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A cohort study on the association between fasting plasma glucose level over 5. 3 mmol / L and risks of abnormal glucose metabolism and cardiovascular diseases in the elderly
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作者 赵明星 《China Medical Abstracts(Internal Medicine)》 2016年第3期150-151,共2页
Objective To evaluate the association of fasting plasma glucose(FPG)level over 5.3 mmol/L with the development of abnormal glucose metabolism and cardiovascular disease(CVD).Methods This was a retrospec-tive cohort st... Objective To evaluate the association of fasting plasma glucose(FPG)level over 5.3 mmol/L with the development of abnormal glucose metabolism and cardiovascular disease(CVD).Methods This was a retrospec-tive cohort study with 1 064 non-diabetic subjects(980males;84 females)aged 60 or over,who carried out annual health check-up in Chinese PLA General 展开更多
关键词 FPG IGR A cohort study on the association between fasting plasma glucose level over 5 L and risks of abnormal glucose metabolism and cardiovascular diseases in the elderly MMOL OVER
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Proteomic analysis of overweight/obesity and related abnormal glucose and lipid metabolism caused by phlegm-dampness retention 被引量:1
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作者 Jiayi Ma Shuxian Sun +7 位作者 Cheng Ni Lingru Li Jing Xia Houqin Li Huirong Song Xujun Heng Dandan Hu Yuanyuan Li 《Journal of Traditional Chinese Medical Sciences》 2021年第3期224-237,共14页
Objective:To investigate the proteomic characteristics of overweight/obesity and related abnormal glucose and lipid metabolism caused by phlegm-dampness retention to identify related biomarkers.Methods:Seventy-one sub... Objective:To investigate the proteomic characteristics of overweight/obesity and related abnormal glucose and lipid metabolism caused by phlegm-dampness retention to identify related biomarkers.Methods:Seventy-one subjects were enrolled in the study.We assessed blood glucose,blood lipids,body mass index(BMI),and phlegm-dampness pattern,which was confirmed by a traditional Chinese medicine clinician.Of the participants,we included healthy participants with normal weight(NW,n=23),overweight/obese participants with normal metabolism(ONM,n=19),overweight/obese participants with pre-diabetes(OPD,n=12),and overweight/obese participants with marginally-elevated blood lipids(OML,n=17).Among them,the ONM,OPD,and OML groups were diagnosed with phlegmdampness pattern.The data-independent acquisition(DIA)method was first used to analyze the plasma protein expression of each group,and the relevant differential proteins of each group were screened.The co-expressed proteins were evaluated by Venn analysis.The pathway analyses of the differential proteins were analyzed using Ingenuity Pathway Analysis(IPA)software.Parallel reaction monitoring(PRM)was used to verify the differential and common proteins in each group.Results:After comparing ONM,OPD,and OML groups with NW group,we identified the differentially expressed proteins(DEPs).Next,we determined the DEPs among OPD,OML,and ONM groups.Using Venn analysis of the DEPs in each group,24 co-expressed proteins were screened.Two co-expressed proteins were verified by PRM.IPA analysis showed that pathways including LXR/RXR activation,acute phase response signaling,and FXR/RXR activation were common to all three groups of phlegmdamp overweight/obesity participants.However,the activation or inhibition of these pathways was different among the three groups.Conclusion:Participants with overweight/obesity have similar proteomic characteristics,though each type shows specific proteomic characteristics.Two co-expressed proteins,VTN and ORM1,are potential biomarkers for glucose and lipid metabolism diseases with overweight/obesity caused by phlegmdampness retention. 展开更多
关键词 Phlegm-dampness retention OVERWEIGHT OBESITY abnormal glucose and lipid metabolism Biomarkers
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Inflammatory bowel disease and diabetes:Is there a link between them?
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作者 Miao-Miao Sang Zi-Lin Sun Tong-Zhi Wu 《World Journal of Diabetes》 SCIE 2022年第2期126-128,共3页
Patients with inflammatory bowel disease(IBD)are reported to have an increased risk of diabetes.IBD therapies may also modulate blood glucose substantially.These observations are indicative of mechanistic connection(s... Patients with inflammatory bowel disease(IBD)are reported to have an increased risk of diabetes.IBD therapies may also modulate blood glucose substantially.These observations are indicative of mechanistic connection(s)between IBD and diabetes. 展开更多
关键词 Inflammatory bowel disease abnormal glucose metabolism
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