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The Effects of the Aerobics Exercise Program on the Cardiopulmoner Capacity and Disease Symptoms of the Patients with Primary Fibromialgia Syndrome
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作者 Berat Meryem Alkan Sumru Ozel +1 位作者 Serap Tomruk Sütbeyaz Canan Culha 《Open Journal of Rheumatology and Autoimmune Diseases》 2013年第4期202-208,共7页
Backgrounds: To observe the effects of aerobic exercise program on the illness symptoms and cardiopulmonary capacity of the patients with primary Fibromyalgia Syndrome (FMS) and to find out whether there is a differen... Backgrounds: To observe the effects of aerobic exercise program on the illness symptoms and cardiopulmonary capacity of the patients with primary Fibromyalgia Syndrome (FMS) and to find out whether there is a difference or not in terms of cardiovascular capacity among the patients with primary FMS and sedentary healthy people. Materials and Methods: The study has been done on 20 female patients with primary FMS. Before the study and after a 6-week controlled aerobic exercise program, a cardiopulmonary exercise test has been applied on all cases. The symptoms, psychological state and life quality of the cases have been evaluated before and after the exercise program. The first cardiopulmonary results of the cases with FMS have been compared with a control group of 15 sedentary healthy. Results: When the patient and control groups are compared, although maksimal oxygen uptake (VO2 max) was lower in the patient group, this was not a significant difference. VO2 max showing the aerobic condition after the exercise increased significantly in the patients. Conclusions: Aerobic exercise programs lasting six to eight weeks are quite effective for the patients with FMS. There is not any limitation in the increase of the cardiopulmonary capacity of the patients after the exercise program. 展开更多
关键词 Aerobic Exercise Cardiopulmonary Capacity Primary Fibromyalgia Syndrome
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Synergistic catalysis of the N-hydroxyphthalimide on flower-like bimetallic metal-organic frameworks for boosting oxidative desulfurization
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作者 Jing He Kun Zhu +5 位作者 Wei Jiang Dong-Ao Zhu Lin-Hua Zhu Hai-Yan Huang Wen-Shuai Zhu Hua-Ming Li 《Petroleum Science》 SCIE EI CAS CSCD 2024年第1期674-682,共9页
Synergic catalytic effect between active sites and supports greatly determines the catalytic activity for the aerobic oxidative desulfurization of fuel oils.In this work,Ni-doped Co-based bimetallic metal-organic fram... Synergic catalytic effect between active sites and supports greatly determines the catalytic activity for the aerobic oxidative desulfurization of fuel oils.In this work,Ni-doped Co-based bimetallic metal-organic framework(CoNi-MOF)is fabricated to disperse N-hydroxyphthalimide(NHPI),in which the whole catalyst provides plentiful synergic catalytic effect to improve the performance of oxidative desulfurization(ODS).As a bimetallic MOF,the second metal Ni doping results in the flower-like morphology and the modification of electronic properties,which ensure the exposure of NHPI and strengthen the synergistic effect of the overall catalyst.Compared with the monometallic Co-MOF and naked NHPI,the NHPI@CoNi-MOF triggers the efficient activation of molecular oxygen and improves the ODS performance without an initiator.The sulfur removal of dibenzothiophene-based model oil reaches 96.4%over the NHPI@CoNi-MOF catalyst in 8 h of reaction.Furthermore,the catalytic product of this aerobic ODS reaction is sulfone,which is adsorbed on the catalyst surface due to the difference in polarity.This work provides new insight and strategy for the design of a strong synergic catalytic effect between NHPI and bimetallic supports toward high-activity aerobic ODS materials. 展开更多
关键词 Metal-organic frameworks DOPED BIMETALLIC N-HYDROXYPHTHALIMIDE Aerobic processes Oxidative desulfurization
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Direct-Seeded Rice: Genetic Improvement of Game-Changing Traits for Better Adaption
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作者 Priyanka NEGI Jagadish RANE +10 位作者 Rajendra Sadashiv WAGH Tukaram Jayaram BHOR Dipti Digambar GODSE Priyanka JADHAV C.ANILKUMAR Dasari SREEKANTH K.SAMMI REDDY Sharad Ramrao GADAKH K.M.BORAIH C.B.HARISHA P.S.BASAVARAJ 《Rice science》 SCIE CSCD 2024年第4期417-433,共17页
The sustainability of rice production continues to be a subject of uncertainty and inquiry attributed to shifts in climatic conditions. In light of the impending climate change crisis and the high labor and water cost... The sustainability of rice production continues to be a subject of uncertainty and inquiry attributed to shifts in climatic conditions. In light of the impending climate change crisis and the high labor and water costs accompanying it, direct-seeded rice(DSR) is unquestionably one of the most practical solutions. Despite its resource and climate-friendly advantages, early maturing rice faces weed competitiveness and seedling establishment challenges. Resolving these issues is crucial for promoting its wider adoption among farmers, presenting it as a more effective sustainable rice cultivation method globally. Diverse traditional and contemporary breeding methods are employed to mitigate the limitations of the DSR approach, leveraging advanced techniques such as speed breeding and genome editing. Focusing on key traits like mesocotyl length elongation, early seedling vigor, root system architecture, and weed competitiveness holds promise for transformative improvements in DSR adaptation at a broader scale within farming communities. This review aims to summarize how these features contribute to increased crop production in DSR conditions and explore the research efforts focusing on enhancing DSR adaptation through these traits. Emphasizing the pivotal role of these game-changing traits in DSR adaptation, our analysis sheds light on their potential transformative impact and offers valuable insights for advancing DSR practices. 展开更多
关键词 climate change direct-seeded rice aerobic rice early vigor trait
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Intervention control of aerobic exercise in maintaining quality of life and pulmonary hypertension in hemodialysis patients
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作者 Dan-Dan Wang Min Cheng Chun-Ying Chen 《World Journal of Clinical Cases》 SCIE 2024年第20期4217-4229,共13页
BACKGROUND Pulmonary hypertension is a serious complication in the treatment of maintenance hemodialysis patients,which seriously affects the quality of life of patients and threatens their life safety.Prevention,trea... BACKGROUND Pulmonary hypertension is a serious complication in the treatment of maintenance hemodialysis patients,which seriously affects the quality of life of patients and threatens their life safety.Prevention,treatment and improvement of pulmonary hypertension are of great significance to improve the quality of life of patients.AIM To investigate the intervention and control of pedal-powered bicycle in maintaining quality of life and pulmonary hypertension in hemodialysis patients.METHODS 73 patients with maintenance hemadialysis combined with pulmonary arterial hypertension at a hemodialysis center in a certain hospital from May 2021 to May 2022 are selected.Patients are divided into two groups,37 cases in the control group(group C)and 36 cases in the intervention group(group I).Patients are divided into two groups,group C is treated with oral administration of betaglandin sodium combined with routine nursing care.Based on group C,group I conducts power cycling exercises.RESULTS After treatment,group I patients had higher muscle strength,36-Item Short Form Health Survey scores,and Kidney Disease Targets Areas scores;The 6-minute walk distance test index level was higher and the Borg score was lower;The group I had lower systolic blood pressure,greater vital capacity,higher positive emotion,lower systolic pulmonary artery pressure index level,higher arterial partial oxygen pressure level,lower pulmonary vascular resistance index level,and higher blood oxygen saturation level[158.91±11.89 vs 152.56±12.81,1795.01±603.18 vs 1907.20±574.15,24.00(22.00,29.00)vs 24.00(22.00,28.00),P<0.001].CONCLUSION Aerobic exercise combined with Western medicine treatment can effectively improve patients'pulmonary hypertension,alleviate their negative emotions,and enable them to achieve a higher level of quality of life. 展开更多
关键词 Aerobic exercise HEMODIALYSIS Pulmonary arterial hypertension Cycle ergometer Quality of life
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Impact of a 12-wk physical conditioning program on the aerobic capacity of aviation cadets
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作者 Hao Luo Ding-Yu Zhao Juan Li 《World Journal of Clinical Cases》 SCIE 2024年第20期4239-4246,共8页
BACKGROUND Flight cadets need to have good physical fitness to cope with the challenges of flying missions.The continuous development of science and technology has led to the constant upgrading of fighter jets and the... BACKGROUND Flight cadets need to have good physical fitness to cope with the challenges of flying missions.The continuous development of science and technology has led to the constant upgrading of fighter jets and the improvement of their performance,which has resulted in new and higher requirements for the physical fitness of flight personnel.The traditional physical training mode,method,and assessment have been used for many years and do not meet current fitness needs.AIM To investigate the impact of a 12-wk comprehensive anti-G fitness training program on the aerobic capacity of aviation cadets and to evaluate its effectiveness.METHODS Fifty-five cadets were randomly assigned to control and experimental groups using a randomized,single-blind design.The control group maintained their existing training regimen,while the experimental group participated in a 12-wk comprehensive training intervention.The training program comprised strength training twice per week,high-intensity interval training three times per week,and supplemental nutritional and psychological support.Maximal oxygen uptake(VO2max),lower limb strength,and hemoglobin levels were measured at baseline,at 6 wk and 12 wk post-intervention.RESULTS Repeated measures analysis of variance revealed significant differences of both VO2max and relative VO2 in both groups across time points(P<0.05).However,no significant time-group interaction was observed(P>0.05).Paired t-tests comparing baseline and 12-wk results showed that VO2max and relative VO2 were significantly higher in the experimental group than the control group(P<0.05).This suggests that the training program effectively enhanced the aerobic capacity of the experimental group.Key indicators of aerobic capacity,bilateral lower limb strength and hemoglobin levels,were also significantly different over time and between groups(P<0.05).No significant differences were noted in heart-rate metrics(P>0.05).CONCLUSION A 12-wk comprehensive anti-G fitness training program significantly improved the aerobic capacity of aviation cadets,thereby enhancing their overall capacity and laying a physiological foundation for enduring high-G flights. 展开更多
关键词 Aviation cadets Aerobic capacity Physical training High-intensity interval training Anti-G fitness
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Role of aerobic glycolysis in alzheimer's disease and research progress of traditional Chinese medicine
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作者 LIAO Nai-bin CHEN Wei +5 位作者 ZHU Xiao-min LIAO Shi-feng LI Qian-qian LIANG Yi MAI Fang-yu HE Ai-xin 《Journal of Hainan Medical University》 CAS 2024年第3期69-73,共5页
Alzheimer's disease (AD) is an irreversible neurodegenerative disease with a variety of pathogenic factors and complex pathogenesis, so that the disease has a high prevalence and mortality in the world. Although t... Alzheimer's disease (AD) is an irreversible neurodegenerative disease with a variety of pathogenic factors and complex pathogenesis, so that the disease has a high prevalence and mortality in the world. Although the current diagnosis and treatment equipment and drug research and development keep pace with the times, the current medical technology still can not completely cure the disease, so it is of great significance to explore the pathogenesis and treatment target of AD. The disorder of energy metabolism is one of the characteristic changes in the pathological process of AD. Aerobic glycolysis (AEG) is a special metabolic pathway in the brain, which can rapidly consume glucose to produce energy and substrate for neurons, improve synaptic plasticity, neuroinflammation and oxidative damage, and contribute to the recovery of memory and cognitive function. In recent years, many literatures have reported the mechanism of AEG in AD and the intervention of Tradit Chin Med on this mechanism. The purpose of this paper is to summarize the role of AEG in AD and the related research on the regulation and control of AEG in the treatment of AD by Tradit Chin Med, in order to provide reference and ideas for the prevention and treatment of AD with Tradit Chin Med in the future. 展开更多
关键词 Alzheimer disease Aerobic glycolysis Traditional Chinese medicine Energy metabolism
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Behavior,toxicity and diffusive flux of metals in a sediment core and pore-water from Anzali wetland
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作者 Y.Mehdizadeh A.R.Karbassi +1 位作者 T.Nasrabadi A.Sarang 《Acta Geochimica》 EI CAS CSCD 2023年第2期309-331,共23页
Concentrations of metals along with pH,potential redox(Eh),total dissolved solid(TDS),electrical conductivity(EC)and salinity were measured for sediments of different layers,pore and surface water in the Anzali wetlan... Concentrations of metals along with pH,potential redox(Eh),total dissolved solid(TDS),electrical conductivity(EC)and salinity were measured for sediments of different layers,pore and surface water in the Anzali wetland.Also,the diffusive flux of metals was calculated ad compared with the values in other aquatic bodies.The abundance of metals in sediments was Al>Fe>Ca>Ti>Mn>Zn>V>Cr>Ni>Cu>Pb>Co>As>Mo>Ag>Cd,while the pore-water results indicated a different concentration profile:Ca>Mn>Fe>Al>V>Mo>As>Ni>Cu>Co.Anzali wetland is classified within a high ecological risk.Pore-water toxicity test showed it is in non-polluted condition.Eh–pH diagrams showed that all species of elements are in a stable state in surface and pore-waters.However,Mn and Co(in some layers)are in soluble form and free ions and thus are bioavailable to the organisms.V and As are also present in the form of hydrogen compounds and Ni in the form of hydroxides,therefore,they are toxic to aquatic animals due to their solubility and ionic forms.Diffusive fluxes for As,Al,Fe,Ca,Cu,Mn,Mo,Ni and V are 0.43,1.80,48.52,43,147.50,0.12,1.47,0.15,1.28,0.21μg/m^(2)/day,respectively.Cluster analysis showed that in a solid phase of sediments,elements such as Cr,As and Ti are of petroleum and terrestrial origin.In pore-waters,Cu is of petroleum and biological origin,and Mo,As,Cu and Co are controlled by p H. 展开更多
关键词 AQUATIC Environment Pollution AEROBIC GEOCHEMISTRY Elements
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Non-exercise estimated cardiorespiratory fitness and cancer incidence:The NIH-AARP diet and health study
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作者 Baruch Vainshelboim Jonathan Myers Charles EMatthews 《Journal of Sport and Health Science》 SCIE CAS CSCD 2023年第6期739-746,共8页
Background Non-exercise estimated cardiorespiratory fitness(NEE-CRF)has been shown to be associated with mortality,although its association with cancer incidence is unknown.The study aimed to assess the prospective as... Background Non-exercise estimated cardiorespiratory fitness(NEE-CRF)has been shown to be associated with mortality,although its association with cancer incidence is unknown.The study aimed to assess the prospective association between NEE-CRF and cancer incidence in a large cohort of men and women.Methods The National Institutes of Health-American Association of Retired Persons diet and health study is a prospective cohort that included 402,548 participants aged 50–71 years who were free from cancer at baseline(1995–1996)(men(n=238,835)and women(n=163,713))and were followed until December 31,2015.The exposure variable was NEE-CRF expressed in metabolic equivalents.NEE-CRF was estimated using a validated equation of self-reported predictors on demographics and lifestyle behaviors derived from baseline questionnaires.Primary outcomes were total cancer incidence and incidence of prostate,breast,lung,and colorectal cancers.Cox proportional hazards models were analyzed for the association between NEE-CRF and cancer incidence outcomes adjusted for established cancer risk factors.Results During 13.7±3.2 years of follow-up(mean±SD),64,344 men and 31,315 women developed a new cancer.For every 1-metabolic equivalent higher NEE-CRF,the hazard ratios and 95%confidence intervals(95%CIs)were 0.96(95%CI:0.94–0.97)and 0.88(95%CI:0.84–0.92)of total and colorectal cancer incidence among men,and 0.95(95%CI:0.93–0.97)and 0.94(95%CI:0.91–0.97)of total and breast cancer incidence among women,respectively(all p<0.001).NEE-CRF was not associated with incidence of prostate and lung cancers in men or colorectal and lung cancers in women.Conclusion These results suggest that higher CRF levels,as assessed by the applied non-exercise estimated method,may provide preventive benefits against the development of cancer,while low CRF could potentially serve as a modifiable cancer risk factor.Integrating NEE-CRF into screening paradigms and referring low-fit individuals to improve CRF could complement the public health prevention strategy against cancer. 展开更多
关键词 Aerobic capacity Breast cancer Cancer risk Colorectal cancer VO_(2max)
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Assessing quinoline removal performances of an aerobic continuous moving bed biofilm reactor(MBBR) bioaugmented with Pseudomonas citronellolis LV1
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作者 Hu Chen Ying Wang +1 位作者 Puyu Wang Yongkang Lv 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2023年第5期132-140,共9页
This study evaluated the bioaugmentation potential of a quinoline-degrading strain Pseudomonas citronellolis LV1 inoculation into activated sludge for treating quinoline wastewater, and results indicated the inoculati... This study evaluated the bioaugmentation potential of a quinoline-degrading strain Pseudomonas citronellolis LV1 inoculation into activated sludge for treating quinoline wastewater, and results indicated the inoculation of LV1 in aerobic continuous MBBR could substantially improve the quinoline removal performance with an improved removal efficiency of 34% averagely when quinoline was used as the sole carbon and nitrogen source. Additionally, efficient removal of quinoline in enhanced MBBR occurred at the influent p H of 7.0–8.0, hydraulic retention time(HRT) of 24–28 h and influent quinoline concentration of 100–700 mg·L^(-1). High-throughput sequencing analysis indicated that bioaugmentation could increase microbial diversity and shape the microbial community structure. Although the inoculant LV1 did not remain its dominance in stage Ⅲ, bioaugmentation indeed induced the formation of effective microbial community, and the indigenous microbes including Flavobacterium, Pseudoxanthomonas,Pseudomonas, Vermamoeba, Dyadobacter and Sphingomonas might play the key role in quinoline removal.According to the PICRUSt, the enhanced genes encoding aromatic ring-cleavage enzyme, especially for Nheterocyclic ring-cleavage enzymes, could lead to the improved removal performance of quinoline in bioaugmentation stage. Moreover, the enhanced MBBR treated well actual coking wastewater, as indicated by high removal performance of quinoline, phenol and COD. 展开更多
关键词 Aerobic quinoline degradation Pseudomonas citronellolis LV1 BIOAUGMENTATION Microbial community Coking wastewater
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Study on the catalytic degradation of sodium lignosulfonate to aromatic aldehydes over nano-CuO:Process optimization and reaction kinetics
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作者 Yingjie Song Shuqi Zhong +5 位作者 Yingjiao Li Kun Dong Yong Luo Guangwen Chu Haikui Zou Baochang Sun 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2023年第1期300-309,共10页
As one of the few renewable aromatic resources,the research of depolymerization of lignin into highvalue chemicals has attracted extensive attention in recent years.Catalytic wet aerobic oxidation(CWAO)is an effective... As one of the few renewable aromatic resources,the research of depolymerization of lignin into highvalue chemicals has attracted extensive attention in recent years.Catalytic wet aerobic oxidation(CWAO)is an effective technology to convert lignin like sodium lignosulfonate(SL),a lignin derivative,into aromatic aldehydes such as vanillin and syringaldehyde.However,how to improve the yield of aromatic aldehyde and conversion efficiency is still a challenge,and many operating conditions that significantly affect the yield of these aromatic compounds have rarely been investigated systematically.In this work,we adopted the stirred tank reactor(STR)for the CWAO process with nano-CuO as catalyst to achieve the conversion of SL into vanillin and syringaldehyde.The effect of operating conditions including reaction time,oxygen partial pressure,reaction temperature,SL concentration,rotational speed,catalyst amount,and NaOH concentration on the yield of single phenolic compound was systematically investigated.The results revealed that all these operating conditions exhibit a significant effect on the aromatic aldehyde yield.Therefore,they should be regulated in an optimal value to obtain high yield of these aldehydes.More importantly,the reaction kinetics of the lignin oxidation was explored.This work could provide basic data for the optimization and design of industrial operation of lignin oxidation. 展开更多
关键词 NANO-CUO Sodium lignosulfonate Catalytic wet aerobic oxidation(CWAO) Aromatic aldehyde Reaction kinetics
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Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect
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作者 Piao Luo Qian Zhang +10 位作者 Tian-Yu Zhong Jia-Yun Chen Jun-Zhe Zhang Ya Tian Liu-Hai Zheng Fan Yang Ling-Yun Dai Chang Zou Zhi-Jie Li Jing-Hua Liu Ji-Gang Wang 《Military Medical Research》 SCIE CAS CSCD 2023年第1期17-31,共15页
Background: Sepsis involves life-threatening organ dysfunction and is caused by a dysregulated host response to infection. No specific therapies against sepsis have been reported. Celastrol(Cel) is a natural anti-infl... Background: Sepsis involves life-threatening organ dysfunction and is caused by a dysregulated host response to infection. No specific therapies against sepsis have been reported. Celastrol(Cel) is a natural anti-inflammatory compound that shows potential against systemic inflammatory diseases. This study aimed to investigate the pharmacological activity and molecular mechanism of Cel in models of endotoxemia and sepsis.Methods: We evaluated the anti-inflammatory efficacy of Cel against endotoxemia and sepsis in mice and macrophage cultures treated with lipopolysaccharide(LPS). We screened for potential protein targets of Cel using activity-based protein profiling(ABPP). Potential targets were validated using biophysical methods such as cellular thermal shift assays(CETSA) and surface plasmon resonance(SPR). Residues involved in Cel binding to target proteins were identified through point mutagenesis, and the functional effects of such binding were explored through gene knockdown.Results: Cel protected mice from lethal endotoxemia and improved their survival with sepsis, and it significantly decreased the levels of pro-inflammatory cytokines in mice and macrophages treated with LPS(P <0.05). Cel bound to Cys424 of pyruvate kinase M2(PKM2), inhibiting the enzyme and thereby suppressing aerobic glycolysis(Warburg effect). Cel also bound to Cys106 in high mobility group box 1(HMGB1) protein, reducing the secretion of inflammatory cytokine interleukin(IL)-1β. Cel bound to the Cys residues in lactate dehydrogenase A(LDHA).Conclusions: Cel inhibits inflammation and the Warburg effect in sepsis via targeting PKM2 and HMGB1 protein. 展开更多
关键词 CELASTROL SEPSIS Pyruvate kinase M2 High mobility group box 1 Aerobic glycolysis
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Synergy in magnetic Ni_(x)Co_(1)O_(y) oxides enables base-free selective oxidation of 5-hydroxymethylfurfural on loaded Au nanoparticles
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作者 Hao Zhang Yinghao Wang +5 位作者 Qizhao Zhang Bang Gu Qinghu Tang Qiue Cao Kun Wei Wenhao Fang 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2023年第3期526-536,I0014,共12页
The base-free aerobic oxidation of 5-hydroxymethylfurfural(HMF) to 2,5-furandicarboxylic acid(FDCA)in water is recognized as an important and sustainable upgrading process for cellulosic carbohydrates.However,selectiv... The base-free aerobic oxidation of 5-hydroxymethylfurfural(HMF) to 2,5-furandicarboxylic acid(FDCA)in water is recognized as an important and sustainable upgrading process for cellulosic carbohydrates.However,selectivity control still remains a challenge.Here,we disclose that the unique synergy in magnetic Ni_(x)Co_(1)O_(y)(x=1,3 and 5) bimetallic oxides can induce reactive oxygen defects and simultaneously stabilize small-sized metallic Au nanoparticles in the Au/Ni_(x)Co_(1)O_(y)catalysts.Such catalytic features render effective adsorption and activation of O_(2),OH and C=O groups,realizing selective oxidation of HMF to FDCA.On a series of magnetic Au/Ni_(x)Co_(1)O_(y)catalysts with almost identical Au loadings(ca.0.5 wt%) and particle sizes(ca.2.7 nm),the variable Ni/Co molar ratios give rise to the tunable electron density of Au sites and synergistic effect between NiO and CoO_(y).The initial conversion rates of HMF and its derived intermediates(i.e., DFF,HMFCA and FFCA) show a volcano-like dependence on the number of oxygen defects(i.e.,O_(2)^(-)and O^(-)) and electron-rich Au0sites.The optimum Au/Ni3Co1Oycatalyst exhibits a highest productivity of FDCA(12.5 mmol_(FDCA)mol_(Au)^(-1)h^(-1)) among all the Au catalysts in the literature and achieves> 99% yield of FDCA at 120℃ and 10 bar of O_(2).In addition,this catalyst can be easily recovered by a magnet and show superior stability and reusability during six consecutive cycling tests.This work may shed a light on Au catalysis for the base-free oxidation of biomass compounds by smartly using the synergy in bimetallic oxide carriers. 展开更多
关键词 Aerobic oxidation 2 5-Furandicarboxylic acid C=O group conversion Magnetic catalyst Oxygen defects Synergistic effect
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MiR-194-5p suppresses the warburg effect in ovarian cancer cells through the IGF1R/PI3K/AKT axis
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作者 LIJUN DU KAIKAI DOU +2 位作者 NIANHAI LIANG JIANMIN SUN RU BAI 《BIOCELL》 SCIE 2023年第3期547-554,共8页
Background:The Warburg effect is considered as a hallmark of various types of cancers,while the regulatory mechanism is poorly understood.Our previous study demonstrated that miR-194-5p directly targets and regulates ... Background:The Warburg effect is considered as a hallmark of various types of cancers,while the regulatory mechanism is poorly understood.Our previous study demonstrated that miR-194-5p directly targets and regulates insulin-like growth factor1 receptor(IGF1R).In this study,we aimed to investigate the role of miR-194-5p in the regulation of the Warburg effect in ovarian cancer cells.Methods:The stable ovarian cell lines with miR-194-5p overexpression or silencing IGF1R expression were established by lentivirus infection.ATP generation,glucose uptake,lactate production and extracellular acidification rate(ECAR)assay were used to analyze the effects of aerobic glycolysis in ovarian cancer cells.Gene expression was analyzed by quantitative polymerase chain reaction(qPCR)and western blot.Immunohistochemistry assays were performed to assess the expression of the IGF1R protein in ovarian cancer tissues.Results:Overexpression of miR-194-5p or silencing IGF1R expression in ovarian cancer cells decreases ATP generation,glucose uptake,lactate production,and ECAR and inhibits both the mRNA and protein expression of PKM2,LDHA,GLUT1,and GLUT3.While the knockdown of miR-194-5p expression led to opposite results.Overexpression of miR-194-5p or silencing IGF1R expression suppressed the phosphatidylinositol-3-kinase/protein kinase B(PI3K/AKT)pathway,whose activation can sustain aerobic glycolysis in cancer cells,and the knockdown of miR-194-5p expression promoted the activation of the PI3K/AKT pathway.Conclusion:Our results suggest that miR-194-5p can inhibit the Warburg effect by negative regulation of IGF1R and further repression of the PI3K/AKT pathway,which provides a theoretical basis for further test of miR-194-5p as a target in the treatment of ovarian cancer. 展开更多
关键词 Ovarian cancer Aerobic glycolysis MICRORNA
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Exercise interventions for patients with type 1 diabetes mellitus:A narrative review with practical recommendations
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作者 Fernando Martin-Rivera Sergio Maroto-Izquierdo +1 位作者 David García-López Jesús Alarcón-Gómez 《World Journal of Diabetes》 SCIE 2023年第5期539-548,共10页
Type 1 diabetes mellitus(T1DM)is a chronic endocrine disease that results from autoimmune destruction of pancreatic insulin-producingβcells,which can lead to microvascular(e.g.,retinopathy,neuropathy,and nephropathy)... Type 1 diabetes mellitus(T1DM)is a chronic endocrine disease that results from autoimmune destruction of pancreatic insulin-producingβcells,which can lead to microvascular(e.g.,retinopathy,neuropathy,and nephropathy)and macrovascular complications(e.g.,coronary arterial disease,peripheral artery disease,stroke,and heart failure)as a consequence of chronic hyperglycemia.Despite the widely available and compelling evidence that regular exercise is an efficient strategy to prevent cardiovascular disease and to improve functional capacity and psychological well-being in people with T1DM,over 60%of individuals with T1DM do not exercise regularly.It is,therefore,crucial to devise approaches to motivate patients with T1DM to exercise,to adhere to a training program,and to inform them of its specific characteristics(e.g.,exercise mode,intensity,volume,and frequency).Moreover,given the metabolic alterations that occur during acute bouts of exercise in T1DM patients,exercise prescription in this population should be carefully analyzed to maximize its benefits and to reduce its potential risks. 展开更多
关键词 Type 1 diabetes mellitus EXERCISE Resistance training High-intensity interval training Aerobic training Quality of life
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Meta-analysis of the effects of high-intensity intermittent exercise on cardiopulmonary function rehabilitation in patients with stroke
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作者 WANG Cheng-shuo WU Sheng-zhu +3 位作者 WU Liang XU Ya-nan ZHANG Lin-li YONG Ming-jin 《Journal of Hainan Medical University》 CAS 2023年第23期56-63,共8页
Objective:Systematically evaluate the rehabilitation effect of high-intensity intermittent exercise(HIIT)on cardiovascular function in stroke patients,in order to provide a basis for selecting the best rehabilitation ... Objective:Systematically evaluate the rehabilitation effect of high-intensity intermittent exercise(HIIT)on cardiovascular function in stroke patients,in order to provide a basis for selecting the best rehabilitation plan for stroke patients.Methods:Computer retrieval of CNKI,WanFang Data,VIP,CBM,Pubmed,EMbase,Web of science,The Cochrane Library databases was conducted from the establishment of the database until March 2023.Randomized controlled trials on HIIT improving cardiovascular function in stroke patients were included,and the included literature was screened,data extracted,and bias risk evaluated.Then,metaanalysis was conducted using RevMan 5.4 software and Stata17.0 software.Results:In the end,9 articles met the research criteria,with a total of 428 patients.The meta-analysis results showed that compared with the control group,HIIT had significant effects on peak oxygen uptake(VO2peak)[MD=3.87,95%CI(3.43,4.31),P<0.00001],minute ventilation(VE)[MD=7.14,95%CI(4.34,9.94),P<0.00001],peak power(WRpeak)[MD=17.13,95%CI(13.7320.54),P<0.00001],6-minute walking distance(6MWD)[MD=43.82,95%CI(16.08,71.56),P=0.002],The intervention effect of the 10 meter walking test(10MWT)[MD=-2.00,95%CI(-2.91,-1.08),P<0.0001]was better than that of the control group.Conclusion:The current analysis results show that compared to conventional rehabilitation therapy or continuous aerobic exercise,HIIT has more advantages in improving the cardiopulmonary function of stroke patients. 展开更多
关键词 High intensity intermittent exercise Continuous aerobic exercise STROKE Cardiopulmonary function Meta analysis
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Effect of Resistance Training,Aerobic Exercise Before Doula-Assisted Delivery on the Psychological Well-Being and Labor Duration of Parturients
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作者 Jing Zhou Sha Tang +2 位作者 Li Zhou Cong Jiang Wenjian Fan 《Journal of Clinical and Nursing Research》 2023年第6期118-123,共6页
Objective:To investigate the impact of resistance training and aerobic exercise before doula-assisted delivery on the psychological well-being and labor duration of parturients.Methods:105 cases of parturients who gav... Objective:To investigate the impact of resistance training and aerobic exercise before doula-assisted delivery on the psychological well-being and labor duration of parturients.Methods:105 cases of parturients who gave birth in our hospital from February 2021 to April 2023 were included in this study.The patients were divided into a control group of 52 cases and an observation group of 53 cases.The patients in the control group received no particular intervention before delivery and only received doula assistance.The patients in the observation group received resistance training,aerobic exercise,and doula assistance prior to giving birth.After delivery,the mothers were observed for 2 hours in the delivery room and then returned to the maternal and infant ward.The observation indicators of the two groups were compared.Results:In comparison to the control group,the observation group exhibited shorter durations in the first,second,and third stages of labor,as well as the total delivery time.Additionally,the amount of postpartum blood loss at 2 hours was smaller in the observation group.The rate of cesarean section was lower,and the rate of vaginal natural delivery was higher in the observation group.Following the intervention,both groups of postpartum women showed decreased SAS and SDS scores compared to before the intervention.Moreover,the observation group had lower scores than the control group.These differences were all statistically significant(P<0.05).Conclusion:Resistance training and aerobic exercise before doula-assisted delivery can effectively improve the psychological state of parturients,shorten labor duration,increase the rate of natural vaginal delivery,and reduce pain and postpartum hemorrhage. 展开更多
关键词 Doula assistance Resistance training Aerobic exercise PARTURIENT Psychological state Labor duration
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The assessment of good and bad bacteria in holy basil(Ocimum sanctum)leaves
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作者 Bhoj R Singh Mudit Chandra +3 位作者 Himani Agri Ravichandran Karthikeyan Akanksha Yadav Varsha Jayakumar 《Infectious Diseases Research》 2023年第4期1-21,共21页
Holy basil(Tulsi,Ocimum sanctum)is considered to be a pious plant.It is used not only in many of the rituals of Hindus but is also known for its innumerable medicinal qualities.Holy basil leaves(HBLs)are often consume... Holy basil(Tulsi,Ocimum sanctum)is considered to be a pious plant.It is used not only in many of the rituals of Hindus but is also known for its innumerable medicinal qualities.Holy basil leaves(HBLs)are often consumed raw thus it is pertinent to detect the bacteria on Tulsi leaves.This study was conducted to understand the diversity of the aerobically growing microbiome of edible holy basil leaves.A total of 112 samples of leaves were collected from households of six localities in and around Bareilly,India for detecting culturable bacteria growing aerobically.A sum of 579 bacterial isolates belonging to 106 different species was identified.Pantoea agglomerans isolates were detected in 43 samples followed by isolates Virgibacillus pantothenticus(21),Bacillus coagulans(18),Bacillus cereus(17),Geobacillus stearothermophilus(16),Klebsiella pneumoniae(13),Citrobacter freundii(12),Lysinibacillus sphaericus(12),Acinetobacter calcoaceticus(11),Escherichia coli(11),and Xenorhabdus bovienii(11).Isolates of 95 species of bacteria were detected on<10 samples of HBLs.Of 579 isolates,161 isolates detected in 68(60.71%)samples were of putatively good bacteria belonging to eight genera(Bacillus,Brevibacillus,Lysinibacillus,Paenibacillus,Photobacter,Siccibacter,Virgibacillus,Xenoirhabdus)and 23 species.However,418 bacterial isolates detected in 108(96.43%)of the HBL samples were classified as potentially pathogenic for humans and animals belonging to 34 genera and 73 species.There were only four samples(three from Mahanagar and one from Bhojipura)that had no potential pathogenic bacteria detected in this study.The analysis indicated that HBL leaves from the ICAR-IVRI campus had a lower probability(P<0.04)of harbouring good bacteria than samples from Bhojpura,Mahanagar,North City and Rajendra Nagar.Cinnamaldehyde inhibiting 96.72%of the isolates and carvacrol inhibiting 96.37%of the isolates were the best herbal antimicrobials and among antibiotics,meropenem inhibited 98.96%of bacterial isolates.Antimicrobial resistance in non-pathogenic or good bacteria was significantly more common(P<0.01)for ajowan oil but they were more often(P<0.05)susceptible to holy basil oil,lemongrass oil,citral,P.embalica leaf extract,P.longifolia seed oil,nitrofurantoin,ciprofloxacin,chloramphenicol,colistin and minocycline than isolates of potentially pathogenic bacteria.The study concludes that HBLs may harbour both good and bacteria,and should be consumed raw only after proper decontamination. 展开更多
关键词 Ocimum sanctum antimicrobial susceptibility assay aerobic culture isolation good and bad bacteria
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需氧菌性阴道炎198例的临床分析 被引量:4
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作者 刘智慧 于慧君 史小荣 《中国药物与临床》 CAS 2016年第7期1065-1067,共3页
阴道炎症是妇科门诊最常见的疾病之一,对该病的分类、临床特征及诊断、治疗方法等一系列问题,临床上已经有较为深入的研究和比较统一的认识。但是工作中时常会遇到,反复发病、难以治愈的阴道炎患者。由此引发人们对其他未知致病菌的探索... 阴道炎症是妇科门诊最常见的疾病之一,对该病的分类、临床特征及诊断、治疗方法等一系列问题,临床上已经有较为深入的研究和比较统一的认识。但是工作中时常会遇到,反复发病、难以治愈的阴道炎患者。由此引发人们对其他未知致病菌的探索,2002年Donders等首先等提出需氧菌性阴道(aerobic vaginitis)的概念及显微镜湿片法诊断标准。 展开更多
关键词 需氧菌 阴道炎症 混合菌群 湿片 阴道疾病 阴道微生态 AEROBIC 细菌性阴道病 外阴阴道 滴虫性阴道炎
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有氧舞蹈融入高校健美操教学的实践研究——以安徽工贸职业技术学院为例 被引量:2
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作者 江楠 《集宁师范学院学报》 2018年第3期71-76,共6页
将有氧舞蹈融入到健美操教学实践中,通过一学期的教学实验,了解学生的感受和教师的反馈,从而为有氧舞蹈今后在淮南市高校健美操课程中的推广提供一定的理论参考。结果表明:融入曲风多样、动作自由多变等元素的有氧舞蹈内容的健美操教学... 将有氧舞蹈融入到健美操教学实践中,通过一学期的教学实验,了解学生的感受和教师的反馈,从而为有氧舞蹈今后在淮南市高校健美操课程中的推广提供一定的理论参考。结果表明:融入曲风多样、动作自由多变等元素的有氧舞蹈内容的健美操教学,增强了学生的参与意识,提高了学生的学习积极性和学习兴趣,从而激发了学生的内部动机。相对于对照组单一的健美操教学,实验组融入的有氧舞蹈教学,由于其开放和积极向上的作用,更有利于提高学生的沟通意识和合作精神。实验组考试成绩高于对照组的原因源于学习兴趣、积极性等各方面因素的综合。 展开更多
关键词 AEROBIC DANCE COLLEGES and UNIVERSITIES AEROBIC teaching practice a case study
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3M测纸片检测原料乳菌落总数的比较试验 被引量:5
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作者 宋春花 《中国食品工业》 2004年第A11期60-61,共2页
传统的原料乳微生物检测是按照国标的方法,其主要缺点为:需配制培养基,消毒及清洗操作繁琐且工作量大,培养所占空间很大。这种传统检验方法的所需人力较多、耗时长,很难适应现代化品质管理要求,国外微生物快速检测技术日新月异,本文对美... 传统的原料乳微生物检测是按照国标的方法,其主要缺点为:需配制培养基,消毒及清洗操作繁琐且工作量大,培养所占空间很大。这种传统检验方法的所需人力较多、耗时长,很难适应现代化品质管理要求,国外微生物快速检测技术日新月异,本文对美国3M公司生产的已获得AOAC,AFNOR等国际组织认可的细菌总数测试片进行了对比实验。 1 实验材料 1.1 3M Petrifilm Aerobic Count Plates测试片(以下简称AC测试片) 展开更多
关键词 原料乳 测试片 微生物检测 菌落总数 快速检测技术 AEROBIC 细菌总数 菌落计数 清洗操作
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