In the present paper,the clinical curative effects of catgut embedding therapyand traditional acupuncture therapy for treatment of lumbar muscle strain were compared.The sameacupoints were used in both groups.Results ...In the present paper,the clinical curative effects of catgut embedding therapyand traditional acupuncture therapy for treatment of lumbar muscle strain were compared.The sameacupoints were used in both groups.Results showed that the effective rates were 100% and 92.5%respectively in 80 cases of the catgut embedding group and 40 cases of the acupuncture group.Therewas a significant difference between the two groups(P【0.005).It indicates that the catgut embed-ding therapy is an effective method for treatment of lumbar muscle strain.展开更多
Aim: To observe the therapeutic effect of acupoint catgut embedding in the treatment of epilepsy rats. Methods: 40 Wistar rats were randomly and evenly divided into normal control, model, medication (Natrii Valproas s...Aim: To observe the therapeutic effect of acupoint catgut embedding in the treatment of epilepsy rats. Methods: 40 Wistar rats were randomly and evenly divided into normal control, model, medication (Natrii Valproas syrup), and catgut embedding groups. Epilepsy model was established by intraperitoneal injection of sodium penicillin (0.4 mu/100 g), twice every week, continuously for 4 weeks. Electroencephalograph (EEG) was used as the index for assessing the effect of catgut embedding on epilepsy. Results: In epilepsy rats of model group, the amplitude and frequency of EEG increased significantly in comparison with control group (P<0.05). While the amplitude and frequency of EEG of catgut embedding group and medication group were all significantly lower than those of model group (P<0.05, 0.01). The frequency of EEG of catgut embedding group was significantly lower than that of medication group (P<0.05). These findings show that both acupoint catgut embedding and medication can apparently improve epileptic electrical activities of the brain in the rat, and the effect of catgut embedding is better than that of medication in lowering the frequency of EEG.展开更多
Objective:To evaluate the effectiveness and safety of acupoint catgut embedding(ACE)in combination with Chinese herbal medicine(CHM)in treating chronic urticaria(CU).Methods:We thoroughly searched Embase,PubMed,Cochra...Objective:To evaluate the effectiveness and safety of acupoint catgut embedding(ACE)in combination with Chinese herbal medicine(CHM)in treating chronic urticaria(CU).Methods:We thoroughly searched Embase,PubMed,Cochrane Library,Web of Science,China National Knowledge Infrastructure(CNKI),Wangfang database,Chinese Scientific Journal Database(VIP),and Chinese biomedical literature database(SinoMed)for relevant studies from inception until May 2022.Randomized controlled trials(RCTs)on ACE combined with CHM for CU were included.Literature search,data extraction,and risk of bias assessment were independently conducted by two authors.Results:A total of 15 RCTs with 1065 participants were included in this review.Five trials reported that the combined therapy showed a higher total effective rate,and four trials reported that the combined therapy was associated with a lower level of serum immunoglobulin E.Furthermore,two,four,and four trials reported that the combined therapy was more effective in reducing itching degree,size,and number of wheals,respectively.The combined therapy was reported to be associated with a lower recurrence rate in three trials,and with a fewer adverse reaction rate in two trials.Conclusions:ACE in combination with CHM appears to be a safe and effective therapy for patients with CU.Given the relatively low quality of the included trials,these findings should be interpreted cautiously.Further high-quality RCTs are needed to confirm our findings.展开更多
Background:Obesity,as an epidemic public health issue in the world today,not only brings a heavy medical burden to society but also seriously affects people’s quality of life.In the context of new evidence for the ef...Background:Obesity,as an epidemic public health issue in the world today,not only brings a heavy medical burden to society but also seriously affects people’s quality of life.In the context of new evidence for the efficacy of acupoint catgut embedding(ACE)in abdominal obesity(AO),it is necessary to elucidate the mechanism of ACE for AO.The intestinal flora is closely associated with obesity,and the study of its intestinal flora may provide evidence to clarify the mechanism of obesity treatment by ACE.Methods:75 participants will be recruited in this study,including 60 eligible female patients diagnosed with AO and 15 healthy female participants.60 female AO patients will be randomized to ACE group,sham ACE group,and waiting list(WL)group in a ratio of 1:1:1.Patients in two ACE groups will receive one ACE treatment per week for 12 consecutive weeks,and in the WL group will not receive any treatment;only their data will be extracted.The primary outcome is the mean change in body mass index.Secondary effects include waist circumference,body weight,the visual analog score of appetite,and the Gastrointestinal Symptom Rating Scale.High-throughput 16S ribosomal ribonucleic acid gene sequencing will be used to detect intestinal flora in each group before and after the intervention.Conclusion:The results of this trial are expected to identify the critical intestinal flora causing AO and the target intestinal flora of AO regulated by ACE,providing further theoretical support for ACE in the clinical treatment of obesity.展开更多
Acupoint catgut embedding therapy(ACET),filling the gaps of traditional Chinese medicine acupuncture treatment,has been widely used for the treatment of many diseases with significant effects.The aim of this paper is ...Acupoint catgut embedding therapy(ACET),filling the gaps of traditional Chinese medicine acupuncture treatment,has been widely used for the treatment of many diseases with significant effects.The aim of this paper is to obtain polyglycollide acid(PGA)fibers with higher performance at a lower cost,and ensure that PGA can meet the clinical requirements as well.PGA fibers with different diameters were spun as embedding materials.The mechanical performance,thermodynamic and biodegradable properties of PGA fibers were studied under different spinning process parameters,including spinning speed,drawing temperature and stretching ratio.The experimental results showed that the optimum spinning parameters were the spinning speed at 150 m/min,the drawing temperature of 45 ℃,and the stretching ratio of 4.0.The initial modulus of PGA fibers was 3.876 N/tex.The crystallization degree was 68% and the degradation performance was in consistent with treatment cycle of patients.展开更多
It is reported that 245 cases of peptic ulcer were treated with catgut implantationat Pishu（BL 20）-through-Weishu（BL 21）,Shangwan（CV 13）-through-Xiawan（CV 10）and Zusanli（ST 36）points.Catgut was embedded subc...It is reported that 245 cases of peptic ulcer were treated with catgut implantationat Pishu（BL 20）-through-Weishu（BL 21）,Shangwan（CV 13）-through-Xiawan（CV 10）and Zusanli（ST 36）points.Catgut was embedded subcutaneously and left for 15 days as a course.As a resuit,121 cases（49.39％）were cured and 124（50.61％）improved.The total effective was 100％.展开更多
Objective:To explore the clinical effect of embedding thread combined with Jianpi Qushi Huayu ointment in the treatment of bronchiectasis in remission period,and to observe the effect on the level of inflammatory cyto...Objective:To explore the clinical effect of embedding thread combined with Jianpi Qushi Huayu ointment in the treatment of bronchiectasis in remission period,and to observe the effect on the level of inflammatory cytokines.Methods:150 patients with bronchiectasis in remission period were divided into three groups(50 cases in each group),western medicine group(treated with salmeterol fluticasone and low dose erythromycin),combined group(treated with Jianpi Qushi Huayu plaster),observation group(treated with western medicine+Jianpi Qushi Huayu plaster+embedding thread),and the clinical treatment of the three groups were compared.Result:before and after treatment,the improvement of TCM syndrome score,the improvement of pulmonary ventilation index,the improvement of inflammatory cytokines,and the change of adverse reactions.Results:the treatment efficiency of the observation group and the combination group was significantly higher than that of the western medicine group P The peak level of expiratory flow velocity,the maximum expiratory flow,the forced expiratory volume in one second and the ratio of forced expiratory volume in one second to vital capacity in the observation group and the combined group were significantly better than those in the western medicine group and the pre-treatment level(P<0.05),and the improvement in the observation group was better than that in the combined group After treatment,the expression of IL-13,IL-10 and IL-4 in the combined group was significantly better than that in the western medicine group and before treatment(P<0.05),and the improvement in the observation group was better than that in the combined group;there was no significant difference in the incidence of adverse reactions among the three groups(P>0.05).Conclusion:catgut embedding combined with Jianpi Qushi Huayu ointment can significantly alleviate the related clinical symptoms and signs,effectively control the further aggravation of the disease,improve the lung function of patients,regulate the level of inflammatory cytokines to reduce the degree of inflammatory reaction,and do not significantly aggravate the adverse reactions of drugs.展开更多
Objective This review aimed to systematically evaluate the evidence on the effects of acupoint catgut embedding （ACE） therapy for patients with polycystic ovary syndrome （PCOS）. Methods Five databases （CBM, CNKI,...Objective This review aimed to systematically evaluate the evidence on the effects of acupoint catgut embedding （ACE） therapy for patients with polycystic ovary syndrome （PCOS）. Methods Five databases （CBM, CNKI, Wanfang Database, VlP Database, and PubMed） were searched to identify relevant studies published before June 2027. The outcomes were resumption of menstruation and serum levels of testosterone （T）. The methodological quality of the included studies was judged using the Cochrane risk of bias tool. The overall level of evidence was judged by the Grading of Recommendations Assessment, Development, and Evaluation （GRADE） criteria. Results Twenty- five randomized controlled trials were included. ACE therapy significantly lowered serum T levels, and patients receiving ACE treatment reported resumption of menstruation. However, these results should be interpreted with caution due to a high risk of randomization and blinding bias, and likely publication bias. The level of evidence for resumption of menstruation and serum T levels was assessed as ＂low＂ and ＂low＂, respectively, using GRADE. Conclusion The current evidence on ACE therapy for PCOS is insufficient to draw firm conclusions due to the poor methodological quality. Future well- designed trials are needed to validate the therapeutic efficacy, safety, and mechanisms of ACE in patients with PCOS.展开更多
Objective:To explore the therapeutic effect of acupoint catgut embedding combined with gingerseparated moxibustion for sequelae of peripheral facial paralysis and whether surface electromyography(sEMG)can be an outcom...Objective:To explore the therapeutic effect of acupoint catgut embedding combined with gingerseparated moxibustion for sequelae of peripheral facial paralysis and whether surface electromyography(sEMG)can be an outcome to evaluate the effect of this disease.Methods:Thirty-five patients with sequelae of peripheral facial paralysis were treated with catgut embedding at the acupoints selected according to their individual symptoms and traditional Chinese medicine(TCM)differentiated syndromes.At the same time,the ginger-separated moxibustion was applied at Yifeng(翳风TE17)and Qianzheng(牵正EX-HN16)of the affected side.The catgut embedding was applied once every 15 days,one time of treatment is of one course,and a total of three courses were given.The moxibustion would be taken after 5 days of catgut embedding each time,once every other day,5 times as one course,a total of 3 courses are given.After treatment,the recovery of facial nerve functions was evaluated by House-Brackmann(H-B)facial nerve function evaluation grading system.Before and after treatment,the surface electromyography(sEMG)was used to detect the root-mean-square(RMS)of frontal muscles,cheek muscles,and orbicularis oris muscles to compare the RMS ratio of these muscles of affected side and healthy side.Results:After 3 courses of treatment,9 cases were cured,22 cases were effective,and 4 cases were ineffective.The total effective rate was 88.6%(31/35).After treatment,the RMS of frontal muscles,cheek muscles,and orbicularis oris muscles of the affected side were 31.56±4.25,34.13±4.28,and 7.46±1.53 respectively,significantly increased in comparing with 11.69±2.45,12.98±3.34,and 2.62±1.41 respectively before treatment(all P<0.05).After treatment,the RMS ratios of frontal muscles,cheek muscles,and orbicularis oris muscles of the affected side and healthy side were 0.73±0.09,0.71±0.11,and 0.68±0.08 respectively,greatly increased in comparing with 0.28±0.10,0.27±0.08,and 0.22±0.09 respectively before treatment(all P<0.05).Conclusion:Acupoint catgut embedding and ginger-separated moxibustion in combination can significantly improve the facial nerve functions,and sEMG used for evaluating the therapeutic effect can objectively reflect the effect of treatment.展开更多
OBJECTIVE: To evaluate the clinical effectiveness and safety of acupoint catgut embedding and acupuncture on simple obesity by Meta-analysis. METHODS: Studies on clinical randomized controlled trials of acupoint catgu...OBJECTIVE: To evaluate the clinical effectiveness and safety of acupoint catgut embedding and acupuncture on simple obesity by Meta-analysis. METHODS: Studies on clinical randomized controlled trials of acupoint catgut embedding for simple obesity which were published from January 2015 to November 2020 were searched in Cochrane Central Register of Control Trials(Central), Pub Med, China Science and Technology Journal Database, China National Knowledge Infrastructure Database and Wanfang databases. And those that met the inclusion criteria were screened. Rev Man5.3 was used for Meta-analysis. The “Risk of Bias” tool was used to evaluate the quality of included studies. R studio software was used for the measurement of publication bias. RESULTS: A total of 33 studies were included for Metaanalysis, including 2685 patients with simple obesity. Meta-analysis results showed the comparison of effectiveness rate was relative risk(RR) = 1.12, 95%CI(1.08, 1.16), body mass index(BMI) was mean difference(MD) =-1.12, 95%CI(-2.09,-0.14), waist circumference was MD =-2.14, 95%CI(-4.22,-0.06), and body mass was MD =-2.36, 95%CI(-3.99,-0.73). On the basis of diet and exercise intervention, the effectiveness rate [RR = 1.12, 95%CI(1.05, 1.19)], BMI [MD =-0.88, 95%CI(-1.35,-0.40)], waist circumference [MD =-1.10, 95%CI(-4.27, 2.07)], and body mass [MD =-0.68, 95%CI(-2.90, 1.54)]. The risk of bias of included literatures was low. CONCLUSIONS: Acupoint catgut embedding therapy was slightly better than acupuncture therapy in most of the outcomes. Moreover, the treatment frequency of acupoint catgut embedding is less with larger stimulation intensity, which is more conducive to clinical promotion.展开更多
Objective： To observe the influence of acupoint catgut-embedding therapy on the quality of life （QOL）,the reproductive endocrine and bone metabolism of postmenopausal women.Methods：AA ttoottaall of 65 women with c...Objective： To observe the influence of acupoint catgut-embedding therapy on the quality of life （QOL）,the reproductive endocrine and bone metabolism of postmenopausal women.Methods：AA ttoottaall of 65 women with climacteric syndrome were enrolled and randomly assigned to two groups,thirty-three in the treatment group on whom acupoint catgut-embedding was performed with Shenshu （BL23）,Sanyinjiao （SP6） and Guanyuan （CV4） as main acupoints,and thirty-two in the control group who were only medicated with Fufuchun Capsule （妇复春胶囊））..The treatment course for both groups was 3 months.Before and aafftteerr treatment,the clinical symptoms,the QOL score,serum follicle stimulating hormone （FSH）,luteinizing hormone （LH）,eessttrraaddiiooll （（EE 2 ）,testosterone （T）,osteocalcin （BGP）,parathyroid hormone （PTH）,,ccaallcciittoonniinn （CT） aaannnddd alkaline phosphatase （AKP） were measured.In addition,another 28 women with childbearing potential and normal regular menstrual cycle were selected and the reproductive endocrine hormone were tested in the ovulatory period as controls.Results： The levels of serum FSH and LH of postmenopausal women were higher,and serum E 2 and T were lower than those of normal women （P〈00..0011））..After treatment,the levels of serum EE 2 in both groups and T in the treatment group were increased,while in the control group the serum E 2 increase was more significant than that in the treatment group （P〈0.05）,and serum T showed no statistical difference.The levels of serum FSH,LH,BGP,CT,PTH and AKP were reduced significantly in both groups after treatment （P〈00..0055））..The QOL scores were increased remarkably in both groups on physiological functioning,bbooddiillyy pain,general health,vitality,and mental health after treatment （P〈00..0055））,,but the improvement of bodily ppaaiinn and mental health in the treatment group were better than those in the control group （P〈0.01）.There was no significant difference in the therapeutic effect between the two groups after treatment （P〉00..0055））..Conclusions： Acupoint catgut-embedding showed an obvious effect on climacteric syndrome,and enhanced the QOL in postmenopausal women.The therapy could regulate the hypothalamic-pituitary-ovarian axis to raise the serum E 2 level which may be significant in preventing and curing the osteoporosis in postmenopausal women.展开更多
OBJECTIVE:To systematically review and analyze the effect of acupuncture and acupoint catgut embedding in treatment of abdominal obesity to provide a more reasonable clinical treatment regimen.METHODS:Ten databases we...OBJECTIVE:To systematically review and analyze the effect of acupuncture and acupoint catgut embedding in treatment of abdominal obesity to provide a more reasonable clinical treatment regimen.METHODS:Ten databases were searched as of August 2022:the English databases Pub Med,Embase,Cochrane Library,Web of Science,Wiley,and Scopus and the Chinese databases China National Knowledge Infrastructure Database,China Science and Technology Journal Database,Wanfang,and Sino Med/Chinese Biomedical Literature Database.Randomized controlled trials(RCTs)of acupuncture and acupoint catgut embedding as the main interventions to treat abdominal obesity were extracted.The investigators imported the citations into End Note version X9.1 for deduplication,screening,extraction,and integration.The risk of bias in the included RCTs was assessed according to the Cochrane Handbook.Rev Man 5.4 software was used to conduct a Meta-analysis of RCTs that met the inclusion criteria.RESULTS:Thirteen RCTs(1069 patients)were included in this study,and the data of eleven RCTs(966 patients)were include in the Meta-analysis.The results showed that acupoint catgut embedding can significantly change the weight and waist circumference of patients with abdominal obesity when compared to sham acupuncture or no treatment[mean difference(MD)=2.32,95%confidence interval(CI)(1.88,2.76),P<0.00001],[MD=3.47,95%CI(1.99,4.94),P<0.00001].The change in hip circumference after acupuncture was also significant[MD=0.89,95%CI(0.12,1.66),P=0.02].CONCLUSION:This study found that acupuncture and acupoint catgut embedding can effectively treat abdominal obesity,therefore,these interventions can be used as clinical supplements and alternative therapies.The diagnostic criteria of the existing studies and the intervention measures of the control group are not unified.It will be necessary to improve the clinical study protocols and expand the sample size to further validate the reliability of the results obtained of this study.展开更多
OBJECTIVE:To explore the difference of catgut embedding effect between acupoints and non-acupoints in patients with abdominal obesity(AO).METHODS:In this multicenter,double-blind,randomized controlled trial,all subjec...OBJECTIVE:To explore the difference of catgut embedding effect between acupoints and non-acupoints in patients with abdominal obesity(AO).METHODS:In this multicenter,double-blind,randomized controlled trial,all subjects were randomly assigned into the acupoint catgut embedding(ACE)group and control group(catgut embedding at non-acupoints).With a 12-week actual intervention period and a 4-week period of follow-up.Waist circumference(WC),body weight,body mass index(BMI),hip circumference(HC)and appetite were applied and assessed at baseline and after 6,12 and 16 weeks.RESULTS:After the total intervention phase(12 weeks),the WC,body weight,BMI,HC and visual analogue scale scores of appetite,decreased significantly in the two groups as compared to the baseline(P<0.001).Meanwhile,after the 4-week follow-up,the indicators still decreased significantly in the ACE group(P<0.001).At 12 and 16 weeks,catgut embedding at acupoints showed significantly advantages to non-acupoints in WC and appetite(P<0.05).No serious adverse events were observed in ACE group and control group.CONCLUSIONS:Catgut embedding at acupoints and non-acupoints are all effective and safe for AO.ACE can effectively treat AO as expected and deliver lasting results.展开更多
OBJECTIVE:To assess the efficacy of acupoint catgut embedding(ACE)for simple obesity in preclinical animal experiments.METHODS:We searched the following 14 electronic databases:PubM ed,Cochrane Library,EMBASE,Oriental...OBJECTIVE:To assess the efficacy of acupoint catgut embedding(ACE)for simple obesity in preclinical animal experiments.METHODS:We searched the following 14 electronic databases:PubM ed,Cochrane Library,EMBASE,Oriental Medicine Advanced Searching Integrated System,KoreaMed,Korean Studies Information Service System,Science-on,Research Information Sharing Service,Korea Citation Index,Korea Traditional Knowledge Portal,China Network Knowledge Infrastructure Database,Wanfang Database,Chinese Science and Technology Journal Database,and Chinese Biology Medicine Database,from inception to November 2021 without language limitation.The assessment was performed according to the guidelines of Animal Research:Reporting of in vivo experiments;and Metaanalysis was performed using Reviewer Manager 5.4.1 software.RESULTS:Twenty-four studies involving 813 animals were selected.Meta-analysis showed that ACE was beneficial for weight control[n=40,MD=-50.63,95%CI(-57.59,-43.67),P<0.00001,I 2=0%]and reduced the Lee index[n=40,MD=-18.79,95%CI(-20.01,-17.57),P<0.00001,I 2=0%].However,when efficacy of ACE was compared with that of manual acupuncture,electroacupuncture,or oilistat therapy,statistical difference was not observed between the two groups.CONCLUSIONS:This systematic review suggests that ACE may be efficacious in treating obesity.Moreover,the analyses highlighted the necessity to perform welldesigned,higher-quality experiments.展开更多
文摘In the present paper,the clinical curative effects of catgut embedding therapyand traditional acupuncture therapy for treatment of lumbar muscle strain were compared.The sameacupoints were used in both groups.Results showed that the effective rates were 100% and 92.5%respectively in 80 cases of the catgut embedding group and 40 cases of the acupuncture group.Therewas a significant difference between the two groups(P【0.005).It indicates that the catgut embed-ding therapy is an effective method for treatment of lumbar muscle strain.
文摘Aim: To observe the therapeutic effect of acupoint catgut embedding in the treatment of epilepsy rats. Methods: 40 Wistar rats were randomly and evenly divided into normal control, model, medication (Natrii Valproas syrup), and catgut embedding groups. Epilepsy model was established by intraperitoneal injection of sodium penicillin (0.4 mu/100 g), twice every week, continuously for 4 weeks. Electroencephalograph (EEG) was used as the index for assessing the effect of catgut embedding on epilepsy. Results: In epilepsy rats of model group, the amplitude and frequency of EEG increased significantly in comparison with control group (P<0.05). While the amplitude and frequency of EEG of catgut embedding group and medication group were all significantly lower than those of model group (P<0.05, 0.01). The frequency of EEG of catgut embedding group was significantly lower than that of medication group (P<0.05). These findings show that both acupoint catgut embedding and medication can apparently improve epileptic electrical activities of the brain in the rat, and the effect of catgut embedding is better than that of medication in lowering the frequency of EEG.
基金This research was supported by Key Research Program of the Chinese Academy of Sciences(ZDRW-ZS-2021-1-2).
文摘Objective:To evaluate the effectiveness and safety of acupoint catgut embedding(ACE)in combination with Chinese herbal medicine(CHM)in treating chronic urticaria(CU).Methods:We thoroughly searched Embase,PubMed,Cochrane Library,Web of Science,China National Knowledge Infrastructure(CNKI),Wangfang database,Chinese Scientific Journal Database(VIP),and Chinese biomedical literature database(SinoMed)for relevant studies from inception until May 2022.Randomized controlled trials(RCTs)on ACE combined with CHM for CU were included.Literature search,data extraction,and risk of bias assessment were independently conducted by two authors.Results:A total of 15 RCTs with 1065 participants were included in this review.Five trials reported that the combined therapy showed a higher total effective rate,and four trials reported that the combined therapy was associated with a lower level of serum immunoglobulin E.Furthermore,two,four,and four trials reported that the combined therapy was more effective in reducing itching degree,size,and number of wheals,respectively.The combined therapy was reported to be associated with a lower recurrence rate in three trials,and with a fewer adverse reaction rate in two trials.Conclusions:ACE in combination with CHM appears to be a safe and effective therapy for patients with CU.Given the relatively low quality of the included trials,these findings should be interpreted cautiously.Further high-quality RCTs are needed to confirm our findings.
基金supported by The Youth Special of Yunnan Province Ten-thousand Plan(YNWR-QNBJ-2019-257)the Human Resources and Social Security Department of Yunnan Province and Yunnan Provincial Science Plan Project-Joint of Traditional Chinese Medicine(2017FF117-011,2019FF002-021,202101AZ070001-096)the Science&Technology Department of Yunnan Province.
文摘Background:Obesity,as an epidemic public health issue in the world today,not only brings a heavy medical burden to society but also seriously affects people’s quality of life.In the context of new evidence for the efficacy of acupoint catgut embedding(ACE)in abdominal obesity(AO),it is necessary to elucidate the mechanism of ACE for AO.The intestinal flora is closely associated with obesity,and the study of its intestinal flora may provide evidence to clarify the mechanism of obesity treatment by ACE.Methods:75 participants will be recruited in this study,including 60 eligible female patients diagnosed with AO and 15 healthy female participants.60 female AO patients will be randomized to ACE group,sham ACE group,and waiting list(WL)group in a ratio of 1:1:1.Patients in two ACE groups will receive one ACE treatment per week for 12 consecutive weeks,and in the WL group will not receive any treatment;only their data will be extracted.The primary outcome is the mean change in body mass index.Secondary effects include waist circumference,body weight,the visual analog score of appetite,and the Gastrointestinal Symptom Rating Scale.High-throughput 16S ribosomal ribonucleic acid gene sequencing will be used to detect intestinal flora in each group before and after the intervention.Conclusion:The results of this trial are expected to identify the critical intestinal flora causing AO and the target intestinal flora of AO regulated by ACE,providing further theoretical support for ACE in the clinical treatment of obesity.
基金“111 Project” Biomedical Textile Materials Science and Technology,China(No.B07024)
文摘Acupoint catgut embedding therapy(ACET),filling the gaps of traditional Chinese medicine acupuncture treatment,has been widely used for the treatment of many diseases with significant effects.The aim of this paper is to obtain polyglycollide acid(PGA)fibers with higher performance at a lower cost,and ensure that PGA can meet the clinical requirements as well.PGA fibers with different diameters were spun as embedding materials.The mechanical performance,thermodynamic and biodegradable properties of PGA fibers were studied under different spinning process parameters,including spinning speed,drawing temperature and stretching ratio.The experimental results showed that the optimum spinning parameters were the spinning speed at 150 m/min,the drawing temperature of 45 ℃,and the stretching ratio of 4.0.The initial modulus of PGA fibers was 3.876 N/tex.The crystallization degree was 68% and the degradation performance was in consistent with treatment cycle of patients.
文摘It is reported that 245 cases of peptic ulcer were treated with catgut implantationat Pishu（BL 20）-through-Weishu（BL 21）,Shangwan（CV 13）-through-Xiawan（CV 10）and Zusanli（ST 36）points.Catgut was embedded subcutaneously and left for 15 days as a course.As a resuit,121 cases（49.39％）were cured and 124（50.61％）improved.The total effective was 100％.
基金2020 Hebei provincial research project of Chinese medicine(No.2020374)
文摘Objective:To explore the clinical effect of embedding thread combined with Jianpi Qushi Huayu ointment in the treatment of bronchiectasis in remission period,and to observe the effect on the level of inflammatory cytokines.Methods:150 patients with bronchiectasis in remission period were divided into three groups(50 cases in each group),western medicine group(treated with salmeterol fluticasone and low dose erythromycin),combined group(treated with Jianpi Qushi Huayu plaster),observation group(treated with western medicine+Jianpi Qushi Huayu plaster+embedding thread),and the clinical treatment of the three groups were compared.Result:before and after treatment,the improvement of TCM syndrome score,the improvement of pulmonary ventilation index,the improvement of inflammatory cytokines,and the change of adverse reactions.Results:the treatment efficiency of the observation group and the combination group was significantly higher than that of the western medicine group P The peak level of expiratory flow velocity,the maximum expiratory flow,the forced expiratory volume in one second and the ratio of forced expiratory volume in one second to vital capacity in the observation group and the combined group were significantly better than those in the western medicine group and the pre-treatment level(P<0.05),and the improvement in the observation group was better than that in the combined group After treatment,the expression of IL-13,IL-10 and IL-4 in the combined group was significantly better than that in the western medicine group and before treatment(P<0.05),and the improvement in the observation group was better than that in the combined group;there was no significant difference in the incidence of adverse reactions among the three groups(P>0.05).Conclusion:catgut embedding combined with Jianpi Qushi Huayu ointment can significantly alleviate the related clinical symptoms and signs,effectively control the further aggravation of the disease,improve the lung function of patients,regulate the level of inflammatory cytokines to reduce the degree of inflammatory reaction,and do not significantly aggravate the adverse reactions of drugs.
文摘目的 研究针刺、穴位埋线联合治疗过敏性鼻炎的疗效及对炎症因子白介素-4(interleukin-4,IL-4),白介素-6(interleukin-6,IL-6),白介素-10(interleukin-10,IL-10)的影响。方法 选取2021年6月—2022年6月医院诊治的过敏性鼻炎患者106例作为研究对象,根据随机数字表法均分为两组,对照组53例、观察组53例。对照组进行穴位埋线治疗,观察组采用针刺、穴位埋线联合治疗。治疗4周后观察两组患者的疗效,炎症因子IL-4、IL-6、IL-10水平变化,生活质量以及不良反应情况。结果 观察组、对照组总有效率分别为98.11%、84.91%,观察组显著高于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者炎症因子IL-4、IL-6、IL-10水平差异无统计学意义(P>0.05),治疗后,两组IL-4、IL-6水平均显著下降,IL-10水平显著升高差异有统计学意义(P<0.05),并且观察组IL-4、IL-6水平显著低于对照组,IL-10水平显著高于对照组差异有统计学意义(P<0.05)。治疗前两组鼻结膜炎生活质量调查问卷(rhinoconjunctivitis quality of life questionnaire, RQLQ)评分差异均无统计学意义(P>0.05),治疗后两组RQLQ各维度评分及总分均显著降低差异有统计学意义(P<0.05),且观察组RQLQ鼻部症状、眼部症状评分及总分显著低于对照组,差异有统计学意义(P<0.05)。观察组、对照组不良反应发生率分别为9.43%、5.66%,组间差异无统计学意义(P>0.05)。结论 针刺、穴位埋线联合治疗过敏性鼻炎的疗效显著,并且能够显著改善炎症因子水平及患者生活质量,同时保证良好的安全性,具有临床应用价值。
文摘Objective This review aimed to systematically evaluate the evidence on the effects of acupoint catgut embedding （ACE） therapy for patients with polycystic ovary syndrome （PCOS）. Methods Five databases （CBM, CNKI, Wanfang Database, VlP Database, and PubMed） were searched to identify relevant studies published before June 2027. The outcomes were resumption of menstruation and serum levels of testosterone （T）. The methodological quality of the included studies was judged using the Cochrane risk of bias tool. The overall level of evidence was judged by the Grading of Recommendations Assessment, Development, and Evaluation （GRADE） criteria. Results Twenty- five randomized controlled trials were included. ACE therapy significantly lowered serum T levels, and patients receiving ACE treatment reported resumption of menstruation. However, these results should be interpreted with caution due to a high risk of randomization and blinding bias, and likely publication bias. The level of evidence for resumption of menstruation and serum T levels was assessed as ＂low＂ and ＂low＂, respectively, using GRADE. Conclusion The current evidence on ACE therapy for PCOS is insufficient to draw firm conclusions due to the poor methodological quality. Future well- designed trials are needed to validate the therapeutic efficacy, safety, and mechanisms of ACE in patients with PCOS.
文摘Objective:To explore the therapeutic effect of acupoint catgut embedding combined with gingerseparated moxibustion for sequelae of peripheral facial paralysis and whether surface electromyography(sEMG)can be an outcome to evaluate the effect of this disease.Methods:Thirty-five patients with sequelae of peripheral facial paralysis were treated with catgut embedding at the acupoints selected according to their individual symptoms and traditional Chinese medicine(TCM)differentiated syndromes.At the same time,the ginger-separated moxibustion was applied at Yifeng(翳风TE17)and Qianzheng(牵正EX-HN16)of the affected side.The catgut embedding was applied once every 15 days,one time of treatment is of one course,and a total of three courses were given.The moxibustion would be taken after 5 days of catgut embedding each time,once every other day,5 times as one course,a total of 3 courses are given.After treatment,the recovery of facial nerve functions was evaluated by House-Brackmann(H-B)facial nerve function evaluation grading system.Before and after treatment,the surface electromyography(sEMG)was used to detect the root-mean-square(RMS)of frontal muscles,cheek muscles,and orbicularis oris muscles to compare the RMS ratio of these muscles of affected side and healthy side.Results:After 3 courses of treatment,9 cases were cured,22 cases were effective,and 4 cases were ineffective.The total effective rate was 88.6%(31/35).After treatment,the RMS of frontal muscles,cheek muscles,and orbicularis oris muscles of the affected side were 31.56±4.25,34.13±4.28,and 7.46±1.53 respectively,significantly increased in comparing with 11.69±2.45,12.98±3.34,and 2.62±1.41 respectively before treatment(all P<0.05).After treatment,the RMS ratios of frontal muscles,cheek muscles,and orbicularis oris muscles of the affected side and healthy side were 0.73±0.09,0.71±0.11,and 0.68±0.08 respectively,greatly increased in comparing with 0.28±0.10,0.27±0.08,and 0.22±0.09 respectively before treatment(all P<0.05).Conclusion:Acupoint catgut embedding and ginger-separated moxibustion in combination can significantly improve the facial nerve functions,and sEMG used for evaluating the therapeutic effect can objectively reflect the effect of treatment.
基金Supported by National Administration of Traditional Chinese Medicine Project:Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine (No. ZYYCXTD-C-202006)。
文摘OBJECTIVE: To evaluate the clinical effectiveness and safety of acupoint catgut embedding and acupuncture on simple obesity by Meta-analysis. METHODS: Studies on clinical randomized controlled trials of acupoint catgut embedding for simple obesity which were published from January 2015 to November 2020 were searched in Cochrane Central Register of Control Trials(Central), Pub Med, China Science and Technology Journal Database, China National Knowledge Infrastructure Database and Wanfang databases. And those that met the inclusion criteria were screened. Rev Man5.3 was used for Meta-analysis. The “Risk of Bias” tool was used to evaluate the quality of included studies. R studio software was used for the measurement of publication bias. RESULTS: A total of 33 studies were included for Metaanalysis, including 2685 patients with simple obesity. Meta-analysis results showed the comparison of effectiveness rate was relative risk(RR) = 1.12, 95%CI(1.08, 1.16), body mass index(BMI) was mean difference(MD) =-1.12, 95%CI(-2.09,-0.14), waist circumference was MD =-2.14, 95%CI(-4.22,-0.06), and body mass was MD =-2.36, 95%CI(-3.99,-0.73). On the basis of diet and exercise intervention, the effectiveness rate [RR = 1.12, 95%CI(1.05, 1.19)], BMI [MD =-0.88, 95%CI(-1.35,-0.40)], waist circumference [MD =-1.10, 95%CI(-4.27, 2.07)], and body mass [MD =-0.68, 95%CI(-2.90, 1.54)]. The risk of bias of included literatures was low. CONCLUSIONS: Acupoint catgut embedding therapy was slightly better than acupuncture therapy in most of the outcomes. Moreover, the treatment frequency of acupoint catgut embedding is less with larger stimulation intensity, which is more conducive to clinical promotion.
基金Supported by the 3rd Special Fund of China Postdoctoral Science Foundation (No.201003344)Guangdong Provincial Adminstration of Traditional Chinese Medicine(No.2007166)Guangdong Natural Science Foundation (No.8451063101001809)
文摘Objective： To observe the influence of acupoint catgut-embedding therapy on the quality of life （QOL）,the reproductive endocrine and bone metabolism of postmenopausal women.Methods：AA ttoottaall of 65 women with climacteric syndrome were enrolled and randomly assigned to two groups,thirty-three in the treatment group on whom acupoint catgut-embedding was performed with Shenshu （BL23）,Sanyinjiao （SP6） and Guanyuan （CV4） as main acupoints,and thirty-two in the control group who were only medicated with Fufuchun Capsule （妇复春胶囊））..The treatment course for both groups was 3 months.Before and aafftteerr treatment,the clinical symptoms,the QOL score,serum follicle stimulating hormone （FSH）,luteinizing hormone （LH）,eessttrraaddiiooll （（EE 2 ）,testosterone （T）,osteocalcin （BGP）,parathyroid hormone （PTH）,,ccaallcciittoonniinn （CT） aaannnddd alkaline phosphatase （AKP） were measured.In addition,another 28 women with childbearing potential and normal regular menstrual cycle were selected and the reproductive endocrine hormone were tested in the ovulatory period as controls.Results： The levels of serum FSH and LH of postmenopausal women were higher,and serum E 2 and T were lower than those of normal women （P〈00..0011））..After treatment,the levels of serum EE 2 in both groups and T in the treatment group were increased,while in the control group the serum E 2 increase was more significant than that in the treatment group （P〈0.05）,and serum T showed no statistical difference.The levels of serum FSH,LH,BGP,CT,PTH and AKP were reduced significantly in both groups after treatment （P〈00..0055））..The QOL scores were increased remarkably in both groups on physiological functioning,bbooddiillyy pain,general health,vitality,and mental health after treatment （P〈00..0055））,,but the improvement of bodily ppaaiinn and mental health in the treatment group were better than those in the control group （P〈0.01）.There was no significant difference in the therapeutic effect between the two groups after treatment （P〉00..0055））..Conclusions： Acupoint catgut-embedding showed an obvious effect on climacteric syndrome,and enhanced the QOL in postmenopausal women.The therapy could regulate the hypothalamic-pituitary-ovarian axis to raise the serum E 2 level which may be significant in preventing and curing the osteoporosis in postmenopausal women.
基金Supported by National Key Research and Development Project:Clinical Evaluation of the Interventional Techniques for Abdominal Obesity(No.2019YFC1710102)。
文摘OBJECTIVE:To systematically review and analyze the effect of acupuncture and acupoint catgut embedding in treatment of abdominal obesity to provide a more reasonable clinical treatment regimen.METHODS:Ten databases were searched as of August 2022:the English databases Pub Med,Embase,Cochrane Library,Web of Science,Wiley,and Scopus and the Chinese databases China National Knowledge Infrastructure Database,China Science and Technology Journal Database,Wanfang,and Sino Med/Chinese Biomedical Literature Database.Randomized controlled trials(RCTs)of acupuncture and acupoint catgut embedding as the main interventions to treat abdominal obesity were extracted.The investigators imported the citations into End Note version X9.1 for deduplication,screening,extraction,and integration.The risk of bias in the included RCTs was assessed according to the Cochrane Handbook.Rev Man 5.4 software was used to conduct a Meta-analysis of RCTs that met the inclusion criteria.RESULTS:Thirteen RCTs(1069 patients)were included in this study,and the data of eleven RCTs(966 patients)were include in the Meta-analysis.The results showed that acupoint catgut embedding can significantly change the weight and waist circumference of patients with abdominal obesity when compared to sham acupuncture or no treatment[mean difference(MD)=2.32,95%confidence interval(CI)(1.88,2.76),P<0.00001],[MD=3.47,95%CI(1.99,4.94),P<0.00001].The change in hip circumference after acupuncture was also significant[MD=0.89,95%CI(0.12,1.66),P=0.02].CONCLUSION:This study found that acupuncture and acupoint catgut embedding can effectively treat abdominal obesity,therefore,these interventions can be used as clinical supplements and alternative therapies.The diagnostic criteria of the existing studies and the intervention measures of the control group are not unified.It will be necessary to improve the clinical study protocols and expand the sample size to further validate the reliability of the results obtained of this study.
基金Yunnan Expert Workstation-Liang Fanrong Station:Study and Transformation of Classical Syndrome Differentiation System on Acupuncture and Moxibustion(No.202305AF150072)Yunnan Province Ten-thousand Plan:Youth Special-Guo Taipin(No.YNWR-QNBJ-2019-257)+2 种基金Yunnan Provincial Science Project:Study on the Bidirectional Regulation Mechanism of Central Network of ShuMu Catgut Embedding in Abdominal Obesity of Stomach Heat-Spleen Deficiency Type Which based on Multimodal Technique(No.2017FF117-011)Study on the Central Mechanism of Synergistic Potentiation of Shu-Mu Catgut Embedding in Abdominal Obesity(No.2019FF002-021)Study on the Brain Network Mechanism of Shu-Mu Catgut Embedding in Abdominal Obesity which based on Multi-Modal Technique(No.202101AZ070001-096)。
文摘OBJECTIVE:To explore the difference of catgut embedding effect between acupoints and non-acupoints in patients with abdominal obesity(AO).METHODS:In this multicenter,double-blind,randomized controlled trial,all subjects were randomly assigned into the acupoint catgut embedding(ACE)group and control group(catgut embedding at non-acupoints).With a 12-week actual intervention period and a 4-week period of follow-up.Waist circumference(WC),body weight,body mass index(BMI),hip circumference(HC)and appetite were applied and assessed at baseline and after 6,12 and 16 weeks.RESULTS:After the total intervention phase(12 weeks),the WC,body weight,BMI,HC and visual analogue scale scores of appetite,decreased significantly in the two groups as compared to the baseline(P<0.001).Meanwhile,after the 4-week follow-up,the indicators still decreased significantly in the ACE group(P<0.001).At 12 and 16 weeks,catgut embedding at acupoints showed significantly advantages to non-acupoints in WC and appetite(P<0.05).No serious adverse events were observed in ACE group and control group.CONCLUSIONS:Catgut embedding at acupoints and non-acupoints are all effective and safe for AO.ACE can effectively treat AO as expected and deliver lasting results.
基金the Korea Institute of Oriental Medicine(Grant No.KSN1823211 and KSN20234115)。
文摘OBJECTIVE:To assess the efficacy of acupoint catgut embedding(ACE)for simple obesity in preclinical animal experiments.METHODS:We searched the following 14 electronic databases:PubM ed,Cochrane Library,EMBASE,Oriental Medicine Advanced Searching Integrated System,KoreaMed,Korean Studies Information Service System,Science-on,Research Information Sharing Service,Korea Citation Index,Korea Traditional Knowledge Portal,China Network Knowledge Infrastructure Database,Wanfang Database,Chinese Science and Technology Journal Database,and Chinese Biology Medicine Database,from inception to November 2021 without language limitation.The assessment was performed according to the guidelines of Animal Research:Reporting of in vivo experiments;and Metaanalysis was performed using Reviewer Manager 5.4.1 software.RESULTS:Twenty-four studies involving 813 animals were selected.Meta-analysis showed that ACE was beneficial for weight control[n=40,MD=-50.63,95%CI(-57.59,-43.67),P<0.00001,I 2=0%]and reduced the Lee index[n=40,MD=-18.79,95%CI(-20.01,-17.57),P<0.00001,I 2=0%].However,when efficacy of ACE was compared with that of manual acupuncture,electroacupuncture,or oilistat therapy,statistical difference was not observed between the two groups.CONCLUSIONS:This systematic review suggests that ACE may be efficacious in treating obesity.Moreover,the analyses highlighted the necessity to perform welldesigned,higher-quality experiments.
