The Anthropocene proposal suggested that the Earth may have entered a new geological epoch,in which human activity and climate change are influencing the environment at global scale.Arrival of the Anthropocene is brin...The Anthropocene proposal suggested that the Earth may have entered a new geological epoch,in which human activity and climate change are influencing the environment at global scale.Arrival of the Anthropocene is bringing an unprecedented challenge to the biodiversity that is essential to humans,and enhancing many benefits of nature to human being.However,biodiversity loss is aggravating in the rhythm of inevitable change in the Anthropocene,and the adaptation of biodiversity to the anthropogenic disturbance seems unable to keep pace with the human activity and climate change.Therefore,re-examination of the assumptions and practices upon the current conservation endeavor are needed.We suggested that biodiversity conservation should be paid more attention to the response from biodiversity to the human activity and climate change in the Anthropocene.Thus,the concept of biodiversity arks in the Anthropocene is proposed,that is,biodiversity arks in the Anthropocene are the areas where vulnerable biodiversity is sheltered to alleviate human activity and buffered from climate change under the anthropogenic disturbance.The concept should be implemented for biodiversity conservation to fill gaps between our knowledge and build on successful conservation and sustainability in the Anthropocene.It will be certainly important to conservation policy instruction and management under climate change,especially the implementation of climate buffering zones preserving biodiversity in the face of warming climate.展开更多
ARK5(AMPK-related protein kinase 5,又称NUAK1)是AMPK(AMP-activated protein kinase)的亚家族成员之一,其是Akt的下游信号分子。ARK5在各种肿瘤细胞系中表达,有研究表明ARK5能促进肿瘤的发生和抑制肿瘤细胞的凋亡,且Akt-ARK5通路与...ARK5(AMPK-related protein kinase 5,又称NUAK1)是AMPK(AMP-activated protein kinase)的亚家族成员之一,其是Akt的下游信号分子。ARK5在各种肿瘤细胞系中表达,有研究表明ARK5能促进肿瘤的发生和抑制肿瘤细胞的凋亡,且Akt-ARK5通路与肿瘤的恶性发展密切相关。该文对ARK5在肿瘤侵袭和转移中的作用,及其与肿瘤侵袭相关的信号分子的相互关系进行综述。展开更多
基金This work was financially supported by the Southeast Asia Biodiversity Research Institute,Chinese Academy of Sciences(Y4ZK111B01)the Youth Innovation Promotion Association,Chinese Academy of Sciences(2018432).
文摘The Anthropocene proposal suggested that the Earth may have entered a new geological epoch,in which human activity and climate change are influencing the environment at global scale.Arrival of the Anthropocene is bringing an unprecedented challenge to the biodiversity that is essential to humans,and enhancing many benefits of nature to human being.However,biodiversity loss is aggravating in the rhythm of inevitable change in the Anthropocene,and the adaptation of biodiversity to the anthropogenic disturbance seems unable to keep pace with the human activity and climate change.Therefore,re-examination of the assumptions and practices upon the current conservation endeavor are needed.We suggested that biodiversity conservation should be paid more attention to the response from biodiversity to the human activity and climate change in the Anthropocene.Thus,the concept of biodiversity arks in the Anthropocene is proposed,that is,biodiversity arks in the Anthropocene are the areas where vulnerable biodiversity is sheltered to alleviate human activity and buffered from climate change under the anthropogenic disturbance.The concept should be implemented for biodiversity conservation to fill gaps between our knowledge and build on successful conservation and sustainability in the Anthropocene.It will be certainly important to conservation policy instruction and management under climate change,especially the implementation of climate buffering zones preserving biodiversity in the face of warming climate.
文摘ARK5(AMPK-related protein kinase 5,又称NUAK1)是AMPK(AMP-activated protein kinase)的亚家族成员之一,其是Akt的下游信号分子。ARK5在各种肿瘤细胞系中表达,有研究表明ARK5能促进肿瘤的发生和抑制肿瘤细胞的凋亡,且Akt-ARK5通路与肿瘤的恶性发展密切相关。该文对ARK5在肿瘤侵袭和转移中的作用,及其与肿瘤侵袭相关的信号分子的相互关系进行综述。
