The enantioselective reduction of acetophenone analogues catalyzed by carrot and celeriac was performed in moderate conversions and excellent enantiomeric excesses.The steric factors and electronic effects of the subs...The enantioselective reduction of acetophenone analogues catalyzed by carrot and celeriac was performed in moderate conversions and excellent enantiomeric excesses.The steric factors and electronic effects of the substituents at the aromatic ring were found to significantly affect the efficiency of the enantioselective reduction of acetophenone analogues,while they had a little effect on the enantioselectivity of acetophenone analogues reduction.It was also found that the conversions of acetophenone anal...展开更多
α,α-dimethoxy-α-Phenyl acetophenone (DMPA) is an efficient and thermally stable photoinitiator. Here its spectral characteristics in the transient state were shown. The transient species were identified as a benz...α,α-dimethoxy-α-Phenyl acetophenone (DMPA) is an efficient and thermally stable photoinitiator. Here its spectral characteristics in the transient state were shown. The transient species were identified as a benzoyl radical and a dimethoxyi benzyl radical that played a primary initiation role in polymerization. The kinetics and mechanism of the bulk polymerization of MMA were investigated. The exponent of DMPA concentration and k<sub>p</sub>/k<sub>1</sub><sup>1/2</sup> value were found to be 0.5 and 0.066 mol(-1/2)l<sup>1/2</sup>s<sup>-1/2</sup>, respectively. The existence of oxygen led to obtain the polymer with higher molecular weight, which can be attributed to the occurrence of the subsequent polymerization induced by active polymer end group. In the photocrosslinking reaction, the dependence of DMPA content on initial rate has been found. A principal reason is that the sample contained higher percentage of DMPA has higher light-absorbed efficiency. In solid film, higher concentration of DMPA is permitted to be used because there is little excited state self-quenching effect in the rigid medium.展开更多
[Objectives] To develop a method for separation and purification of acetophenones from Cynanchum bengei Decne root bark by combination of silica gel and high-speed counter-current chromatography( HSCCC). [Methods]The ...[Objectives] To develop a method for separation and purification of acetophenones from Cynanchum bengei Decne root bark by combination of silica gel and high-speed counter-current chromatography( HSCCC). [Methods]The crude extract of Cynanchum bengei Decne root bark was separated by silica gel column chromatography,and parts A and B containing acetophenones were obtained. Then,parts A and B were separated by HSCCC with a two-phase solvent system composed of petroleum ether-ethyl acetate-methanol-water( 4∶ 6∶ 4. 5∶ 5. 5 and4∶ 6 ∶ 3 ∶ 7, V/V), respectively. [Results] From 260 mg of part A, four compounds with p-dihydroxybenzene 3. 9 mg(Ⅰ),4-hydroxyacetophenone 17. 1 mg( Ⅱ),2,5-di-hydroxyacetophenone 13. 3 mg(Ⅲ) and 2,4-dihydroxyaceto-phenone 21. 0 mg(Ⅳ) were obtained. And from 300 mg of part B,136 mg of Radix Cynanchi Bungei benzophenone(Ⅴ) was obtained. The purity of compounds determined by HPLC was 97. 0%,96. 6%,99. 2%,99. 7%,99. 5%,respectively. [Conclusions] The established method is simple and efficient. It can be used for separation of acetophenones from Cynanchum bengei Decne root bark and has better practical value,which could provide a reference basis for development and utilization of Cynanchum bengei Decne root bark.展开更多
A new C2-Symmetric diamine/diphosphine Ruthenium (Ⅱ) complex, RuCl2P2N2H4 was used as an excellent catalyst to carry out the catalytic hydrogen transfer reduction of acetophenone,The conversion of acetophenone to 2-p...A new C2-Symmetric diamine/diphosphine Ruthenium (Ⅱ) complex, RuCl2P2N2H4 was used as an excellent catalyst to carry out the catalytic hydrogen transfer reduction of acetophenone,The conversion of acetophenone to 2-phenylethanol was up to 99% under the following reaction conditions: substrate: Ru: (CH3)2 CHOK=200:1:12; reaction temperature of 65℃, reaction time of 2 h:normal pressure. A hydride transfer mechanism was also discussed.展开更多
The Indian meal moth,Plodia interpunctella(Lepidoptera:Pyralidae),a globally distributed storage pest,relies on odors that are emitted from stored foods to select a suitable substrate for oviposition.However,the molec...The Indian meal moth,Plodia interpunctella(Lepidoptera:Pyralidae),a globally distributed storage pest,relies on odors that are emitted from stored foods to select a suitable substrate for oviposition.However,the molecular mechanism underlying the chemical communication between P.interpunctella and its host remains elusive.In this study,130 chemosensory genes were identified from the transcriptomes of 7 P.interpunctella tissues,and the quantitative expression levels of all 56 P.interpunctella odorant receptor genes(PintORs)were validated using real-time quantitative polymerase chain reaction.The functional characteristics of 5 PintORs with female antennae-biased expression were investigated using 2-electrode voltage clamp recordings in Xenopus laevis oocytes.PintOR23 was found to be specifically tuned to acetophenone.Acetophenone could elicit a significant electrophysiological response and only attracted mated females when compared with males and virgin females.In addition,molecular docking predicted that the hydrogen bonding sites,TRP-335 and ALA-167,might play key roles in the binding of PintOR23 to acetophenone.Our study provides valuable insights into the olfactory mechanism of oviposition substrate detection and localization in P.interpunctella and points toward the possibility of developing eco-friendly odorant agents to control pests of stored products.展开更多
Asymmetric reduction of 3,5-bistrifluoromethyl acetophenone to produce(S)-3,5-bistrifluoromethylphenyl ethanol was successfully carried out with sodium alginate immobilized Saccharomyces rhodotorula cells in an aqueou...Asymmetric reduction of 3,5-bistrifluoromethyl acetophenone to produce(S)-3,5-bistrifluoromethylphenyl ethanol was successfully carried out with sodium alginate immobilized Saccharomyces rhodotorula cells in an aqueous-organic solvent biphasic system.The possible influential factors were examined thoroughly according to their effects on conversion rate and e.e of the product.Organic solvents were rated by their biocompatibility and conversion potential.The immobilized cells [125 mg/mL in 20 mmol/L Tris-HCl buffer and 5%(j) octane at pH 8] showed the best conversion with a substrate concentration of 1.42 g/L at 30℃ with glucose as co-substrate for cofactor regeneration.Sequential 8-batch process was carried out with immobilized cells with a slow decrease in conversion and e.e.The immobilized cells showed stable catalytic activity with 50% reserved activity and are superior especially in reusability in comparison with resting cells.展开更多
This study involves initial Hartree-Fock and Density Functional theory calculations onthe molecular recognition of the cyclodextrins. The α-cyclodextrin-acetophenone complexationsystem was investigated with PM3, HF/3...This study involves initial Hartree-Fock and Density Functional theory calculations onthe molecular recognition of the cyclodextrins. The α-cyclodextrin-acetophenone complexationsystem was investigated with PM3, HF/3-21G* and B3LYP/3-21G* methods. The results indicatedthat the inclusion orientation in which the acetyl group of the acetophenone points towards thesecondary hydroxyls of the a-cyclodextrin was preferable in energy. The steric effect wassupposed as the physical reason of such a behavior Hence, the simple rule the anti-parallelarrangement of the dipoles of the host and guest molecules in the cyclodextrin complexqtion is notgenerally applicable.展开更多
Experimental results on solubility of the styrene, phenol, methylphenylcarbinol, acetophenone, ethyl benzene, propylene glycol and molybdenum as a complex with Trilon B in supercritical CO2 obtained using a dynamic (f...Experimental results on solubility of the styrene, phenol, methylphenylcarbinol, acetophenone, ethyl benzene, propylene glycol and molybdenum as a complex with Trilon B in supercritical CO2 obtained using a dynamic (flow) method are presented. The obtained data are described in the framework of Peng-Robinson equation. The results of the experients on the extraction of organic components from waste formed in the olefin epoxidation process at Nizhnekam-skneftekhim Inc., on the analysis of extract composition, and on the testing of the extract as an epoxidation catalyst are presented. The supercritical water oxidation (SCWO) process of epoxidation process waste was conducted in periodical and continuous mode. The analysis results of reaction product are given. Pilot experiments on dry sediment formation were conducted using Radio Frequency (RF) Inductively Coupled Plasma (ICP) of low pressure.展开更多
3-(Dimethylamino)-1-phenylprop-2-en-1-ones (formylated acetophenones) 1 reacted with aliphatic diamines in water assisted by KHSO4 to give bis-enaminones 2a-h in good yields. Compound 1 also reacted with o-phenylenedi...3-(Dimethylamino)-1-phenylprop-2-en-1-ones (formylated acetophenones) 1 reacted with aliphatic diamines in water assisted by KHSO4 to give bis-enaminones 2a-h in good yields. Compound 1 also reacted with o-phenylenediamine under similar conditions to produce bis-enaminones 3 instead of benzodiazepines 4 in excellent yields.展开更多
Microwave-assisted reactions are an environmentally friendly approach for synthesizing organic compounds. In this study, oximation of acetylferrocene and acetophenone was conducted under both microwave irradiation and...Microwave-assisted reactions are an environmentally friendly approach for synthesizing organic compounds. In this study, oximation of acetylferrocene and acetophenone was conducted under both microwave irradiation and conventional heating conditions. Acetylferrocene and acetophenone were subjected to oximation under the two conditions in various solvent mixtures, and the extent of conversion was determined by </span><sup><span style="font-family:Verdana;">1</span></sup><span style="font-family:Verdana;">H nuclear magnetic resonance spectroscopy. Microwave irradiation was found to accelerate the rate of oximation of both acetylferrocene and acetophenone. Acceleration of the reaction under microwave irradiation was attributed to the efficient absorption of microwaves by the ferrocene nucleus.展开更多
Homoisoflavonoids are in the subclass of the larger family of flavonoids having one more alkyl carbon than flavonoids. Among them, 8-C-Methylated homoisoflavones have not been extensively studied for synthesis and bio...Homoisoflavonoids are in the subclass of the larger family of flavonoids having one more alkyl carbon than flavonoids. Among them, 8-C-Methylated homoisoflavones have not been extensively studied for synthesis and biological evaluation. Author’s current objective is to synthesize 8-C-Methylated homoisoflavones by the reaction of 3-C-methylated dihydrochalcones with N,N’-dimethyl (chloromethylene) ammonium chloride generated<em> in situ</em> from DMF and PCl<sub>5</sub> for one carbon extension at about room temperature. The 3-C-methylated dihydrochalcones were synthesized by the reduction of 3-C-methylated chalcones, which were prepared from 3-C-methylated acetophenones and aromatic aldehydes in the presence of base. All the synthesized novel homoisoflavones’s structures were characterized by NMR and Tandem Mass Spectrometry.展开更多
The determination of catalytically active sites is crucial for the design of efficient and stable catalysts toward desired reactions.However,the complexity of supported noble metal catalysts has led to controversy ove...The determination of catalytically active sites is crucial for the design of efficient and stable catalysts toward desired reactions.However,the complexity of supported noble metal catalysts has led to controversy over the locations of catalytically active sites(e.g.,metal,support,and metal/support interface).Here we develop a structurally controllable catalyst system(Pd/SBA-15)to reveal the catalytic active sites for the selective hydrogenation of ketones to alcohol using acetophenone hydrogenation as model reaction.Systematic investigations demonstrated that unsupported Pd nanocrystals have no catalytic activity for acetophenone hydrogenation.However,oxidized Pd species were catalytically highly active for acetophenone hydrogenation.The catalytic activity decreased with the decreased oxidation state of Pd.This work provides insights into the hydrogenation mechanism of ketones but also other unsaturated compounds containing polar bonds,e.g.,nitrobenzene,N-benzylidene-benzylamine,and carbon dioxide.展开更多
Seven chiral thiazolidines bound rhodium complexes were synthesized and their catalytic asymmetric hydrosilation properties were investigated It was found through investigation that the configuration of newly formed c...Seven chiral thiazolidines bound rhodium complexes were synthesized and their catalytic asymmetric hydrosilation properties were investigated It was found through investigation that the configuration of newly formed chiral centre C2 of substituted chiral thiazolidines prepared from L-cysteine or its esters has no effect on the final results of catalytic asymmetric hydrosilation.The direct reason for causing this phenomenon is reported by the present quantitative results for the first time:the rapid racemation of chiral center C2 of chiral thiazolidine ligands takes place under the catalysis of rhodium(Ⅰ) complex [Rh(COD)展开更多
The favorable microbes for the asymmetric reduction of prochiral aromatic ketones was isolated from soil using acetophenone as the sole carbon source,when the asymmetric reduction of acetophenone(ACP)to chiral a-phene...The favorable microbes for the asymmetric reduction of prochiral aromatic ketones was isolated from soil using acetophenone as the sole carbon source,when the asymmetric reduction of acetophenone(ACP)to chiral a-phenethyl alcohol(PEA)was chosen as the model reaction.Two microbe strains with excellent catalytic activity were obtained.They were Geotrichum candidum and Pichia pastoris identified by bacteria identification.The product of the asymmetric reduction of ACP catalyzed by Pichia pastoris was mainly R-PEA and that by Geotrichum candidum was mainly S-PEA.The yield and enantiomeric excesses(e.e.)could respectively reach 75%and 90%for Pichia pastoris,and 80%and 70%for Geotrichum candidum,much higher than those catalyzed by baker’s yeast.展开更多
A heterogeneous chiral catalyst Fe(III)-CS(chitosan)complex/mesoporous molecular sieve SBA-15(Santa Barbara Amorphous)was prepared.The asymmetric transfer hydrogenations of prochiral acetophenone and 4-methyl-2-pentan...A heterogeneous chiral catalyst Fe(III)-CS(chitosan)complex/mesoporous molecular sieve SBA-15(Santa Barbara Amorphous)was prepared.The asymmetric transfer hydrogenations of prochiral acetophenone and 4-methyl-2-pentanone to corresponding chiral alcohols were carried out on Fe-CS/SBA-15 at atmosphere pressure using 2-propanol as hydrogen donor.Effects of Fe content in cata-lyst,reaction temperature,reaction time and promoter KOH concentration on the conversion of substrates and enantio-selectivity were investigated.Fe-CS/SBA-15 with 2.2%mass fraction Fe exhibits considerable enantioselectivity and cata-lytic activity for the asymmetric transfer hydrogenations of aromatic ketone and aliphatic ketone.Under optimal reaction conditions:KOH concentration 0.03 mol/L,reaction tem-perature 70℃ and reaction time 4 h,enantiomer excess(ee)of(R)-1-phenylethanol and conversion of acetophenone can reach 87.4%and 27.7%,respectively.Under the above KOH concentration and reaction temperature and reaction time of 8 h,the ee of(R)-4-methyl-2-pentanol and conversion 4-methyl-2-pentanone amounted to 50.2%and 25.5%,respectively.展开更多
基金supported by the National Natural Science Foundation of China(No.20672037)the National Special Fund for State Key Laboratory of Bioreactor Engineering(No.2060204)
文摘The enantioselective reduction of acetophenone analogues catalyzed by carrot and celeriac was performed in moderate conversions and excellent enantiomeric excesses.The steric factors and electronic effects of the substituents at the aromatic ring were found to significantly affect the efficiency of the enantioselective reduction of acetophenone analogues,while they had a little effect on the enantioselectivity of acetophenone analogues reduction.It was also found that the conversions of acetophenone anal...
文摘α,α-dimethoxy-α-Phenyl acetophenone (DMPA) is an efficient and thermally stable photoinitiator. Here its spectral characteristics in the transient state were shown. The transient species were identified as a benzoyl radical and a dimethoxyi benzyl radical that played a primary initiation role in polymerization. The kinetics and mechanism of the bulk polymerization of MMA were investigated. The exponent of DMPA concentration and k<sub>p</sub>/k<sub>1</sub><sup>1/2</sup> value were found to be 0.5 and 0.066 mol(-1/2)l<sup>1/2</sup>s<sup>-1/2</sup>, respectively. The existence of oxygen led to obtain the polymer with higher molecular weight, which can be attributed to the occurrence of the subsequent polymerization induced by active polymer end group. In the photocrosslinking reaction, the dependence of DMPA content on initial rate has been found. A principal reason is that the sample contained higher percentage of DMPA has higher light-absorbed efficiency. In solid film, higher concentration of DMPA is permitted to be used because there is little excited state self-quenching effect in the rigid medium.
基金Supported by National Natural Science Foundation Item of 2014(81373941)Shandong Natural Science Foundation Item of 2012(ZR2012HM047)+1 种基金Science and Technology Development Plan Item of Shandong(2014G2X219003)Major Project of the State Administration of Traditional Chinese Medicine(201407002)
文摘[Objectives] To develop a method for separation and purification of acetophenones from Cynanchum bengei Decne root bark by combination of silica gel and high-speed counter-current chromatography( HSCCC). [Methods]The crude extract of Cynanchum bengei Decne root bark was separated by silica gel column chromatography,and parts A and B containing acetophenones were obtained. Then,parts A and B were separated by HSCCC with a two-phase solvent system composed of petroleum ether-ethyl acetate-methanol-water( 4∶ 6∶ 4. 5∶ 5. 5 and4∶ 6 ∶ 3 ∶ 7, V/V), respectively. [Results] From 260 mg of part A, four compounds with p-dihydroxybenzene 3. 9 mg(Ⅰ),4-hydroxyacetophenone 17. 1 mg( Ⅱ),2,5-di-hydroxyacetophenone 13. 3 mg(Ⅲ) and 2,4-dihydroxyaceto-phenone 21. 0 mg(Ⅳ) were obtained. And from 300 mg of part B,136 mg of Radix Cynanchi Bungei benzophenone(Ⅴ) was obtained. The purity of compounds determined by HPLC was 97. 0%,96. 6%,99. 2%,99. 7%,99. 5%,respectively. [Conclusions] The established method is simple and efficient. It can be used for separation of acetophenones from Cynanchum bengei Decne root bark and has better practical value,which could provide a reference basis for development and utilization of Cynanchum bengei Decne root bark.
文摘A new C2-Symmetric diamine/diphosphine Ruthenium (Ⅱ) complex, RuCl2P2N2H4 was used as an excellent catalyst to carry out the catalytic hydrogen transfer reduction of acetophenone,The conversion of acetophenone to 2-phenylethanol was up to 99% under the following reaction conditions: substrate: Ru: (CH3)2 CHOK=200:1:12; reaction temperature of 65℃, reaction time of 2 h:normal pressure. A hydride transfer mechanism was also discussed.
基金This research was supported by the China Postdoctoral Science Foundation(2021M690588)the Fundamental Research Funds for the Central Universities(135111010)+1 种基金the Young Science and Technology Talent Support Project of Jilin Province(QT202121)The authors would like to thank all the reviewers who participated in the review,as well as MJEditor(www.mjeditor.com)for providing English editing services during the preparation of this manuscript.
文摘The Indian meal moth,Plodia interpunctella(Lepidoptera:Pyralidae),a globally distributed storage pest,relies on odors that are emitted from stored foods to select a suitable substrate for oviposition.However,the molecular mechanism underlying the chemical communication between P.interpunctella and its host remains elusive.In this study,130 chemosensory genes were identified from the transcriptomes of 7 P.interpunctella tissues,and the quantitative expression levels of all 56 P.interpunctella odorant receptor genes(PintORs)were validated using real-time quantitative polymerase chain reaction.The functional characteristics of 5 PintORs with female antennae-biased expression were investigated using 2-electrode voltage clamp recordings in Xenopus laevis oocytes.PintOR23 was found to be specifically tuned to acetophenone.Acetophenone could elicit a significant electrophysiological response and only attracted mated females when compared with males and virgin females.In addition,molecular docking predicted that the hydrogen bonding sites,TRP-335 and ALA-167,might play key roles in the binding of PintOR23 to acetophenone.Our study provides valuable insights into the olfactory mechanism of oviposition substrate detection and localization in P.interpunctella and points toward the possibility of developing eco-friendly odorant agents to control pests of stored products.
文摘Asymmetric reduction of 3,5-bistrifluoromethyl acetophenone to produce(S)-3,5-bistrifluoromethylphenyl ethanol was successfully carried out with sodium alginate immobilized Saccharomyces rhodotorula cells in an aqueous-organic solvent biphasic system.The possible influential factors were examined thoroughly according to their effects on conversion rate and e.e of the product.Organic solvents were rated by their biocompatibility and conversion potential.The immobilized cells [125 mg/mL in 20 mmol/L Tris-HCl buffer and 5%(j) octane at pH 8] showed the best conversion with a substrate concentration of 1.42 g/L at 30℃ with glucose as co-substrate for cofactor regeneration.Sequential 8-batch process was carried out with immobilized cells with a slow decrease in conversion and e.e.The immobilized cells showed stable catalytic activity with 50% reserved activity and are superior especially in reusability in comparison with resting cells.
文摘This study involves initial Hartree-Fock and Density Functional theory calculations onthe molecular recognition of the cyclodextrins. The α-cyclodextrin-acetophenone complexationsystem was investigated with PM3, HF/3-21G* and B3LYP/3-21G* methods. The results indicatedthat the inclusion orientation in which the acetyl group of the acetophenone points towards thesecondary hydroxyls of the a-cyclodextrin was preferable in energy. The steric effect wassupposed as the physical reason of such a behavior Hence, the simple rule the anti-parallelarrangement of the dipoles of the host and guest molecules in the cyclodextrin complexqtion is notgenerally applicable.
文摘Experimental results on solubility of the styrene, phenol, methylphenylcarbinol, acetophenone, ethyl benzene, propylene glycol and molybdenum as a complex with Trilon B in supercritical CO2 obtained using a dynamic (flow) method are presented. The obtained data are described in the framework of Peng-Robinson equation. The results of the experients on the extraction of organic components from waste formed in the olefin epoxidation process at Nizhnekam-skneftekhim Inc., on the analysis of extract composition, and on the testing of the extract as an epoxidation catalyst are presented. The supercritical water oxidation (SCWO) process of epoxidation process waste was conducted in periodical and continuous mode. The analysis results of reaction product are given. Pilot experiments on dry sediment formation were conducted using Radio Frequency (RF) Inductively Coupled Plasma (ICP) of low pressure.
文摘3-(Dimethylamino)-1-phenylprop-2-en-1-ones (formylated acetophenones) 1 reacted with aliphatic diamines in water assisted by KHSO4 to give bis-enaminones 2a-h in good yields. Compound 1 also reacted with o-phenylenediamine under similar conditions to produce bis-enaminones 3 instead of benzodiazepines 4 in excellent yields.
文摘Microwave-assisted reactions are an environmentally friendly approach for synthesizing organic compounds. In this study, oximation of acetylferrocene and acetophenone was conducted under both microwave irradiation and conventional heating conditions. Acetylferrocene and acetophenone were subjected to oximation under the two conditions in various solvent mixtures, and the extent of conversion was determined by </span><sup><span style="font-family:Verdana;">1</span></sup><span style="font-family:Verdana;">H nuclear magnetic resonance spectroscopy. Microwave irradiation was found to accelerate the rate of oximation of both acetylferrocene and acetophenone. Acceleration of the reaction under microwave irradiation was attributed to the efficient absorption of microwaves by the ferrocene nucleus.
文摘Homoisoflavonoids are in the subclass of the larger family of flavonoids having one more alkyl carbon than flavonoids. Among them, 8-C-Methylated homoisoflavones have not been extensively studied for synthesis and biological evaluation. Author’s current objective is to synthesize 8-C-Methylated homoisoflavones by the reaction of 3-C-methylated dihydrochalcones with N,N’-dimethyl (chloromethylene) ammonium chloride generated<em> in situ</em> from DMF and PCl<sub>5</sub> for one carbon extension at about room temperature. The 3-C-methylated dihydrochalcones were synthesized by the reduction of 3-C-methylated chalcones, which were prepared from 3-C-methylated acetophenones and aromatic aldehydes in the presence of base. All the synthesized novel homoisoflavones’s structures were characterized by NMR and Tandem Mass Spectrometry.
基金supported by the National Natural Science Foundation of China(Nos.92261207,21890752,and 22002126)。
文摘The determination of catalytically active sites is crucial for the design of efficient and stable catalysts toward desired reactions.However,the complexity of supported noble metal catalysts has led to controversy over the locations of catalytically active sites(e.g.,metal,support,and metal/support interface).Here we develop a structurally controllable catalyst system(Pd/SBA-15)to reveal the catalytic active sites for the selective hydrogenation of ketones to alcohol using acetophenone hydrogenation as model reaction.Systematic investigations demonstrated that unsupported Pd nanocrystals have no catalytic activity for acetophenone hydrogenation.However,oxidized Pd species were catalytically highly active for acetophenone hydrogenation.The catalytic activity decreased with the decreased oxidation state of Pd.This work provides insights into the hydrogenation mechanism of ketones but also other unsaturated compounds containing polar bonds,e.g.,nitrobenzene,N-benzylidene-benzylamine,and carbon dioxide.
基金Project supported by the Natural Science Foundation of Tianjin ScienceTechnology Commission
文摘Seven chiral thiazolidines bound rhodium complexes were synthesized and their catalytic asymmetric hydrosilation properties were investigated It was found through investigation that the configuration of newly formed chiral centre C2 of substituted chiral thiazolidines prepared from L-cysteine or its esters has no effect on the final results of catalytic asymmetric hydrosilation.The direct reason for causing this phenomenon is reported by the present quantitative results for the first time:the rapid racemation of chiral center C2 of chiral thiazolidine ligands takes place under the catalysis of rhodium(Ⅰ) complex [Rh(COD)
基金This work was supported by the Specialized Research Fund for the Doctoral Program of Higher Education of China(Grant No.20050335131)Wuhan Youth Scientist Dawn Foundation(200750731288)Natural Science Foundation of Wuhan University of Science and Technology(2005XY15).
文摘The favorable microbes for the asymmetric reduction of prochiral aromatic ketones was isolated from soil using acetophenone as the sole carbon source,when the asymmetric reduction of acetophenone(ACP)to chiral a-phenethyl alcohol(PEA)was chosen as the model reaction.Two microbe strains with excellent catalytic activity were obtained.They were Geotrichum candidum and Pichia pastoris identified by bacteria identification.The product of the asymmetric reduction of ACP catalyzed by Pichia pastoris was mainly R-PEA and that by Geotrichum candidum was mainly S-PEA.The yield and enantiomeric excesses(e.e.)could respectively reach 75%and 90%for Pichia pastoris,and 80%and 70%for Geotrichum candidum,much higher than those catalyzed by baker’s yeast.
基金supported by the State Key Program of Fundamental Research(Grant No.2004CCA05900)the National Natural Science Foundation of China(Grant No.50662004).
文摘A heterogeneous chiral catalyst Fe(III)-CS(chitosan)complex/mesoporous molecular sieve SBA-15(Santa Barbara Amorphous)was prepared.The asymmetric transfer hydrogenations of prochiral acetophenone and 4-methyl-2-pentanone to corresponding chiral alcohols were carried out on Fe-CS/SBA-15 at atmosphere pressure using 2-propanol as hydrogen donor.Effects of Fe content in cata-lyst,reaction temperature,reaction time and promoter KOH concentration on the conversion of substrates and enantio-selectivity were investigated.Fe-CS/SBA-15 with 2.2%mass fraction Fe exhibits considerable enantioselectivity and cata-lytic activity for the asymmetric transfer hydrogenations of aromatic ketone and aliphatic ketone.Under optimal reaction conditions:KOH concentration 0.03 mol/L,reaction tem-perature 70℃ and reaction time 4 h,enantiomer excess(ee)of(R)-1-phenylethanol and conversion of acetophenone can reach 87.4%and 27.7%,respectively.Under the above KOH concentration and reaction temperature and reaction time of 8 h,the ee of(R)-4-methyl-2-pentanol and conversion 4-methyl-2-pentanone amounted to 50.2%and 25.5%,respectively.