Once a patient has initiated an antiepileptic drug (AED) and achieved a sustained period of seizure freedom, the decision to discontinue AED should be balanced against continuation of AED therapy indefinitely. Studies...Once a patient has initiated an antiepileptic drug (AED) and achieved a sustained period of seizure freedom, the decision to discontinue AED should be balanced against continuation of AED therapy indefinitely. Studies show that the rate of seizure recurrence after AED withdrawal is about two to three times the rate in patients who continue AEDs. However, there are many benefits to AED withdrawal that should be evaluated on an individualized basis. AED discontinuation may be considered in patients whose seizures have been completely controlled for a prolonged period. There are several factors that would increase risk of recurrences which will be reviewed and discussed. As a consequence, the decision to withdraw or withhold treatment must be still individualized. In any patient, the decision to discontinue treatment should also take into effect the social aspects like driving license, job and leisure activities as well as emotional and personal factors and patients with adverse effects or drug interactions. Patients will ultimately have to decide themselves whether they wish to discontinue drug treatment.展开更多
生酮饮食（ketogenic diet,KD）是一种高脂肪、适量蛋白质、低碳水化合物的饮食组合,通过模拟饥饿状态下机体主要分解脂肪产生能量,进而利用脂肪代谢产物—酮体（乙酰乙酸、β-羟丁酸和丙酮）而抑制癫痫发作。1921年Wilder R M博士[1]...生酮饮食（ketogenic diet,KD）是一种高脂肪、适量蛋白质、低碳水化合物的饮食组合,通过模拟饥饿状态下机体主要分解脂肪产生能量,进而利用脂肪代谢产物—酮体（乙酰乙酸、β-羟丁酸和丙酮）而抑制癫痫发作。1921年Wilder R M博士[1]就曾提出禁食后通过改变饮食中营养素的比例可减少癫痫的发生,展开更多
癫痫持续状态（status epilepticus,SE）是指一次痫性发作持续30 min以上,或2次及以上痫性发作而意识不能恢复至正常状态持续30 min以上。临床上根据有无惊厥发作将SE分为惊厥癫痫持续状态（convulsive status epilepticus,CSE）和非惊...癫痫持续状态（status epilepticus,SE）是指一次痫性发作持续30 min以上,或2次及以上痫性发作而意识不能恢复至正常状态持续30 min以上。临床上根据有无惊厥发作将SE分为惊厥癫痫持续状态（convulsive status epilepticus,CSE）和非惊厥性癫痫持续状态（nonconvulsive status epilepticus,NCSE）。早于19世纪初期,展开更多
文摘Once a patient has initiated an antiepileptic drug (AED) and achieved a sustained period of seizure freedom, the decision to discontinue AED should be balanced against continuation of AED therapy indefinitely. Studies show that the rate of seizure recurrence after AED withdrawal is about two to three times the rate in patients who continue AEDs. However, there are many benefits to AED withdrawal that should be evaluated on an individualized basis. AED discontinuation may be considered in patients whose seizures have been completely controlled for a prolonged period. There are several factors that would increase risk of recurrences which will be reviewed and discussed. As a consequence, the decision to withdraw or withhold treatment must be still individualized. In any patient, the decision to discontinue treatment should also take into effect the social aspects like driving license, job and leisure activities as well as emotional and personal factors and patients with adverse effects or drug interactions. Patients will ultimately have to decide themselves whether they wish to discontinue drug treatment.
文摘生酮饮食（ketogenic diet,KD）是一种高脂肪、适量蛋白质、低碳水化合物的饮食组合,通过模拟饥饿状态下机体主要分解脂肪产生能量,进而利用脂肪代谢产物—酮体（乙酰乙酸、β-羟丁酸和丙酮）而抑制癫痫发作。1921年Wilder R M博士[1]就曾提出禁食后通过改变饮食中营养素的比例可减少癫痫的发生,
文摘癫痫持续状态（status epilepticus,SE）是指一次痫性发作持续30 min以上,或2次及以上痫性发作而意识不能恢复至正常状态持续30 min以上。临床上根据有无惊厥发作将SE分为惊厥癫痫持续状态（convulsive status epilepticus,CSE）和非惊厥性癫痫持续状态（nonconvulsive status epilepticus,NCSE）。早于19世纪初期,
