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hsa_circ_0102049通过miR-96-5p/AK3轴促进结直肠癌细胞EMT介导的增殖和转移 被引量:1
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作者 刘胜楠 陈卓 《医学研究杂志》 2022年第11期154-159,共6页
目的探讨环状RNA(circRNA)hsa_circ_0102049调控结直肠癌(colorectal cancer,CRC)细胞增殖和转移能力的机制。方法从GEO数据库下载GSE126094数据集并通过R软件筛选差异表达的circRNA,构建hsa_circ_0102049的小干扰RNA(small interfering... 目的探讨环状RNA(circRNA)hsa_circ_0102049调控结直肠癌(colorectal cancer,CRC)细胞增殖和转移能力的机制。方法从GEO数据库下载GSE126094数据集并通过R软件筛选差异表达的circRNA,构建hsa_circ_0102049的小干扰RNA(small interfering RNA,siRNA)以敲低hsa_circ_0102049的表达量并通过RT-qPCR、CCK-8、Transwell和Western blot法等检测转染后CRC细胞的增殖和转移能力变化并探寻相关机制。结果在GSE126094数据集中,hsa_circ_0102049在癌组织中表达量显著高于癌旁组织(P<0.001)。在HCT116和DLD-1细胞中干扰hsa_circ_0102049后,细胞的增殖和迁移侵袭能力减弱(P<0.05),Western blot法检测结果显示,E-cadherin的表达量升高而N-cadherin和Vimentin的表达量降低(P<0.05)。为了探寻hsa_circ_0102049的作用机制,数据库分析筛选出可以与hsa_circ_0102049结合的小RNA(microRNA,miRNA)miR-96-5p以及miR-96-5p的下游靶标AK3,并且敲低hsa_circ_0102049引起miR-96-5p的升高和AK3的降低(P<0.05)。结论在CRC细胞中,高表达的hsa_circ_0102049通过miR-96-5p/AK3轴促进上皮-间质转化(epithelial-mesenchymal transformation,EMT)从而增强细胞的增殖和转移。 展开更多
关键词 结直肠癌 hsa_circ_0102049 miR-96-5p ak3 上皮-间质转化
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Dynamics and adaptive control of a dual-arm space robot with closed-loop constraints and uncertain inertial parameters 被引量:20
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作者 Ying-Hong Jia Quan Hu Shi-Jie Xu 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2014年第1期112-124,共13页
A dynamics-based adaptive control approach is proposed for a planar dual-arm space robot in the presence of closed-loop constraints and uncertain inertial parameters of the payload. The controller is capable of contro... A dynamics-based adaptive control approach is proposed for a planar dual-arm space robot in the presence of closed-loop constraints and uncertain inertial parameters of the payload. The controller is capable of controlling the po- sition and attitude of both the satellite base and the payload grasped by the manipulator end effectors. The equations of motion in reduced-order form for the constrained system are derived by incorporating the constraint equations in terms of accelerations into Kane's equations of the unconstrained system. Model analysis shows that the resulting equations perfectly meet the requirement of adaptive controller design. Consequently, by using an indirect approach, an adaptive control scheme is proposed to accomplish position/attitude trajectory tracking control with the uncertain parameters be- ing estimated on-line. The actuator redundancy due to the closed-loop constraints is utilized to minimize a weighted norm of the joint torques. Global asymptotic stability is proven by using Lyapunov's method, and simulation results are also presented to demonstrate the effectiveness of the proposed approach. 展开更多
关键词 space robot Dynamics. Adaptive control Closed-loop constraint Parameter uncertainty - Kane's equation
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α-干扰素和CD_3AK阻断慢性乙型肝炎演变肝硬化和肝细胞癌的10年观察 被引量:2
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作者 周岳进 陈成伟 许雪延 《实用肝脏病杂志》 CAS 2004年第3期177-178,共2页
目的 观察α 干扰素和CD3 AK细胞阻断慢性乙型肝炎演变为肝硬化和肝细胞癌 (HCC)的有效性。方法61例CHB分为A、B两组 ,A组 3 1例用IFN α3Mu深部皮下注射 ,第一月每日 1次 ,第 2~ 6月隔日 1次 ;CD3 AK每周 1次静滴 ,12次为一疗程 ;B组... 目的 观察α 干扰素和CD3 AK细胞阻断慢性乙型肝炎演变为肝硬化和肝细胞癌 (HCC)的有效性。方法61例CHB分为A、B两组 ,A组 3 1例用IFN α3Mu深部皮下注射 ,第一月每日 1次 ,第 2~ 6月隔日 1次 ;CD3 AK每周 1次静滴 ,12次为一疗程 ;B组 3 0例用辅助对症治疗。治疗后 6月检测血清ALT ,HBeAg ,抗 HBe ,HBVDNA ,AFP ,蛋白电泳 ,B型超声 ,CT扫描 ,连续观察 10年。结果 A组ALT复常 ,HBeAg阴转 ,抗 HBe阳转 ,HBVDNA阴转 ,分别为 80 .6%,48.3 %,45 .2 %和 5 1.6%;B组分别为 67%,10 %,6.7%和 6.7%;A组肝硬化 ,HCC发病率分别为 3 .2 %和 0 %,B组为 3 3 %和 16.7%。结论 HBV是LC、HCC的主要病因 ,抗病毒和免疫治疗不仅是治疗CHB的有效方法 ,而且是阻断CHB演变为LC、HCC的有效方法之一。 展开更多
关键词 Α-干扰素 CD3ak阻断慢性乙型肝炎 肝硬化 肝细胞癌
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Perfect Matrix Algebras ∑(λ)(Ⅱ)-AK-Property
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作者 吴从炘 《Northeastern Mathematical Journal》 CSCD 2001年第4期392-396,共5页
In this paper, we introduce the concept of AK-property for the perfect ma-trix algebras ∑(λ) and give some characterizations of∑(λ)possessing AK-property.
关键词 perfect sequence space perfect matrix algebra ak-property row-ak-property column-ak-property
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Eigen-Space Decomposition(ESD)Method for the Design of Internal Model Controller(IMC)from Noisy Input and Output Plant Data
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作者 吴国海 华建兴 《Journal of China Textile University(English Edition)》 EI CAS 1999年第4期13-16,共4页
A novel approach to design Internal Model Controller(IMC)is proposed in this paper directly from measuredinput and output plant data,which are assumed to becontaminated by measurement noise.In order to avoidthe compli... A novel approach to design Internal Model Controller(IMC)is proposed in this paper directly from measuredinput and output plant data,which are assumed to becontaminated by measurement noise.In order to avoidthe complicated structure-identification problem inmost cases,two Finite Impulse Response(FIR)modelsare taken to represent the plant model and the internalmodel controller respectively.Taking account of mea-surement noise both in the plant input and its output,anESD based Total Least Squares(TLS)solution is appliedfor the unbiased identification of the plant model and itsinverse model,the latter constitutes the internal modelcontroller according to the principle that the internalmodel controller approximates the inverse dynamics ofthe plant model.Simulations are given for a testifica-tion. 展开更多
关键词 Internal model control total least SQUARES EIGEN - space DECOMPOSITION parameter estimation identification
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The Novel cPLA2 Inhibitor AK106-001616 Has a Protective Effect on SOD1G93A-Induced Cell Death in NSC34 Murine Motor Neuron-Like Cell
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作者 Kazuki Ohuchi Kazuhiro Tsuruma +2 位作者 Masamitsu Shimazawa Junji Nakamura Hideaki Hara 《Pharmacology & Pharmacy》 2016年第5期193-199,共7页
The expression of cytosolic phospholipase A2 (cPLA2) expression is up-regulated in animal model of ALS and in patients with familial amyotrophic lateral sclerosis (fALS). Inhibition of cyclooxygenase 2 (COX2), which i... The expression of cytosolic phospholipase A2 (cPLA2) expression is up-regulated in animal model of ALS and in patients with familial amyotrophic lateral sclerosis (fALS). Inhibition of cyclooxygenase 2 (COX2), which is a downstream enzyme of cPLA2, ameliorates the impairment of motor function in the ALS model mice. Therefore, the arachidonic acid cascade, including the cPLA2-COX2 pathway, is an important therapeutic target of ALS. The current study was designed to investigate the potential of AK106-001616, an inhibitor of cPLA2, in protection of motor neuron cell death induced by mutant superoxide dismutase (SOD1<sup>G93A</sup>). AK106-001616 (1 - 10 μM) protected NSC34 cells (mouse motor neuron like cells) against SOD1<sup>G93A</sup>-induced motor neuron cell death. Furthermore, aspirin, an inhibitor of COX1/2, reduced the SOD1<sup>G93A</sup>-induced motor neuron cell death at a concentration that inhibited COX2. Celecoxib, a selective COX2 inhibitor, also reduced the SOD1<sup>G93A</sup>-induced motor neuron cell death. These results suggest that the arachidonic acid cascade is important for SOD1<sup>G93A</sup>-induced motor neuron cell death and AK106-001616 has a potent neuroprotective effect against it. AK106-001616 may be a useful therapeutic agent against SOD1<sup>G93A</sup>-induced ALS. 展开更多
关键词 ak106-001616 Amyotrophic Lateral Sclerosis CPLA2 NSC34 SOD1G93A
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Suppressive Influence of Time- Space White Noise on the Explosion of Solutions of Stochastic Fokker- Planck Delay Differential Equations
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作者 Augustine O. Atonuje Jonathan Tsetimi 《Journal of Mathematics and System Science》 2016年第7期284-290,共7页
It is generally known that the solutions of deterministic and stochastic differential equations (SDEs) usually grow linearly at such a rate that they may become unbounded after a small lapse of time and may eventual... It is generally known that the solutions of deterministic and stochastic differential equations (SDEs) usually grow linearly at such a rate that they may become unbounded after a small lapse of time and may eventually blow up or explode in finite time. If the drift and diffusion functions are globally Lipschitz, linear growth may still be experienced, as well as a possible blow-up of solutions in finite time. In this paper, a nonlinear scalar delay differential equation with a constant time lag is perturbed by a multiplicative Ito-type time - space white noise to form a stochastic Fokker-Planck delay differential equation. It is established that no explosion is possible in the presence of any intrinsically slow time - space white noise of Ito - type as manifested in the resulting stochastic Fokker- Planck delay differential equation. Time - space white noise has a role to play since the solution of the classical nonlinear equation without it still exhibits explosion. 展开更多
关键词 Explosion non-linear stochastic Fokker Planck delay differential equation time - space white noise finite time.
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LOFT L9-3 Experiment Simulation Using the SPACE Code
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作者 Chang-Keun Yang Yo-Han Kim Sang-Jun Ha 《Journal of Energy and Power Engineering》 2014年第10期1695-1702,共8页
The KHNP (Korea Hydro & Nuclear Power Co.) has developed a multipurpose nuclear safety analysis code called SPACE (the safety and performance analysis code) for nuclear power plants. SPACE code is a best-estimate... The KHNP (Korea Hydro & Nuclear Power Co.) has developed a multipurpose nuclear safety analysis code called SPACE (the safety and performance analysis code) for nuclear power plants. SPACE code is a best-estimated two-phase three-field thermal-hydraulic analysis code used to analyze the safety and performance of pressurized water reactors. In this paper, LOFT (loss of fluid test) L9-3 experiment using the SPACE code was selected to confirm the capability of SPACE code and the results calculated by the SPACE code are compared with those measured through the experiment. The results were compared with the experimental data and those of the other code simulations. Throughout the simulation result, it was concluded that the SPACE code can effectively simulate LOFT L9-3 experiment. 展开更多
关键词 space code LOFT L9-3 ATWS.
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关于λ-数乘收敛级数的不变性 被引量:7
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作者 武俊德 曲文波 崔成日 《数学进展》 CSCD 北大核心 2002年第3期279-283,共5页
本文证得(1)若λ具有弱滑脊性,那么λ-数乘收敛级数具有对偶不变性.(2)若λc00,那么λ-数乘收敛级数具有全程不变性的充要条件为(λ,β(λ,λβ))是AK-空间.
关键词 λ-数乘收敛 弱滑脊性 对偶不变性 全程不变性 ak-空间 级数
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AngiostatinK(1-3)裸DNA治疗人脑胶质瘤的实验研究 被引量:6
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作者 吴景文 章翔 +3 位作者 高大宽 屈延 郭衍 梁景文 《解放军医学杂志》 CAS CSCD 北大核心 2000年第2期94-96,共3页
探讨AngiostatinK( 1 3) [AK( 1 3) ]裸DNA治疗人脑胶质瘤的可行性和作用机制。用脂质体包埋法将AK( 1 3)基因的真核表达载体 pcDNA SAK( 1 3)注入裸鼠皮下SHG44人脑胶质瘤 ,观察肿瘤生长情况并计算抑瘤率 ,结合PCR、免疫组化、电... 探讨AngiostatinK( 1 3) [AK( 1 3) ]裸DNA治疗人脑胶质瘤的可行性和作用机制。用脂质体包埋法将AK( 1 3)基因的真核表达载体 pcDNA SAK( 1 3)注入裸鼠皮下SHG44人脑胶质瘤 ,观察肿瘤生长情况并计算抑瘤率 ,结合PCR、免疫组化、电镜、微血管和瘤体坏死区计数 ,确定抗血管生成基因治疗人脑胶质瘤的特点。AK( 1 3)裸DNA在荷瘤裸鼠瘤体内获得表达 ,裸鼠皮下胶质瘤血管生成能力显著下降 ,肿瘤生长受到抑制 ,抑瘤率达 43%。本研究证明 ,AK( 1 3)裸DNA能抑制人脑胶质瘤生长 ,为非病毒载体介导的抗血管生成基因治疗的应用奠定了基础。 展开更多
关键词 裸DNA 脑胶质瘤 ak(1-3)基因 基因治疗
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Angiostatin kringle(1-3)体外诱导人脐静脉内皮细胞凋亡 被引量:5
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作者 高大宽 章翔 +3 位作者 吴景文 荆俊杰 梁景文 刘先珍 《第四军医大学学报》 2000年第9期1051-1053,共3页
目的 探讨 angiostatin kringle (1- 3) [简称 AK(1-3) ]抑制血管内皮细胞增殖的作用机制 .方法 以加入重组人 AK(1- 3)蛋白 (30 0 nmol· L- 1 )的含 10 0 m L· L- 1小牛血清 DMEM培养基培养人脐静脉内皮细胞 ECV30 4,72 h... 目的 探讨 angiostatin kringle (1- 3) [简称 AK(1-3) ]抑制血管内皮细胞增殖的作用机制 .方法 以加入重组人 AK(1- 3)蛋白 (30 0 nmol· L- 1 )的含 10 0 m L· L- 1小牛血清 DMEM培养基培养人脐静脉内皮细胞 ECV30 4,72 h后 ,采用透射电镜、流式细胞术细胞周期分析和核 DNA琼脂糖凝胶 (15 g· L- 1 )电泳检测重组 AK(1- 3)蛋白作用后血管内皮细胞的凋亡情况 .结果 实验组 ECV30 4细胞检测到了典型的凋亡 .透射电镜下可见细胞核染色质浓缩、边集、核碎裂及胞质浓缩等凋亡细胞典型的形态学改变 ;流式细胞术周期分析显示在 G1期峰前存在一个凋亡峰 (2 0 .6 % ) ;核琼脂糖凝胶(DNA15 g· L- 1 )电泳呈梯状 .对照组 ECV30 4细胞表现正常 .结论 重组人 AK(1- 3)蛋白诱导了血管内皮细胞的凋亡 。 展开更多
关键词 ak(1-3) 人脐静脉 内皮细胞 ANGIOSTATIN
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Angiostatin K(1-3)基因的原核表达和活性鉴定 被引量:2
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作者 吴景文 章翔 +3 位作者 高大宽 屈延 荆俊杰 李侠 《解放军医学杂志》 CAS CSCD 北大核心 2000年第2期90-93,共4页
将人AngiostatinK( 1 3)基因在原核细胞表达并鉴定其活性。构建和鉴定AngiostatinK ( 1 3)原核表达载体并在大肠杆菌DH5α内表达 ,诱导表达蛋白用SDS PAGE分析和Westernblot鉴定 ,采用人脐带静脉内皮细胞抑制实验和鸡胚绒毛膜尿囊膜... 将人AngiostatinK( 1 3)基因在原核细胞表达并鉴定其活性。构建和鉴定AngiostatinK ( 1 3)原核表达载体并在大肠杆菌DH5α内表达 ,诱导表达蛋白用SDS PAGE分析和Westernblot鉴定 ,采用人脐带静脉内皮细胞抑制实验和鸡胚绒毛膜尿囊膜试验验证其活性。AngiostatinK( 1 3)功能区段基因在原核细胞获得成功表达 ,目的蛋白占菌体总蛋白的 1 5 .7%。该表达蛋白能抑制内皮细胞增殖活性 ,具有剂量依赖效应。正确表达的AngiostatinK( 1 3)基因为实体瘤抗血管生成治疗提供了条件。 展开更多
关键词 原核细胞 脑胶质瘤 基因治疗 ak(1-3)基因
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肌萎缩侧索硬化患者脑脊液及血清MCP-1和VEGF蛋白表达的变化 被引量:1
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作者 王敏健 杨志华 +1 位作者 秦琴保 李泽 《现代预防医学》 CAS 北大核心 2008年第14期2721-2722,2731,共3页
[目的]通过检测ALS患者脑脊液及血清中MCP-1及VEGF含量及表达变化来探讨ALS的发病机制及是否能作为ALS的临床指标。[方法]分别采用ELISA法测定16例ALS患者和8例门诊头痛患者的脑脊液及血清中的MCP-1和VEGF水平。[结果]ALS患者血清及脑... [目的]通过检测ALS患者脑脊液及血清中MCP-1及VEGF含量及表达变化来探讨ALS的发病机制及是否能作为ALS的临床指标。[方法]分别采用ELISA法测定16例ALS患者和8例门诊头痛患者的脑脊液及血清中的MCP-1和VEGF水平。[结果]ALS患者血清及脑脊液中MCP-1含量均明显高于对照组(P﹤0.01),ALS患者脑脊液中VEGF含量明显低于对照组(P﹤0.01),ALS患者血清中VEGF含量低于对照组,差异无统计学意义(P﹥0.05)。[结论]MCP-1和VEGF参与了肌萎缩侧索硬化的病理生理过程,可以作为肌萎缩侧索硬化的临床诊断指标。 展开更多
关键词 肌萎缩侧索硬化(akS) 单核细胞趋化蛋白-1(MCP-1) 血管内皮生长因子(VEGF)
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鞅变换Φ-不等式 被引量:3
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作者 金雁鸣 《数学杂志》 CSCD 北大核心 2004年第3期291-294,共4页
本文对于可预报鞅证明了鞅变换的均方函数、极大函数的Φ 不等式 ,并讨论了鞅变换的极大函数的αLΦ 范数与鞅的αKΦ
关键词 鞅变换 Ф-函数 均方函数 极大函数 可预报鞅 akФ鞅空间
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s-乘数收敛的Orlicz-Pettis定理(英文)
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作者 陶元红 卜繁强 《延边大学学报(自然科学版)》 CAS 2010年第3期192-195,共4页
讨论乘数收敛级数的Orlicz-Pettis型定理.首先给出一个新的Helliger Tplitz拓扑δ(X,X′),然后证明若数列空间s包含c00,则(s,δ(s,sβ))是AK-空间;若数列空间s具有性质G,则(s,c(s,sβ))是AK-空间.
关键词 s-乘数收敛 ak-空间 Helliger Tplitz拓扑
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关于λ-乘数收敛级数的Orlicz-Pettis定理
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作者 顾娟 单净 姜文彪 《高师理科学刊》 2014年第4期12-14,共3页
为深入研究λ-乘数收敛级数的不变性,利用Antosik-Mikusinski基本矩阵定理,证明了若一般序列空间λ具有弱滑脊性,则(λ,c(λ,λβ))为AK-空间,进而得到关于λ-乘数收敛的一个Orlicz-Pettis定理.
关键词 λ-乘数收敛 弱滑脊性 ak-空间
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福建姜黄挥发油化学成分的HS-SPME-GC-MS分析 被引量:16
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作者 强悦越 韦航 +4 位作者 方灵 吴妙鸿 谭索 曾绍校 傅建炜 《中国食品添加剂》 CAS 2020年第1期147-153,共7页
采用水蒸气蒸馏法提取福建姜黄挥发油,应用顶空固相微萃取进样结合气相色谱-串联质谱联用技术(HS-SPME-GC-MS)分析姜黄挥发油的化学成分。结果表明:姜黄挥发油含有量为7.2%(mL/g),从姜黄挥发油中共分出62个色谱峰,初步鉴定出了其中的51... 采用水蒸气蒸馏法提取福建姜黄挥发油,应用顶空固相微萃取进样结合气相色谱-串联质谱联用技术(HS-SPME-GC-MS)分析姜黄挥发油的化学成分。结果表明:姜黄挥发油含有量为7.2%(mL/g),从姜黄挥发油中共分出62个色谱峰,初步鉴定出了其中的51种化学成分,占总挥发油总量的98.41%。在鉴定的化合物中,主要为单萜类化合物和倍半萜类化合物,其中新发现一种主要成分为β-柏木烯,相对含量占比高达26.58%,这可作为福建姜黄挥发油的特征成分和主要品质指标。本研究结果将为福建姜黄植物药材的品质评价提供科学依据。 展开更多
关键词 姜黄挥发油 顶空固相微萃取技术(Head space solid phase micro-extraction HS-SPME) 气相色谱-质谱联用技术(Gas chromatography-mass spectrometry GC-MS) 化学成分
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Stress redistribution in multi-stage hydraulic fracturing of horizontal wells in shales 被引量:6
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作者 Yi-Jin Zeng Xu Zhang Bao-Ping Zhang 《Petroleum Science》 SCIE CAS CSCD 2015年第4期628-635,共8页
Multi-stage hydraulic fracturing of horizontal wells is the main stimulation method in recovering gas from tight shale gas reservoirs, and stage spacing deter- mination is one of the key issues in fracturing design. T... Multi-stage hydraulic fracturing of horizontal wells is the main stimulation method in recovering gas from tight shale gas reservoirs, and stage spacing deter- mination is one of the key issues in fracturing design. The initiation and propagation of hydraulic fractures will cause stress redistribution and may activate natural fractures in the reservoir. Due to the limitation of the analytical method in calculation of induced stresses, we propose a numerical method, which incorporates the interaction of hydraulic fractures and the wellbore, and analyzes the stress distri- bution in the reservoir under different stage spacing. Simulation results indicate the following: (1) The induced stress was overestimated from the analytical method because it did not take into account the interaction between hydraulic fractures and the horizontal wellbore. (2) The hydraulic fracture had a considerable effect on the redis- tribution of stresses in the direction of the horizontal wellbore in the reservoir. The stress in the direction per- pendicular to the horizontal wellbore after hydraulic frac- turing had a minor change compared with the original in situ stress. (3) Stress interferences among fractures were greatly connected with the stage spacing and the distance from the wellbore. When the fracture length was 200 m, and the stage spacing was 50 m, the stress redistribution due to stage fracturing may divert the original stress pat- tern, which might activate natural fractures so as to generate a complex fracture network. 展开更多
关键词 Shale gas - Horizontal well Multi-stagefracturing Complex fracture Stage spacing - Inducedstress
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嗜水气单胞菌胞内聚3-羟基丁酸-3-羟基己酸酯(PHBHHx)提取方法的研究 被引量:3
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作者 邓媛 《化工时刊》 CAS 2008年第3期10-13,16,共5页
以嗜水气单胞菌利用月桂酸发酵生产PHBHHx,比较多种溶剂对提取率和产品质量的影响,建立了嗜水气单胞菌胞内提取PHBHHx的新方法。本方法使用湿细胞提取,节省干燥细胞的能耗,仲丁醇无异味、毒性小、价格低廉,而且可以循环多次利用、对相... 以嗜水气单胞菌利用月桂酸发酵生产PHBHHx,比较多种溶剂对提取率和产品质量的影响,建立了嗜水气单胞菌胞内提取PHBHHx的新方法。本方法使用湿细胞提取,节省干燥细胞的能耗,仲丁醇无异味、毒性小、价格低廉,而且可以循环多次利用、对相对分子质量影响小,解决了工业生产上能耗高,生产成本高,溶剂回收难,安全隐患多,提取率不高、产品质量低等问题。用仲丁醇作溶剂,预处理细胞提取率提高13%,相对分子质量达83万,提取率达78%,产品纯度达99%以上。 展开更多
关键词 聚羟基脂肪酸酯(PHA) 3-羟基丁酸和3-羟基己酸共聚物(PHBHHx) 嗜水气单胞菌(Aeromonas HYDROPHILA 4ak4) 发酵 提取 仲丁醇
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The use of laser ranging to measure space debris 被引量:21
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作者 Zhong-Ping Zhang 1,2,Fu-Min Yang 1,Hai-Feng Zhang 1,Zhi-Bo Wu 1,2,Ju-Ping Chen 1,2,Pu Li 1 and Wen-Dong Meng 1 1 Shanghai Astronomical Observatory,Chinese Academy of Sciences,Shanghai 200030,China 2 Key Laboratory of Space Object and Debris Observation,Chinese Academy of Science,Nanjing 210008,China 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2012年第2期212-218,共7页
Space debris is a major problem for all the nations that are currently active in space. Adopting high-precision measuring techniques will help produce a reliable and accurate catalog for space debris and collision avo... Space debris is a major problem for all the nations that are currently active in space. Adopting high-precision measuring techniques will help produce a reliable and accurate catalog for space debris and collision avoidance. Laser ranging is a kind of real-time measuring technology with high precision for space debris observation. The first space-debris laser-ranging experiment in China was performed at the Shanghai Observatory in July 2008 with a ranging precision of about 60-80 cm. The experi- mental results showed that the return signals from the targets with a range of 900 km were quite strong, with a power of 40W (2J at 20 Hz) using a 10ns pulse width laser at 532 nm wavelength. The performance of the preliminary laser ranging system and the observed results in 2008 and 2010 are also introduced. 展开更多
关键词 astrometry - catalogs - space debris - laser ranging - observation
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