1)and guanine nucleotide binding protein(G protein)beta polypeptide 3(GNB3)genes and systolic BP(SBP),diastolic BP(DBP),and mean arterial pressure(MAP)responses to potassium-supplementation.We conducted a 7-day high-sodium intervention(307.8 mmol sodium/day)followed by a 7-day high-sodium with potassium-supplementation(60 mmol potassium/day)among 1906 Han Chinese participants from rural north China.BP measurements were obtained at the end of each intervention period using a random-zero sphygmomanometer.We identified significant associations between ADD1 variant rs17833172 and SBP,DBP,and MAP responses to potassium-supplementation(all P<0.0001)that remained significant after adjustment for multiple comparisons.In participants that were heterozygous or homozygous for the G allele of this marker,SBP,DBP,and MAP response to potassium-supplementation were–3.52(–3.82,–3.21),–1.41(–1.66,–1.15)and–2.12(–2.37,–1.87),respectively,as compared to the corresponding responses of 1.99(0.25,3.73),–0.65(–0.10,–0.21),and–0.23(–0.37,0.83),respectively,for those who were homozygous for A allele.In addition,participants with at least one copy of the G allele of rs12503220 of the ADD1 gene had significantly increased DBP and MAP response to potassium-supplementation(P=0.0041 and 0.01,respectively),which was also significant after correction for multiple testing.DBP and MAP responses to potassiumsupplementation were–1.36(–1.63,–1.10)and–2.07(–2.32,–1.82)for those with at least G allele compared to corresponding responses of 0.86(–0.68,2.40)and–0.45(–1.74,0.84)for those who were homozygous for A allele.In summary,our study identified novel associations between genetic variants of the ADD1 gene and BP response to potassium-supplementation,which could have important clinical and public health implications.Future studies aimed at replicating these novel findings are warranted.展开更多
文摘目的 系统评价ADD1基因Gly460Trp多态性与原发性高血压发病风险的相关性。方法 查计算机检索PubMed、Embase、CBM、VIP、Wanfang Data和CNKI，查找关于ADD1基因Gly460Trp多态性与原发性高血压发病相关性的病例对照研究，检索时限均为各数据库建库至2015年8月。由两名评价员同时进行文献筛选及资料提取，采用Stata 12.0软件进行Meta分析。结果 共纳入文献43篇，包括12 309例原发性高血压患者，13 833例对照。Meta分析结果显示，ADD1基因Gly460Trp多态性与原发性高血压之间的相关性在等位基因模型（T vs. G：OR=1.10，95%CI：1.03～1.17）、显性基因模型（TT+GT vs. GG：OR=1.10，95%CI：1.00～1.20)、隐性基因模型（TT vs. GG+GT：OR=1.17，95%CI：1.07～1.29）和纯合子模型（TT vs. GG：OR=1.20，95%CI：1.06～1.35）中有统计学意义，尤其是在亚洲人群中。结论 本Meta分析表明，ADD1基因Gly460Trp位点多态性与原发性高血压发病风险有相关性，尤其是亚洲人群。
基金supported by research grants(Nos.U01HL072507,R01HL087263,and R01HL090682)from the National Heart,LungBlood Institute,National Institutes of Health,Bethesda,MD.Upsher-Smith Laboratories,Maple Grove,MN,has provided Klor-Con M20 potassium tablets for the GenSalt study.
文摘Dietary potassium-supplementation has been associated with a decreased risk of hypertension and other cardiovascular outcomes.However,blood pressure(BP)responses to potassium supplementation vary among individuals.This study was designed to examine the association between 12 single nucleotide polymorphisms(SNPs)in the adducin 1 alpha(ADD1)and guanine nucleotide binding protein(G protein)beta polypeptide 3(GNB3)genes and systolic BP(SBP),diastolic BP(DBP),and mean arterial pressure(MAP)responses to potassium-supplementation.We conducted a 7-day high-sodium intervention(307.8 mmol sodium/day)followed by a 7-day high-sodium with potassium-supplementation(60 mmol potassium/day)among 1906 Han Chinese participants from rural north China.BP measurements were obtained at the end of each intervention period using a random-zero sphygmomanometer.We identified significant associations between ADD1 variant rs17833172 and SBP,DBP,and MAP responses to potassium-supplementation(all P<0.0001)that remained significant after adjustment for multiple comparisons.In participants that were heterozygous or homozygous for the G allele of this marker,SBP,DBP,and MAP response to potassium-supplementation were–3.52(–3.82,–3.21),–1.41(–1.66,–1.15)and–2.12(–2.37,–1.87),respectively,as compared to the corresponding responses of 1.99(0.25,3.73),–0.65(–0.10,–0.21),and–0.23(–0.37,0.83),respectively,for those who were homozygous for A allele.In addition,participants with at least one copy of the G allele of rs12503220 of the ADD1 gene had significantly increased DBP and MAP response to potassium-supplementation(P=0.0041 and 0.01,respectively),which was also significant after correction for multiple testing.DBP and MAP responses to potassiumsupplementation were–1.36(–1.63,–1.10)and–2.07(–2.32,–1.82)for those with at least G allele compared to corresponding responses of 0.86(–0.68,2.40)and–0.45(–1.74,0.84)for those who were homozygous for A allele.In summary,our study identified novel associations between genetic variants of the ADD1 gene and BP response to potassium-supplementation,which could have important clinical and public health implications.Future studies aimed at replicating these novel findings are warranted.
