Cobalt-catalyzed asymmetric hydrogenation of ketones:A remarkable additive effect on enantioselectivity

A chiral cobalt pincer complex,when combined with an achiral electron-rich mono-phosphine ligand,catalyzes efficient asymmetric hydrogenation of a wide range of aryl ketones,affording chiral alcohols with high yields and moderate to excellent enantioselectivities(29 examples,up to 93%ee).Notably,the achiral mono-phosphine ligand shows a remarkable effect on the enantioselectivity of the reaction.

Enantioselective synthesis of 2-amino-3-nitrile-chromenes catalyzed by cinchona alkaloids:A remarkable additive effect

2-Amino-3-nitrile-chromenes with potential antitumor activity were constructed by a novel catalytic system. In combination with a-naphthol, quinine could effectively promote the Michael-cyclization process of malononitrile with functionalized chalcones in high yields and moderate to good enantioselectivity（up to 84% ee）. It is notable that the enantioselectivity could be greatly improved when a-naphthol was employed as additive.

Path analysis and estimation of additive and epistatic gene effects of barley SSD lines

In the paper presented, 99 single seed descent barley lines as well as their parental forms Roland and Apex were studied. The grain weight components and their interrelations were analyzed using simple coefficients of correlation. The direct and indirect effects of such components on grain weight per plant and 1 000-grain weight were estimated using path analysis. In the 2006 and 2007, the spike length and number of spikelets per spike were the determinants of grain weight. Genetic parameters as additive and epistasis effects were estimated for all studied traits. The results indicate the importance of both additive and epistasis gene effects of number of spikes per plant, grain weight per spike, grain number per plant and grain weight per plant in this study.

Lack of an Additive Effect between the Deletions of Klf5 and Nkx3-1 in Mouse Prostatic Tumorigenesis

Prostate cancer is one of the most common malignancies.The development and progression of prostate cancer are driven by a series of genetic and epigenetic events including gene amplification that activates oncogenes and chromosomal deletion that inactivates tumor suppressor genes.Whereas gene amplification occurs in human prostate cancer,gene deletion is more common,

Interaction of cyclodextrins with 1,3-di(1-naphthyl)propane and the additive effects of ionic surfactants

The interaction between cyclodextrins (CDs) and 1,3-di(1-naphthyl)propane (1) in aqueous methanol (V: V=1:1) has been investigated by means of fluorescence emission and UV absorption. Fluorescence enhancement and absorption spectra reveal that β- or γ-CD can form inclusion complexes with 1, but α-CD cannot. One of these complexes is identified as ground state complex (2:1), i.e. the eclipsed conformer of 1 is included. Molecule 1 can be driven out of the CD cavity by sodium dodecylsulfate (SDS) molecule, but cannot by cetyltrimethylammonium bromide (CTAB) or sodium cetylsulfate (SCS) molecules due to their alkyl chain coiling.

Additive mixed models to study the effect of tree age and climatic factors on stem radial growth of Eucalyptus trees

The effect of tree age and climatic variables on stem radial growth of two hybrid clones of Eucalyptus was determined using longitudinal data from eastern South Africa.The stem radius of was measured weekly as the response variable.In addition to tree age,average weekly temperature,solar radiation,relative humidity and wind speed were simultaneously recorded with total rainfall at the site.An additive mixed effects model that incorporates a non-parametric smooth function was used.The results of the analysis indicate that the relationship between stem radius and each of the covariates can be explained by nonlinear functions.Models that account for the effect of clone and season together with their interaction in the parametric part of the additive mixed model were also fitted.The interaction between clone and season was not significant in all cases.For analyzing the joint effect all the covariates,additive mixed models that included two or more covariates were fitted.A significant effect of tree age was found in all cases.Although tree age was the key determinant of stem radial growth,weather variables also had a significant effect that was dependent on season.

The Effect and Mechanism of Nano-Cu Lubricating Additives on the Electroless Deposited Ni-W-P Coating

The coating and deposition process with excellent anti wear and suitable for industrial application were developed, and the optimum bath composition and process were obtained by studying the influence of the bath composition, temperature and pH value on the deposition rate and the plating solution stability. Moreover, the tribological properties of nano-Cu lubricating additives and electroless deposited Ni-W-P coating as well as their synergistic effect are researched using ring-block abrasion testing machine and energy dispersive spectrometer. Research results show that Ni-W-P alloy coating and nano-Cu lubricating additive have excellent synergistic effect, e g, the wear resistance of Ni-W-P alloy coating （with heat treatment and the oil with nano-Cu additives） has increased hundreds times than 45 steel as the metal substrate with the basic oil, and zero wear is achieved, which breaks through the bottleneck of previous separate research of the above-mentioned two aspects.

Effects of Thermal Annealing on the Solvent Additive P3HT PC61BM Bulk Heterojunction Solar Cells

Effects of thermal annealing on the optical, electrical and structural properties of 3 vol% 1,8-diiodoctane added P3HT：PC61BM active layers are investigated, concerning the performance of the bulk heterojunction polymer so- lar cells by changing the heat temperature. The structure information of the active layer is analyzed by using the grazing incidence wide angle scattering diffraction combined with the optical microscope, light absorption, pho- toluminescence and the external quantum efficiency spectra. The relationship between the detail of morphology and the optical, electrical properties is investigated.

Ligand Size Effect on PdLn Oxidative Addition with Aryl Bromide： A DFT Study

The process and mechanism of the ligand volume controlled Pd（PR3）2 （PR3=PH3, PMe3, and PtBu3） oxidative addition with aryl bromide were investigated, using density functional theory method with the conductor-like screening model. Association pathway and dissocia-tion pathway were investigated by the comparison of several energies. The cleavage energy of Pd（PR3）2 complex was calculated, as well as the oxidative addition reaction barrier energy of Pd（PR3）n （n=1,2） with aryl bromide in N,N-dimethylformamide solvent. This study proved that the ligands volume possessed a great impact on the mechanism of oxidative addition： less bulky ligand palladium associated with aryl bromide via two donor ligands,but larger bulky ligand palladium coordinated via monoligand.

Antioxidant and Immunopotentiating Effects of <i>Cordyceps </i>Mycelium Extract, Chicken Essence, and Their Combination in Experimental Models

Cordyceps mycelium extract (Cs-4), Chicken Essence (CE), and their combination were investigated for antioxidant and immunomodulatory activities in mouse models. Long-term treatment with Cs-4 or CE at equivalent human doses improved antioxidant status in various tissues, as evidenced by the enhancement of mitochondrial glutathione redox status in the brain, liver, heart, and kidney of mice. Cs-4 or CE treatment also produced an immunomodulatory action, as indicated by the potentiation of Concanavalin A-/lipopolysaccharide-induced proliferation of mouse splenocytes ex vivo. While doubling of the equivalent human doses of Cs-4 and CE did not further enhance their antioxidant or immunopotentiating effects, the combined treatment with Cs-4 and CE at their respective equivalent human doses produced an additive effect, with the extents of stimulation being larger than those produced by Cs-4 or CE alone. The results have demonstrated for the first time that the combined use of Cs-4 and CE can produce an additive effect on both antioxidation and immunopotentiation that cannot otherwise be achieved by increasing the equivalent human doses of Cs-4 or CE alone.

Effects of Ta Addition on NiTi Shape Memory Alloys

The effect of Ta addition on the martensitic transformation characteristics and the X-ray visibility on NiTi shape memory alloy have been studied in (Ni51Ti49)1-xTax system. It was found that the transformation temperatures of the Ni51Ti49 binary alloy increased drastically by an addition of 0～4 at. pet Ta, but only slightly when the concentration exceeded 4 at. pct; the addition of Ta greatly decreases the sensitivity of the martensitic transformations to the variation in the Ni-Ti ratio. The addition of Ta to the NiTi binary alloy can improve its X-ray visibility.

Effects of Additional Elements on Microstructure and Precipitation Behaviour in Rapidly Solidified Al-Ti Base Alloys

Rapidly solidified Al-Ti base alloys were prepared by melt spinning at the cooling rate about 107 K/s. The melt-spun ribbons were used to observe the dricrostructures after heat treatment.In the supersaturated Al-Tl-Si alloy, age hardening occurred after 1 h anneal in the temperature range of 4000~500℃, which seems to be attributed to the precipitation of metastable Ll2- (Al,Si)3Ti phase. However. the microhardness was relatively low because of the low v/o and the insufflcient stability of precipitates. Thus. Cr was added to Al-Ti-Si alloys in order to stabilize the microstructures and to increase the v/o of precipitate5. As a result. the alIoys containing Cr were evaluated to possess the improved properties at the service temperature.

Effect of Respective Additions of Ga, Zr and Combined Additions of Co, Ga, Zr on Magnetic Properties of Remanence-enhanced Nd_(8.4) Fe_(87.1) B_(4.5) Alloy

The effect of a partial substitution of Zr, Ga; Co and Ga; Co. Ga and Zr; respectively, for Fe on the structure and magnetic properties of Nd_8.4Fe_87.1B_4.5 alloy prepared by mechanical alloying has been studied in detail. It has been shown that, intrinsic coercivity μ0 H_c and maximum magnetic energy product (BH)_max increase for only Zr or Ga-containing samples, which is mainly due to the refinement of soft grains. The combined addition of Co and Ga is less effective for improving μoH_c and (BH)_max than the respective addition of Co or Ga. which may be due to the formation of CsCl-type CoGa. μoH_c and (BH)_max for combined Co, Ga. Zr-added alloy are higher than those for the combined Co, Ga-added alloy but lower than those for only Zr-containing alloy.

Genetic Effect on Yield and Fiber Quality Traits of 16 Chromosome Substitution Lines in Upland Cotton

Evaluation of the genetic effect on yield and fiber quality can provide useful information on cotton breeding. Sixteen CSB lines and TM-1 introduced from USDA/ARS were used as male and top-crossed with three elite cultivars and the 51 F1 hybrids, 16 CSB lines, TM-1, and 3 elite cultivars were planted at the Cotton Research Institute of CAAS, Anyang, Henan Province and Xiajin, Shandong Province, China. The yield traits and fiber quality data were obtained and additive and dominance effect on each trait were measured by AD model. Boll weight takes the largest additive proration, whereas boll number takes the least additive proration. The largest and the least dominant proration for lint yield and boll weight were measured, respectively. Fiber length has the additive and dominance effect, and dominance effect was slightly more than additive effect. Larger additive and no dominance effect on uniformity, micronaire, and fiber strength were measured. Significantly, positive additive effect on boll weight of CSB06 and CSB12Sh was observed. CSB14Sh and CSB01 have significantly positive additive effect on 4 and 3 traits of fiber quality, respectively. CSB01 has the greatest dominant effect on lint yield among CSB lines. The dominant effect on fiber length of CSB lines showed positive. It is beneficial to use CSB06 and CSB12Sh as parents to improve boll size, to use CSB14Sh and CSB01 as parents to improve fiber quality. As for hybrid cotton breeding, it is reasonable using CSB01 to improve lint yield traits, and using CSB01, CSB11Sh, and CSB06 to improve fiber length.

Effects of Ta Addition on Microstructure and Transformation Behavior of Ni-Ti Alloys

The effect of adding Ta on the changes of microstructure and Ms temperature of a dualphase shape memory alloy with compositions of (Ni51 Ti49)1 -x.Tax. and Ni50-Ti50 -g.Ta.g were systematically studied. An optical microscope, SEM, X-ray diffraction and DSC were utilized in this work. The evolution of the microstructure as a function of Ta content was characterized. The variation of the Ni/Ti ratio in the NiTi phase plays an important role in the change of the Ms temperatures due to the addition of Ta. A pseudobinary NiTi-Ta phase diagram was proposed based on these results.

Effect of Al Addition on the Glass-Forming Ability and Magnetic Properties of a Gd-Co Binary Amorphous Alloy

The glass-forming ability （CFA） and magnetic properties of the Cd50 Co50-based amorphous alloy with AI addition substitution for Co are investigated. It is found that the CFA and magneto-caloric effect of the Gd50Co45Al5 amorphous alloy are better than Cd50Co50 amorphous alloy. The maximum magnetic entropy change （-△ Sm^peak） and the magnetic refrigerant capacity- of the amorphous alloy under a field of 5 T are about 6.64 J·kg^-1 K^-1 and 764 J·kg^-1, respectively. The field dependence of magnetic entropy change meets the one predicted by the mean field theory, which is investigated for a better understanding of the magneto-caloric behaviors of the Gdso Co45Al5 amorphous alloy.

Effects of A1 Additions on Microstructure and Mechanical Properties of MoSi_2

The effects of Al additions on the microstructure and mechanical properties of MoSi2 have been studied. With the A1 additions from 2.5 wt pct to 5 wt pct, the siliceous grain boundary phase in hot pressed samples was eliminated because of the formation of Al2O3 particles. It was shown that Al and SiO2 reacted at 860℃. During the reaction, A1 atoms were mainly transferred to Al2O3 particles, and to some extent, diffused into MoSi2 grains. Both the toughness and strength of Al containing composites exceeded those of pure MoSi2 material. Bending strength and fracture toughness reach the highest value of 350 MPa, 4.05 MPa.m1/2, respectively, at ambient temperature when Al addition was of 3.5 wt pct.

Effect of Li and Ti Additions on Lα(Al)+Mg_2Si Pseudobinary Eutectic Reaction

Effect of Li and Ti additions on Lα(AI)+Mg2Si pseudobinary eutectic reaction in ternary Al-Mg-Si system has been investigated by thermoanalysis, directional solidification and metallographic techniques in this study. It has been found that Li addition causes decreasing of the volume fraction of Mg2Si, while a little amount of Ti causes to increasing, which is of a great importance to the adjustment of phase constitution and alloy properties. Doping components have little influence on the eutectic temperature.

A stable and major QTL region on chromosome 2 conditions pod shape in cultivated peanut(Arachis hyopgaea L.)

Peanut pod shape is a heritable trait which affects the market acceptance of in-shell peanut products.In order to determine the genetic control of pod shape,six component traits of pod shape(pod length,pod width,pod length/width ratio,pod roundness,beak degree and constriction degree)were measured using an image-based phenotyping method.A recombinant inbred line(RIL)population consisting of 181 lines was phenotyped across three environments.Continuous distributions and transgressive segregations were demonstrated in all measured traits and environments.Significant correlations were found among most component traits with broad-sense heritability ranging from 0.87 to 0.95.Quantitative trait locus(QTL)analysis yielded 26 additive QTLs explaining 3.79 to 52.37%phenotypic variations.A novel,stable and major QTL region conditioning multiple shape features was detected on chromosome 2,which spans a 10.81-Mb genomic region with 543 putative genes.Bioinformatics analysis revealed several candidate genes in this region.In addition,73 pairs of epistatic interactions involving 92 loci were identified for six component traits explaining 0.94–6.45%phenotypic variations.These results provide new genetic loci to facilitate genomics-assisted breeding of peanut pod shape.

A novel procedure for identifying a hybrid QTL-allele system for hybrid-vigor improvement, with a case study in soybean(Glycine max)yield

“Breeding by design” for pure lines may be achieved by construction of an additive QTL-allele matrix in a germplasm panel or breeding population, but this option is not available for hybrids, where both additive and dominance QTL-allele matrices must be constructed. In this study, a hybrid-QTL identification approach, designated PLSRGA, using partial least squares regression(PLSR) for model fitting integrated with a genetic algorithm(GA) for variable selection based on a multi-locus, multi-allele model is described for additive and dominance QTL-allele detection in a diallel hybrid population(DHP). The PLSRGA was shown by simulation experiments to be superior to single-marker analysis and was then used for QTL-allele identification in a soybean DPH yield experiment with eight parents. Twenty-eight main-effect QTL with 138 alleles and nine QTL × environment QTL with 46 alleles were identified, with respective contributions of 61.8% and 23.5% of phenotypic variation. Main-effect additive and dominance QTL-allele matrices were established as a compact form of the DHP genetic structure. The mechanism of heterosis superior-to-parents(or superior-to-parents heterosis, SPH) was explored and might be explained by a complementary locus-set composed of OD+(showing positive over-dominance, most often), PD+(showing positive partial-to-complete dominance, less often) and HA+(showing positive homozygous additivity, occasionally) loci, depending on the parental materials. Any locus-type, whether OD+, PD + and HA+, could be the best genotype of a locus. All hybrids showed various numbers of better or best genotypes at many but not necessarily all loci, indicating further SPH improvement. Based on the additive/dominance QTL-allele matrices, the best hybrid genotype was predicted, and a hybrid improvement approach is suggested. PLSRGA is powerful for hybrid QTL-allele detection and cross-SPH improvement.