为解决在空间狭小、条件简陋的平台上使用DGPS和AHRS不便的问题,提出了一种基于ARM9的手持式DGPS/AHRS组合导航系统设计方案。采用S3C2440AARM芯片作为主控芯片,选用DGPS模块和AHRS模块进行硬件设计。在Windows CE 6.0平台上采用Visual ...为解决在空间狭小、条件简陋的平台上使用DGPS和AHRS不便的问题,提出了一种基于ARM9的手持式DGPS/AHRS组合导航系统设计方案。采用S3C2440AARM芯片作为主控芯片,选用DGPS模块和AHRS模块进行硬件设计。在Windows CE 6.0平台上采用Visual Studio2008开发导航软件,通过RS232串口读取DGPS模块和AHRS模块输出的数据信息,解析后用于实时显示和导航参数计算。实验结果表明,该系统能准确采集各种导航信息,运行稳定可靠,具有重要的实用价值。展开更多
Genetic variants in super-enhancers(SEs)are increasingly implicated as a disease risk-driving mechanism.Previous studies have reported an associations between benzo[a]pyrene(BaP)exposure and some malignant tumor risk....Genetic variants in super-enhancers(SEs)are increasingly implicated as a disease risk-driving mechanism.Previous studies have reported an associations between benzo[a]pyrene(BaP)exposure and some malignant tumor risk.Currently,it is unclear whether BaP is involved in the effect of genetic variants in SEs on prostate cancer risk,nor the associated intrinsic molecular mechanisms.In the current study,by using logistic regression analysis,we found that rs5750581T>C in 22q-SE was significantly associated with prostate cancer risk(odds ratio=1.26,P=7.61×10^(-5)).We also have found that the rs6001092T>G,in a high linkage disequilibrium with rs5750581T>C(r^(2)=0.98),is located in a regulatory aryl hydrocarbon receptor(AhR)motif and may interact with the FAM227A promoter in further bioinformatics analysis.We then performed a series of functional and BaP acute exposure experiments to assess biological function of the genetic variant and the target gene.Biologically,the rs6001092-G allele strengthened the transcription factor binding affinity to AhR,thereby upregulating FAM227A,especially upon exposure to BaP,which induced the malignant phenotypes of prostate cancer.The current study highlights that AhR acts as an environmental sensor of BaP and is involved in the SE-mediated prostate cancer risk,which may provide new insights into the etiology of prostate cancer associated with the inherited SE variants under environmental carcinogen stressors.展开更多
文摘为解决在空间狭小、条件简陋的平台上使用DGPS和AHRS不便的问题,提出了一种基于ARM9的手持式DGPS/AHRS组合导航系统设计方案。采用S3C2440AARM芯片作为主控芯片,选用DGPS模块和AHRS模块进行硬件设计。在Windows CE 6.0平台上采用Visual Studio2008开发导航软件,通过RS232串口读取DGPS模块和AHRS模块输出的数据信息,解析后用于实时显示和导航参数计算。实验结果表明,该系统能准确采集各种导航信息,运行稳定可靠,具有重要的实用价值。
文摘Genetic variants in super-enhancers(SEs)are increasingly implicated as a disease risk-driving mechanism.Previous studies have reported an associations between benzo[a]pyrene(BaP)exposure and some malignant tumor risk.Currently,it is unclear whether BaP is involved in the effect of genetic variants in SEs on prostate cancer risk,nor the associated intrinsic molecular mechanisms.In the current study,by using logistic regression analysis,we found that rs5750581T>C in 22q-SE was significantly associated with prostate cancer risk(odds ratio=1.26,P=7.61×10^(-5)).We also have found that the rs6001092T>G,in a high linkage disequilibrium with rs5750581T>C(r^(2)=0.98),is located in a regulatory aryl hydrocarbon receptor(AhR)motif and may interact with the FAM227A promoter in further bioinformatics analysis.We then performed a series of functional and BaP acute exposure experiments to assess biological function of the genetic variant and the target gene.Biologically,the rs6001092-G allele strengthened the transcription factor binding affinity to AhR,thereby upregulating FAM227A,especially upon exposure to BaP,which induced the malignant phenotypes of prostate cancer.The current study highlights that AhR acts as an environmental sensor of BaP and is involved in the SE-mediated prostate cancer risk,which may provide new insights into the etiology of prostate cancer associated with the inherited SE variants under environmental carcinogen stressors.
