The law of anti-VCAM-1 targeted microbubbles adhesion to activated endothelial cells under controlled shear flow

Microbubbles can enhance the detection in noninvasive ultrasound imaging.Recently,targeted microbubbles have been developed to selectively adhere to specific and overexpressed p molecules in endothelial cells in some pathologic conditions.However,the law of

Thermal-sensitive ionogel with NIR-light controlled adhesion for ultrasoft strain sensor

With the widespread prevailing of flexible electronics in human-machine interfaces,health monitor,and human motion detection,ultrasoft flexible sensors are urgently desired with critical demands in conformality.Herein,a temperature-sensitive ionogel with near-infrared(NIR)-light controlled adhesion is prepared by electrostatic interaction of poly(diallyl dimethylammonium chloride)(PDDA)and acrylic acid,as well as the incorporation of the conductive polydopamine modified polypyrrole nanoparticles(PPy-PDA NPs).The PPy-PDA NPs could weaken the tough interaction between polymer chains and depress the Young’s modulus of the ionogel,thus promoting the ionogel ultrasoft(34 kPa)and highly stretchable(1,013%)performance to tensile deformations.In addition,the high photothermal conversion capacity of PPy-PDA NPs ensured the ionogel excellent NIR-light controlled adhesion and temperature sensitivity,which facilitated the ionogel on-demand removal and promised a reliable thermal sensor.Moreover,the resulted ultrasoft flexible sensor exhibited high sensitivity and stability to both strain and pressure in a broad range of deformations,enabling a precise monitoring on various human motions and physiological activities.The temperature-sensitive,ultrasoft,and controlled adhesive capabilities prompted great potential of the flexible ionogel in medical diagnosis and wearable electronics.

A Hierarchical Conical Array with Controlled Adhesion and Drop Bounce Ability for Reducing Residual Non-Newtonian Liquids

As a result of frequent food waste and environmental pollution,there has been an increasing demand for the development of packaging materials that intrinsically inhibit and reduce likelihood of non-Newtonian liquids adherence.In this work,inspired from ciliary structures on the leg of water strider,the hierarchical conical array was formed by magnetic field control and laser etching without any mask.Due to the tapered geometry of the cones and the multiscale surface roughness of the array,the droplets would bounce many times after impacting with the superhydrophobic surface(SHS)and roll off.By changing the spaces and apex angles of conical microcolumns the SHS has controlled adhesion,superior self-cleaning property and droplets bounce performance for a variety of non-Newtonian viscous liquids.After suffering from various types of damage including repeated tape tearing,finger touch and folding test,the SHS still maintained excellent superhydrophobic property,which may have potential application as all kinds of packaging interface materials.We demonstrate that the excellent droplets bounce behavior of the hierarchical array enables the efficient and robust prevention of food liquids adhesion.

Controllable Protein Adsorption and Bacterial Adhesion on Polypyrrole Nanocone Arrays

In this research, polypyrrole nanocone arrays doped with β-Naphthalene sulphonic acid （PPy-NSA） were built. This film was expected to control protein adsorption and bacterial adhesion by potential-induced reversibly redox. The scanning Kelvin probe microscopy （SKPM） and surface contact angles （SCA） tests suggested that the surface potential and wettability of PPy-NSA nanocone arrays could be controlled by simply controlling its redox property via applying potential. The controllable surface potential and wettability in return controlled the adsorption of protein and adhesion of bacteria. The proposed material might find application in the preparation of smart biomaterial surfaces that can regulate proteins and bacterial adhesion by a simple potential switching.

Fabrication of a biomimetic controllable adhesive surface by ultraprecision multistep and layered scribing and casting molding

Wedge-shaped microstructures have the ability to reproduce the excellent adhesive properties of geckos’feet because of their unique anisotropic structure.In particular,the controllability of the wedge-shaped microstructures on adhesion is beneficial to the undisturbed grasp or the capture of space targets.However,the problem currently remains of how to process it efficiently and with high quality.Here a strategy called ultraprecision multistep and layered scribing is proposed for the manufacture of the biomimetic controllable adhesive surface.The results show that the metal master mold prepared based on the manufacturing strategy has not only good surface topography but also high reliability and durability.Furthermore,the controllable adhesive surface of 1.96 cm2,fabricated by the proposed manufacturing strategy,has a normal adhesion of 1.012 N,and the corresponding shear friction and adhesion coefficient are 3.105 N and 4.82,respectively.Additionally,the controllable adhesive surface has been shown to be approximately superhydrophobic and also to possess the properties of controllable adhesion and dynamic adhesion.Also,after 250 adhesion-detachment cycles,the normal adhesion and shear friction only decrease by 5%and 3%,respectively.The research realizes an environmentally friendly and efficient method by which to manufacture a durable metal mold for fabricating a biomimetic controllable adhesive surface,laying a foundation for its effective application in the adherence of space-floating targets.