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6G New Multiple Access Technology
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作者 Yifei Yuan Yongpeng Wu +3 位作者 Lei Wang Zhifeng Yuan Wei Bai Yuanwei Liu 《China Communications》 SCIE CSCD 2024年第1期I0002-I0005,共4页
As a basic technology at physical layer of mobile communications,non-orthogonal multiple access has been attracting wide attention across the academia and the industry.During the standardization of the fifth-generatio... As a basic technology at physical layer of mobile communications,non-orthogonal multiple access has been attracting wide attention across the academia and the industry.During the standardization of the fifth-generation(5G)of mobile communications,3GPP conducted preliminary study on non-orthogonal multiple access without reaching the consensus to standardize the technology. 展开更多
关键词 TECHNOLOGY ACCESS attracting
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Diagnosis and treatment of refractory infectious diseases using nanopore sequencing technology:Three case reports
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作者 Qing-Mei Deng Jian Zhang +5 位作者 Yi-Yong Zhang Min Jia Du-Shan Ding Yu-Qin Fang Hong-Zhi Wang Hong-Cang Gu 《World Journal of Clinical Cases》 SCIE 2024年第22期5208-5216,共9页
BACKGROUND Infectious diseases are still one of the greatest threats to human health,and the etiology of 20%of cases of clinical fever is unknown;therefore,rapid identification of pathogens is highly important.Traditi... BACKGROUND Infectious diseases are still one of the greatest threats to human health,and the etiology of 20%of cases of clinical fever is unknown;therefore,rapid identification of pathogens is highly important.Traditional culture methods are only able to detect a limited number of pathogens and are time-consuming;serologic detection has window periods,false-positive and false-negative problems;and nucleic acid molecular detection methods can detect several known pathogens only once.Three-generation nanopore sequencing technology provides new options for identifying pathogens.CASE SUMMARY Case 1:The patient was admitted to the hospital with abdominal pain for three days and cessation of defecation for five days,accompanied by cough and sputum.Nanopore sequencing of the drainage fluid revealed the presence of orallike bacteria,leading to a clinical diagnosis of bronchopleural fistula.Cefoperazone sodium sulbactam treatment was effective.Case 2:The patient was admitted to the hospital with fever and headache,and CT revealed lung inflammation.Antibiotic treatment for Streptococcus pneumoniae,identified through nanopore sequencing of cerebrospinal fluid,was effective.Case 3:The patient was admitted to our hospital with intermittent fever and an enlarged neck mass that had persisted for more than six months.Despite antibacterial treatment,her symptoms worsened.The nanopore sequencing results indicate that voriconazole treatment is effective for Aspergillus brookii.The patient was diagnosed with mixed cell type classical Hodgkin's lymphoma with infection.CONCLUSION Three-generation nanopore sequencing technology allows for rapid and accurate detection of pathogens in human infectious diseases. 展开更多
关键词 Nanopore sequencing technology Third-generation sequencing technology INFECTION PATHOGEN Case report
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Geospatial Technology Integration in Smart City Frameworks for Achieving Climate Neutrality by 2050: A Case Study of Limassol Municipality, Cyprus
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作者 Antonis Papantoniou Chris Danezis Diofantos Hadjimitsis 《Journal of Geographic Information System》 2024年第1期44-60,共17页
This study investigated the integration of geospatial technologies within smart city frameworks to achieve the European Union’s climate neutrality goals by 2050. Focusing on rapid urbanization and escalating climate ... This study investigated the integration of geospatial technologies within smart city frameworks to achieve the European Union’s climate neutrality goals by 2050. Focusing on rapid urbanization and escalating climate challenges, the research analyzed how smart city frameworks, aligned with climate neutrality objectives, leverage geospatial technologies for urban planning and climate action. The study included case studies from three leading European cities, extracting lessons and best practices in implementing Climate City Contracts across sectors like energy, transport, and waste management. These insights highlighted the essential role of EU and national authorities in providing technical, regulatory, and financial support. Additionally, the paper presented the application of a WEBGIS platform in Limassol Municipality, Cyprus, demonstrating citizen engagement and acceptance of the proposed geospatial framework. Concluding with recommendations for future research, the study contributed significant insights into the advancement of urban sustainability and the effectiveness of geospatial technologies in smart city initiatives for combating climate change. 展开更多
关键词 Smart Cities Geospatial Technologies Smart City Frameworks Geospatial Integration
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Modern technology-based exploration of mechanism of traditional Chinese medicine in prevention and treatment of gastric cancer
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作者 De-Hui Li Rui-Qi Feng 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第9期3747-3751,共5页
This review comments on the article“To explore the mechanism of Yigong San anti-gastric cancer and immune regulation”.We are interested that the article applied network pharmacology and bioinformatics techniques to ... This review comments on the article“To explore the mechanism of Yigong San anti-gastric cancer and immune regulation”.We are interested that the article applied network pharmacology and bioinformatics techniques to elucidate the mechanism of action of Yigong Sang,a traditional Chinese medicine(TCM),in the treatment of gastric cancer(GC).The mechanism of action of Yigong Sang in the treatment of GC has not yet been elucidated because it is composed of multiple Chinese medicines with multiple components and multiple targets.The emergence of network pharmacology and bioinformatics analysis helps explain the mechanism of action of TCM in preventing and treating GC,and provides a possibility for TCM to transform from empirical to evidence-based medicine.This is of great significance for the application of TCM in oncology,new drug development,formula optimization,and the improvement of clinical efficacy. 展开更多
关键词 Gastric cancer Traditional Chinese medicine MECHANISM Network pharmacology BIOINFORMATICS New technology
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Analysis of the Effectiveness of Modified Non- Traumatic Filling Technology in the Treatment of Pediatric Dental Caries
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作者 Yi Liu 《Journal of Clinical and Nursing Research》 2024年第3期95-100,共6页
Objective:To analyze the effectiveness of modified non-traumatic filling technology in the treatment of pediatric dental caries.Methods:Ninety-seven children with dental caries who were treated in our hospital(Panyu M... Objective:To analyze the effectiveness of modified non-traumatic filling technology in the treatment of pediatric dental caries.Methods:Ninety-seven children with dental caries who were treated in our hospital(Panyu Maternal and Child Care Service Center of Guangzhou)from January 2022 to December 2023 were selected and randomly divided into two groups,with 48 cases in the experimental group and 49 in the control group.The experimental group was treated with modified non-traumatic filling techniques,while the control group was treated with conventional filling techniques.Observation indicators such as the total effectiveness of the treatment,incidence of adverse events,treatment compliance,and pain scores were analyzed after the intervention.Result:After intervention,the total effectiveness of the treatment in the experimental group was higher than that in the control group(P<0.05).The incidence of adverse events in the experimental group was lower than that of the control group(P<0.05).The treatment compliance of patients in the experimental group was higher than that in the control group(P<0.05).The pain score of the experimental group was lower than that of the control group(P<0.05).Conclusion:The application of modified non-traumatic filling technology in the treatment of pediatric dental caries showed good therapeutic outcomes.After the intervention,the child’s symptoms were significantly alleviated,the incidence of adverse events such as filling material falling off was reduced,their compliance was improved,and the pain was relieved.This procedure is worth to be promoted for clinical application. 展开更多
关键词 Improved non-traumatic filling technology Treatment effect Pediatric caries
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Analysis of Municipal Water Supply and Drainage Pipe Design Technology
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作者 Liang Liu 《Journal of Architectural Research and Development》 2024年第3期69-74,共6页
The quality and safety of residents’water rely heavily on the design of municipal water supply and drainage pipes.Therefore,this paper aims to enhance the optimization of municipal water supply and drainage pipe desi... The quality and safety of residents’water rely heavily on the design of municipal water supply and drainage pipes.Therefore,this paper aims to enhance the optimization of municipal water supply and drainage pipe design by focusing on design requirements,principles,and key elements.Drawing from relevant design optimization experiences,technology advancements,and optimization measures,the research will analyze and consolidate the essential aspects of municipal water supply and drainage pipe design.The goal is to fundamentally elevate the quality standards of these designs,ensuring they meet the criteria for engineering project excellence.Through this comprehensive approach,we aim to contribute to the improvement and sustainability of water supply and drainage systems,safeguarding the well-being of residents. 展开更多
关键词 Municipal water supply and drainage Pipe layout RAINWATER SEWAGE Design technology
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网络通信中嵌入式TCP/IP协议单片机技术的应用 被引量:2
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作者 刘崇巍 《中国高新科技》 2024年第5期47-49,共3页
嵌入式系统已经是当前网络通信的主要技术。单片机在嵌入式系统开发与实现中的多个环节发生作用。为此,文章重点探讨在网络通信系统嵌入式协议中单片机的具体应用。首先对嵌入式协议技术的总体架构与技术细节进行了汇总;其次对单片机技... 嵌入式系统已经是当前网络通信的主要技术。单片机在嵌入式系统开发与实现中的多个环节发生作用。为此,文章重点探讨在网络通信系统嵌入式协议中单片机的具体应用。首先对嵌入式协议技术的总体架构与技术细节进行了汇总;其次对单片机技术及其作用进行了探讨;最后从多个方面分别分析了单片机在具体电路中的应用。以期为后续的产品开发与技术应用奠定基础。 展开更多
关键词 网络通信 嵌入式 协议 单片机技术
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基于IPD技术的LC滤波器制备工艺
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作者 徐亚新 梁广华 +4 位作者 庄治学 龚孟磊 刘晓兰 周拥华 王康 《电子工艺技术》 2024年第1期6-9,38,共5页
介质层制备工艺是基于IPD技术的LC滤波器制备的关键工艺。从介质层的制备流程入手,研究了影响PI介质层质量的匀胶、曝光、固化三个关键工艺因素,确定了LC滤波器中介质层的制备工艺参数,实现了厚度8μm、厚度均匀性优于5%、最小互连孔径2... 介质层制备工艺是基于IPD技术的LC滤波器制备的关键工艺。从介质层的制备流程入手,研究了影响PI介质层质量的匀胶、曝光、固化三个关键工艺因素,确定了LC滤波器中介质层的制备工艺参数,实现了厚度8μm、厚度均匀性优于5%、最小互连孔径25μm的介质层制备。按此工艺参数加工,得到LC滤波器样件,经性能测试,所制备LC滤波器的电学性能满足设计指标要求。 展开更多
关键词 IPD技术 LC滤波器 介质层
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O-TRKIPES“半翻转”教学模型的搭建及其在分析化学课程中的应用
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作者 穆瑞花 刘斌 +4 位作者 吴艳光 常薇 秋列维 安凤秋 赵亚梅 《化工设计通讯》 CAS 2024年第2期69-71,共3页
“半翻转”课堂课程设计合理,能充分发挥学生的主观能动性,能正确引导学生合作学习,因此备受国内外教育界的广泛关注。基于此背景,首先搭建了一种O-TRKIPES“半翻转”教学模型,然后将该模型应用到分析化学的课程教学中。以西安工程大学... “半翻转”课堂课程设计合理,能充分发挥学生的主观能动性,能正确引导学生合作学习,因此备受国内外教育界的广泛关注。基于此背景,首先搭建了一种O-TRKIPES“半翻转”教学模型,然后将该模型应用到分析化学的课程教学中。以西安工程大学化学工程与工艺专业的学生为研究对象,分别考察了该专业不同年级和相同年级两个班学生在O-TRKIPES“半翻转”教学模型下的学习效果。结果表明O-TRKIPES“半翻转”教学模式下,该专业学生期末考试成绩中,优秀学生的人数显著增加,中等和差的学生人数明显减少,取得了较为良好的教学效果。 展开更多
关键词 “半翻转”课堂 教学效果 现代教育技术
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面向Chiplet集成的三维互连硅桥技术
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作者 赵瑾 于大全 秦飞 《电子与封装》 2024年第6期1-11,I0003,共12页
摩尔定律的发展速度放缓和集成电路产品应用的多元化趋势,共同推动了先进封装技术的快速发展。先进互连技术是先进封装的核心,在高速、高频传输、功耗、超细节距互连以及系统集成能力等方面均展现出显著优势。硅桥技术作为Chiplet以及... 摩尔定律的发展速度放缓和集成电路产品应用的多元化趋势,共同推动了先进封装技术的快速发展。先进互连技术是先进封装的核心,在高速、高频传输、功耗、超细节距互连以及系统集成能力等方面均展现出显著优势。硅桥技术作为Chiplet以及异构集成封装的重要解决方案,可以以较低的成本实现多芯片间的局部高密度互连,在处理器、存储器、射频器件中被广泛应用。介绍了业界主流的硅桥技术,并对硅桥技术的结构特点和关键技术进行了分析和总结。深入讨论了硅桥技术的发展趋势及挑战,为相关领域的进一步发展提供参考。 展开更多
关键词 先进互连技术 Chiplet 硅桥技术 高密度互连
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A frequency servo SoC with output power stabilization loop technology for miniaturized atomic clocks 被引量:1
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作者 Hongyang Zhang Xinlin Geng +3 位作者 Zonglin Ye Kailei Wang Qian Xie Zheng Wang 《Journal of Semiconductors》 EI CAS CSCD 2024年第6期13-22,共10页
A frequency servo system-on-chip(FS-SoC)featuring output power stabilization technology is introduced in this study for high-precision and miniaturized cesium(Cs)atomic clocks.The proposed power stabilization loop(PSL... A frequency servo system-on-chip(FS-SoC)featuring output power stabilization technology is introduced in this study for high-precision and miniaturized cesium(Cs)atomic clocks.The proposed power stabilization loop(PSL)technique,incorporating an off-chip power detector(PD),ensures that the output power of the FS-SoC remains stable,mitigating the impact of power fluctuations on the atomic clock's stability.Additionally,a one-pulse-per-second(1PPS)is employed to syn-chronize the clock with GPS.Fabricated using 65 nm CMOS technology,the measured phase noise of the FS-SoC stands at-69.5 dBc/Hz@100 Hz offset and-83.9 dBc/Hz@1 kHz offset,accompanied by a power dissipation of 19.7 mW.The Cs atomic clock employing the proposed FS-SoC and PSL obtains an Allan deviation of 1.7×10^(-11) with 1-s averaging time. 展开更多
关键词 CMOS technology atomic clock phase-locked loop output power stabilization 1PPS
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Development and technology status of energy storage in depleted gas reservoirs 被引量:1
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作者 Jifang Wan Yangqing Sun +4 位作者 Yuxian He Wendong Ji Jingcui Li Liangliang Jiang Maria Jose Jurado 《International Journal of Coal Science & Technology》 EI CAS CSCD 2024年第2期198-221,共24页
Utilizing energy storage in depleted oil and gas reservoirs can improve productivity while reducing power costs and is one of the best ways to achieve synergistic development of"Carbon Peak–Carbon Neutral"a... Utilizing energy storage in depleted oil and gas reservoirs can improve productivity while reducing power costs and is one of the best ways to achieve synergistic development of"Carbon Peak–Carbon Neutral"and"Underground Resource Utiliza-tion".Starting from the development of Compressed Air Energy Storage(CAES)technology,the site selection of CAES in depleted gas and oil reservoirs,the evolution mechanism of reservoir dynamic sealing,and the high-flow CAES and injection technology are summarized.It focuses on analyzing the characteristics,key equipment,reservoir construction,application scenarios and cost analysis of CAES projects,and sorting out the technical key points and existing difficulties.The devel-opment trend of CAES technology is proposed,and the future development path is scrutinized to provide reference for the research of CAES projects in depleted oil and gas reservoirs. 展开更多
关键词 Depleted gas reservoirs Technology and development Siting analysis Safety evaluation Compressed air energy storage
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Cardiac rehabilitation after cardiac surgery:An important underutilized treatment strategy 被引量:1
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作者 Christos Kourek Stavros Dimopoulos 《World Journal of Cardiology》 2024年第2期67-72,共6页
Physical inactivity remains in high levels after cardiac surgery,reaching up to 50%.Patients present a significant loss of functional capacity,with prominent muscle weakness after cardiac surgery due to anesthesia,sur... Physical inactivity remains in high levels after cardiac surgery,reaching up to 50%.Patients present a significant loss of functional capacity,with prominent muscle weakness after cardiac surgery due to anesthesia,surgical incision,duration of cardiopulmonary bypass,and mechanical ventilation that affects their quality of life.These complications,along with pulmonary complications after surgery,lead to extended intensive care unit(ICU)and hospital length of stay and significant mortality rates.Despite the well-known beneficial effects of cardiac rehabilitation,this treatment strategy still remains broadly underutilized in patients after cardiac surgery.Prehabilitation and ICU early mobilization have been both showed to be valid methods to improve exercise tolerance and muscle strength.Early mobilization should be adjusted to each patient’s functional capacity with progressive exercise training,from passive mobilization to more active range of motion and resistance exercises.Cardiopulmonary exercise testing remains the gold standard for exercise capacity assessment and optimal prescription of aerobic exercise intensity.During the last decade,recent advances in healthcare technology have changed cardiac rehabilitation perspectives,leading to the future of cardiac rehabilitation.By incorporating artificial intelligence,simulation,telemedicine and virtual cardiac rehabilitation,cardiac surgery patients may improve adherence and compliance,targeting to reduced hospital readmissions and decreased healthcare costs. 展开更多
关键词 Cardiac rehabilitation Cardiac surgery Cardiopulmonary exercise testing Early mobilization TREATMENT TECHNOLOGY
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Orthogonal Frequency Division Multiplexing Adaptive Technology for Multinode Users of Seawater Channel Based on Inductively Coupled Mooring Chain
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作者 ZHENG Yu LIU Yingjie +3 位作者 REN Yuanhong FEI Chen ZHANG Shijiang LI Hongzhi 《Journal of Ocean University of China》 SCIE CAS CSCD 2023年第5期1243-1252,共10页
As an important part of buoy-type ocean monitoring systems,the inductively coupled mooring chain solves the problem of data cotransmission through the multinode sensors that it carries,which is significant for the rap... As an important part of buoy-type ocean monitoring systems,the inductively coupled mooring chain solves the problem of data cotransmission through the multinode sensors that it carries,which is significant for the rapid acquisition of fish,hydrology,and other information.This paper is based on a seawater channel transmission model with a depth of 300 m and a bandwidth of 2 MHz.An orthogonal frequency division multiplexing(OFDM)technology is used to overcome the multipath effect of signal transmission on a seawater medium.The adaptive technology is integrated into the OFDM,and an improved joint subcarrier and bit power allocation algorithm is proposed.This algorithm solves the problem of dynamic subcarrier allocation during the cotransmission of underwater multinode user data in seawater channels.The results show that the algorithm complexity can be reduced by 0.18126×10^(-2)s during one complete OFDM system data transmission by the improved greedy algorithm,and a total of 216 bits are transmitted by the OFDM.The normalized channel capacity can be improved by 0.012 bit s^(-1)Hz^(-1).At the bit error ratio(BER)of 10^(-3),the BER performance can be improved by approximately 6 d B.When the numbers of users are 4 and 8,the improved algorithm increases the channel capacity,and the higher the number of users,the more evident the channel capacity improvement effect is.The results of this paper have an important reference value for enhancing the transmission performance of inductively coupled mooring chain underwater multinode data. 展开更多
关键词 inductively coupled mooring chain seawater channel multinode users OFDM adaptive technology
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Application of Information Technology in Institutions and Challenges of Human Resources-Case Study: Administration of the Municipality of Ferizaj
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作者 Egzona Selimi 《Journal of Computer and Communications》 2023年第5期84-92,共9页
This study aims to investigate how information technology is applied in the administration of the municipality of Ferizaj and what are the challenges with human resources, the work was carried out through a case study... This study aims to investigate how information technology is applied in the administration of the municipality of Ferizaj and what are the challenges with human resources, the work was carried out through a case study in the municipality. This paper highlights that the use of information technology provides higher efficiency for the performance of daily work in the municipality, thus also the provision of better services to citizens. However, the level of use of information technology in the Municipality of Ferizaj leaves much to be desired in terms of efficiency because a significant number of employees have not attended adequate training for the effective and efficient use of various IT applications and have not are still adapted to the digital environment in the municipality. Therefore, the recommendation derived from this paper is that the information technology environment in the municipality of Ferizaj needs to be improved by providing staff with adequate qualifications, while for those who are currently engaged in the municipality and who do not have adequate qualifications, training should be provided in a way that all users of IT applications are fully integrated into the digitized environment in order to be effective and efficient in providing services to citizens. This simultaneously gives the municipal staff job security and motivation for better services for citizens. Also, information technology enables a better control over the activity of the municipality because every action is recorded as data which can then be used to analyze the performance of the municipality. 展开更多
关键词 Information Technology Human Resources Administration of the Municipality of Ferizaj DIGITALIZATION
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风险投资异质性对IPO抑价的影响——基于科创板的研究
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作者 于健南 马君仪 《财经理论研究》 2024年第1期1-11,共11页
本文主要从信息不对称角度分析风险投资异质性对IPO抑价的影响。本文选取2019—2022年科创板上市公司作为样本,通过实证研究发现:科创板上市公司中有风险投资机构参与的企业IPO抑价水平会提高;风险投资机构资本背景的差异对IPO抑价率有... 本文主要从信息不对称角度分析风险投资异质性对IPO抑价的影响。本文选取2019—2022年科创板上市公司作为样本,通过实证研究发现:科创板上市公司中有风险投资机构参与的企业IPO抑价水平会提高;风险投资机构资本背景的差异对IPO抑价率有不同的影响。其中,对IPO抑价水平影响最明显的是政府背景的风险投资机构,公司背景的风险投资机构影响程度中等,独立背景的风险投资机构影响程度最低。基于此,本文认为在解决信息不对称问题上,不同背景风险投资机构的处理能力存在差异。 展开更多
关键词 风险投资异质性 IPO抑价 科创板
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一种面向职业学院的兼容可靠IPv6平滑升级改造方案
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作者 孙九凌 《自动化应用》 2024年第14期237-239,共3页
研究发现,从现存不堪重负的IPv4网络过渡到先进可靠的IPv6网络是每个高校必须迈过的门槛。基于此,通过研究几种主流的过渡技术,比较他们的技术特征并进行技术测试,根据学校的现实特点进行选择,以期为职业院校向IPv6过渡提供一种可行的... 研究发现,从现存不堪重负的IPv4网络过渡到先进可靠的IPv6网络是每个高校必须迈过的门槛。基于此,通过研究几种主流的过渡技术,比较他们的技术特征并进行技术测试,根据学校的现实特点进行选择,以期为职业院校向IPv6过渡提供一种可行的解决方案。 展开更多
关键词 IPV6 校园网 过渡技术
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基于ISATAP隧道技术的IPv4/IPv6物联网智能家居仿真实现
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作者 李清平 《广东水利电力职业技术学院学报》 2024年第2期44-48,58,共6页
IPv4/IPv6过渡技术为物联网的发展提供了IP地址的支撑,ISATAP隧道技术由于无须大量升级更换设备、相对容易实现而成为三种IPv4/IPv6过渡技术的优选方案。对此,基于Packet Tracer7.3平台,部署一个采用ISATAP隧道技术的物联网智能家居仿... IPv4/IPv6过渡技术为物联网的发展提供了IP地址的支撑,ISATAP隧道技术由于无须大量升级更换设备、相对容易实现而成为三种IPv4/IPv6过渡技术的优选方案。对此,基于Packet Tracer7.3平台,部署一个采用ISATAP隧道技术的物联网智能家居仿真场景,设计了网络拓扑图,使用静态、DHCP和DHCPv6三种方式配置IPv4和IPv6地址,对物联网中的关键设备采取Python语言进行编码。仿真结果表明,双栈终端能自动获取IPv4或IPv6地址,IoT设备在物联网服务器注册后,可按设定条件在双栈终端的调控下智能有效地运行,从而为过渡技术在物联网中的应用提供一种研究方法。 展开更多
关键词 ISATAP隧道技术 IPV4/IPV6 物联网 智能家居
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Research Progress and Prospects for the Evolution Process and Treatment Technology of Urban Black and Smelly Water
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作者 Zhuolin LI Weijie XU 《Meteorological and Environmental Research》 CAS 2023年第1期68-69,75,共3页
Water is an important material resource for human survival,and with the increasing development of society,the amount of urban industrial wastewater and domestic sewage is gradually increasing.However,wastewater collec... Water is an important material resource for human survival,and with the increasing development of society,the amount of urban industrial wastewater and domestic sewage is gradually increasing.However,wastewater collection and treatment facilities lag behind,so that a large number of wastewater enters urban water,making urban water become gradually black and smelly.In order to provide a good living environment for human beings,a large number of scholars actively explore the treatment technology of black and smelly water.In this paper,the evolution process of black and smelly water was introduced firstly,and then the treatment technology of black and smelly water was summarized.Finally,the prospects for the development of the treatment technology were put forward. 展开更多
关键词 Black and smelly water Evolution process Treatment technology Research progress PROSPECTS
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Diagnosis and treatment of Whipple disease after kidney transplantation:A case report
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作者 Qian Chen Yu-Lin Niu Tao Zhang 《World Journal of Clinical Cases》 SCIE 2023年第25期6019-6024,共6页
BACKGROUND Kidney transplantation is the standard treatment for end-stage renal disease.Particularly,rare and specific pathogenic infections which are asymptomatic are often difficult to diagnose,causing delayed and i... BACKGROUND Kidney transplantation is the standard treatment for end-stage renal disease.Particularly,rare and specific pathogenic infections which are asymptomatic are often difficult to diagnose,causing delayed and ineffective treatment and thus seriously affecting prognosis.Tropheryma whipplei(T.whipplei)is a Gram-positive actinomycete widely found in soil,sewage,and other external environments and is present in the population as an asymptomatic pathogen.There is relatively little documented research on T.whipplei in renal transplant patients,and there are no uniform criteria for treating this group of post-transplant patients.This article describes the treatment of a 42-year-old individual with post-transplant T.whipplei infection following kidney transplantation.CASE SUMMARY To analyze clinical features of Whipple’s disease and summarize its diagnosis and treatment effects after renal transplantation.Clinical data of a Whipple’s disease patient treated in the affiliated hospital of Guizhou Medical University were collected and assessed retrospectively.The treatment outcomes and clinical experience were then summarized via literature review.The patient was admitted to the hospital due to recurrent diarrhea for 1 mo,shortness of breath,and 1 wk of fever,after 3 years of renal transplantation.The symptoms of the digestive and respiratory systems were not significantly improved after adjusting immunosuppressive regimen and anti-diarrheal,empirical antibiotic treatments.Bronchoscopic alveolar fluid was collected for meta-genomic next-generation sequencing(mNGS).The deoxyribonucleic acid sequence of Tropheryma whipplei was detected,and Whipple’s disease was diagnosed.Meropenem,ceftriaxone,and other symptomatic treatments were given,and water-electrolyte balance was maintained.Symptoms resolved quickly,and the patient was discharged after 20 d of hospitalization.The compound sulfamethoxazole tablet was continued for 3 mo after discharge.No diarrhea,fever,and other symptoms occurred during the 6-month follow-up.CONCLUSION Whipple’s disease is rare,with no specific symptoms,which makes diagnosis difficult.Polymerase chain reaction or mNGS should be immediately performed when the disease is suspected to confirm the diagnosis. 展开更多
关键词 Kidney transplantation IMMUNOSUPPRESSION Whipple disease Whipple’s nutrient barrier Macrogenomics secondgeneration sequencing technology Case report
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