Exploration of the Clinical Regularity of Acupuncture-moxibustion Treatment for Depression

To review year 1956-2007 literature on acupuncture-moxibustion, explore point selection and methods for acupuncture-moxibustion treatment of depression. A comprehensive analysis was made by a method of metrological analysis according to the data from ＂China modem acupuncture-moxibustion information databank＂. The results show that Baihui （GV 20） and Neiguan （PC 6） were the points most frequently used. As an acupuncture-moxibustion treatment for depression, acupuncture ranked first. It is proposed to use Baihui （GV 20） and Neiguan （PC 6） as a basic prescription for acupuncture-moxibustion treatment of depression, other points can be selected according to the syndrome.

Evidence-based clinical practice guidelines for acupuncture-moxibustion treatment of scapulohumeral periarthritis

The aim of this study was to establish clinical practice guidelines for acupuncture-moxibustion by retrieving relevant literature and adopting the best current national and international evidence, according to experts＇ experience and patients＇ values. This was achieved using the Grade of Recommendations Assessment, Development and Evaluation（GRADE） system combined with a wide range of national experts＇ consensus, in order to provide reliable evidence for acupuncture-moxibustion treatment of scapulohumeral periarthritis, and to ensure the safety and effectiveness of the treatment.

Metrological Analysis and Evaluation of Acupuncture-Moxibustion Treatment for Diarrhea in Modern Literature

Objective： To review year 1957-2005 literature on acupuncture and moxibustion and explore point selection and methods for acupuncture-moxibustion treatment of diarrhea in order to provide objective and reliable data for research on acupuncture and moxibustion standardization. Methods： A comprehensive analysis was made by a method of metrological analysis according to the data from ＂China modem acupuncture-moxibustion information database＂. Results： Points Zusanli （ST 36）, Tianshu （ST 25） and Shenque （CV 8） were the most frequently used and the optimal combination for acupuncture-moxibustion treatment of diarrhea. Chronic adult diarrhea was often treated by moxibustion. Acute childhood diarrhea was often treated by point application and injection. Conclusion： Diarrhea is often treated by needling and moxaing methods in acupuncture-moxibustion treatment. It is proposed to use Zusanli （ST 36） and Tianshu （ST 25） as a basic prescription for acupuncture-moxibustion treatment of diarrhea and to select points according to the syndrome.

Clinical Study on Acupuncture-moxibustion Treatment for Insomnia in Heart-spleen Deficiency

Objective： To observe the clinical effects of ZHAO＇s thunder-fire moxibustion in the treatment of insomnia in heart-spleen deficiency. Methods： 70 patients were randomly divided into two groups, 35 cases in the treatment group, managed by thunder-fire moxibustion and acupuncture, 35 cases in the control group, managed by single acupuncture treatment. Results： The results showed cure in 8 cases, remarkable effect in 15 cases, effect in 10 cases, failure in 2 cases and the total effective rate in 91.4% in the treatment group, and cure in 4 cases, remarkable effect in 11 cases, effect in 11 cases, failure in 9 cases, and the total effective rate in 74.2% in the control group. The difference is statistically significant in comparison of the total effective rates between the two groups （P 〈 0.05）. Conclusion： Thunder-fire moxibustion gives a better therapeutic effect in the acupuncture treatment of insomnia in heart-spleen deficiency.

Points selection pattern in acupuncture-moxibustion treatment of gouty arthritis:an analysis based on bibliometrics

To discuss the selection pattern of points and meridians in acupuncture-moxibustion treatment of gouty arthritis （GA） by analyzing clinical literatures related to GA, and to provide reference for acupuncture-moxibustion treatment of GA. Methods： Clinical literatures related to GA treated with acupuncture-moxibustion published between January 1981 and July 2017 were collected from Chinese databases. The points, meridians, frequency and treatment methods were analyzed. Results： A total of 78 studies were included. For meridians, the top 5 meridians used were the Spleen Meridian （67 times）, Liver Meridian （59 times）, Stomach Meridian （53 times）, Kidney Meridian （49 times） and Large Intestine Meridian （44 times）. For points selection, the leading 5 points were Taichong （LR 3） （79 times）, Taibai （SP 3） （68 times）, Sanyinjiao （SP 6） （61 times）, Taixi （KI 3） （57 times） and Yinlingquan （SP 9） （55 times）. For major and adjunct points, the 5 most significant major points were Taichong （LR 3） （79 times）, Taibai （SP 3） （68 times）, Sanyinjiao （SP 6） （61 times）, Yinlingquan （SP 9） （37 times） and Taixi （KI 3） （32 times）. The 5 most significant adjunct points were Yanglingquan （GB 34） （31 times）, Fenglong （ST 40） （30 times）, Xuehai （SP 10） （29 times）, Taixi （KI 3） （25 times） and Quchi （LI 11） （21 times）. For treatment methods, the top 5 methods used were acupuncture-moxibustion alone for 15 studies, acupuncture-moxibustion combined with medicina electroacupuncture combined with bloodletting for 5 studies studies, acupuncture combined with medicinal herbs for 11 herbs for 10 studies, acupuncture alone for 7 studies, and Conclusion： The main meridians chosen in acupuncture-moxibustion treatment of GA were the Spleen, Liver, Stomach, Kidney and Large Intestine Meridians, conforming to the syndrome differentiation principle of tonifying spleen and kidney, clearing heat and draining dampness. Points mainly locate at lower limbs and feet around the affected area, which was a reflection of peripheral treatment function of points. The data mining results of meridian and point selection in acupuncture-moxibustion treatment of GA conform to the disease and syndrome differentiation theory and provide references for acupuncture-moxibustion treatment of GA.

Analysis of acupoint-selection patterns in acupuncture-moxibustion treatment of polycystic ovarian syndrome based on data mining

Objective:To analyze the meridian and acupoint-selection patterns in acupuncture-moxibustion treatment of polycystic ovarian syndrome (PCOS) by data mining technique,for exploring acupoints that could be effective for PCOS and providing suggestion and reference in selecting acupoints for the acupuncture-moxibustion treatment of PCOS.Methods:Literatures related to the acupuncture-moxibustion treatment of PCOS published before April 2018 were collected.By a self-made data mining program developed using Microsoft Excel 2007,a database of acupuncture-moxibustion treatment of PCOS was then established.The correlation analysis was performed for the frequency of use of acupoints and acupoint groups.Cluster analysis was also conducted.Results:A total of 92 articles were recruited finally.Sanyinjiao (SP 6),Conception Vessel and chest-abdomen region ranked the top on the list of the most frequently used acupoints,meridians and regions,respectively.Correlation analysis showed that the acupoint group with the highest confidence was Sanyinjiao (SP 6) and Zusanli (ST 36),and the group with the highest support was Sanyinjiao (SP 6) and Guanyuan (CV 4).Cluster analysis revealed five effective clusters:Guanyuan (CV 4) and Sanyinjiao (SP 6);Zhongwan (CV 12) and Tianshu (ST 25);Zhongji (CV 3),Zusanli (ST 36) and Qihai (CV 6);Xuehai (SP 10),Shenshu (BL 23),Taichong (LR 3) and Guilai (ST 29);Ganshu (BL 18),Taixi (KI 3),Yinlingquan (SP 9) and Pishu (BL 20).Conclusion:According to the confidence and support report,Sanyinjiao (SP 6) and Zusanli (ST 36) or Sanyinjiao (SP 6) and Guanyuan (CV 4) are recommended in acupuncture-moxibustion treatment of PCOS,with adjunct points selected for different patterns,e.g.Zhongwan (CV 12) and Tianshu (ST 25) for tonifying spleen and expelling dampness;Zhongji (CV 3) and Qihai (CV 6) for supplementing qi and cultivating blood;Xuehai (SP 10),Shenshu (BL 23),Taichong (LR 3) and Guilai (ST 29) for tonifying kidney and dissolving stasis;Ganshu (BL 18),Taixi (KI 3),Yinlingquan (SP 9) and Pishu (BL 20) for tonifying kidney and spleen and regulating liver.

Acupoints selection pattern in acupuncture-moxibustion treatment of perimenopausal syndrome from 2007 to 2016

Objective： To discuss the acupoints selection pattern in acupuncture-moxibustion treatment of perimenopausal syndrome（PMS） from 2007 to 2016. Methods： Clinical literatures related to PMS treated with acupuncture-moxibustion published from 2007 to 2016 were collected from Chinese Biomedical Literature Database（CBM）, Chongqing VIP Database（CQVIP）, China National Knowledge Infrastructure（CNKI）, and Wanfang Academic Journal Full-text Database（Wanfang）. The retrieved data underwent descriptive analysis, cluster analysis and association pattern analysis to determine the acupoints selection principle in acupuncture-moxibustion treatment of PMS. Results： The top five acupoints used in acupuncture-moxibustion treatment of PMS were Sanyinjiao（SP 6）, Shenshu（BL 23）, Guanyuan（CV 4）, Baihui（GV 20）, and Shenmen（HT 7）. The leading 4 meridians were Bladder Meridian, Conception Vessel, Spleen Meridian, and Governor Vessel. The clustering analysis showed that the 5 core acupoint groups were：（1） Sanyinjiao（SP 6）;（2） Shenshu（BL 23） and Guanyuan（CV 4）;（3） Baihui（GV 20）, Shenmen（HT 7）, Zusanli（ST 36）, Ganshu（BL 18） and Taichong（LR 3）;（4） Taixi（KI 3）, Pishu（BL 20）, Xinshu（BL 15）, Qihai（CV 6） and Neiguan（PC 6）;（5） Sishencong（EX-HN 1）, Zhongwan（CV 12）, Hegu（LI 4）, Yintang（GV 29）, Fengchi（GB 20）, Zhongji（CV 3） and Feishu（BL 13）. The three most significant acupoints were Sanyinjiao（SP 6）, Shenshu（BL 23） and Guanyuan（CV 4）. Acupoint groups based on syndrome differentiation included：（1） Hegu（LI 4）, Zhongwan（CV 12） and Sishencong（EX-HN 1）;（2） Feishu（BL 13）, Zhongji（CV 3）, Fengchi（GB 20） and Yintang（GV 29）;（3） Xinshu（BL 15）, Pishu（BL 20）, Qihai（CV 6）, Neiguan（PC 6） and Taixi（KI 3）;（4） Ganshu（BL 18）, Zusanli（ST 36）, Shenmen（HT 7）, Taichong（LR 3） and Baihui（GV 20）. The analysis of association pattern elaborated that Shenshu（BL 23） and Sanyinjiao（SP 6） won the highest support rate in the paired groups; Ganshu（BL 18）, Shenshu（BL 23） and Sanyinjiao（SP 6） had the highest support rate among the acupoint groups. Conclusion： The data mining results of acupuncture-moxibustion treatment of PMS substantially conform to the general principle in traditional acupuncture-moxibustion theories, able to reflect the acupoints selection and grouping pattern and provide references for acupuncture-moxibustion treatment of PMS.

Influence of Acupuncture-moxibustion Treatment on Cognition Disorder

Objective： To observe the influence of acupuncture-moxibustion treatment on patients with mild cognition disorder. Methods： Sixty patients with mild cognition disorder were randomly divided into a treatment group and a control group, with 30 cases in each group. Acupuncture-moxibustion treatment was used in the treatment group, while Western medicine was taken by the patients in the control group. The differences of intra-group and inter-group comparisons were assessed by 3 measurement scales including Mini-mental State Examination （MMSE）, Activity of Daily Living （ADL） and Montreal Cognitive Assessment （MoCA）. Results： After treatment, the MMSE, MoCA and ADL scores of both groups were higher than those before treatment （P〈0.05）. The MMSE, MoCA and ADL scores of the treatment group have more noticeable improvement than those of the control group （P〈0.05）. Conclusion： Acupuncture-moxibustion treatment can effectively improve cognitive function of the patients with mild cognitive impairment.

Analysis of clinical application patterns in acupuncture-moxibustion treatment of Alzheimer disease

Objective:To summarize the clinical application patterns in acupuncture-moxibustion treatment of AD by reviewing the clinical literatures on acupuncture-moxibustion for Alzheimer disease(AD)published between January 2009 and December 2019.Methods:China National Knowledge Infrastructure(CNKI),Wanfang Academic Journal Full-text Database(Wanfang),Chongqing VIP Database(CQVIP),Chinese Medicine Acupuncture-moxibustion Information Database,PubMed Medical Data Retrieval Service System,Springer Database and Ovid Technologies(OVID)were retrieved to screen clinical studies of acupuncture-moxibustion treatment of AD according to the inclusion and exclusion criteria to conduct quantitative,clustering and association analyses.Results:In acupuncture-moxibustion treatment of AD,the frequently used points were Baihui(GV 20),Zusanli(ST 36),Sishencong(EX-HN 1),Taixi(KI 3),Sanyinjiao(SP 6),and Neiguan(PC 6)in the descending order.Regarding meridians,the most frequently used one was the Governor Vessel,followed by the Stomach Meridian of Foot Yangming and Gallbladder Meridian of Foot Shaoyang.From the perspective of body regions,the points in the head-face region and the lower-limb region had the highest frequencies,followed by the upper-limb,back and chest-abdomen regions.The point group,Baihui(GV 20)and Sishencong(EX-HN 1)-Neiguan(PC 6)-Sanyinjiao(SP 6),showed the most significant association,and the group winning the second place was Baihui(GV 20)and Sishencong(EX-HN 1)-Neiguan(PC 6)-Zusanli(ST 36).The clustering analysis showed that the commonly used point pairs included Zusanli(ST 36)-Sishencong(EX-HN 1)and Taixi(KI 3)-Sanyinjiao(SP 6),which were closely associated with Baihui(GV 20).By analyzing the three commonly used acupuncture-moxibustion methods,acupuncture plus medication was found achieving the best result in the total effective rate and mini-mental state examination(MMSE)score,followed by monotherapy of electroacupuncture therapy,and these two methods were superior to acupuncture alone(P<0.05);the scores of MMSE,Alzheimer disease assessment scale-cognitive section(ADAS-cog)and activity of daily living scale(ADL)showed significant improvements after treatment(all P<0.01).Conclusion:In the acupuncture-moxibustion prescriptions for AD,the main points are Baihui(GV 20),Sishencong(EX-HN 1),Neiguan(PC 6),Zusanli(ST 36),Sanyinjiao(SP 6)and Taixi(KI 3).Monotherapy of acupuncture has the highest frequency amongst the treatment methods,but its effective rate is lower than that of acupuncture plus medication and monotherapy of electroacupuncture.

Exploration of Clinical Regularities in Acupuncture-moxibustion Treatment for Infertility

Objective：To review the acupuncture-moxibustion literature of year 1949-2007 and explore the regularities in points selection and therapeutic methods for acupuncture-moxibustion treatment of infertility.Methods：A comprehensive analysis was made by a method of metrological analysis according to the data from China Modern Acupuncture-moxibustion Information Databank.Results：Sanyinjiao （SP 6）,Guanyuan （CV 4）,Zhongji （CV 3） and Zigong （Ex-CA 1） were most frequently used.Acupuncture and combined use of acupuncture and medicine were the major treatments.It is proposed that points Sanyinjiao （SP 6）,Guanyuan （CV 4）,Zhongji （CV 3） and Zigong （Ex-CA 1） are used as a basic prescription for acupuncture-moxibustion treatment of infertility and acupoints are selected according to the syndrome.Conclusion：Combined use of acupuncture and medicine can improve the therapeutic effect on infertility.

Clinical regularities in acupuncture-moxibustion treatment of cancer pain in recent 30 years

Objective: To explore the clinical regularities in acupuncture-moxibustion treatment of cancer pain by reviewing the re leva nt studies published betwee n 1985 and 2017. Methods: Based on the Chinese Medicine Acupuncture-moxibustion Information Database, quantitative analysis, correlation an alysis and Chi-square test were applied to an a lyze the comm only used acupoi nts, meridia n affiliatio ns and body regi on distributi ons, comm only used methods and acupoi nt correlati ons, treatme nt method correlati ons, the efficacy of acupuncture- moxibusti on plus the three-step an algesic ladder for can cer pain, and in dicators. Results: Zusanli (ST 36), Ashi point and Sanyinjiao (SP 6) ranked the top on the list of frequency;points from Bladder Meridian of Foot Taiyang and Stomach Meridian of Foot Yangming were often used;points from the lower limbs and back had high frequencies. The most commonly used treatment method was acupuncture-moxibustion plus medication. Acupuncture-moxibusti on plus the three-step an algesic ladder showed certai n adva ntage compared with the two methods used separately, and among the integrated methods, acupoint application plus the three-step analgesic ladder produced the most significant efficacy. It took (44.77±55.54) min for the analgesic effect to act and the effect lasted for (12.81±14.59) h. Numerical rati ng scale (NRS), visual an alog scale (VAS) and Kar nofsky performa nee status (KPS) scores all showed sign ifica nt changes after interventions (all P<0.01);there was no significant change in the score of quality of life (QOL) after interventions (P>0.05). Conclusion: Zusa nli (ST 36), Ashi point and Sanyin jiao (SP 6) are comm only selected in acup un cture-moxibusti on treatment of cancer pain;acupuncture and acupoint application are often used;acupuncture-moxibustion plus the three-step an algesic ladder can boost the treatme nt efficacy.

Acupuncture-moxibustion Treatment for Polycystic Ovary Infertility:A Report of 20 Cases

The incidence rate of polycystic ovary syndrome （PCOS） is about 5%-10% in the women of childbearing age and accounts for 30%-60% in the patients with anovulatory infertility. From 2005 to 2008, I treated 20 cases of polycystic ovary infertility by acupuncture-moxibustion plus acupressure along the meridians. Now, the report is given as follows.

CLINICAL STUDY ON THE TREATMENT OF EARLY DIABETIC NEPHROPATHY BY WESTERN MEDICINE COMBINED WITH ACUPUNCTURE-MOXIBUSTION AND CHINESE HERBS

In this paper, 48 cases of early diabetic nephropathy were treated by acupuncture-moxi- bustion and Chinese berbs based on Western medicine, and using Western medicine as control. Results show that the total effective rate of combined treatment is 93. 2%, while it is 58. 3% in control group. It suggests that the combined treatment plays an important role in reducing urinary albumin and improving the renal function.

Late effects of the treatment of childhood cancer

Excellent progress has been made in the last few decades in the cure rates of pediatric malignancies,with more than 80%of children with cancer who have access to contemporary treatment being cured.However,the therapies responsible for this survival can also produce adverse physical and psychological long-term outcomes,referred to as late effects,which appear months to years after the completion of cancer treatment.Research has shown that 60%to 90%of childhood cancer survivors(CCSs)develop one or more chronic health conditions,and 20%to 80%of survivors experience severe or life-threatening complications during adulthood.Therefore,understanding the late side effects of such treatments is important to improve the health and quality of life of the growing population of CCSs.

Exploration of Clinical Regularities in Acupuncture-moxibustion Treatment for Cancer Pain

Objective： To review acupuncture-moxibustion literature of year 1954-2009 and explore the regularities in point selection and therapeutic methods for acupuncture-moxibustion treatment of cancer pain. Methods： A comprehensive analysis was made by a method of metrological analysis according to the data from China Modem Acupuncture-moxibustion Information Databank. Results： Zusanli （ST 36）, Ashi point and Sanyinjiao （SP 6） were most frequently used. Zusanli （ST 36） and Sanyinjiao （SP 6） were optimal points combination. Acupuncture and the combination of acupuncture and moxibustion were the major treatments. It proposed that Zusanli （ST 36）, Ashi point and Sanyinjiao （SP 6） can be used as a basic prescription for acupuncture-moxibustion treatment for cancer pain, and acupoints selection according to the syndrome may be added. Conclusion： The combination of acupuncture and moxibustion can improve the therapeutic effect on cancer pain.

Analysis of Clinical Regularities in Acupuncture-moxibustion Treatment for Stomach Diseases in Recent 10 Years

Objective：To objectively and dynamically assess the therapeutic effects of acupuncturemoxibustion on stomach diseases by a review and statistical analysis of year 2000-2009 literature on acupuncture-moxibustion treatment for stomach diseases,facilitate the development of clinical acupuncturemoxibustion from the summarization of individual experience to the study of group experience and further exploit the advantages of acupuncture-moxibustion science.Methods：Statistical and expert analyses were made on the basis of the data from China Modem Acupuncture-moxibustion Information Databank.Results：There were 11 kinds of diseases in the acupuncture-moxibustion spectrum of stomach diseases.It was suggested that points Zusanli（ST 36）,Zhongwan（CV 12）,Weishu（BL 21）,Pishu（BL 20）,Neiguan（PC 6）and Sanyinjiao（SP 6）be used as a basic prescription for acupuncture-moxibustion treatment of stomach diseases and corresponding treatment be selected according to the character of each disease.Conclusion：acupuncturemoxibustion has a certain therapeutic effect on stomach diseases,but the clinical application and observed cases should be increased.

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

Epilepsy is a severe,relapsing,and multifactorial neurological disorder.Studies regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of epilepsy.The pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota composition.Satisfactory results are lacking for conventional treatments for epilepsy.Surgical resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with epilepsy.Non-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research focus.This review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of epilepsy.It also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current stimulation.Numerous studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic seizures.Additionally,many new technologies for the diagnosis and treatment of epilepsy are being explored.However,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

Analysis of point-selection pattern in acupuncture-moxibustion treatment of amblyopia

Objective：To analyze and summarize the characteristics and pattern in the selection of points and meridians by searching the clinical research literature about acupuncture-moxibustion treatment of amblyopia in the recent 17 years.Methods：By searching Chinese and English databases,such as China National Knowledge Infrastructure （CNKI）,PubMed,etc.,the points in 52 articles in conformity with the requirements were analyzed by frequency statistics by the order of meridians,major points,and adjunct points to summarize the rules and characteristics of the point selection.Results：In 52 articles,there were 21 articles on ear acupuncture and 31 articles on acupuncture-moxibustion treatment.Ten meridians were involved in acupuncture-moxibustion treatment of amblyopia,and the leading 3 meridians were the Bladder,Stomach and Gallbladder Meridians.There were 34 points,10 extraordinary points and 37 ear points were used in acupuncture-moxibustion treatment of amblyopia.The top 10 major points were Jingming （BL 1）,Taiyang （EX-HN 5）,Cuanzhu （BL 2）,Fengchi （GB 20）,Baihui （GV 20）,Hegu （LI 4）,Guangming （GB 37）,Sibai （ST 2）,Chengqi （ST 1） and Sizhukong （TE 23）.The top 5 adjunct points were Zusanli （ST 36）,Shenshu （BL 23）,Ganshu （BL 18）,Sanyinjiao （SP 6） and Taixi （KI 3）.Conclusion：Acupuncture-moxibustion treatment of amblyopia is characterized by the selection of the points mainly from yang meridians,based upon syndromes differentiation plus personal experience,and the points mainly around the eyes and by stressed use of ear points.

Controversies around the treatment of peritoneal metastases of colorectal cancer

In this editorial we examine the article by Wu et al published in the World Journal of Gastrointestinal Oncology.Surgical resection for peritoneal metastases from colorectal cancer(CRC)has been gradually accepted in the medical oncology community.A randomized trial(PRODIGE 7)on cytoreductive surgery(CRS)with hyperthermic intraperitoneal chemotherapy(HIPEC)failed to prove any benefit of oxaliplatin in the overall survival of patients with peritoneal metastases from colorectal origin.Nevertheless,isolated systemic chemotherapy for CRC stage IV has demonstrated a reduced response in peritoneal metastases than that obtained in other metastatic sites such as the liver.Another tool is required in those patients to achieve more local control of the disease.Surgical groups in peritoneal surgery continue to use HIPEC in their procedures,using other agents than oxaliplatin for peritoneal cavity infusion,such as mitomycin C.These patients present with complex surgical issues to manage,and consequently a large burden of complications has to be anticipated.Therefore,identifying patients who will benefit from CRS with or without HIPEC would be of great interest.

Advancing treatment strategies:Insights from network meta-analysis of hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma

This study examines the pivotal findings of the network meta-analysis of Zhou et al,which evaluated the efficacy of hepatic arterial infusion chemotherapy and combination therapies for advanced hepatocellular carcinoma(HCC).This meta-analysis suggests that therapeutic combinations have greater efficacy than do standard treatments.The article highlights the key insights that have the potential to shift current clinical practice and enhance outcomes for patients with advanced HCC.Additionally,this article discusses further research that can be conducted to optimize these treatments and achieve personalized care for patients with HCC.