1) Background: Rapid and acurate diagnostic testing for case identification, quarantine, and contact tracing is essential for managing the COVID 19 pandemic. Rapid antigen detection tests are available, however, it is...1) Background: Rapid and acurate diagnostic testing for case identification, quarantine, and contact tracing is essential for managing the COVID 19 pandemic. Rapid antigen detection tests are available, however, it is important to evaluate their performances before use. We tested a rapid antigen detection of SARS-CoV-2, based on the immunochromatography (Boson Biotech SARS-CoV-2 Ag Test (Xiamen Boson Biotech Co., Ltd., China)) and the results were compared with the real time reverse transcriptase-Polymerase chain reaction (RT-PCR) (Gold standard) results;2) Methods: From November 2021 to December 2021, samples were collected from symptomatic patients and asymptomatic individuals referred for testing in a hospital during the second pandemic wave in Gabon. All these participants attending “CTA Angondjé”, a field hospital set up as part of the management of COVID-19 in Gabon. Two nasopharyngeal swabs were collected in all the patients, one for Ag test and the other for RT-PCR;3) Results: A total of 300 samples were collected from 189 symptomatic and 111 asymptomatic individuals. The sensitivity and specificity of the antigen test were 82.5% [95%CI 73.8 - 89.3] and 97.9 % [95%CI 92.2 - 98.2] respectively, and the diagnostic accuracy was 84.4% (95% CI: 79.8 - 88.3%). The antigen test was more likely to be positive for samples with RT-PCR Ct values ≤ 32, with a sensitivity of 89.8%;4) Conclusions: The Boson Biotech SARS-CoV-2 Ag Test has good sensitivity and can detect SARS-CoV-2 infection, especially among symptomatic individuals with low viral load. This test could be incorporated into efficient testing algorithms as an alternative to PCR to decrease diagnostic delays and curb viral transmission.展开更多
目的:分析计时起立-行走测试(TUGT)对老年2型糖尿病周围神经病变病人跌倒风险的评估价值。方法:回顾性分析2020年1月—2022年12月在我院内分泌科纳入治疗的2型糖尿病周围神经病变病人120例为研究对象,收集病人一般资料、TUGT测试结果,采...目的:分析计时起立-行走测试(TUGT)对老年2型糖尿病周围神经病变病人跌倒风险的评估价值。方法:回顾性分析2020年1月—2022年12月在我院内分泌科纳入治疗的2型糖尿病周围神经病变病人120例为研究对象,收集病人一般资料、TUGT测试结果,采用SPSS 22.0、R Studio 1.4.1103进行联合数据分析,研究相关性和预测价值。结果:本研究纳入的120例病人均顺利完成TUGT测试,完成率为100%,数据收集率为100%。所有病人TUGT时间为(16.03±3.29)s。Spearman相关性分析结果显示,TUGT时间与跌倒史、性别之间呈正相关(P<0.05);TUGT时间与2型糖尿病病程、合并周围神经病变病程、年龄之间无明显相关关系。TUGT时间用于预测老年2型糖尿病周围神经病变病人跌倒风险的最佳临界值为14.19 s,受试者工作特征曲线(ROC)曲线下面积(AUC)值为0.773,敏感度为86.29%,特异度为67.16%。结论:跌倒史、性别是影响老年2型糖尿病周围神经病变病人TUGT时间的危险因素,同时,TUGT时间对老年2型糖尿病周围神经病变病人跌倒具有良好的预测价值。展开更多
文摘1) Background: Rapid and acurate diagnostic testing for case identification, quarantine, and contact tracing is essential for managing the COVID 19 pandemic. Rapid antigen detection tests are available, however, it is important to evaluate their performances before use. We tested a rapid antigen detection of SARS-CoV-2, based on the immunochromatography (Boson Biotech SARS-CoV-2 Ag Test (Xiamen Boson Biotech Co., Ltd., China)) and the results were compared with the real time reverse transcriptase-Polymerase chain reaction (RT-PCR) (Gold standard) results;2) Methods: From November 2021 to December 2021, samples were collected from symptomatic patients and asymptomatic individuals referred for testing in a hospital during the second pandemic wave in Gabon. All these participants attending “CTA Angondjé”, a field hospital set up as part of the management of COVID-19 in Gabon. Two nasopharyngeal swabs were collected in all the patients, one for Ag test and the other for RT-PCR;3) Results: A total of 300 samples were collected from 189 symptomatic and 111 asymptomatic individuals. The sensitivity and specificity of the antigen test were 82.5% [95%CI 73.8 - 89.3] and 97.9 % [95%CI 92.2 - 98.2] respectively, and the diagnostic accuracy was 84.4% (95% CI: 79.8 - 88.3%). The antigen test was more likely to be positive for samples with RT-PCR Ct values ≤ 32, with a sensitivity of 89.8%;4) Conclusions: The Boson Biotech SARS-CoV-2 Ag Test has good sensitivity and can detect SARS-CoV-2 infection, especially among symptomatic individuals with low viral load. This test could be incorporated into efficient testing algorithms as an alternative to PCR to decrease diagnostic delays and curb viral transmission.
文摘目的:分析计时起立-行走测试(TUGT)对老年2型糖尿病周围神经病变病人跌倒风险的评估价值。方法:回顾性分析2020年1月—2022年12月在我院内分泌科纳入治疗的2型糖尿病周围神经病变病人120例为研究对象,收集病人一般资料、TUGT测试结果,采用SPSS 22.0、R Studio 1.4.1103进行联合数据分析,研究相关性和预测价值。结果:本研究纳入的120例病人均顺利完成TUGT测试,完成率为100%,数据收集率为100%。所有病人TUGT时间为(16.03±3.29)s。Spearman相关性分析结果显示,TUGT时间与跌倒史、性别之间呈正相关(P<0.05);TUGT时间与2型糖尿病病程、合并周围神经病变病程、年龄之间无明显相关关系。TUGT时间用于预测老年2型糖尿病周围神经病变病人跌倒风险的最佳临界值为14.19 s,受试者工作特征曲线(ROC)曲线下面积(AUC)值为0.773,敏感度为86.29%,特异度为67.16%。结论:跌倒史、性别是影响老年2型糖尿病周围神经病变病人TUGT时间的危险因素,同时,TUGT时间对老年2型糖尿病周围神经病变病人跌倒具有良好的预测价值。
