Different ENSO Impacts on Eastern China Precipitation Patterns in Early and Late Winter Associated with Seasonally-Varying Kuroshio Anticyclonic Anomalies

Winter precipitation over eastern China displays remarkable interannual variability,which has been suggested to be closely related to El Niño-Southern Oscillation(ENSO).This study finds that ENSO impacts on eastern China precipitation patterns exhibit obvious differences in early(November-December)and late(January-February)winter.In early winter,precipitation anomalies associated with ENSO are characterized by a monopole spatial distribution over eastern China.In contrast,the precipitation anomaly pattern in late winter remarkably changes,manifesting as a dipole spatial distribution.The noteworthy change in precipitation responses from early to late winter can be largely attributed to the seasonally varying Kuroshio anticyclonic anomalies.During the early winter of El Niño years,anticyclonic circulation anomalies appear both over the Philippine Sea and Kuroshio region,enhancing water vapor transport to the entirety of eastern China,thus contributing to more precipitation there.During the late winter of El Niño years,the anticyclone over the Philippine Sea is further strengthened,while the one over the Kuroshio dissipates,which could result in differing water vapor transport between northern and southern parts of eastern China and thus a dipole precipitation distribution.Roughly the opposite anomalies of circulation and precipitation are displayed during La Niña winters.Further analysis suggests that the seasonally-varying Kuroshio anticyclonic anomalies are possibly related to the enhancement of ENSO-related tropical central-eastern Pacific convection from early to late winter.These results have important implications for the seasonal-tointerannual predictability of winter precipitation over eastern China.

A Comparison between Late Preterm and Term Infants with Respiratory Distress Syndrome, Early-Onset Sepsis, and Neonatal Jaundice in Ecuadorian Newborns

Background: To examine the differences in prevalence of respiratory distress syndrome, early-onset sepsis and jaundice, between late preterm infants versus term infants in Ecuadorian newborns. Methods: Study design: Epidemiological, observational, and cross-sectional, with two cohorts of patients. Settings: IESS Quito Sur Hospital at Quito, Ecuador, from February to April of 2020. Participants: This study included 204 newborns, 102 preterm infants, 102 term infants. Results: There are significant differences between late preterm infants and term infants, with a p-value of 0.000 in the prevalence of early sepsis, 70.59% vs. 35.29%. In respiratory distress syndrome between late and term premature infants, significant differences were observed with a p-value of 0.000, the proportion being 55.58% vs. 24.51% respectively. The prevalence of jaundice is higher in term infants with a p value of 0.002, 72.55%, versus 51.96% in late preterm infants, and the mean value of bilirubins in mg/dL was higher in term infants 14.32 versus 12.33 in late preterm infants;this difference is statistically significant with a p value of 0.004. Admission to the NICU is more frequent in late preterm infants with a p-value of 0.000, being 42.16% for late preterm infants vs. 7.84% in term infants;the mean of the hospital days with p-value 0.005, was higher in late preterm infants 4.97 days vs. 3.55 days for term newborns. Conclusion: Due to the conditions of their immaturity, late preterm infants are 2.86 times more likely to present early sepsis than full-term newborns. It is shown that late preterm infants are 2.69 times more likely to have respiratory distress syndrome compared to term infants, therefore, late preterm infants have a longer hospital stay of 4.97 days versus 3.55 days in term infants. Jaundice and mean bilirubin levels are higher in term infants due to blood group incompatibility and insufficient breastfeeding.

<i>ABNORMAL SHOOT IN YOUTH</i>, a Homolog of Molybdate Transporter Gene, Regulates Early Shoot Development in Rice

We analyzed the abnormal shoot in youth (asy) mutant to understand the phase-specific regulation of shoot development. asy showed various shoot abnormalities, including small leaves due to the precocious termination of cell division, defects in leaf blade-sheath boundary formation, and abnormal shoot apical meristem maintenance at the early vegetative stage. These defects recovered with advanced development. ASY encodes a DUF791 domain protein, which is part of the major facilitator superfamily. Despite stage-specific phenotypes, the ASY expression level was roughly constant throughout development. A paralog of ASY, ASL, exists in the rice genome and is supposed to have redundant functions. ASL expression was relatively low in early-stage embryos but increased at later stages. Thus, asy phenotypes were limited to the stage when ASL expression was suppressed. A homology search revealed that ASY is a homolog of the Chlamydomonas CrMoT2 gene, which encodes a molybdate transporter. ASY was suggested to encode a molybdate transporter based on its sequence similarity with CrMoT2 and predicted transmembrane topology. This is the first report of a CrMOT2-type molybdate transporter in higher plants.

Predictors of early and late hepatocellular carcinoma recurrence

Hepatocellular carcinoma(HCC)is the most frequent liver neoplasm,and its incidence rates are constantly increasing.Despite the availability of potentially curative treatments(liver transplantation,surgical resection,thermal ablation),long-term outcomes are affected by a high recurrence rate(up to 70%of cases 5 years after treatment).HCC recurrence within 2 years of treatment is defined as“early”and is generally caused by the occult intrahepatic spread of the primary neoplasm and related to the tumor burden.A recurrence that occurs after 2 years of treatment is defined as“late”and is related to de novo HCC,independent of the primary neoplasm.Early HCC recurrence has a significantly poorer prognosis and outcome than late recurrence.Different pathogenesis corresponds to different predictors of the risk of early or late recurrence.An adequate knowledge of predictive factors and recurrence risk stratification guides the therapeutic strategy and post-treatment surveillance.Patients at high risk of HCC recurrence should be referred to treatments with the lowest recurrence rate and when standardized to combined or adjuvant therapy regimens.This review aimed to expose the recurrence predictors and examine the differences between predictors of early and late recurrence.

Petrogenesis of the Late Eocene to Early Oligocene Yao'an Shoshonitic Complex,Southeastern Tibet:Partial Melting of an Ancient Continental Lithospheric Mantle beneath the Yangtze Block

Cenozoic potassic-ultrapotassic igneous rocks are widespread in the southeastern Tibetan Plateau.Their petrogenesis and magmatic processes remain subject to debate in spite of numerous publications.Almost all of the Cenozoic extrusive and intrusive rocks in the Yao’an area,western Yunnan Province,SW China,are geochemically shoshonitic,collectively termed here the Yao’an Shoshonitic Complex(YSC).The YSC is located in the(south)easternmost part of the ENE-WSW-trending,~550 km-long and~250 km-wide Cenozoic magmatic zone;the latter separates the orthogonal and oblique collision belts of the India-Eurasia collision orogen.Previously published geochronological and thermochronological data revealed that the rocks of the YSC were emplaced over a short timespan of 34-32 Ma.This and our new data suggest that the primary magma of the YSC likely was formed by partial melting of ancient continental lithospheric mantle beneath the Yangtze Block.This part of the continental lithospheric mantle had likely not been modified by any oceanic subduction.Fractionation crystallization of an Mg-and Ca-bearing mineral and TiFe oxides during the magmatic evolution probably account for the variable lithologies of the YSC.

Contribution and Modern Public Debt:On the Nature of Patriotic Public Debt in the Late Qing Dynasty and the Early Republic of China

There are different opinions about the first modern domestic debt in China.The theorists judge whether a certain public debt has modernity according to whether it has modern public debt form,ignoring the inconsistency between form and content,institutional provisions and actual implementation.The modern nature of public debt must have both the form and content of modern public debt.Based on the analysis of the issuing background,system design,collection and repayment of patriotic bonds in the late Qing Dynasty and the early Republic of China,it is considered that the part of patriotic bonds subscribed by the Qing royal family is still the nature of donation and return,while the part subscribed by ordinary businessmen and people in the early Republic of China has a modern nature.The dual nature of patriotic bonds is closely related to the social background when the bonds are issued.

Tracheostomy-related data from an intensive care unit for two consecutive years before the COVID-19 pandemic

BACKGROUND Tracheostomy is commonly used in intensive care unit(ICU)patients who are expected to be on long-term mechanical ventilation or suffer from emergency upper airway obstruction.However,some studies have conflicting findings regarding the optimal technique and its timing and benefits.AIM To provide evidence of practice,characteristics,and outcome concerning tracheostomy in an ICU of a tertiary care hospital.METHODS This was a retrospective cohort study including adult critical care patients in a single ICU for two consecutive years.Patients’demographic characteristics,severity of illness(APACHE II score),level of consciousness[Glasgow Coma Scale(GCS)],comorbidities,timing and type of tracheostomy procedure performed and outcome were recorded.We defined late as tracheostomy placement after 8 days or no tracheotomy.RESULTS Data of 660 patients were analyzed(median age of 60 years),median APACHE II score of 19 and median GCS score of 12 at admission.Tracheostomy was performed in 115 patients,of whom 63 had early and 52 late procedures.Early tracheostomy was mainly executed in case of altered level of consciousness and severe critical illness polyneuromyopathy,however there were no significant statistical results(47.6%vs 36.5%,P=0.23)and(23.8%vs 19.2%,P=0.55)respectively.Regarding the method selected,early surgical tracheostomy(ST)was conducted in patients with maxillofacial injuries(50.0%vs 0.0%,P=0.033),whereas late surgical tracheostomy was selected for patients with goiter(44.4%vs 0.0%P=0.033).Patients with early tracheostomy spent significantly fewer days on mechanical ventilation(15.3±8.5 vs 22.8±9.6,P<0.001)and in ICU in general(18.8±9.1 vs 25.4±11.5,P<0.001).Percutaneous dilatation tracheostomy(PDT)vs ST was preferable in older critical care patients in the case of Central Nervous System underlying cause of admission(62.5%vs 26.3%,P=0.004).ST was the method of choice in compromised airway(31.6%,vs 7.3%P=0.008).A large proportion of patients(88/115)with tracheostomy managed to wean from mechanical ventilation and were transferred out of the ICU(100%vs 17.4%,P<0.001).CONCLUSION PDT was performed more frequently in our cohort.This technique did not affect mechanical ventilation days,ventilator-associated pneumonia(VAP),ICU length of stay,or survival.No complications were observed in the percutaneous or surgical tracheostomy groups.Patients undergoing early tracheostomy benefited in terms of mechanical ventilation days and ICU length of stay but not of discharge status,presence of VAP,or survival.

Optimal duration of the early and late recurrence of hepatocellular carcinoma after hepatectomy

AIM: To determine the best cut-off value between the early and late recurrence periods after the initial recurrence of hepatocellular carcinoma(HCC).METHODS: The clinical records of 404 patients who underwent macroscopic curative hepatectomy for HCC between 1980 and 2010 were retrospectively examined. We divided the 252 patients experienced a recurrence of HCC into two groups, the early and late recurrence groups using the "minimum P-value" approach. Factors for early recurrence were investigated using all 404 patients, and factors related to late recurrence were investigated in the patients who were confirmed to be recurrence free at the end of the early recurrence period.RESULTS: For the 252 patients who experienced a recurrence, the optimal cut-off value for differentiating early and late recurrence based on the overall survival after initial recurrence was 17 mo(5-year overall survival after initial recurrence: 15.4% vs 36.3%, P = 0.000018). Cox proportional hazard analysis identified early recurrence(P = 0.003) as one of the independent prognostic factors associated with overall survival after initial recurrence. A logistic regression model showed that an alpha-fetoprotein level > 100 ng/m L(P < 0.001), multiple HCC(P < 0.001), serosal invasion(P = 0.031), and microvascular invasion(P = 0.012) were independent factors associated with early recurrence, whereas the only independent factor related to late recurrence was liver cirrhosis(P = 0.002).CONCLUSION: Seventeen months after hepatectomy is a useful cut-off value between early and late recurrence of HCC based on the prognosis and different etiologies.

A Titanosaurian Sauropod Dinosaur with Opisthocoelous Caudal Vertebrae from the Early Late Cretaceous of Liaoning Province, China

We describe a new titanosaurian sauropod dinosaur, Borealosaurus wimani gen. et sp. nov., based on a distinctive mid-distal caudal vertebra from the early Late Cretaceous Sunjiawan Formation exposed in the Shuangmiao village of Beipiao in Liaoning, China. We provisionally refer an isolated tooth crown, a middle caudal vertebra, and a right humerus from the same locality and horizon to this taxon. Borealosaurus is distinguished from other sauropods in its possession of opisthocoelous mid-distal caudal vertebrae. The occurrence of opisthocoelous caudals in Borealosaurus and the Mongolian sauropod Opisthocoelicaudia raises the possibility that these taxa pertain to an as-yet unrecognized titanosaurian subclade endemic to the Cretaceous Asia.

A New Titanosauriform Sauropod from the Early Late Cretaceous of Dongyang,Zhejiang Province

A new titanosauriform sauropod Dongyangosaurus sinensis gen. et sp. nov. from the early Late Cretaceous of Dongyang County, Zhejiang Province, is erected based on a partial postcranial skeleton. It is characterized by complex laminae on the lateral surface of the neural spines and postzygapophyses of dorsal vertebrae, a distinct fossa on the ventral surfaces of the prezygapophyses of dorsal vertebrae, distinct fossae are also present on the lateral surface of the postzygapophysis of anterior caudal vertebrae; pubis is shorter than ischium, the small obturator foramen of pubis elongated, and nearly closed. The lamina complexity of dorsal vertebrae in Dongyangosaurus indicates that a higher diversity of titanosauriformes occurred during the early Late Cretaceous in China.

Late Tremadoc and Early Floian Graptolites from Central Hunan,China

Fourteen graptolite species of the Late Tremadoc and Early Floian are described from the Nanba section in the Yiyang area,Hunan Province.Among them,Paradelograptus onubensis, Kiaerograptus bulmani,K.kutchini and Paratemnograptus isolatus of the Late Tremadoc are first found in China.Based on the current graptolite materials,the correspondingly complete graptolite zones of Upper Tremadocian in China are recognized as follows（in ascending order）：the Adelograptus tenellus Zone,the Aorograptus victoriae Zone,the Araneograptus murrayi Zone and the Hunnegraptus copiosus Zone.In the Nanba section,the Hunnegraptus copiosus Zone is overlain directly by the Tetragraptus approximatus Zone,there is no hiatus below the base of Floian.

FROM BACK-ARC BASIN TO BACK-ARC FORELAND BASIN—THE SEDIMENTARY BASIN AND TECTONIC EVOLUTION OF THE LATE CALEDONIAN—EARLY HERCYNIAN STAGES IN CORRIDOR AND NORTH QILIAN MTS

Qilian orogenic belt is a typical orogenic belt formed by polycyclic collisions between the North China plate and Qaidam microplate. Qilian ocean originated from the rift of the late Proterozoic Rodinia continent(Pangea\|850), evolved through rift basin and became an archipelagic ocean in the Caledonian stage. The Lower Proterozoic strata in Qilian area are mid\|high\|rank metamorphic rocks that constitute the metamorphic basement of the area. The “Huangyuan Movement" (in South Qilian and Central Qilian) and "Alashan Movement" (in North Qilian) in the latest Late Proterozoic formed a regional unconformity. The middle Proterozoic in the area are mudstones and carbonate rocks with stromatolites and ooids. The Qingbaikou System of the upper Proterozoic in the North Qilian and Corridor region is also mudstone and carbonate rock with stromatolites. The Qingbaikou System in Central Qilian is sandstones and mudstones. There are alkaline and tholeiite in the Sinian System in North Qilian and Corridor. The contact between Qingbaikou System and Sinian System is a regional unconformity (Quanji Movement). Qilian ocean began to rift away in Caledonian tectonic stage on the Pre\|Sinian basement.

An abnormal resting-state functional brain network indicates progression towards Alzheimer's disease

Brain structure and cognitive function change in the temporal lobe, hippocampus, and prefrontal cortex of patients with mild cognitive impairment and Alzheimer＇s disease, and brain network-connection strength, network efficiency, and nodal attributes are abnormal. However, existing research has only analyzed the differences between these patients and normal controls. In this study, we constructed brain networks using resting-state functional MRI data that was extracted from four populations （nor- mal controls, patients with early mild cognitive impairment, patients with late mild cognitive impairment, and patients with Alzheimer＇s disease） using the Alzheimer＇s Disease Neuroimaging Initiative data set. The aim was to analyze the characteristics of resting-state functional neural networks, and to observe mild cognitive impairment at different stages before the transformation to Alzheimer＇s disease. Results showed that as cognitive deficits increased across the four groups, the shortest path in the rest- ing-state functional network gradually increased, while clustering coefficients gradually decreased. This evidence indicates that dementia is associated with a decline of brain network efficiency. In addi- tion, the changes in functional networks revealed the progressive deterioration of network function across brain regions from healthy elderly adults to those with mild cognitive impairment and AIz- heimer＇s disease. The alterations of node attributes in brain regions may reflect the cognitive functions in brain regions, and we speculate that early impairments in memory, hearing, and language function can eventually lead to diffuse brain injury and other cognitive impairments.

Petrogenesis of Early and Late Carboniferous Volcanic Rocks in the Yining Block:Constraints from Sr-Nd Isotope

The Yining Block is located in the southwestern part of the Central Asian Orogenic Belt （CAOB）,which is characterized by widespread Carboniferous volcanic rocks.Recently,we carried out the National Nature Science Foundation of China （No.41273033） and Special Fund for Basic Scientific Research of Central Colleges （No.310827153407） project,and focused on two suits volcanic rocks from the Early Carboniferous Dahalajunshan Formation and the Late Carboniferous Yishijilike Formation.Field observations,zircon U-Pb dating,and Sr-Nd isotopic dating were conducted to evaluate the petrogenesis.

Late Ordovician to Early Silurian Tectonic Events in the Himalayan Terrain

ObjectiveThe Himalaya terrain together with the ribbon terrains （e.g., Lhasa, Qiangtang, and Sibumasu blocks） of the Gondwana supercontinent has experienced episodic tectonic events since the Neoproterozoic. However, almost not any documentation with regard to the tectonic processes links the peri-Gondwana subduction between 510-480 Ma with the Carboniferous-Permian （-360-260 Ma） continental rifting event. This possible link is important for testing and formulating the tectonic model for the evolution of the present-day Himalayan orogenic belt, if we consider this belt has also experienced typical Wilson cycle plate tectonics. Recently, we have found several lines of evidence which imply that the Himalayan terrain and possibly other ribbon terrains of the eastern Gondwana have experienced unrecognized tectonic processes during the Late Ordovician to Early Silurian.

Late Carboniferous-Early Permian Mafic-Ultramafic Complexes in Beishan,Southwestern Central Asian Orogenic Belt and Their Significance

Numeral Permian mafic-ultramafic complexes occur in the Beishan terrane atthe northeastern margin of the Tarim craton,southwestern Central Asian Orogenic Belt,including the Pobei,Cantoushan,Bijiashan,Hongshishan,Xuanwoling,Zhongposhan and Luodong etc.,intrusions(Qin et al.,2011;Zhang et al.,2017;Xue et al.,2018).These Beishan mafic-ultramafic complexes are composed of peridotite,pyroxenite.

Method to Improve the Tracking Speed of the Early-Late Synchronizer

A new early-late synchronizer is proposed to improve tracking speed. The performance of the traditional early-late synchronizer is analyzed in detail, the result shows that the different location and length of integral period can influence the discriminator characteristic, an improved integral structure is provided which can tracking the synchronization error better. According to the good tracking performance of Kalman filter, a new loop filter is designed. The new early-late synchronizer adopts both the new integral structure and the new loop filter. The analysis with loop theory and simulation results in Simulink show that the new bit synchronizer possesses higher tracking speed than the traditional early-late synchronizer.

Late Jurassic and Early Cretaceous Radiolarians from Zhilong,Gyangse,Tibet

Abundant well-preserved Late Jurassic-Early Cretaceous radiolarian fossils were extracted from 31 bedded green chert samples collected from Zhilong section,Gyangse,southern Tibet.This

Discovery of Fossil Charophytes from the Late Triassic Xujiahe Formation and Early Jurassic Lower Yimen Formation, Sichuan Province, and Its Significance

This paper describes the fossil charophytes collected from the Late Triassic Xujiahe Formation in Dazuand Early Jurassic Lower Yimen Formation in Xichang, Sichuan Province, and their significance. Up to now,papers dealing with fossil charophytes of the Late Triassic, especially of the Early Jurassic, have been rarelypublished. The description of the two new species of Porochara, P. dazuensis and P. xichangensis, and theirfossil assemblage not only provides an important basis for classification and correlation of red beds insouthwestern China but reveals for the first time the features of the charophyte flora of the Late Triassic-EarlyJurassic in the area, thus offering valuable data for the establishment of Triassic and Jurassic charophyte fossilzones in China.