Traumatic brain injury （TBI） poses a significant socioeconomic burden in the world. The long lasting consequences in cognitive impairments are often underreported and its mechanisms are unclear. In this perspective,...Traumatic brain injury （TBI） poses a significant socioeconomic burden in the world. The long lasting consequences in cognitive impairments are often underreported and its mechanisms are unclear. In this perspective, cholinergic dysfunction and thera-peutic strategy targeting this will be reviewed. Novel agents that can target specific subtype of acetylcholine receptors have been developed over the recent years and are at various stages of development, which include AR-R 17779, GTS-21, SSR- 180711A, AR-R17779, and PNU-282987. A detailed review on this topic has been previously published （Shin and Dixon, 2015）.展开更多
Electrophysiological studies have shown that acetylcholine may be one of the neurotransmitters in the nucleus isthmi (NI) of amphibians and reptiles, but little (in amphibians) or nothing (in reptiles) is known about ...Electrophysiological studies have shown that acetylcholine may be one of the neurotransmitters in the nucleus isthmi (NI) of amphibians and reptiles, but little (in amphibians) or nothing (in reptiles) is known about the distribution of its hydrolase,acetylcholinesterase (AChE), within NI. However, abundant AChE is a necessary con-展开更多
文摘Traumatic brain injury （TBI） poses a significant socioeconomic burden in the world. The long lasting consequences in cognitive impairments are often underreported and its mechanisms are unclear. In this perspective, cholinergic dysfunction and thera-peutic strategy targeting this will be reviewed. Novel agents that can target specific subtype of acetylcholine receptors have been developed over the recent years and are at various stages of development, which include AR-R 17779, GTS-21, SSR- 180711A, AR-R17779, and PNU-282987. A detailed review on this topic has been previously published （Shin and Dixon, 2015）.
文摘Electrophysiological studies have shown that acetylcholine may be one of the neurotransmitters in the nucleus isthmi (NI) of amphibians and reptiles, but little (in amphibians) or nothing (in reptiles) is known about the distribution of its hydrolase,acetylcholinesterase (AChE), within NI. However, abundant AChE is a necessary con-
