A pair of novel geometrically isomeric triterpenoid saponins named escins IVa and IVb, together with known escins Ia and Ib. were isolated from the seeds of Aesculus chinensis. Their structures were determined on the ...A pair of novel geometrically isomeric triterpenoid saponins named escins IVa and IVb, together with known escins Ia and Ib. were isolated from the seeds of Aesculus chinensis. Their structures were determined on the basis of spectroscopic evidences and comparison.展开更多
A new triterpenoid saponin named escin IV e was isolated from the seeds of Aesculus chinensis. Its structure was established as 28-tigloylprotoaescigenin-3 beta-O- [beta-D-glucopyranosyl (1-2)] [beta-D-glucopyranosyl ...A new triterpenoid saponin named escin IV e was isolated from the seeds of Aesculus chinensis. Its structure was established as 28-tigloylprotoaescigenin-3 beta-O- [beta-D-glucopyranosyl (1-2)] [beta-D-glucopyranosyl (1-4)] -beta-D-glucopyranosiduronic acid.展开更多
Two new triterpenoid saponins were isolated from the seeds of Aesculus chinensis by preparative HPLC. On the basis of chemical evidence and spectral data, their structures were established as 21 beta-tigloyl-28-acetyl...Two new triterpenoid saponins were isolated from the seeds of Aesculus chinensis by preparative HPLC. On the basis of chemical evidence and spectral data, their structures were established as 21 beta-tigloyl-28-acetylprotoaescigenin 3 beta-O-[beta-D-xylopyranosyl (1 --> 2)] [beta-D-glucopyranosyl (1 --> 4)]-beta-D-glucopyranosiduronic acid (isoescin IIa, 1) and 21 beta-tigloyl-28-acetylprotoaescigenin 3 beta-O-[beta-D-xylopyranosyl (1 --> 2)] [beta-D-glucopyranosyl (1 --> 4)]-beta-D-glucopyranosiduronic acid (isoescin IIb, 2), which are a pair of geometrical isomers.展开更多
Two new triterpenoid saponins, named isoescins IIIa (1) and IIIb (2) were isolated from the seeds of Aesculus chinensis and identified by spectroscopic analysis and chemical hydrolysis. Their structures were establish...Two new triterpenoid saponins, named isoescins IIIa (1) and IIIb (2) were isolated from the seeds of Aesculus chinensis and identified by spectroscopic analysis and chemical hydrolysis. Their structures were established as 21 beta-tigloyl-28-acetylbarringtogenol C-3 beta-O-[beta D-galactopyranosyl( 1-->2)] [beta-D-glucopyranosyl (1-->])1-beta-D-glucopyranosiduronic acid (1) and 21 beta-angeloyl-28-acetylbarringtogenol C-3 beta-O-[beta-D;galactopyranosyl (1-->2)] [beta-D-glucopyranosyl(1 -->4)]-beta-D-glucopyranosiduronic acid (2), which are geometrically isomeric.展开更多
Six new triterpenoid saponins,aesculusosides A-F(1-6),together with 19 known ones,were isolated from the seeds of Aesculus chinensis.The new structures were elucidated through extensive spectroscopic analyses and by c...Six new triterpenoid saponins,aesculusosides A-F(1-6),together with 19 known ones,were isolated from the seeds of Aesculus chinensis.The new structures were elucidated through extensive spectroscopic analyses and by comparison with previously reported data.Some of the isolates were evaluated for their cytotoxic activities against MCF-7 cell line by an MTT assay,and compounds 15,16,19,and 23-25 exhibited inhibitory activities against MCF-7 with IC50 values ranging from 7.1 to 31.3μM.展开更多
A new flavonol oligosaccharide, quercetin-3-O-[b-D-xylopyranosyl-(12)- a-L-rhamnopyranosyl-(16)]-b-D-glucopyranoside-3-O-b-D-glucopyranoside, named aescuflavoside was isolated from Aesculus chinensis. Its structure w...A new flavonol oligosaccharide, quercetin-3-O-[b-D-xylopyranosyl-(12)- a-L-rhamnopyranosyl-(16)]-b-D-glucopyranoside-3-O-b-D-glucopyranoside, named aescuflavoside was isolated from Aesculus chinensis. Its structure was elucidated by spectra FAB-MS, 1D NMR and 2D NMR including 1H NMR, 13C NMR, HMQC and HMBC techniques.展开更多
Three new triterpenoid saponins, escins IVg (1), IVh (2) and VIb (3) were isolatedfrom the seeds of Aesculus chinensis along with two known saponins, escin IIIa (4) anddesacylescin I (5). Their structures were elucida...Three new triterpenoid saponins, escins IVg (1), IVh (2) and VIb (3) were isolatedfrom the seeds of Aesculus chinensis along with two known saponins, escin IIIa (4) anddesacylescin I (5). Their structures were elucidated by spectroscopic analysis and chemicalhydrolysis.展开更多
Three new triterpenoid saponins, escins IVc (1), IVd (2) and IVf (3) were isolated from the seeds of Aesculus chinensis. They were. determined as 22 alpha-tigloyl-28-acetylprotoaescigenin-3 beta-O- [beta-D-glucopyrano...Three new triterpenoid saponins, escins IVc (1), IVd (2) and IVf (3) were isolated from the seeds of Aesculus chinensis. They were. determined as 22 alpha-tigloyl-28-acetylprotoaescigenin-3 beta-O- [beta-D-glucopyranosyl (1-->2)] [beta-D-glucopyranosyl (1-->4)]-beta-D-glucopyranosiduronic acid 1, 22 alpha-angeloyl-28-acetylprotoaescigenin-3 beta-O- [beta-D-glucopyranosyl (1-->2)] [beta-D-glucopyrano- syl (1-->4)]-beta-D-glucopyranosiduronic acid 2 and 28-tigloyl protoaescigenin-3 beta-O- [beta-D-gluco-pyranosyl (12)] [beta-D-glucopyranosyl (1-->4)] -beta-D-glucopyranosiduronic acid 3.展开更多
文摘A pair of novel geometrically isomeric triterpenoid saponins named escins IVa and IVb, together with known escins Ia and Ib. were isolated from the seeds of Aesculus chinensis. Their structures were determined on the basis of spectroscopic evidences and comparison.
文摘A new triterpenoid saponin named escin IV e was isolated from the seeds of Aesculus chinensis. Its structure was established as 28-tigloylprotoaescigenin-3 beta-O- [beta-D-glucopyranosyl (1-2)] [beta-D-glucopyranosyl (1-4)] -beta-D-glucopyranosiduronic acid.
文摘Two new triterpenoid saponins were isolated from the seeds of Aesculus chinensis by preparative HPLC. On the basis of chemical evidence and spectral data, their structures were established as 21 beta-tigloyl-28-acetylprotoaescigenin 3 beta-O-[beta-D-xylopyranosyl (1 --> 2)] [beta-D-glucopyranosyl (1 --> 4)]-beta-D-glucopyranosiduronic acid (isoescin IIa, 1) and 21 beta-tigloyl-28-acetylprotoaescigenin 3 beta-O-[beta-D-xylopyranosyl (1 --> 2)] [beta-D-glucopyranosyl (1 --> 4)]-beta-D-glucopyranosiduronic acid (isoescin IIb, 2), which are a pair of geometrical isomers.
文摘Two new triterpenoid saponins, named isoescins IIIa (1) and IIIb (2) were isolated from the seeds of Aesculus chinensis and identified by spectroscopic analysis and chemical hydrolysis. Their structures were established as 21 beta-tigloyl-28-acetylbarringtogenol C-3 beta-O-[beta D-galactopyranosyl( 1-->2)] [beta-D-glucopyranosyl (1-->])1-beta-D-glucopyranosiduronic acid (1) and 21 beta-angeloyl-28-acetylbarringtogenol C-3 beta-O-[beta-D;galactopyranosyl (1-->2)] [beta-D-glucopyranosyl(1 -->4)]-beta-D-glucopyranosiduronic acid (2), which are geometrically isomeric.
基金support from the independent topics supported by operational expenses for basic research of China Academy of Chinese Medical Sciences(ZXKT15032).
文摘Six new triterpenoid saponins,aesculusosides A-F(1-6),together with 19 known ones,were isolated from the seeds of Aesculus chinensis.The new structures were elucidated through extensive spectroscopic analyses and by comparison with previously reported data.Some of the isolates were evaluated for their cytotoxic activities against MCF-7 cell line by an MTT assay,and compounds 15,16,19,and 23-25 exhibited inhibitory activities against MCF-7 with IC50 values ranging from 7.1 to 31.3μM.
文摘A new flavonol oligosaccharide, quercetin-3-O-[b-D-xylopyranosyl-(12)- a-L-rhamnopyranosyl-(16)]-b-D-glucopyranoside-3-O-b-D-glucopyranoside, named aescuflavoside was isolated from Aesculus chinensis. Its structure was elucidated by spectra FAB-MS, 1D NMR and 2D NMR including 1H NMR, 13C NMR, HMQC and HMBC techniques.
文摘Three new triterpenoid saponins, escins IVg (1), IVh (2) and VIb (3) were isolatedfrom the seeds of Aesculus chinensis along with two known saponins, escin IIIa (4) anddesacylescin I (5). Their structures were elucidated by spectroscopic analysis and chemicalhydrolysis.
