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Study of Aerobics Effects on Female College Students' Health
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作者 Xinli Xing 《International Journal of Technology Management》 2013年第12期95-97,共3页
Aerobics includes gymnastics, music, dance and aesthetics, using specialized equipment by hand and holding light equipment to achieve fitness and operation of exercises, it is a bodybuilding methods centering for the ... Aerobics includes gymnastics, music, dance and aesthetics, using specialized equipment by hand and holding light equipment to achieve fitness and operation of exercises, it is a bodybuilding methods centering for the purpose of emerging entertainment and ornamental sports, and it is also a strong public artistic gymnastics. It is with superb skill, charming and colorful parade of action, posture which is coordinated with the music to demonstrate the extraordinary artistic charm, thus attracting more and more students to participate in. Because it is different from traditional hand gymnastic exercises, and does not have too high demands for space and equipment. Practicing it just needs fast-paced and lively musical accompaniment, and dynamic movements can make people feel good, so it wins the majority of young people, especially girls. Calisthenics is as one of the means to work out for students; in particular, it develops a lifelong habit of physical exercise and plays an important role for college girls' lifelong fitness awareness. The topic is studying female college students on aerobics body shape, function, quality and impact of mental health to promote the development of physical education reform. 展开更多
关键词 aerobics College Students HEALTH FITNESS
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Study on the Points Needing Attention in Aerobics Training of Junior College Students
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作者 Dan MIAO 《International Journal of Technology Management》 2013年第6期53-55,共3页
With the continuously increasing competition in the modern society, the learning pressure of students is getting greater and greater and many students are in shortage of reasonable time to take physical exercises so t... With the continuously increasing competition in the modern society, the learning pressure of students is getting greater and greater and many students are in shortage of reasonable time to take physical exercises so that they are in a state of sub-health for a long time. Aerobics, as a combination of music and sports, has been more and more popular among teachers and students. However, in aerobics training, the injuries to the physical bodies of students will be caused due to the improper training methods. Therefore, in this paper, the points needing attention in aerobics training is studied, and then scientific aerobics training methods are proposed. 展开更多
关键词 Junior College Students aerobics INJURIES Points Needing Attention
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Study on the Research and Application of Network Teaching Courseware in Aerobics in Colleges and Universities
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作者 Xiangxin Meng Huanxiang Ding +1 位作者 Yongjun Zhao Xueqin Zhuang 《International English Education Research》 2014年第11期41-45,共5页
Aerobics teaching in colleges and universities is the most important part of higher education, and the important means to carry out quality-oriented education and cultivate all-round developed talents. The reform of a... Aerobics teaching in colleges and universities is the most important part of higher education, and the important means to carry out quality-oriented education and cultivate all-round developed talents. The reform of aerobics teaching in colleges and universities should be geared to the demands of the times, and explore new innovation and continual development. In this paper, using the research methods of documentation, courseware development, teaching experiment and mathematical statistics, we study on the making and application of college aerobics network teaching courseware. It is revealed that, with the combination of modem network technology and college aerobics teaching, the resulted college aerobics network teaching courseware is the important media to not only upgrades college aerobics teaching quality, but also help develop students' habits of doing physical exercise, and promote physical health. Therefore, this is meaningful and practical in promoting the education of college students in physical quality development. 展开更多
关键词 Colleges and Universities aerobics the Network Teaching Courseware Prepare Test Application
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The influence that aerobics have on mental health of college students
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作者 Xinli Xing 《International Journal of Technology Management》 2013年第11期93-95,共3页
Aerobics become an indispensable item in college physical education class. The article will talk about the influence of aerobics on mental health of college students aiming at the fact that mass aerobics haven' t dev... Aerobics become an indispensable item in college physical education class. The article will talk about the influence of aerobics on mental health of college students aiming at the fact that mass aerobics haven' t developed very well. Aerobics expand the traditional pattern of school physical education, in addition to improve and animate sports classroom atmosphere; students can be fully met the physical and mental demand, so as students can be guided to actively participate in physical exercise, making further promotion of students' body and function development; students' physical fitness involving coordination, softness, power and endurance can also be fully developed. Students can develop good body posture, shape their physical beauty and performance of actions, cultivate sentiments and further demonstrate the beauty and health of themselves. 展开更多
关键词 aerobics mental health college students
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Research on Remote Aerobics Network Learning System based on B/S
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作者 Chao Fan 《International Journal of Technology Management》 2013年第1期14-16,共3页
through the design of teaching aerobics web-based course and application practice, the instructional design process based on B/ S learning are analyzed, and discusses several key problems in the design and teaching. T... through the design of teaching aerobics web-based course and application practice, the instructional design process based on B/ S learning are analyzed, and discusses several key problems in the design and teaching. This paper presents the resource based learning aerobics teaching design network course should adapt to the application mode of network teaching and traditional classroom combination; that will provide teaching demonstration, teaching contents for students as well as the function of self testing evaluation and provide the job management, teacher online Q & A, database and knowledge base construction, greatly improving the "aerobics" teaching efficiency. 展开更多
关键词 CAI B/S structure aerobics
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The Effects of the Aerobics Exercise Program on the Cardiopulmoner Capacity and Disease Symptoms of the Patients with Primary Fibromialgia Syndrome
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作者 Berat Meryem Alkan Sumru Ozel +1 位作者 Serap Tomruk Sütbeyaz Canan Culha 《Open Journal of Rheumatology and Autoimmune Diseases》 2013年第4期202-208,共7页
Backgrounds: To observe the effects of aerobic exercise program on the illness symptoms and cardiopulmonary capacity of the patients with primary Fibromyalgia Syndrome (FMS) and to find out whether there is a differen... Backgrounds: To observe the effects of aerobic exercise program on the illness symptoms and cardiopulmonary capacity of the patients with primary Fibromyalgia Syndrome (FMS) and to find out whether there is a difference or not in terms of cardiovascular capacity among the patients with primary FMS and sedentary healthy people. Materials and Methods: The study has been done on 20 female patients with primary FMS. Before the study and after a 6-week controlled aerobic exercise program, a cardiopulmonary exercise test has been applied on all cases. The symptoms, psychological state and life quality of the cases have been evaluated before and after the exercise program. The first cardiopulmonary results of the cases with FMS have been compared with a control group of 15 sedentary healthy. Results: When the patient and control groups are compared, although maksimal oxygen uptake (VO2 max) was lower in the patient group, this was not a significant difference. VO2 max showing the aerobic condition after the exercise increased significantly in the patients. Conclusions: Aerobic exercise programs lasting six to eight weeks are quite effective for the patients with FMS. There is not any limitation in the increase of the cardiopulmonary capacity of the patients after the exercise program. 展开更多
关键词 Aerobic Exercise Cardiopulmonary Capacity Primary Fibromyalgia Syndrome
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Exercise training mode effects on myokine expression in healthy adults:A systematic review with meta-analysis 被引量:1
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作者 Francesco Bettariga Dennis R.Taaffe +6 位作者 Daniel A.Galvao Pedro Lopez Chris Bishop Anna Maria Markarian Valentina Natalucci Jin-Soo Kim Robert U.Newton 《Journal of Sport and Health Science》 SCIE CAS CSCD 2024年第6期764-779,共16页
Background:The benefits of exercise are well known;however,many of the underlying molecular mechanisms are not fully understood.Skeletal muscle secretes myokines,which mediate muscleorgan crosstalk.Myokines regulate s... Background:The benefits of exercise are well known;however,many of the underlying molecular mechanisms are not fully understood.Skeletal muscle secretes myokines,which mediate muscleorgan crosstalk.Myokines regulate satellite-cell proliferation and migration,inflammatory cascade,insulin secretion,angiogenesis,fatty oxidation,and cancer suppression.To date,the effects of different exercise modes(namely,aerobic and resistance exercise)on myokine response remain to be elucidated.This is crucial considering the clinical implementation of exercise to enhance general health and wellbeing and as a medical treatment.Methods:A systematic search was undertaken in PubMed,MEDLINE,CINAHL,Embase,SPORTDiscus,andWeb of Science in April 2023.Eligible studies examining the effects of a single bout of exercise on interleukin15(IL-15),irisin,secreted protein acidic and rich in cysteine(SPARC),oncostatinM(OSM),and decorin were included.A random-effects meta-analysis was also undertaken to quantify the magnitude of change.Results:Sixty-two studies were included(n=1193).Overall,exercise appeared to induce small to large increases in myokine expression,with effects observed immediately after to 60 min post-exercise,although these were mostly not statistically significant.Both aerobic and resistance exercise resulted in changes in myokine levels,without any significant difference between training modes,and with the magnitude of change differing across myokines.Myokine levels returned to baseline levels within 180 min to 24 h post-exercise.However,owing to potential sources of heterogeneity,most changes were not statistically significant,indicating that precise conclusions cannot be drawn.Conclusion:Knowledge is limited but expanding with respect to the impact of overall and specific effects of exercise on myokine expression at different time points in the systemic circulation.Further research is required to investigate the effects of different exercise modes at multiple time points on myokine response. 展开更多
关键词 MYOKINE Resistance exercise Aerobic exercise CYTOKINE Systemic circulation
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Synergistic catalysis of the N-hydroxyphthalimide on flower-like bimetallic metal-organic frameworks for boosting oxidative desulfurization
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作者 Jing He Kun Zhu +5 位作者 Wei Jiang Dong-Ao Zhu Lin-Hua Zhu Hai-Yan Huang Wen-Shuai Zhu Hua-Ming Li 《Petroleum Science》 SCIE EI CAS CSCD 2024年第1期674-682,共9页
Synergic catalytic effect between active sites and supports greatly determines the catalytic activity for the aerobic oxidative desulfurization of fuel oils.In this work,Ni-doped Co-based bimetallic metal-organic fram... Synergic catalytic effect between active sites and supports greatly determines the catalytic activity for the aerobic oxidative desulfurization of fuel oils.In this work,Ni-doped Co-based bimetallic metal-organic framework(CoNi-MOF)is fabricated to disperse N-hydroxyphthalimide(NHPI),in which the whole catalyst provides plentiful synergic catalytic effect to improve the performance of oxidative desulfurization(ODS).As a bimetallic MOF,the second metal Ni doping results in the flower-like morphology and the modification of electronic properties,which ensure the exposure of NHPI and strengthen the synergistic effect of the overall catalyst.Compared with the monometallic Co-MOF and naked NHPI,the NHPI@CoNi-MOF triggers the efficient activation of molecular oxygen and improves the ODS performance without an initiator.The sulfur removal of dibenzothiophene-based model oil reaches 96.4%over the NHPI@CoNi-MOF catalyst in 8 h of reaction.Furthermore,the catalytic product of this aerobic ODS reaction is sulfone,which is adsorbed on the catalyst surface due to the difference in polarity.This work provides new insight and strategy for the design of a strong synergic catalytic effect between NHPI and bimetallic supports toward high-activity aerobic ODS materials. 展开更多
关键词 Metal-organic frameworks DOPED BIMETALLIC N-HYDROXYPHTHALIMIDE Aerobic processes Oxidative desulfurization
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Direct-Seeded Rice: Genetic Improvement of Game-Changing Traits for Better Adaption
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作者 Priyanka NEGI Jagadish RANE +10 位作者 Rajendra Sadashiv WAGH Tukaram Jayaram BHOR Dipti Digambar GODSE Priyanka JADHAV C.ANILKUMAR Dasari SREEKANTH K.SAMMI REDDY Sharad Ramrao GADAKH K.M.BORAIH C.B.HARISHA P.S.BASAVARAJ 《Rice science》 SCIE CSCD 2024年第4期417-433,共17页
The sustainability of rice production continues to be a subject of uncertainty and inquiry attributed to shifts in climatic conditions. In light of the impending climate change crisis and the high labor and water cost... The sustainability of rice production continues to be a subject of uncertainty and inquiry attributed to shifts in climatic conditions. In light of the impending climate change crisis and the high labor and water costs accompanying it, direct-seeded rice(DSR) is unquestionably one of the most practical solutions. Despite its resource and climate-friendly advantages, early maturing rice faces weed competitiveness and seedling establishment challenges. Resolving these issues is crucial for promoting its wider adoption among farmers, presenting it as a more effective sustainable rice cultivation method globally. Diverse traditional and contemporary breeding methods are employed to mitigate the limitations of the DSR approach, leveraging advanced techniques such as speed breeding and genome editing. Focusing on key traits like mesocotyl length elongation, early seedling vigor, root system architecture, and weed competitiveness holds promise for transformative improvements in DSR adaptation at a broader scale within farming communities. This review aims to summarize how these features contribute to increased crop production in DSR conditions and explore the research efforts focusing on enhancing DSR adaptation through these traits. Emphasizing the pivotal role of these game-changing traits in DSR adaptation, our analysis sheds light on their potential transformative impact and offers valuable insights for advancing DSR practices. 展开更多
关键词 climate change direct-seeded rice aerobic rice early vigor trait
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Intervention control of aerobic exercise in maintaining quality of life and pulmonary hypertension in hemodialysis patients
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作者 Dan-Dan Wang Min Cheng Chun-Ying Chen 《World Journal of Clinical Cases》 SCIE 2024年第20期4217-4229,共13页
BACKGROUND Pulmonary hypertension is a serious complication in the treatment of maintenance hemodialysis patients,which seriously affects the quality of life of patients and threatens their life safety.Prevention,trea... BACKGROUND Pulmonary hypertension is a serious complication in the treatment of maintenance hemodialysis patients,which seriously affects the quality of life of patients and threatens their life safety.Prevention,treatment and improvement of pulmonary hypertension are of great significance to improve the quality of life of patients.AIM To investigate the intervention and control of pedal-powered bicycle in maintaining quality of life and pulmonary hypertension in hemodialysis patients.METHODS 73 patients with maintenance hemadialysis combined with pulmonary arterial hypertension at a hemodialysis center in a certain hospital from May 2021 to May 2022 are selected.Patients are divided into two groups,37 cases in the control group(group C)and 36 cases in the intervention group(group I).Patients are divided into two groups,group C is treated with oral administration of betaglandin sodium combined with routine nursing care.Based on group C,group I conducts power cycling exercises.RESULTS After treatment,group I patients had higher muscle strength,36-Item Short Form Health Survey scores,and Kidney Disease Targets Areas scores;The 6-minute walk distance test index level was higher and the Borg score was lower;The group I had lower systolic blood pressure,greater vital capacity,higher positive emotion,lower systolic pulmonary artery pressure index level,higher arterial partial oxygen pressure level,lower pulmonary vascular resistance index level,and higher blood oxygen saturation level[158.91±11.89 vs 152.56±12.81,1795.01±603.18 vs 1907.20±574.15,24.00(22.00,29.00)vs 24.00(22.00,28.00),P<0.001].CONCLUSION Aerobic exercise combined with Western medicine treatment can effectively improve patients'pulmonary hypertension,alleviate their negative emotions,and enable them to achieve a higher level of quality of life. 展开更多
关键词 Aerobic exercise HEMODIALYSIS Pulmonary arterial hypertension Cycle ergometer Quality of life
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Impact of a 12-wk physical conditioning program on the aerobic capacity of aviation cadets
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作者 Hao Luo Ding-Yu Zhao Juan Li 《World Journal of Clinical Cases》 SCIE 2024年第20期4239-4246,共8页
BACKGROUND Flight cadets need to have good physical fitness to cope with the challenges of flying missions.The continuous development of science and technology has led to the constant upgrading of fighter jets and the... BACKGROUND Flight cadets need to have good physical fitness to cope with the challenges of flying missions.The continuous development of science and technology has led to the constant upgrading of fighter jets and the improvement of their performance,which has resulted in new and higher requirements for the physical fitness of flight personnel.The traditional physical training mode,method,and assessment have been used for many years and do not meet current fitness needs.AIM To investigate the impact of a 12-wk comprehensive anti-G fitness training program on the aerobic capacity of aviation cadets and to evaluate its effectiveness.METHODS Fifty-five cadets were randomly assigned to control and experimental groups using a randomized,single-blind design.The control group maintained their existing training regimen,while the experimental group participated in a 12-wk comprehensive training intervention.The training program comprised strength training twice per week,high-intensity interval training three times per week,and supplemental nutritional and psychological support.Maximal oxygen uptake(VO2max),lower limb strength,and hemoglobin levels were measured at baseline,at 6 wk and 12 wk post-intervention.RESULTS Repeated measures analysis of variance revealed significant differences of both VO2max and relative VO2 in both groups across time points(P<0.05).However,no significant time-group interaction was observed(P>0.05).Paired t-tests comparing baseline and 12-wk results showed that VO2max and relative VO2 were significantly higher in the experimental group than the control group(P<0.05).This suggests that the training program effectively enhanced the aerobic capacity of the experimental group.Key indicators of aerobic capacity,bilateral lower limb strength and hemoglobin levels,were also significantly different over time and between groups(P<0.05).No significant differences were noted in heart-rate metrics(P>0.05).CONCLUSION A 12-wk comprehensive anti-G fitness training program significantly improved the aerobic capacity of aviation cadets,thereby enhancing their overall capacity and laying a physiological foundation for enduring high-G flights. 展开更多
关键词 Aviation cadets Aerobic capacity Physical training High-intensity interval training Anti-G fitness
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Role of aerobic glycolysis in alzheimer's disease and research progress of traditional Chinese medicine
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作者 LIAO Nai-bin CHEN Wei +5 位作者 ZHU Xiao-min LIAO Shi-feng LI Qian-qian LIANG Yi MAI Fang-yu HE Ai-xin 《Journal of Hainan Medical University》 CAS 2024年第3期69-73,共5页
Alzheimer's disease (AD) is an irreversible neurodegenerative disease with a variety of pathogenic factors and complex pathogenesis, so that the disease has a high prevalence and mortality in the world. Although t... Alzheimer's disease (AD) is an irreversible neurodegenerative disease with a variety of pathogenic factors and complex pathogenesis, so that the disease has a high prevalence and mortality in the world. Although the current diagnosis and treatment equipment and drug research and development keep pace with the times, the current medical technology still can not completely cure the disease, so it is of great significance to explore the pathogenesis and treatment target of AD. The disorder of energy metabolism is one of the characteristic changes in the pathological process of AD. Aerobic glycolysis (AEG) is a special metabolic pathway in the brain, which can rapidly consume glucose to produce energy and substrate for neurons, improve synaptic plasticity, neuroinflammation and oxidative damage, and contribute to the recovery of memory and cognitive function. In recent years, many literatures have reported the mechanism of AEG in AD and the intervention of Tradit Chin Med on this mechanism. The purpose of this paper is to summarize the role of AEG in AD and the related research on the regulation and control of AEG in the treatment of AD by Tradit Chin Med, in order to provide reference and ideas for the prevention and treatment of AD with Tradit Chin Med in the future. 展开更多
关键词 Alzheimer disease Aerobic glycolysis Traditional Chinese medicine Energy metabolism
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Research and Practice of Cardiopulmonary Rehabilitation Training Programs
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作者 Na Yan Maiding He +9 位作者 Jinyue Jiang Juan Luo Ping Zhan Xichan Wang Xia Gao Jianzhu Wang Na Yin Fang Ye Jinghua Yu Shiying Zhang 《World Journal of Cardiovascular Diseases》 CAS 2024年第9期557-566,共10页
In today’s society, the incidence of cardiopulmonary diseases is increasing annually, seriously affecting patients’ quality of life. Therefore, developing a scientific and effective rehabilitation training program i... In today’s society, the incidence of cardiopulmonary diseases is increasing annually, seriously affecting patients’ quality of life. Therefore, developing a scientific and effective rehabilitation training program is of great significance. This study first analyzes the theoretical basis of cardiopulmonary rehabilitation training, including the effects of aerobic exercise, interval training, and strength training on cardiopulmonary function. Based on this, a comprehensive rehabilitation training program is designed, which includes personalized training plans, comprehensive interventions, multidisciplinary collaboration, patient education, and regular follow-up visits. The cardiopulmonary rehabilitation training plan developed in this study has certain scientific practicability, which provides a theoretical basis for cardiopulmonary rehabilitation training, and also provides a reference for medical institutions, rehabilitation centers and communities, which is helpful for promotion and application to a wider range of patients with cardiopulmonary diseases. 展开更多
关键词 Cardiopulmonary Function Rehabilitation Training Program Aerobic Exercise Interval Training
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An Innovative Approach towards Selecting Aerobic and Coordinative Exercises in Clinical Practice for Children and Young People with ADHD
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作者 Carsten Vogt 《Journal of Biosciences and Medicines》 2024年第8期258-269,共12页
A growing body of studies and systematic reviews show evidence of the beneficial effects of physical exercise on core symptoms of ADHD. Furthermore, studies indicate that physical exercise as an adjuvant can enhance t... A growing body of studies and systematic reviews show evidence of the beneficial effects of physical exercise on core symptoms of ADHD. Furthermore, studies indicate that physical exercise as an adjuvant can enhance the effects of medication in the treatment of ADHD. Aerobic and coordinative exercises improve executive functioning through their effect on neurocognitive domains that are implicated in ADHD. It is postulated that through their specific modus operandi, aerobic exercise, by raising cortical arousal levels, improves impaired alerting functions whereas coordinative exercises improve the regulation of inhibitory control through the involvement of a higher variety of frontal-dependent cognitive processes. The increasing use of routine neurocognitive testing with continuous performance tests (CPT), such as the QbTest, at clinical assessments for ADHD allows for an innovative approach to identify the assessment impairments in alerting function and inhibition control that are related to ADHD and accordingly choose aerobic or coordinative physical exercise in a more targeted fashion. 展开更多
关键词 ADHD Physical Exercise Aerobic Exercise Coordinative Exercise Continuous Performance Test (CPT) QbTest MEDICATION Treatment
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Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect 被引量:1
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作者 Piao Luo Qian Zhang +10 位作者 Tian-Yu Zhong Jia-Yun Chen Jun-Zhe Zhang Ya Tian Liu-Hai Zheng Fan Yang Ling-Yun Dai Chang Zou Zhi-Jie Li Jing-Hua Liu Ji-Gang Wang 《Military Medical Research》 SCIE CAS CSCD 2023年第1期17-31,共15页
Background: Sepsis involves life-threatening organ dysfunction and is caused by a dysregulated host response to infection. No specific therapies against sepsis have been reported. Celastrol(Cel) is a natural anti-infl... Background: Sepsis involves life-threatening organ dysfunction and is caused by a dysregulated host response to infection. No specific therapies against sepsis have been reported. Celastrol(Cel) is a natural anti-inflammatory compound that shows potential against systemic inflammatory diseases. This study aimed to investigate the pharmacological activity and molecular mechanism of Cel in models of endotoxemia and sepsis.Methods: We evaluated the anti-inflammatory efficacy of Cel against endotoxemia and sepsis in mice and macrophage cultures treated with lipopolysaccharide(LPS). We screened for potential protein targets of Cel using activity-based protein profiling(ABPP). Potential targets were validated using biophysical methods such as cellular thermal shift assays(CETSA) and surface plasmon resonance(SPR). Residues involved in Cel binding to target proteins were identified through point mutagenesis, and the functional effects of such binding were explored through gene knockdown.Results: Cel protected mice from lethal endotoxemia and improved their survival with sepsis, and it significantly decreased the levels of pro-inflammatory cytokines in mice and macrophages treated with LPS(P <0.05). Cel bound to Cys424 of pyruvate kinase M2(PKM2), inhibiting the enzyme and thereby suppressing aerobic glycolysis(Warburg effect). Cel also bound to Cys106 in high mobility group box 1(HMGB1) protein, reducing the secretion of inflammatory cytokine interleukin(IL)-1β. Cel bound to the Cys residues in lactate dehydrogenase A(LDHA).Conclusions: Cel inhibits inflammation and the Warburg effect in sepsis via targeting PKM2 and HMGB1 protein. 展开更多
关键词 CELASTROL SEPSIS Pyruvate kinase M2 High mobility group box 1 Aerobic glycolysis
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MiR-194-5p suppresses the warburg effect in ovarian cancer cells through the IGF1R/PI3K/AKT axis 被引量:1
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作者 LIJUN DU KAIKAI DOU +2 位作者 NIANHAI LIANG JIANMIN SUN RU BAI 《BIOCELL》 SCIE 2023年第3期547-554,共8页
Background:The Warburg effect is considered as a hallmark of various types of cancers,while the regulatory mechanism is poorly understood.Our previous study demonstrated that miR-194-5p directly targets and regulates ... Background:The Warburg effect is considered as a hallmark of various types of cancers,while the regulatory mechanism is poorly understood.Our previous study demonstrated that miR-194-5p directly targets and regulates insulin-like growth factor1 receptor(IGF1R).In this study,we aimed to investigate the role of miR-194-5p in the regulation of the Warburg effect in ovarian cancer cells.Methods:The stable ovarian cell lines with miR-194-5p overexpression or silencing IGF1R expression were established by lentivirus infection.ATP generation,glucose uptake,lactate production and extracellular acidification rate(ECAR)assay were used to analyze the effects of aerobic glycolysis in ovarian cancer cells.Gene expression was analyzed by quantitative polymerase chain reaction(qPCR)and western blot.Immunohistochemistry assays were performed to assess the expression of the IGF1R protein in ovarian cancer tissues.Results:Overexpression of miR-194-5p or silencing IGF1R expression in ovarian cancer cells decreases ATP generation,glucose uptake,lactate production,and ECAR and inhibits both the mRNA and protein expression of PKM2,LDHA,GLUT1,and GLUT3.While the knockdown of miR-194-5p expression led to opposite results.Overexpression of miR-194-5p or silencing IGF1R expression suppressed the phosphatidylinositol-3-kinase/protein kinase B(PI3K/AKT)pathway,whose activation can sustain aerobic glycolysis in cancer cells,and the knockdown of miR-194-5p expression promoted the activation of the PI3K/AKT pathway.Conclusion:Our results suggest that miR-194-5p can inhibit the Warburg effect by negative regulation of IGF1R and further repression of the PI3K/AKT pathway,which provides a theoretical basis for further test of miR-194-5p as a target in the treatment of ovarian cancer. 展开更多
关键词 Ovarian cancer Aerobic glycolysis MICRORNA
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Behavior,toxicity and diffusive flux of metals in a sediment core and pore-water from Anzali wetland
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作者 Y.Mehdizadeh A.R.Karbassi +1 位作者 T.Nasrabadi A.Sarang 《Acta Geochimica》 EI CAS CSCD 2023年第2期309-331,共23页
Concentrations of metals along with pH,potential redox(Eh),total dissolved solid(TDS),electrical conductivity(EC)and salinity were measured for sediments of different layers,pore and surface water in the Anzali wetlan... Concentrations of metals along with pH,potential redox(Eh),total dissolved solid(TDS),electrical conductivity(EC)and salinity were measured for sediments of different layers,pore and surface water in the Anzali wetland.Also,the diffusive flux of metals was calculated ad compared with the values in other aquatic bodies.The abundance of metals in sediments was Al>Fe>Ca>Ti>Mn>Zn>V>Cr>Ni>Cu>Pb>Co>As>Mo>Ag>Cd,while the pore-water results indicated a different concentration profile:Ca>Mn>Fe>Al>V>Mo>As>Ni>Cu>Co.Anzali wetland is classified within a high ecological risk.Pore-water toxicity test showed it is in non-polluted condition.Eh–pH diagrams showed that all species of elements are in a stable state in surface and pore-waters.However,Mn and Co(in some layers)are in soluble form and free ions and thus are bioavailable to the organisms.V and As are also present in the form of hydrogen compounds and Ni in the form of hydroxides,therefore,they are toxic to aquatic animals due to their solubility and ionic forms.Diffusive fluxes for As,Al,Fe,Ca,Cu,Mn,Mo,Ni and V are 0.43,1.80,48.52,43,147.50,0.12,1.47,0.15,1.28,0.21μg/m^(2)/day,respectively.Cluster analysis showed that in a solid phase of sediments,elements such as Cr,As and Ti are of petroleum and terrestrial origin.In pore-waters,Cu is of petroleum and biological origin,and Mo,As,Cu and Co are controlled by p H. 展开更多
关键词 AQUATIC Environment Pollution AEROBIC GEOCHEMISTRY Elements
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Non-exercise estimated cardiorespiratory fitness and cancer incidence:The NIH-AARP diet and health study
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作者 Baruch Vainshelboim Jonathan Myers Charles EMatthews 《Journal of Sport and Health Science》 SCIE CAS CSCD 2023年第6期739-746,共8页
Background Non-exercise estimated cardiorespiratory fitness(NEE-CRF)has been shown to be associated with mortality,although its association with cancer incidence is unknown.The study aimed to assess the prospective as... Background Non-exercise estimated cardiorespiratory fitness(NEE-CRF)has been shown to be associated with mortality,although its association with cancer incidence is unknown.The study aimed to assess the prospective association between NEE-CRF and cancer incidence in a large cohort of men and women.Methods The National Institutes of Health-American Association of Retired Persons diet and health study is a prospective cohort that included 402,548 participants aged 50–71 years who were free from cancer at baseline(1995–1996)(men(n=238,835)and women(n=163,713))and were followed until December 31,2015.The exposure variable was NEE-CRF expressed in metabolic equivalents.NEE-CRF was estimated using a validated equation of self-reported predictors on demographics and lifestyle behaviors derived from baseline questionnaires.Primary outcomes were total cancer incidence and incidence of prostate,breast,lung,and colorectal cancers.Cox proportional hazards models were analyzed for the association between NEE-CRF and cancer incidence outcomes adjusted for established cancer risk factors.Results During 13.7±3.2 years of follow-up(mean±SD),64,344 men and 31,315 women developed a new cancer.For every 1-metabolic equivalent higher NEE-CRF,the hazard ratios and 95%confidence intervals(95%CIs)were 0.96(95%CI:0.94–0.97)and 0.88(95%CI:0.84–0.92)of total and colorectal cancer incidence among men,and 0.95(95%CI:0.93–0.97)and 0.94(95%CI:0.91–0.97)of total and breast cancer incidence among women,respectively(all p<0.001).NEE-CRF was not associated with incidence of prostate and lung cancers in men or colorectal and lung cancers in women.Conclusion These results suggest that higher CRF levels,as assessed by the applied non-exercise estimated method,may provide preventive benefits against the development of cancer,while low CRF could potentially serve as a modifiable cancer risk factor.Integrating NEE-CRF into screening paradigms and referring low-fit individuals to improve CRF could complement the public health prevention strategy against cancer. 展开更多
关键词 Aerobic capacity Breast cancer Cancer risk Colorectal cancer VO_(2max)
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Assessing quinoline removal performances of an aerobic continuous moving bed biofilm reactor(MBBR) bioaugmented with Pseudomonas citronellolis LV1
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作者 Hu Chen Ying Wang +1 位作者 Puyu Wang Yongkang Lv 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2023年第5期132-140,共9页
This study evaluated the bioaugmentation potential of a quinoline-degrading strain Pseudomonas citronellolis LV1 inoculation into activated sludge for treating quinoline wastewater, and results indicated the inoculati... This study evaluated the bioaugmentation potential of a quinoline-degrading strain Pseudomonas citronellolis LV1 inoculation into activated sludge for treating quinoline wastewater, and results indicated the inoculation of LV1 in aerobic continuous MBBR could substantially improve the quinoline removal performance with an improved removal efficiency of 34% averagely when quinoline was used as the sole carbon and nitrogen source. Additionally, efficient removal of quinoline in enhanced MBBR occurred at the influent p H of 7.0–8.0, hydraulic retention time(HRT) of 24–28 h and influent quinoline concentration of 100–700 mg·L^(-1). High-throughput sequencing analysis indicated that bioaugmentation could increase microbial diversity and shape the microbial community structure. Although the inoculant LV1 did not remain its dominance in stage Ⅲ, bioaugmentation indeed induced the formation of effective microbial community, and the indigenous microbes including Flavobacterium, Pseudoxanthomonas,Pseudomonas, Vermamoeba, Dyadobacter and Sphingomonas might play the key role in quinoline removal.According to the PICRUSt, the enhanced genes encoding aromatic ring-cleavage enzyme, especially for Nheterocyclic ring-cleavage enzymes, could lead to the improved removal performance of quinoline in bioaugmentation stage. Moreover, the enhanced MBBR treated well actual coking wastewater, as indicated by high removal performance of quinoline, phenol and COD. 展开更多
关键词 Aerobic quinoline degradation Pseudomonas citronellolis LV1 BIOAUGMENTATION Microbial community Coking wastewater
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Study on the catalytic degradation of sodium lignosulfonate to aromatic aldehydes over nano-CuO:Process optimization and reaction kinetics
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作者 Yingjie Song Shuqi Zhong +5 位作者 Yingjiao Li Kun Dong Yong Luo Guangwen Chu Haikui Zou Baochang Sun 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2023年第1期300-309,共10页
As one of the few renewable aromatic resources,the research of depolymerization of lignin into highvalue chemicals has attracted extensive attention in recent years.Catalytic wet aerobic oxidation(CWAO)is an effective... As one of the few renewable aromatic resources,the research of depolymerization of lignin into highvalue chemicals has attracted extensive attention in recent years.Catalytic wet aerobic oxidation(CWAO)is an effective technology to convert lignin like sodium lignosulfonate(SL),a lignin derivative,into aromatic aldehydes such as vanillin and syringaldehyde.However,how to improve the yield of aromatic aldehyde and conversion efficiency is still a challenge,and many operating conditions that significantly affect the yield of these aromatic compounds have rarely been investigated systematically.In this work,we adopted the stirred tank reactor(STR)for the CWAO process with nano-CuO as catalyst to achieve the conversion of SL into vanillin and syringaldehyde.The effect of operating conditions including reaction time,oxygen partial pressure,reaction temperature,SL concentration,rotational speed,catalyst amount,and NaOH concentration on the yield of single phenolic compound was systematically investigated.The results revealed that all these operating conditions exhibit a significant effect on the aromatic aldehyde yield.Therefore,they should be regulated in an optimal value to obtain high yield of these aldehydes.More importantly,the reaction kinetics of the lignin oxidation was explored.This work could provide basic data for the optimization and design of industrial operation of lignin oxidation. 展开更多
关键词 NANO-CUO Sodium lignosulfonate Catalytic wet aerobic oxidation(CWAO) Aromatic aldehyde Reaction kinetics
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