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Intranasal administration of stem cell-derived exosomes for central nervous system diseases 被引量:1
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作者 Shuho Gotoh Masahito Kawabori Miki Fujimura 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第6期1249-1255,共7页
Exosomes,lipid bilayer-enclosed small cellular vesicles,are actively secreted by various cells and play crucial roles in intercellular communication.These nanosized vesicles transport internalized proteins,mRNA,miRNA,... Exosomes,lipid bilayer-enclosed small cellular vesicles,are actively secreted by various cells and play crucial roles in intercellular communication.These nanosized vesicles transport internalized proteins,mRNA,miRNA,and other bioactive molecules.Recent findings have provided compelling evidence that exosomes derived from stem cells hold great promise as a therapeutic modality for central nervous system disorders.These exosomes exhibit multifaceted properties including antiapoptotic,anti-inflammatory,neurogenic,and vasculogenic effects.Furthermore,exosomes offer several advantages over stem cell therapy,such as high preservation capacity,low immunogenicity,the ability to traverse the blood-brain barrier,and the potential for drug encapsulation.Consequently,researchers have turned their attention to exosomes as a novel therapeutic avenue.Nonetheless,akin to the limitations of stem cell treatment,the limited accumulation of exosomes in the injured brain poses a challenge to their clinical application.To overcome this hurdle,intranasal administration has emerged as a non-invasive and efficacious route for delivering drugs to the central nervous system.By exploiting the olfactory and trigeminal nerve axons,this approach enables the direct transport of therapeutics to the brain while bypassing the blood-brain barrier.Notably,exosomes,owing to their small size,can readily access the nerve pathways using this method.As a result,intranasal administration has gained increasing recognition as an optimal therapeutic strategy for exosomebased treatments.In this comprehensive review,we aim to provide an overview of both basic and clinical research studies investigating the intranasal administration of exosomes for the treatment of central nervous system diseases.Furthermore,we elucidate the underlying therapeutic mechanisms and offer insights into the prospect of this approach. 展开更多
关键词 central nervous system disease EXOSOME extracellular vesicle intranasal administration stem cell
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Hypothalamic circuits and aging:keeping the circadian clock updated 被引量:1
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作者 Rosa Vázquez-Lizarraga Lucia Mendoza-Viveros +3 位作者 Carolina Cid-Castro Sareni Ruiz-Montoya Erick Carreño-Vázquez Ricardo Orozco-Solis 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第9期1919-1928,共10页
Over the past century,age-related diseases,such as cancer,type-2 diabetes,obesity,and mental illness,have shown a significant increase,negatively impacting overall quality of life.Studies on aged animal models have un... Over the past century,age-related diseases,such as cancer,type-2 diabetes,obesity,and mental illness,have shown a significant increase,negatively impacting overall quality of life.Studies on aged animal models have unveiled a progressive discoordination at multiple regulatory levels,including transcriptional,translational,and post-translational processes,resulting from cellular stress and circadian derangements.The circadian clock emerges as a key regulator,sustaining physiological homeostasis and promoting healthy aging through timely molecular coordination of pivotal cellular processes,such as stem-cell function,cellular stress responses,and inter-tissue communication,which become disrupted during aging.Given the crucial role of hypothalamic circuits in regulating organismal physiology,metabolic control,sleep homeostasis,and circadian rhythms,and their dependence on these processes,strategies aimed at enhancing hypothalamic and circadian function,including pharmacological and non-pharmacological approaches,offer systemic benefits for healthy aging.Intranasal brain-directed drug administration represents a promising avenue for effectively targeting specific brain regions,like the hypothalamus,while reducing side effects associated with systemic drug delivery,thereby presenting new therapeutic possibilities for diverse age-related conditions. 展开更多
关键词 AGING ASTROCYTES cellular stress responses circadian clock HYPOTHALAMUS intranasal drug administration metabolic control nutrient sensor SIRT1 sleep homeostasis
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Advances in Polysaccharide-Based Microneedle Systems for the Treatment of Ocular Diseases
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作者 Qingdong Bao Xiaoting Zhang +6 位作者 Zhankun Hao Qinghua Li Fan Wu Kaiyuan Wang Yang Li Wenlong Li Hua Gao 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第12期233-284,共52页
The eye,a complex organ isolated from the systemic circulation,presents significant drug delivery challenges owing to its protective mechanisms,such as the blood-retinal barrier and corneal impermeability.Conventional... The eye,a complex organ isolated from the systemic circulation,presents significant drug delivery challenges owing to its protective mechanisms,such as the blood-retinal barrier and corneal impermeability.Conventional drug administration methods often fail to sustain therapeutic levels and may compromise patient safety and compliance.Polysaccharidebased microneedles(PSMNs)have emerged as a transformative solution for ophthalmic drug delivery.However,a comprehensive review of PSMNs in ophthalmology has not been published to date.In this review,we critically examine the synergy between polysaccharide chemistry and microneedle technology for enhancing ocular drug delivery.We provide a thorough analysis of PSMNs,summarizing the design principles,fabrication processes,and challenges addressed during fabrication,including improving patient comfort and compliance.We also describe recent advances and the performance of various PSMNs in both research and clinical scenarios.Finally,we review the current regulatory frameworks and market barriers that are relevant to the clinical and commercial advancement of PSMNs and provide a final perspective on this research area. 展开更多
关键词 Ocular delivery POLYSACCHARIDE MICRONEEDLES Drug administration
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Corrigendum to“Toward stable and highly reversible zinc anodes for aqueous batteries via electrolyte engineering”[J.Energy Chem.83(2023)209–228]
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作者 Ang Li Jiayi Li +1 位作者 Yurong He Maochun Wua 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第4期323-323,共1页
It is regretful that the Acknowledgments part was lost in the final process of publication.The Acknowledgments part should be added as follow.The work described in this paper was supported by the grants from the Resea... It is regretful that the Acknowledgments part was lost in the final process of publication.The Acknowledgments part should be added as follow.The work described in this paper was supported by the grants from the Research Grants Council of the Hong Kong Special Administrative Region,China(Project No.16205721). 展开更多
关键词 ELECTROLYTE ledgment ADMINISTRATIVE
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In-situ Gelation of Sodium Alginate-chitosan for Oral Delivery of Probiotics
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作者 LI Jie QI Yingxia +3 位作者 SONG Feiyu DAI Fuli QIU Tong ZHANG Xueqiong 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS CSCD 2024年第6期1621-1627,共7页
We developed a new preparation to protect probiotic cells from adverse environmental conditions and improve their livability,which is called Lactobacillus casei-Sodium alginate-Chitosan (LSC).The LSC was prepared by m... We developed a new preparation to protect probiotic cells from adverse environmental conditions and improve their livability,which is called Lactobacillus casei-Sodium alginate-Chitosan (LSC).The LSC was prepared by mixing probiotics with sodium alginate-chitosan sol.The preparation contained complex calcium ions,which were released in the acidic environment of gastric juice,thus crosslinking to form in-situ gel.Different proportions of sodium alginate-chitosan were prepared to add to simulate gastrointestinal fluid to get the best ratio.The optimal ratio of LSC preparation was compared with traditional gel microspheres to observe the survival effect of probiotics in gastrointestinal fluid environment.Compared with sodium alginate sol,the porosity of sodium alginate-chitosan sol is lower,which is beneficial to the protection of probiotics.When the ratio of chitosan to sodium alginate is 1.5:1.5 (w/v),the protective effect is the best.The protective ability of LSC is 64 times that of traditional microspheres,and it has the potential of synergistic anti-tumor.A probiotic preparation with simple preparation process and better protection effect compared with traditional microspheres was prepared,which has joint anti-tumor potential. 展开更多
关键词 sodium alginate in-situ gelation LSC oral administration
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Strengthening pharmacotherapy research for COVID-19-induced pulmonary fibrosis
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作者 Yan-Miao Liu Jing Zhang +2 位作者 Jing-Jing Wu Wei-Wei Guo Fu-Shan Tang 《World Journal of Clinical Cases》 SCIE 2024年第5期875-879,共5页
The global spread of severe acute respiratory syndrome coronavirus 2 has resulted in a significant number of individuals developing pulmonary fibrosis(PF),an irreversible lung injury.This condition can manifest within... The global spread of severe acute respiratory syndrome coronavirus 2 has resulted in a significant number of individuals developing pulmonary fibrosis(PF),an irreversible lung injury.This condition can manifest within a short inter-val following the onset of pneumonia symptoms,sometimes even within a few days.While lung transplantation is a potentially lifesaving procedure,its limited availability,high costs,intricate surgeries,and risk of immunological rejection present significant drawbacks.The optimal timing of medication administration for coronavirus disease 2019(COVID-19)-induced PF remains controversial.Despite this,it is crucial to explore pharmacotherapy interventions,involving early and preventative treatment as well as pharmacotherapy options for advanced-stage PF.Additionally,studies have demonstrated disparities in anti-fibrotic treatment based on race and gender factors.Genetic mutations may also impact therapeutic efficacy.Enhancing research efforts on pharmacotherapy interventions,while considering relevant pharmacological factors and optimizing the timing and dosage of medication administration,will lead to enhanced,personalized,and fair treatment for individuals impacted by COVID-19-related PF.These measures are crucial in lessening the burden of the disease on healthcare systems and improving patients'quality of life. 展开更多
关键词 COVID-19 Pulmonary fibrosis Pharmacotherapy intervention Medication administration TIMING DOSAGE
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Ancylostoma ceylanicum and other zoonotic canine hookworms:neglected public and animal health risks in the Asia-Pacific region
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作者 Jan Clyden B.Tenorio lan Kim B.Tabios +4 位作者 Tawin Inpankaew Adrian P.Ybanez Saruda Tiwananthagorn Sirikachorn Tangkawattana Sutas Suttiprapa 《Animal Diseases》 CAS 2024年第1期59-74,共16页
Zoonotic hookworm infections remain a significant public health problem,causing nearly 500 milion cases globally and approximately four million disability-adjusted life years lost annually.More than one-fth of these c... Zoonotic hookworm infections remain a significant public health problem,causing nearly 500 milion cases globally and approximately four million disability-adjusted life years lost annually.More than one-fth of these cases are attrib-uted to Ancylostoma ceylanicum,an emerging zoonotic health issue in the Asia-Pacific region.This review presents key research gaps regarding the epidemiology,diagnosis,control,prevention and elimination of A.ceylanicum and other canine zoonotic hookworms as neglected health threats.A.ceylanicum is the second most prevalent human hook-worm in the region;it is the most common hookworm among dogs and cats-reservoirs of zoonotic infections.Previous population genetic and phylogenetic analyses revealed that A.ceylanicum has three possible transmis-sion dynamics:zoonotic,animal-only,and human-only pathways.The actual burden of zoonotic ancylostomiasis in most endemic countries remains unknown due to the use of parasitological techniques(e.g.,Kato-Katz thick smear and floatation techniques)that have reduced diagnostic performance and do not allow accurate species identifica-tion in helminth surveys.The emergence of benzimidazole resistance in soil-transmitted helminths(STHs),includ-ing hookworms,is a concern due to the protracted implementation of mass drug administration(MDA).Resistance is conferred by single nucleotide polymorphisms(SNPs)that occur in theβ-tubulin isotype 1 gene.These mutations have been reported in drug-resistant A.caninum but have not been found in A.ceylanicum in the field.A.ceylanicum remains understudied in the Asia-Pacific region.The zoonotic nature of the parasite warrants investigation of its occur-rence in human and animal reservoir hosts to understand the dynamics of zoonotic transmission in different endemic foci.The detection of benzimidazole resistance-associated SNPs in zoonotic hookworms from Asia-Pacific countries has yet to be thoroughly explored.Considering the high level of hookworm endemicity in the region,the circulation of resistant isolates between humans and animals potentially presents a significant One Health threat that can under-mine current MDA and proposed animal deworming-based control efforts. 展开更多
关键词 Soil-transmitted helminths Neglected tropical diseases Mass drug administration DEWORMING Veterinary public health
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Repurposing Loperamide as an Anti-Infection Drug for the Treatment of Intracellular Bacterial Pathogens
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作者 Hongtao Liu Siqi Li +8 位作者 Le Deng Zhenxu Shi Chenxiao Jiang Jingyan Shu Yuan Liu Xuming Deng Jianfeng Wang Zhimin Guo Jiazhang Qiu 《Engineering》 SCIE EI CAS CSCD 2024年第8期180-193,共14页
Infections caused by intracellular bacterial pathogens are difficult to treat since most antibiotics have low cell permeability and undergo rapid degradation within cells.The rapid development and dissemination of ant... Infections caused by intracellular bacterial pathogens are difficult to treat since most antibiotics have low cell permeability and undergo rapid degradation within cells.The rapid development and dissemination of antimicrobial–resistant strains have exacerbated this dilemma.With the increasing knowledge of host–pathogen interactions,especially bacterial strategies for survival and proliferation within host cells,host-directed therapy(HDT)has attracted increased interest and has emerged as a promising antiinfection method for treating intracellular infection.Herein,we applied a cell-based screening approach to a US Food and Drug Administration(FDA)-approved drug library to identify compounds that can inhibit the intracellular replication of Salmonella Typhimurium(S.Typhimurium).This screening allowed us to identify the antidiarrheal agent loperamide(LPD)as a potent inhibitor of S.Typhimurium intracellular proliferation.LPD treatment of infected cells markedly promoted the host autophagic response and lysosomal activity.A mechanistic study revealed that the increase in host autophagy and elimination of intracellular bacteria were dependent on the high expression of glycoprotein nonmetastatic melanoma protein B(GPNMB)induced by LPD.In addition,LPD treatment effectively protected against S.Typhimurium infection in Galleria mellonella and mouse models.Thus,our study suggested that LPD may be useful for the treatment of diseases caused by intracellular bacterial pathogens.Moreover,LPD may serve as a promising lead compound for the development of anti-infection drugs based on the HDT strategy. 展开更多
关键词 Intracellular bacteria US Food and Drug Administration(FDA)-approved drugs Drug repurposing LOPERAMIDE AUTOPHAGY Glycoprotein nonmetastatic melanoma protein B
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Ophthalmic complications of injectable facial fillers
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作者 Prateek Nishant Arvind Kumar Morya +1 位作者 Sony Sinha Ranjeet Kumar Sinha 《World Journal of Clinical Cases》 SCIE 2024年第34期6736-6739,共4页
The recently published mini-review article by Miotti et al is an effort to clarify various aspects regarding the choice between fat grafts and fillers in facial aesthetic surgery.One of the complications associated wi... The recently published mini-review article by Miotti et al is an effort to clarify various aspects regarding the choice between fat grafts and fillers in facial aesthetic surgery.One of the complications associated with the administration of fillers is the possibility of vascular injury and spread of the dermal filler into the orbit,causing unexpected effects at a site distant from that of the initial injection,including ophthalmoplegia,ptosis and even visual compromise.Acute vision loss following filler injection is a devastating complication,occurring in up to 0.0008%of cases.The greatest risk of this complication occurs with nasal augmentation,followed by glabellar wrinkle treatment.While injected autologous fat predominantly occludes the proximal portion of the ophthalmic artery,hyaluronic acid fillers obstruct the ophthalmic artery comparatively distally.Treatment interventions include thrombolysis,hyperbaric oxygen therapy,oral aspirin,cobamamide and acetazolamide and administration of corticosteroids.However,most studies show a poor prognosis in the form of partial or no recovery of vision.Hence,prevention is of paramount importance.A high index of suspicion is also warranted on the part of both those administering as well as receiving injections of facial fillers to prevent potentially vision-threatening complications of this seemingly innocuous procedure. 展开更多
关键词 Adverse effects BLINDNESS Cosmetic techniques Dermal drug administration Hyaluronic acid Iatrogenic disease
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Flexner's legacy and the future of medical education:Embracing challenge and opportunity
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作者 Quzhen Zeren Yan Zeng +1 位作者 Jun-Wen Zhang Jian Yang 《World Journal of Clinical Cases》 SCIE 2024年第33期6650-6654,共5页
This editorial comments on the article by Alzerwi.We focus on the development course,present challenges,and future perspectives of medical education.Modern medical education is gradually undergoing significant and pro... This editorial comments on the article by Alzerwi.We focus on the development course,present challenges,and future perspectives of medical education.Modern medical education is gradually undergoing significant and profound changes worldwide.The emergence of new ideas,methodologies,and techniques has created opportunities for medical education developments and brought new concerns and challenges,ultimately promoting virtuous progress in medical education reform.The sustainable development of medical education needs joint efforts and support from governments,medical colleges,hospitals,researchers,administrators,and educators. 展开更多
关键词 Medical education Medical education reform Abraham Flexner's report Educational administration Challenge and opportunity
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Innovation Analysis of Rural Agricultural Economic Management Model in the Context of the Belt and Road Initiative
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作者 Huabin TANG 《Asian Agricultural Research》 2024年第6期11-12,18,共3页
[Objectives]To explore innovative strategies for rural agricultural economic development in the context of the Belt and Road Initiative.[Methods]This research adopts the method of literature review and field research,... [Objectives]To explore innovative strategies for rural agricultural economic development in the context of the Belt and Road Initiative.[Methods]This research adopts the method of literature review and field research,systematically combs the research results related to the Belt and Road Initiative and rural agricultural economic management,and deeply understands the actual situation of rural agricultural economic management.[Results]The research shows that in the context of the Belt and Road Initiative,the rural agricultural economy is facing new development opportunities and challenges,but there are also some problems.In the new period,we should accelerate the innovative development of rural agricultural economy by promoting market-oriented reform,strengthening scientific and technological innovation,optimizing the industrial structure,deepening international cooperation and other measures.The Belt and Road Initiative provides an important opportunity for the innovation of rural agricultural economic management.Rural agricultural economic management should be actively integrated into the Belt and Road construction to improve the level of rural agricultural economic management.[Conclusions]This study provides useful exploration and reference for the innovation of rural agricultural economic management models,which helps to promote the healthy development of rural agricultural economy and achieve the goal of rural revitalization. 展开更多
关键词 The BELT and ROAD INITIATIVE RURAL areas Agriculture ECONOMY ADMINISTRATION
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What are the underlying causes and dynamics of land use conflicts in metropolitan junction areas?A case study of the central Chengdu–Chongqing region in China
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作者 TIAN Junfeng WANG Binyan +1 位作者 QIU Cheng WANG Shijun 《Regional Sustainability》 2024年第3期81-98,共18页
Land use conflicts(LUCs),as a spatial manifestation of the conflicts in the human-land relationships,have a profound impact on regional sustainable development.For China’s metropolitan junction areas(MJAs),the existe... Land use conflicts(LUCs),as a spatial manifestation of the conflicts in the human-land relationships,have a profound impact on regional sustainable development.For China’s metropolitan junction areas(MJAs),the existence of“administrative district economies”has made the issue of LUCs more prominent.Based on a case study of the central Chengdu–Chongqing region,we conducted an exploratory spatial data analysis of the evolutionary process of regional LUCs.Furthermore,structural equation modeling was utilized to analyze the dynamic mechanism of LUCs in MJAs,with a particular emphasis on exploring the influences of administrative boundary.The results showed that from 2010 to 2020,LUCs in the central Chengdu–Chongqing region continued to worsen,and the spatial process conflict and spatial structure conflict indices increased by more than 30.0%.The intensification of LUCs in the central Chengdu–Chongqing region from 2010 to 2020 was mainly the result of the deterioration of conflicts in evaluation units with low conflict levels.LUCs in China’s metropolitan areas generally presented a circular gradient distribution,weakening from the core to the periphery,but there were some strong isolated conflict zones in the outer regions.LUCs in China’s MJAs were the result of interactions among multiple factors,e.g.,natural environment,socio-economic development,policy and institutional processes,and administrative boundary effects.Administrative boundary affected the flow of socio-economic elements,changing the supply-and-demand competition of stakeholders for land resources,consequently exerting an indirect influence on LUCs.This study advances the theory of the dynamic mechanism of LUCs,and provides theoretical support for the governance of these conflicts in transboundary areas. 展开更多
关键词 Land use conflicts Urban agglomerations Administrative boundary Land resources Structural equation modeling(SEM) Central Chengdu-Chongqing region
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BRICS seeks trade development and standards cooperation
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《China Standardization》 2024年第6期12-12,共1页
The BRICS Economic and Trade Forum was held on October 28 in Beijing, co-organized by the China Council for the Promotion of International Trade(CCPIT), China General Technology(Group) Holding Co., Ltd., and the Chine... The BRICS Economic and Trade Forum was held on October 28 in Beijing, co-organized by the China Council for the Promotion of International Trade(CCPIT), China General Technology(Group) Holding Co., Ltd., and the Chinese chapter of the BRICS Business Council.The forum focused on trade development and standards cooperation among BRICS countries, and aimed to implement the outcomes of the BRICS Leaders' Meeting. It was attended by more than 500 representatives from ISO, standardization administrative departments of BRICS countries, business councils, enterprises, and foreign embassies in China in person or online. 展开更多
关键词 BRICS COOPERATION ADMINISTRATIVE
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Need for education of psychiatric evaluation of offenders with mental disorders:A questionnaire survey for Japanese designated psychiatrists
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作者 Akihiro Shiina Tomihisa Niitsu +1 位作者 Masaomi Iyo Chiyo Fujii 《World Journal of Psychiatry》 SCIE 2024年第5期726-734,共9页
BACKGROUND The management of offenders with mental disorders has been a significant concern in forensic psychiatry.In Japan,the introduction of the Medical Treatment and Supervision Act in 2005 addressed the issue.How... BACKGROUND The management of offenders with mental disorders has been a significant concern in forensic psychiatry.In Japan,the introduction of the Medical Treatment and Supervision Act in 2005 addressed the issue.However,numerous psychiatric patients at risk of violence still find themselves subject to the administrative involuntary hospitalization(AIH)scheme,which lacks clarity and updated standards.AIM To explore current as well as optimized learning strategies for risk assessment in AIH decision making.METHODS We conducted a questionnaire survey among designated psychiatrists to explore their experiences and expectations regarding training methods for psychiatric assessments of offenders with mental disorders.RESULTS The findings of this study’s survey suggest a prevalent reliance on traditional learning approaches such as oral education and on-the-job training.CONCLUSION This underscores the pressing need for structured training protocols in AIH consultations.Moreover,feedback derived from inpatient treatment experiences is identified as a crucial element for enhancing risk assessment skills. 展开更多
关键词 Forensic psychiatry Administrative involuntary hospitalization Psychiatric assessment Risk assessment Mental disorders Training protocols Clinical practice Structured learning Feedback mechanisms Program development
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2023年中国标准化社会关注度评议结果揭晓
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《China Standardization》 2024年第1期18-35,共18页
Looking back at the past year,prominent achievements have been made in China’s standardization field with the promulgation and implementation of policies and administrative measures on standardization and quality wor... Looking back at the past year,prominent achievements have been made in China’s standardization field with the promulgation and implementation of policies and administrative measures on standardization and quality work.Remarkable progress has also been made in the development,revision and management of Chinese standards at various levels,together with the great efforts of experts who contributed their expertise to make Chinese standards more harmonized and applicable. 展开更多
关键词 中国标准化 measures ADMINISTRATIVE
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Adjustment of Administrative Divisions and Upgrading of Industrial Structure in Hefei Metropolitan Area:Taking"Partitions of Chaohu"as a Quasi-natural Experiment
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作者 Yumin DING 《Asian Agricultural Research》 2024年第7期19-23,27,共6页
Administrative regions are an important environment for the operation of China's market economy.The relevant economic subjects cannot predict the policy of adjustment of administrative divisions and carry out cons... Administrative regions are an important environment for the operation of China's market economy.The relevant economic subjects cannot predict the policy of adjustment of administrative divisions and carry out conscious migration behavior,adjustment of administrative divisions can be regarded as a quasi-natural experiment.The three cities of Hefei,Wuhu,and Ma'anshan,which are directly related to the adjustment of the administrative division of Chaohu,are taken as the treatment group,and the seven adjacent cities of Lu'an,Huainan,Chuzhou,Bengbu,Anqing,Chizhou,and Tongling are taken as the control group.Differences-in-Differences method and relevant control variables affecting the upgrading of industrial structure are used to test.The test results show that"Partitions of Chaohu"has a significant industrial structure upgrading effect by promoting the optimization of spatial layout,the cross-regional flow of production factors and the effective management of Chaohu Lake Basin.At the same time,the increase of total retail sales of consumer goods,urban fixed assets investment,public utility expenses in science,education,culture and health,and population plays a significant positive role in promoting the upgrading of industrial structure,while foreign direct investment plays a certain inhibition role in the upgrading of industrial structure.In order to meet the ever-developing space demands and enhance the impact on surrounding areas,the Hefei metropolitan area should be driven by technological innovation,strengthen the integration of industrial chains,improve the business environment and transportation network,and continuously promote the upgrading of industrial structure and the formation and development of new productive forces. 展开更多
关键词 Adjustment of administrative divisions Upgrading of industrial structure Hefei metropolitan area Quasi-natural experiment
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Optimization and Construction of Collaborative Office under the Background of Smart Campus in Universities
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作者 Rong Su 《Intelligent Information Management》 2024年第1期1-9,共9页
At present, with the continuous development of technologies such as the Internet, big data, and artificial intelligence, smart campuses in universities are being rapidly constructed. Improving the informatization leve... At present, with the continuous development of technologies such as the Internet, big data, and artificial intelligence, smart campuses in universities are being rapidly constructed. Improving the informatization level of administrative management work is also an important content. The collaborative office work in multiple departments requires more standardized, convenient, intelligent, and secure office systems. In response to this issue, this article analyzes the optimization and construction process of collaborative office systems based on the development of university informatization, summarizes the operational results, and explores the prospects of smart office. 展开更多
关键词 Collaborative Office Office Automation OA Smart Campus INFORMATIZATION ADMINISTRATION
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Economic Coercion Inhibits Sustainable Global Growth
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作者 Zhang Hui 《China Today》 2024年第6期2-2,共1页
The Biden administration’s tariff hikes on Chinese products came,unsurprisingly,a month or so before the first 2024 presidential debate between incumbent U.S.President Joe Biden and former President Donald Trump.They... The Biden administration’s tariff hikes on Chinese products came,unsurprisingly,a month or so before the first 2024 presidential debate between incumbent U.S.President Joe Biden and former President Donald Trump.They are thus preparing to play the China card once more.Biden has announced tariff increases across key sectors,purportedly to“protect American workers and businesses from China’s unfair trade practices,”according to the White House.The White House Fact Sheet also emphasizes the Biden administration’s creation of jobs in key sectors,as a countermeasure to the Trump administration’s failed China strategy to increase American exports and boost American manufacturing.The administration’s political agenda is thus laid bare. 展开更多
关键词 SUSTAINABLE PREPARING ADMINISTRATION
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A Windy and Rainy Shanghai
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作者 LIU FAN 《China Today》 2024年第5期58-59,共2页
On Suzhou Road in Shanghai,there stood a mercer’s shop.Its shopkeeper was surnamed Yu,but the shop was named Wu’s Silk Shop instead of Yu’s Silk Shop.Yu Jide,the shopkeeper,was born in the town of Yushan,Songjiang ... On Suzhou Road in Shanghai,there stood a mercer’s shop.Its shopkeeper was surnamed Yu,but the shop was named Wu’s Silk Shop instead of Yu’s Silk Shop.Yu Jide,the shopkeeper,was born in the town of Yushan,Songjiang Prefecture(a former administrative area of today’s Shanghai). 展开更多
关键词 SHOP WIND ADMINISTRATIVE
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Succession Plan for Nursing Academic Program Administrators
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作者 Erika Marie Carrasquillo Melendez 《Open Journal of Nursing》 2024年第10期548-553,共6页
Leadership succession in nursing academic programs poses a significant challenge, primarily due to the limited availability of professionals with the competencies required for effective leadership [1]. This study aims... Leadership succession in nursing academic programs poses a significant challenge, primarily due to the limited availability of professionals with the competencies required for effective leadership [1]. This study aims to address this gap by investigating the critical factors in succession planning for nursing program administrators. The research objectives include identifying the competencies necessary for academic administrators, assessing the experience of current administrators, and developing a comprehensive succession plan framework. The research uses qualitative methods, including literature review, interviews with nursing administrators, and analysis of existing succession models. Results highlight the importance of integrating strategic planning into succession processes to ensure smooth transitions and organizational stability. Conclusions suggest that a formalized succession plan, incorporating mentorship and leadership development, can mitigate leadership gaps in nursing academia [2]. 展开更多
关键词 Nursing Administrator Succession Plan ACADEMIA
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