Comparison between synthetic retinoid CD437 and acitretin inhibiting melanoma A375 cell in vitro

Objective： To investigate the effects of synthetic retinoid CD437 and acitretin on cell proliferation, apoptosis, cycle arrest and Bax/ Bcl-2 protein expression of melanoma A375 cell, Methods：MTT assay was used to determine the anti-proliferative effects of CD437 and acitretin on melanoma A375 cell, Flow cytometry was performed to investigate the influence of CD437 and acitretin on cell cycle and cell apoptosis. SABC immunocytochemistry was employed for detection of Bax/bcl-2 protein expressions. Results：10^-5 mol/L CD437 was more effective than acitretin in inhibiting proliferation and inducing apoptosis of A375 cell after 24 h treatment, growth inhibiting ratio and apoptosis ratio（58.6%vs43.25% and 28.03%vs17.13%, P 〈 0.05 respectively）. CD437 promoted G0/G1 arrest in melanoma A375 cell, however acitretin could not. CD437 and acitretin could up-regulate the expression of Bax protein and downregulate the expression of bcl-2 protein（P 〈 0.05）. Conclusion：CD437 is more effective than acitretin in inhibiting proliferation and inducing apoptosis and cycle arrest on A375 cell, CD437 may have more potentialities than acitretin for subsidiary treatment of melanoma. Mitochondrial apoptosis pathway is partially involved in two drugs inducing apoptosis on A375 cell.

A Unique Case? Darier’s Disease Presented as Porcupine-Like Appearance and the Observation on Acitretin Treatment

Dyskeratosis follicularis (Darier’s disease, DD) is rare autosomal dominant disease characterized by hyperkeratotic papules that coalesce into plaques and occur primarily in seborrheic or intertriginous areas. Associated findings include nail abnormalities. A 3-year-old boy presented with porcupine-like appearance for 2 years. The lesion from the back was taken for light microscopy and electron microscopy. He was treated with acitretin (0.31 mg/d to 0.66 mg/d) for 8 years. Light microscopy and electron microscopy showed that the typical features of DD. The patient show good respond to the treatment. During 8 years treatment, the patient had dry mouth and pruritus. The skeletal abnormalities didn’t happen in the patient. The serum lipid profile, liver function and renal function within normal lever after treatment. Our findings showed that porcupine-like appearance is a unique pattern of DD. Acitretin may be a useful therapeutic agent in children with DD and less likely to cause skeletal problems.

Effects of different doses of acitretin on FGF10 mRNA transcription and its protein translation in HaCaT cells

Objective:To observe the effects of different doses of acitretin on the transcription of FGF10 mRNA and the translation of FGF10 protein in cultured HaCaT cells. Methods: HaCaT cells were treated with different doses of acitretin for 48 h, then the changes on the transcription of FGFfO mRNA and the translation of FGF10 protein in these cells were detected by immunofluorescence and in situ hybridization assay. Results: Compared with the control group, the transcription of FGF10 mRNA and the translation of FGF10 protein were gradually decreased along with the increasing dose of acitretin. There were significant differences between different groups (P<0. 01). Conclusion: Acitretin could inhibit the transcription of FGF10 mRNA and the translation of FGF10 protein in HaCaT cells. With the dose of acitretin increased, the stains of both FGF10 mRNA and FGF10 protein in HaCaT cells are reduced.

Impact of Adverse Events Associated With Acitretin Treatment of Moderate-to-Severe Plaque Psoriasis:Based on an Observational,Single-Center Study in Shanghai,China

Objective:Acitretin is a widely used systemic retinoid that is to treat psoriasis but has significant variations in efficacy and adverse events(AEs)among individuals.This study aimed to determine the impact of AEs associated with acitretin treatment of moderate-to-severe plaque psoriasis on the Dermatology Life Quality Index(DLQI)and Hospital Anxiety and Depression Scale(HADS)scores.Methods:This prospective,observational,single-center study was conducted from March 2021 to June 2022 and analyzed 116 patients with moderate-to-severe plaque psoriasis treated with acitretin who were followed up for 12 weeks.The primary outcome was the incidence of AEs related to acitretin,and the secondary objective was to investigate the effect of AEs on the DLQI and HADS scores.The generalized linear models were used to assess the association between AEs related to acitretin and DLQI scores or HADS scores,and the association between the involved system/tissue and DLQI scores or HADS scores.Results:A final total of 45 patients were included in the analysis,and a total of 157 treatment-related AEs involving nine organs or systems were reported in 41 patients.The most common AE was skin-or mucosa-related,with 72 cumulative events in 31 patients.AEs also commonly affected the endocrine,digestive,and genitourinary systems.Compared with the group with 0-2 AEs,the group with 3-5 AEs had a significantly increased DLQI score by 5.49 points(95%CI,1.47-9.51)(P=0.0089).Compared with AEs involving 0 to 1 system,AEs affecting 2 to 3 systems resulted in a significant increase in the DLQI score by 5.75 points(95%CI,1.67-9.83)(P=0.0071).Generalized linear models showed no statistically significant associations between AEs and the HADS scores.Conclusion:Our study demonstrates a high incidence of acitretin-related AEs.These AEs may affect quality of life but rarely cause psychological problems such as anxiety and depression.

窄谱中波紫外线联合阿维A对寻常型银屑病患者的炎症因子、免疫功能的影响探讨

目的探讨窄谱中波紫外线联合阿维A对寻常型银屑病的炎症因子、免疫功能的影响。方法70例符合入选标准的寻常型银屑病患者,按随机数字表法分为对照组(35例)和观察组(35例)。对照组给予窄谱中波紫外线照射治疗,观察组在对照组基础上口服阿维A治疗。比较两组临床疗效、不良反应发生情况及治疗前后T淋巴细胞亚群(CD^3(+)、CD^4(+)、CD^8(+))、炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)]水平。结果观察组临床总有效率94.29%(33/35)明显高于对照组74.29%(26/35)(P<0.05)。与观察组治疗前CD^4(+)(30.06±4.21)%及对照组治疗后CD^4(+)(34.38±3.47)%比较,观察组治疗后CD^4(+)(39.39±3.60)%显著升高(P<0.05);与观察组治疗前CD^8(+)(29.53±2.88)%及对照组治疗后CD^8(+)(26.50±2.48)%比较,观察组治疗后CD^8(+)(21.50±2.25)%明显降低(P<0.05)。观察组治疗后TNF-α(7.1±2.0)ng/ml、IL-6(111.6±20.5)pg/L、CRP(4.4±2.0)mg/L明显低于治疗前(15.3±2.6)ng/ml、(179.3±25.8)pg/L、(9.8±2.8)mg/L及对照组治疗后(9.3±2.2)ng/ml、(138.6±21.2)pg/L、(6.7±2.3)mg/L(P<0.05)。观察组的不良反应发生率为51.43%(18/35),与对照组42.86%(15/35)比较,无显著性差异(χ^(2)=0.516,P=0.473>0.05)。结论窄谱中波紫外线联合阿维A治疗寻常型银屑病可提高临床疗效,调节T淋巴细胞功能失衡,降低炎症细胞因子,且安全性高,值得推广。

Efficacy and Safety of Tripterygium wilfordii Hook F Versus Acitretin in Moderate to Severe Psoriasis Vulgaris：A Randomized Clinical Trial

Background：Few clinical trials have evaluated the efficacy and safety of Tripterygium wilfordii Hook F （TwHF） compared with acitretin in psoriasis.We aimed to compare the efficacy and safety of TwHF compared with acitretin in the treatment of moderate to severe psoriasis vulgaris.Methods：Adults with Psoriasis Area Severity Index （PASI） score ＞ 10 and psoriasis-affected body surface area ＞ 10％ were randomized into a TwHF （20 mg,3 times a day） or acitretin group （30 mg,once a day）.The treatment course lasted for 8 weeks.Patients were assessed at baseline and at 2,4,and 8 weeks.Laboratory tests were performed at baseline,week 4,and week 8.The data were analyzed using paired samples t-test or analysis of variance （ANOVA）.Results：A total of 115 patients was enrolled （58 TwHF; 57 acitretin）.The median PASI score improved in the TwHF group by 50.4％ and in the acitretin group by 42.7％.There was no significant difference in median PASI improvement between two groups at 2,4,and 8 weeks.There was also no significant difference in PASI 25,PASI 50,PASI 75,and PASI 90 response between the two groups at 2,4,and 8 weeks.There was a significant increase in the level of aspartate transaminase and triglycerides in the TwHF group （P =0.026 and P =0.011,respectively）.In the acitretin group,there was a significant increase in the level of alanine transaminase,cholesterol,and high-density lipoprotein （P =0.030,P ＜ 0.01,and P ＜ 0.01,respectively）.Conclusions：There was no significant difference in treatment efficacy between the TwHF and acitretin groups within 8 weeks,but there were fewer treatment-related adverse events in the TwHF group.

Effect of Chinese Herbal Medicine Combined with Acitretin Capsule in Treating Psoriasis of Blood-Heat Syndrome Type

Objective:To observe the clinical curative effect of Chinese herbal medicine combined with acitretin capsule in treating psoriasis of blood-heat syndrome(P-BH).Methods:Eighty patients of P-BH were randomly assigned to two groups,39 in Group A and 41 in Group B.Both was treated with Chinese herbal medicines for clearing heat,cooling blood and removing toxic substance,and acitretin capsule was given to Group A additionally,with 8 weeks as one therapeutic course.The clinical curative effect was compared betwee...

A harlequin ichthyosis pig model with a novel ABCA12 mutation can be rescued by acitretin treatment

Harlequin ichthyosis (HI) is a severe genetic skin disorder and caused by mutation in the ATP-binding cassette A12 (ABCA12) gene. The retinoid administration has dramatically improved long-term survival of HI, but improvements are still needed. However, the ABCA12 null mice failed to respond to retinoid treatment, which impedes the development of novel cure strategies for HI. Here we generated an ethylnitrosourea mutagenic HI pig model (named Z9), which carries a novel deep intronic mutation IVS49-727 A>G in the ABCA12 gene, resulting in abnormal mRNA splicing and truncated protein production. Z9 pigs exhibit significant clinical symptom as human patients with HI. Most importantly, systemic retinoid treatment significantly prolonged the life span of the mutant pigs via improving epidermal maturation, decreasing epidermal apoptosis, and triggering the expression of ABCA6. Taken together, this pig model perfectly resembles the clinical symptom and molecular pathology of patients with HI and will be useful for understanding mechanistic insight and developing therapeutic strategies.

Assessment by HPLC of the degradation behavior of acitretin under hydrolytic,oxidative,photolytic and thermal stress conditions

Acitretin is a photosensitive oral retinoid with very limited data available on its degradation.The official HPLC method for acitretin determination was insufficient to resolve the degradation products generated during stability studies.Therefore,an isocratic RP-HPLC-UV method was developed for the determination of acitretin in the presence of its related impurities and degradation products.Efficient chromatographic separation was achieved on a Thermo beta-basic column C18(100 mm
4.6 mm,5μm)with mobile phase containing 0.3%(v/v)glacial acetic acid with acetonitrile(ACN)and isopropyl alcohol(IPA)in an isocratic ratio of 70:30 at a flow rate of 1.0 mL/min with the eluent monitored at 360 nm.The method was validated for specificity,linearity,precision,accuracy and robustness.The calibration plot was linear over the concentration range of 50-150μg/mL with a correlation coefficient(r2)of 0.999.The proposed method was used to investigate the degradation kinetics of acitretin under the different degradative conditions.The degradation rate constant(K),half-life(t1/2),and t90 were calculated.Degradation of acitretin followed pseudo-first-order kinetics.The drug was found to be less stable under acidic and photolytic degradation conditions:the photolytic degradation constants for acitretin in sunlight and UV light were 0.002698%and 0.0008402%min1,respectively.The LOD for acitretin and the known impurities were at a level below 0.02%.The method shows consistent recoveries for ACTR(99.8%-101.2%)and also for its known impurities(97.2-101.3%).The method was found to be accurate,precise,linear,specific,sensitive,rugged,robust,and useful for characterizing the stability of this chemical.

卡泊三醇联合阿维A胶囊治疗寻常型银屑病的效果分析

目的:分析卡泊三醇联合阿维A胶囊治疗寻常型银屑病的效果。方法:选取2020年6月—2021年6月沂水县人民医院收治的寻常型银屑病患者124例作为研究对象,依据随机数字表法分为两组,各62例。对照组予以阿维A胶囊治疗,观察组在对照组基础上应用卡泊三醇软膏治疗。比较两组治疗效果、皮损情况及不良反应发生率。结果:治疗后,两组皮损严重程度评分低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P=0.013)。观察组不良反应总发生率低于对照组,差异有统计学意义(P=0.027)。结论:卡泊三醇联合阿维A胶囊治疗寻常型银屑病的效果较好,可改善患者临床症状,不良反应发生率低。

丹青胶囊联合阿维A胶囊治疗寻常型银屑病血瘀证的临床研究

目的探讨丹青胶囊联合阿维A胶囊治疗寻常型银屑病血瘀证的临床研究。方法选择2022年1—6月本院门诊治疗的62例寻常型银屑病血瘀证患者作为研究对象,按照随机数表法分为对照组和治疗组两组,每组各31例。对照组采用阿维A胶囊治疗,20 mg/次,1次/d;治疗组在对照组治疗的基础上给予口服丹青胶囊,4粒/次,3次/d,两组共计治疗8周。比较两组治疗后临床疗效、PASI和DLQI评分、Th1、Th2、Th17和Treg细胞百分比及其分泌的细胞因子表达水平的差异。结果8周后,与对照组相比,治疗组总有效率明显升高(96.77%vs.77.42%,χ2=5.167,P=0.023)。治疗后,与对照组相比,治疗组PASI评分[(3.23±0.84)分vs.(7.23±1.02)分]、DLQI[(12.04±3.11)分vs.(15.75±2.97)分]、Th1细胞百分比[(3.74±0.26)%vs.(5.26±0.48)%]、Th1/Th2细胞比值[(1.16±0.13)vs.(1.77±0.10)]、Th17细胞百分比[(5.04±0.63)%vs.(8.17±1.02)%]、Th17/Treg细胞比值[(0.63±0.07)vs.(1.14±0.05)]、IFN-g[(8.74±2.21)pg/ml vs.(15.63±2.79)pg/ml]和IL-17[(11.59±1.53)pg/ml vs.(19.74±1.16)pg/ml]表达水平明显降低,差异均具有统计学意义(P<0.05),而Treg细胞百分比[(8.17±1.25)vs.(6.38±0.69)]、IL-4[(133.04±20.71)pg/ml vs.(102.67±17.52)pg/ml]和TGF-α[(40.55±4.36)pg/ml vs.(32.35±3.49)pg/ml]表达水平明显升高,差异均具有统计学意义(P<0.05)。对照组和治疗组不良反应发生率分别为16.13%和22.58%,组间差异无统计学意义(χ2=0.413,P=0.520)。结论丹青胶囊治疗寻常型银屑病血瘀证临床疗效显著,安全性高,可能与改善Th1/Th2和Th17/Treg细胞失衡有关。

Efficacy of Acitretin Monotherapy on Basal Cell Carcinoma:A Case Report

Introduction:Basal cell carcinoma(BCC)is the most common skin cancer which mainly affects the population over 50 years of age.In addition to surgical treatment,nonsurgical treatment is also an attractive option for some patients.We herein report a case of an 82-year-old man with BCC successfully treated with acitretin.Case presentation:An 82-year-old man presented with BCC on his left nose wing more than 2 years ago.Due to his unwillingness to accept treatment that may lead to pain,discomfort,or trauma,the patient was prescribed oral acitretin 25 mg twice daily[0.8 mg/(kg·d)]and was instructed to apply 2%fusidic acid cream topically once daily for trauma protection.The lesion progressively shrank in size after 4 weeks of treatment,and was almost completely resolved after 28 weeks of follow-up.The patient reported mild adverse effects,such as mild skin fragility and cheilitis,and apparent scaling skin,which caused minor discomfort but did not affect the continuation of treatment.Discussion:The pathogenesis of BCC is still unclear,but it has been demonstrated to be linked to overactive hedgehog signaling and its crosstalk with other pathways such as phosphoinositide 3-kinase and mammalian target of rapamycin.Acitretin could obviously inhibit cell growth and proliferation and down-regulate AMP-dependent protein kinases that plays critical role in the blocking of malignant progression of several tumors including BCC.Conclusion:We provide an effective alternative for the patients with BCC who are unwilling to receive surgical therapy.

口服中成药联合阿维A治疗寻常性银屑病的网状meta分析

目的运用网状meta分析评价口服中成药联合阿维A治疗寻常性银屑病(PV)的效果。方法检索中国知网、维普网、万方数据库、PubMed、EMbase、Web of Science中应用口服中成药联合阿维A治疗PV的随机对照试验(RCT),检索时间为建库至2022年3月。对纳入文献进行筛选、资料提取和质量评价,采用Stata 14.0进行网状meta分析。结果最终纳入38项RCT,涉及12种中成药,受试者3695例。网状meta分析结果显示,口服中成药联合阿维A的有效率、银屑病面积和严重程度指数(PASI)均优于单纯使用阿维A或同时联合其他辅助药物(P<0.05)。在有效率方面,润肤止痒胶囊联合阿维A(OR=16.06,95%CI:2.79~92.32)最佳,紫丹银屑颗粒(OR=8.47,95%CI:1.00~71.94)次之;在PASI方面,紫丹银屑颗粒联合阿维A最佳(SMD=-2.25,95%CI:-3.21~-1.28),克银丸次之(SMD=-1.99,95%CI:-2.96~-1.01)。比较-校正漏斗图显示存在发表偏倚风险可能性较小。结论口服中成药联合阿维A治疗PV效果较好,但在临床上仍应结合患者情况谨慎用药。

阿维A联合中药治疗红皮病型银屑病Meta分析

目的:系统评价阿维A联合中药治疗红皮病型银屑病的临床疗效及安全性。方法:检索中国知网、万方、维普、中国生物医学文献数据库、Pub Med、Embase等数据库中从建库至2022年5月发表的有关阿维A联合中药治疗红皮病型银屑病的文献,研究设计均为随机对照试验;运用Review Man 5.3软件对符合条件的文献进行Meta分析。结果:共纳入文献16篇,涉及病例总数1197例。总有效率:试验组优于对照组[OR=4.49,95%CI=(3.14,6.43),P<0.00001]。银屑病皮损面积和严重程度指数(Psoriasis Area and Severity Index,PASI)评分:试验组低于对照组[MD=-9.20,95%CI=(-11.06,-7.35),P<0.00001]。皮疹消退时间:试验组优于对照组[MD=-5.20,95%CI=(-5.99,-4.41),P<0.00001]。皮疹明显消退时间:试验组优于对照组[MD=-5.80,95%CI=(-6.85,-4.75),P<0.00001]。患者住院时间:试验组短于对照组[MD=-10.85,95%CI=(-12.19,-9.41),P<0.00001]。总不良反应发生率:试验组低于对照组[OR=0.40,95%CI=(0.31,0.53),P<0.00001]。复发率:试验组低于对照组[OR=0.33,95%CI=(0.19,0.59),P=0.0002],四组的差异均具有统计学意义。结论:阿维A联合中药治疗红皮病型银屑病的临床疗效及安全性优于单一阿维A治疗。由于本研究所纳入文献的质量有限且数量不足,故结论仍需高质量、大样本数据加以验证。

紫丹银屑胶囊在血虚风燥型寻常型银屑病中的应用效果分析

目的分析紫丹银屑胶囊在血虚风燥型寻常型银屑病中的应用效果。方法选取2019年3月至2021年3月丹东市中心医院收治的130例血虚风燥型寻常型银屑病患者作为研究对象,并按照随机数表法将其随机分为研究组(65例)与对照组(65例),对照组患者单纯应用阿维A胶囊治疗,研究组患者在阿维A胶囊治疗的基础上联合应用紫丹银屑胶囊,对比观察两组患者血清白细胞介素(IL)-17、IL-18、骨桥蛋白(OPN)水平以及银屑病面积和严重程度指数(PASI)评分与临床疗效。结果治疗1、3个月时,研究组患者血清IL-17、IL-18、OPN水平均明显低于对照组(治疗1个月:t=3.680、5.135、2.899,P<0.001、P<0.001、P=0.004;治疗3个月:t=6.172、7.159、5.600,P均<0.001);治疗3个月时,研究组患者PASI评分明显低于对照组(t=5.029,P<0.001),临床疗效明显优于对照组(Z=-2.055,P=0.040)结论在阿维A胶囊治疗的基础上联合应用紫丹银屑胶囊可明显降低血虚风燥型寻常型银屑病患者的炎症反应程度,改善患者临床症状,疗效显著。

芽生菌样脓皮病1例及文献回顾分析

报道1例芽生菌样脓皮病。患者男,33岁。右下肢疣状增生3个月,左下肢破溃增生2个月。组织病理检查:假上皮瘤样增生和真皮内大量炎性细胞浸润。组织培养出金黄色葡萄球菌及大肠埃希菌生长,真菌及分枝杆菌培养均为阴性。根据临床表现、组织病理检查及组织培养诊断为芽生菌病样脓皮病。治疗予以敏感抗生素联合小剂量阿维A口服治疗,效果满意。回顾近年文献发表的41例病例,对该病相关特点进行分析。

消银胶囊联合阿维A胶囊治疗寻常型银屑病对PASI及DLQI评分的改善研究

目的探讨消银胶囊联合阿维A胶囊治疗寻常型银屑病患者的效果及对其PASI及DLQI评分的改善情况。方法选取2020年4月~2022年4月收治的80例银屑病患者按随机数字表分为两组,给予对照组(40例)患者阿维A胶囊治疗,给予观察组(40例)患者阿维A胶囊+消银胶囊治疗,观察两组患者PASI评分、生活质量、免疫功能以及炎性因子水平等指标水平变化情况。结果治疗后,观察组PASI与DLQI评分较对照组更佳(P<0.05);观察组患者免疫功能水平均较对照组更优(P<0.05);两组患者IFN-γ、IL-2、IL-4及IL-10等水平均显著低于治疗前,且观察组均较对照组更低(P<0.05)。结论寻常型银屑病患者临床治疗中给予阿维A胶囊+消银胶囊联合方案,可有效提升其免疫功能,缓解其炎症反应,提高患者生活质量水平,获得显著的治疗有效性。

注射用烟酰胺联合阿维A胶囊治疗寻常型银屑病的疗效及安全性研究

目的探讨注射用烟酰胺联合阿维A胶囊治疗寻常型银屑病的临床疗效及安全性。方法回顾性分析2021年3月—2022年3月期间在吉林大学第二医院进行治疗的120例寻常型银屑病患者的临床资料,按照治疗方法分为常规组(n=60)和研究组(n=60)。常规组选取单一阿维A胶囊方案治疗,研究组选取注射用烟酰胺联合阿维A胶囊方案治疗,对比两组临床疗效、用药后不良反应发生率、皮损面积与严重性指数(PASI)。结果研究组治疗有效率为96.67%,明显高于常规组的80.00%,差异有统计学意义(χ^(2)=8.086,P=0.004)。治疗后,研究组皮肤干燥、红斑、皮肤瘙痒等不良反应发生率为5.00%低于常规组的20.00%,差异有统计学意义(χ^(2)=6.171,P=0.013)。结论注射用烟酰胺联合阿维A胶囊治疗寻常型银屑病的不良反应少,临床效果显著,可有效降低患者临床症状,对患者疾病转归具有正向积极作用。

CERS3基因变异所致常染色体隐性先天性鱼鳞病一个家系报道

CERS3突变所致的常染色体隐性先天性鱼鳞病在临床上非常罕见。本文收集了一个家系,对先证者外周血DNA进行遗传性皮肤病靶基因外显子测序,检测出CERS3基因c.746A>G(来自于母亲)和exon12缺失(来自于父亲)复合杂合突变,Sanger测序验证了上述突变存在,基因突变与表型符合共分离原则,该家系的2个突变位点均为首次报道。治疗上予口服阿维A胶囊20 mg qd, 3个月后随访,皮疹明显好转。

百癣夏塔热片联合阿维A胶囊对寻常型银屑病患者免疫功能和炎性反应的影响

目的 探讨百癣夏塔热片联合阿维A胶囊对寻常型银屑病患者免疫功能和炎性反应的影响。方法 选择2021年9月至2022年12月杭州市第九人民医院收治的寻常型银屑病患者80例,其中40例(观察组)口服百癣夏塔热片联合阿维A胶囊治疗,另40例(对照组)口服阿维A胶囊治疗。两组患者治疗疗程8周。统计两组临床疗效;比较两组治疗前后银屑病皮损面积和严重程度(PASI)评分、经皮水分散失(TEWL)、免疫功能、炎性反应变化及不良反应发生情况。结果 观察组治疗总有效率高于对照组(P<0.05)。两组治疗后PASI评分和TEWL值均低于治疗前(均P<0.05),且观察组均低于对照组(均P<0.05)。两组治疗后CD_(3)^(+)、CD_(4)^(+)和CD_(4)^(+)/CD_(8)^(+)均高于治疗前(均P<0.05),且观察组均高于对照组(均P<0.05)。两组治疗后血清IL-6和CRP水平均低于治疗前(均P<0.05),且观察组均低于对照组(均P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 百癣夏塔热片联合阿维A胶囊可有效治疗寻常型银屑病,患者免疫功能显著改善,炎性反应显著减轻。