Hypertension in Adult Age and Related Risk Factors

Background： Hypertension is one of the signficant risk factors for further severe cardiovascular diseases. Furthermore, the insidence of hypertension in adult age population has increased gradually. Thus, assessment of hypertension insidence and their risk factors in adult age people has given the beneficience for treating dan preventing program earlier. Aim： To analyze hypertension insidence in adult age and their risk factors that dominanly effect the occurance of hypertension. Method： This study was correlational with survey method. Accidental sampling was conducted to 120 respondents who live around Malioboro district. Hypertension was detected from systole and diastole value, while the risk factors of hypertension were age, gender, family disease history, type of activity, the number of cigarette each day, the length of smoking, random blood glucose, and body mass index. Analyzing the data used Pearson correlation if data were normal, or used Spearman correlation if data were not normal. Findings： From 120 participants, mean of systolic pressure was 120.7 mmHg and mean of diastolic pressure was 78.5 mmHg. Age mean was 39 years old, dominantly was woman amount 83 （69.2%）, and without family disease history as 66 （55%）. Mostly they had moderate physical activity amount 71 （59%）. Mean of cigarette consumtion was 11 pieces/day, for 23 years. Random blood glucose mean was 131 mg/dL and mean of body mass index was 26 kg/m2. Correlation analysis mentioned that body mass index had correlate with systolic and diastolic value significantly （p 〈 0.05）. Conclusion： Systolic and diastolic pressure value in adult age were still normal. Risk factor that correlated significantly with adult age blood pressure was body mass index. Another risk factors such as cholesterol level, blood glucose in fasting condition and two hour post meal, also food consumtion were considered that should be included in next study.

The Impact of Salivary pH Value and Dental Caries Index on Periodontal Status among Adult Age Groups of Patients from Aseer Region, Saudi Arabia

Background: The patients’ age is considered a modified risk factor that causes periodontal disease, dental caries, and their development. Objective: The present study was designed to evaluate the impact of salivary pH value and dental caries index on periodontal status among adult age groups of patients from Aseer region, Saudi Arabia. Methods: A cross-sectional analysis carried out in the college of dentistry, King Khalid University on 750 adult patients (400 males and 350 females). The adults patients were divided into three equal groups according to the patients’ age: group I (20 - 30 years), group II (31 - 40 years), and group III (41 - 50 years). Plaque index (PLI), gingival index (GI), clinical attachment loss (CAL), and the dental caries index (DMFT) recorded as well as salivary pH. All findings collected, then analyzed by an ANOVA test and the t-test. A p-value at <0.05 was considered a statistical significance level. Results: The clinical findings of the current study showed that there were statistically significant differences in the patients’ age of both males and females. Moreover, there were statistically significant differences in GI. On the other hand, there were highly statistically significant differences in PLI and DMFS, but there were no significant differences in CAL of both males and females Moreover, there were no statistically significant differences in salivary pH. Conclusion: We concluded that DMFT Index correlated to periodontal and oral health status and, it increased with the progression of the patient’s age and can be used in the epidemiological evaluation of periodontal and oral health status.

Biological character of human adipose-derived adult stem cells and influence of donor age on cell replication in culture

To investigate the biological character of human adipose-derived adult stem cells (hADAS cells) when cultured in vitro and the relationship between hADAS cell’s replication activity and the donor’s age factor, and to assess the stem cells as a new source for tissue engineering. hADAS cells are isolated from human adipose tissue of different age groups (from adolescents to olds: <20 years old, 21―40 years old, 41―60 years old and >61 years old groups). The protein markers (CD29, CD34, CD44, CD45, CD49d, HLA-DR, CD106) of hADAS cells were detected by flow cytometry (FCM) to identify the stem cell, and the cell cycle was examined for P20 hADAS cells to evaluate the safety of the subculture in vitro. The generative activity of hADAS cells in different age groups was also examined by MTT method. The formula “ log2T D = t logN t ? logN 0” was used to get the time doubling (TD) of the cells. The results showed that the cells kept heredity stabilization by chromosome analysis for at least 20 passages. The TD of these cells increased progressively by ageing, and the TD of the <20 years old group was lower than that of the >61 years old group (statistical analysis of variance (ANOVA), P=0.002, P<0.05). These find- ings suggested that a higher level of hADAS cells replication activity was found in the younger dona- tors, and they represent novel and valuable seed cells for studies of tissue engineering.