This paper develops two models to investigate the effect of team leader positive affectivity (PA) on team member turnover intention and team organizational citizenship behavior (OCB), at the individual and team le...This paper develops two models to investigate the effect of team leader positive affectivity (PA) on team member turnover intention and team organizational citizenship behavior (OCB), at the individual and team levels, respectively. A two-wave longitudinal study was conducted involving a survey of 58 team leaders and 174 team members in a large Chinese telecom company across a three-month period. We found that team members' organization-based self-esteem (OBSE) at Time 1 mediates the relationship between team leader PA at Time 1 and team member turnover intention at Time 2, whereas team aggregated OBSE at Time 1 mediates the relationship between leader PA at Time1 and team OCB at Time 2.展开更多
In this editorial we comment on the article by Zhang et al published in the recent issue of the World Journal of Psychiatry.We focus on identity diffusion,identity perturbations,their origin and developmental pathways...In this editorial we comment on the article by Zhang et al published in the recent issue of the World Journal of Psychiatry.We focus on identity diffusion,identity perturbations,their origin and developmental pathways.This is an upcoming problem in the society as not only school children are affected.Adolescents and young people suffer from uncertainty in gender identity,in self-image,migration effects due to chronic crises caused by war,pandemic disruptions or climate change.We show how such chronic uncertainty can be cared for,treated,and contained.The key is affective holding,reflection and to provide adequate affective mentalizing in a close concomitant way.These key features also depend on ambient conditions,such as psychotherapeutic care.In a qualitative interview study carried out in a cyclical research design with a comparative analysis on the basis of thematic coding using Grounded Theory Methodology we found institu-tionalized defenses in health policies.Professionals request better training and adequat academic knowledge as well as research into unresolved areas for improvement of the ambient conditions for adequat development of the self.Practice points for further clinical and scientific development are given and discussed.展开更多
Painful stimuli elicit first-line reflexive defensive reactions and,in many cases,also evoke second-line recuperative behaviors,the latter of which reflects the sensing of tissue damage and the alleviation of sufferin...Painful stimuli elicit first-line reflexive defensive reactions and,in many cases,also evoke second-line recuperative behaviors,the latter of which reflects the sensing of tissue damage and the alleviation of suffering.The lateral parabrachial nucleus(lPBN),composed of external-(elPBN),dorsal-(dlPBN),and central/superior-subnuclei(jointly referred to as slPBN),receives sensory inputs from spinal projection neurons and plays important roles in processing affective information from external threats and body integrity disruption.However,the organizational rules of lPBN neurons that provoke diverse behaviors in response to different painful stimuli from cutaneous and deep tissues remain unclear.In this study,we used region-specific neuronal depletion or silencing approaches combined with a battery of behavioral assays to show that slPBN neurons expressing substance P receptor(NK1R)(lPBNNK1R)are crucial for driving pain-associated self-care behaviors evoked by sustained noxious thermal and mechanical stimuli applied to skin or bone/muscle,while elPBN neurons are dispensable for driving such reactions.Notably,lPBNNK1R neurons are specifically required for forming sustained somatic pain-induced negative teaching signals and aversive memory but are not necessary for fear-learning or escape behaviors elicited by external threats.Lastly,both lPBNNK1R and elPBN neurons contribute to chemical irritant-induced nocifensive reactions.Our results reveal the functional organization of parabrachial substrates that drive distinct behavioral outcomes in response to sustained pain versus external danger under physiological conditions.展开更多
The mechanisms of oxide metallurgy include inducing the formation of intragranular acicular ferrite(IAF)using micron-sized inclusions and restricting the growth of prior austenite grains(PAGs)by nanosized particles du...The mechanisms of oxide metallurgy include inducing the formation of intragranular acicular ferrite(IAF)using micron-sized inclusions and restricting the growth of prior austenite grains(PAGs)by nanosized particles during welding.The chaotically oriented IAF and refined PAGs inhibit crack initiation and propagation in the steel,resulting in high impact toughness.This work summarizes the com-bined effect of deoxidizers and alloying elements,with the aim to provide a new perspective for the research and practice related to im-proving the impact toughness of the heat affected zone(HAZ)during the high heat input welding.Ti complex deoxidation with other strong deoxidants,such as Mg,Ca,Zr,and rare earth metals(REMs),can improve the toughness of the heat-affected zone(HAZ)by re-fining PAGs or increasing IAF contents.However,it is difficult to identify the specific phase responsible for IAF nucleation because ef-fective inclusions formed by complex deoxidation are usually multiphase.Increasing alloying elements,such as C,Si,Al,Nb,or Cr,con-tents can impair HAZ toughness.A high C content typically increases the number of coarse carbides and decreases the potency of IAF formation.Si,Cr,or Al addition leads to the formation of undesirable microstructures.Nb reduces the high-temperature stability of the precipitates.Mo,V,and B can enhance HAZ toughness.Mo-containing precipitates present good thermal stability.VN or V(C,N)is ef-fective in promoting IAF nucleation due to its good coherent crystallographic relationship with ferrite.The formation of the B-depleted zone around the inclusion promotes IAF formation.The interactions between alloying elements are complex,and the effect of adding dif-ferent alloying elements remains to be evaluated.In the future,the interactions between various alloying elements and their effects on ox-ide metallurgy,as well as the calculation of the nucleation effects of effective inclusions using first principles calculations will become the focus of oxide metallurgy.展开更多
Attention mechanism has been a successful method for multimodal affective analysis in recent years. Despite the advances, several significant challenges remain in fusing language and its nonverbal context information....Attention mechanism has been a successful method for multimodal affective analysis in recent years. Despite the advances, several significant challenges remain in fusing language and its nonverbal context information. One is to generate sparse attention coefficients associated with acoustic and visual modalities, which helps locate critical emotional se-mantics. The other is fusing complementary cross‐modal representation to construct optimal salient feature combinations of multiple modalities. A Conditional Transformer Fusion Network is proposed to handle these problems. Firstly, the authors equip the transformer module with CNN layers to enhance the detection of subtle signal patterns in nonverbal sequences. Secondly, sentiment words are utilised as context conditions to guide the computation of cross‐modal attention. As a result, the located nonverbal fea-tures are not only salient but also complementary to sentiment words directly. Experi-mental results show that the authors’ method achieves state‐of‐the‐art performance on several multimodal affective analysis datasets.展开更多
BACKGROUND Affective disorders(AD)have been linked to inflammatory processes,although the underlying mechanisms of this relationship are still not fully elucidated.It is hypothesized that demographic,somatic,lifestyle...BACKGROUND Affective disorders(AD)have been linked to inflammatory processes,although the underlying mechanisms of this relationship are still not fully elucidated.It is hypothesized that demographic,somatic,lifestyle,and personality variables predict inflammatory parameters in AD.AIM To identify biopsychosocial factors contributing to inflammation in AD measured with two parameters,C-reactive protein(CRP)and leukocytes.METHODS This observational study investigated 186 hospital inpatients diagnosed with AD using demographic parameters,serum inflammatory markers,somatic variables,psychological questionnaires,and lifestyle parameters.Hierarchical regression analyses were used to predict inflammatory markers from demographic,somatic,lifestyle,and personality variables.RESULTS Analyses showed that 33.8%of the variance of CRP was explained by body mass index and other somatic medication(e.g.anti-diabetics),age and education,and age of affective disorder diagnosis.For leukocytes,20.1%of the variance was explained by smoking,diet,metabolic syndrome(MetS),and anti-inflammatory medication(e.g.non-steroidal anti-inflammatory drugs).Other psychiatric or behavioural variables did not reach significance.CONCLUSION Metabolic components seem important,with mounting evidence for a metabolic affective disorder subtype.Lifestyle modifications and psychoeducation should be employed to prevent or treat MetS in AD.展开更多
BACKGROUND Panic disorder(PD)involves emotion dysregulation,but its underlying mechanisms remain poorly understood.Previous research suggests that implicit emotion regulation may play a central role in PD-related emot...BACKGROUND Panic disorder(PD)involves emotion dysregulation,but its underlying mechanisms remain poorly understood.Previous research suggests that implicit emotion regulation may play a central role in PD-related emotion dysregulation and symptom maintenance.However,there is a lack of studies exploring the neural mechanisms of implicit emotion regulation in PD using neurophysiological indicators.AIM To study the neural mechanisms of implicit emotion regulation in PD with eventrelated potentials(ERP).METHODS A total of 25 PD patients and 20 healthy controls(HC)underwent clinical evaluations.The study utilized a case-control design with random sampling,selecting participants for the case group from March to December 2018.Participants performed an affect labeling task,using affect labeling as the experimental condition and gender labeling as the control condition.ERP and behavioral data were recorded to compare the late positive potential(LPP)within and between the groups.RESULTS Both PD and HC groups showed longer reaction times and decreased accuracy under the affect labeling.In the HC group,late LPP amplitudes exhibited a dynamic pattern of initial increase followed by decrease.Importantly,a significant group×condition interaction effect was observed.Simple effect analysis revealed a reduction in the differences of late LPP amplitudes between the affect labeling and gender labeling conditions in the PD group compared to the HC group.Furthermore,among PD patients under the affect labeling,the late LPP was negatively correlated with disease severity,symptom frequency,and intensity.CONCLUSION PD patients demonstrate abnormalities in implicit emotion regulation,hampering their ability to mobilize cognitive resources for downregulating negative emotions.The late LPP amplitude in response to affect labeling may serve as a potentially valuable clinical indicator of PD severity.展开更多
BACKGROUND The outcome of surgical treatment for colorectal cancer(CRC)remains unsatis-factory and warrants further exploration and optimization.AIM To clarify the impact of chemotherapy plus cellular immunotherapy[de...BACKGROUND The outcome of surgical treatment for colorectal cancer(CRC)remains unsatis-factory and warrants further exploration and optimization.AIM To clarify the impact of chemotherapy plus cellular immunotherapy[dendritic cell-cytokine-induced killer(DC-CIK)cell immunotherapy]on patients after CRC surgery and to explore the mediating variables.METHODS A total cohort of 121 patients who underwent CRC surgery between January 2019 and April 2022 were selected.The sample comprised a control group of 55 pa-tients who received the XELOX chemotherapy regimen and a research group of 66 patients who received XELOX+DC-CIK immunotherapy.We performed compa-rative analyses of the clinical and pathological data of the two groups,including efficacy(2-year disease-free survival[DFS]rate),the incidence of adverse events(diarrhea,myelosuppression,gastrointestinal reactions,and peripheral neuritis),serum levels of tumor markers[carcinoembryonic antigens and carbohydrate an-tigens(CA)19-9 and CA242],and T-cell subsets[cluster of differentiation(CD)3+,CD3+CD4+,CD3+CD8+,natural killer(NK),and NK T cells].We also conducted preliminary univariate and mul-tivariate analyses of the variables that affected the efficacy of the treatments.RESULTS We found a significantly higher 2-year DFS rate of treatment efficacy in the research group than in the control group,with a statistically lower incidence of adverse events.Both groups showed a reduction in serum tumor markers after treatment but there was no marked intergroup difference.After treatment,the various T-cell subgroup indicators in the control group were significantly lower than those in the research group.The indices of T-cell subsets in the research group showed no significant change from preoperative levels.Univariate analysis revealed a significant correlation between TNM staging,tumor differentiation,and the rates of nonresponse to treatment in CRC patients after surgery.Multivariate results indicated that the treatment approach significantly affected the efficacy of postoperative CRC treatment.CONCLUSION We concluded that XELOX+DC-CIK immunotherapy for postsurgical CRC patients offers reduced rates of treatment-induced adverse events,extended 2-year DFS,enhanced immunity,and increased physiological antitumor responses.展开更多
As the frontier of intelligent computing technology,affective computing has been used in border inspection,case investigation,crime assessment,public opinion management,traffic management and other scenarios of public...As the frontier of intelligent computing technology,affective computing has been used in border inspection,case investigation,crime assessment,public opinion management,traffic management and other scenarios of public governance.However,there are still public risks associated with its failure to meet the basic requirements of modern public governance,and these risks are rooted in its technical characteristics.The technical characteristics of turning emotions into signals can give rise to such problems as degrading the right to informed consent,de-governance,and undermining human dignity when applied in public governance,and consequently can lead to social rights anxiety.Additionally,the affective modeling characteristics of affective computing tend to incur the rights risks of insufficient algorithm accuracy,algorithmic discrimination,and algorithmic black boxes.To avoid these risks,it is necessary to adopt the dynamic consent model as the premise for applying affective computing in public governance,and to regulate the auxiliary application of affective computing in public governance in a hierarchical manner,to achieve a balance between the application of affective computing technology and the protection of citizens'rights and the maintenance of public ethics.展开更多
Scars, when in good evolution, result in a smooth, thin and discreet tissue. Keloid scars, however, are a type of abnormal and exacerbated repair response to tissue injury, whether in surgical interventions or in vari...Scars, when in good evolution, result in a smooth, thin and discreet tissue. Keloid scars, however, are a type of abnormal and exacerbated repair response to tissue injury, whether in surgical interventions or in various injuries, which present in a prominent and gross way. In this context, there is an excess of collagen deposition in the tissue repair process, which can lead to the formation of keloids. The diagnosis of the condition presented is made by the medical professional or by the patient himself after the surgical intervention or skin injury. Under this analysis, protruding, rough and bad-looking scars are identified. In addition, we highlight the existence of keloids similar to large tumors, described as Jorge Lobo disease. The treatment encompasses massages, compressions, corticosteroids, chemotherapy, collagenase and cryotherapy. At first, we used corticosteroid-based massages, and then we started using compressive dressings until we started intrakeloid infiltrations with injectable triamcinolone. Triamcinolone 10 mg injectable—1/10—in 0.9% saline, with syringe and fixed needle 0.3 mm × 8 mm, intralesional infiltrate, in this context, proved to be effective for its treatment when applied sequentially and linearly. In cases where the medication was applied, there was an improvement after 21 days of application and a definitive improvement 2 months after the injury. In comparison, on the other hand, patients who were not subjected to the application of the medication may improve after 4 months of the injury or worsen compared to the initial case. We have come to the conclusion that this procedure may be one of the chosen ones for the treatment of keloid scars, being one of the most recommended for cases of keloid already installed.展开更多
In advanced otological surgeries, powered instruments form an indispensable part. The risk of deterioration to hearing in the operated ear is a commonly discussed issue, however, there remains a possibility of affecti...In advanced otological surgeries, powered instruments form an indispensable part. The risk of deterioration to hearing in the operated ear is a commonly discussed issue, however, there remains a possibility of affecting the hearing in the contralateral ear due to transcranial vibration. So in this study we aimed to assess the possibility of the non-operated ear being affected by the noise generated during ear surgeries and whether it is temporary or permanent in nature. Methodology: This study included 63 patients diagnosed with unilateral disease who underwent mastoid surgery. Preoperatively all the patients were subjected to Pure tone audiometry (PTA), Transient evoked otoacoustic emission (TEOAE) and Distortion product otoacoustic emission (DPOAE). Patients were operated using both cutting and diamond burrs of ranging from sizes 1 - 6 mm. Total drilling time was recorded. Results: Post-operative hearing evaluation was done at 1 week, 4 weeks and 12 weeks. The sound emitted by various burrs was recorded by Sound Level Meter. Out of the total 58 patients that followed up, 46 showed change in at least one of the hearing parameters. Patients showing changes had a higher drilling time as compared to those with no changes. Of these, the changes associated with the total drilling time and with cutting burr time were found to be significant. The hearing changes seen on PTA, TEOAE and DPOAE were transient in nature with only one patient having a persistent decreased high frequency threshold at the end of 12 weeks. It was also found that cutting burrs produce more sound as compared to diamond burrs and a larger size burr of a type produces more sound than a smaller one of its type. Conclusion: The drilling of mastoid bone during ear surgeries can transiently impair the hearing in the contralateral ear which is of great significance in patients with only one hearing ear.展开更多
[Objective] The research was aimed to study the dynamics of slope runoff and soil erosion in different forest types in karst depression.[Method] Precipitation observation sites at the bottom of karst depression and ru...[Objective] The research was aimed to study the dynamics of slope runoff and soil erosion in different forest types in karst depression.[Method] Precipitation observation sites at the bottom of karst depression and runoff observation sites in different forest types were established to monitor regularly the main indices changes of runoff and soil erosion at fixed position in 4 years.[Result] The surface runoff of different forest types appeared singer peak from February to November,with lowest valley from June to July.The runoff coefficient appeared double peaks from February to May and from July to September.The changing coefficient of runoff appeared three peaks from March to April,from July to August and from September to November.The silt concentration appeared one peak from March to May and The erosion modulus appeared double peaks from March to May and from June to August.Runoff showed annually reduced trend with the growth of forests and the development of vegetation layer's structure.There was a positive correlation between the runoff and its silt concentration in different forest types.Precipitation and evaporation had notable positive correlation with the runoff,and similar correlation but not marked with silt concentration.The fitting analysis results of surface runoff and erosion modulus showed that rocky desertification intensified the unevenness of surface runoff and increased the surface runoff and erosion modulus.The penetrability of surface soil in new planted forest was lower than that in young forest,and that in surface soil of different forest types was higher than in bottom soil.[Conclusion] The research provided theoretical basis for the biological management technologies of water and soil conservation and the control of karst rocky desertification in karst regions.展开更多
The oxidation behavior of Ti?22Al?(27?x)Nb?xZr (x=0, 1, 6) alloys at 800 °C for exposure time up to 100 h was examined. It is shown that oxidation rate of experimental alloys obeys the parabolic kinetics. Ti?22Al...The oxidation behavior of Ti?22Al?(27?x)Nb?xZr (x=0, 1, 6) alloys at 800 °C for exposure time up to 100 h was examined. It is shown that oxidation rate of experimental alloys obeys the parabolic kinetics. Ti?22Al?26Nb?1Zr alloy demonstrates more excellent oxidation resistance than the other two alloys. The main oxidation products are TiO2, Al2O3 and AlNbO4 phases for all these alloys. For the Ti?22Al?26Nb?1Zr alloy, Zr addition can modify the growth mechanism of oxide scale, which can effectively hinder the diffusion of oxygen. Whereas, reaction of Zr with oxygen leads to the formation of ZrO2 precipitates for the Ti?22Al?21Nb?6Zr alloy, which promotes the oxygen ingress into the substrate. Meanwhile, oxidation affected zones, including internal-oxidation layer and oxygen-enriched zone, are present beneath the outmost oxide scale. The difference in these zones is derived from the phase constitution in the starting Ti?22Al?(27?x)Nb?xZr (x=0, 1, 6) alloys.展开更多
[Objective] To research the evolution of drought in China and its impact on agriculture in recent years. [Method] We analyzed land area covered, area affected, and disaster rate arising from severe drought occurring i...[Objective] To research the evolution of drought in China and its impact on agriculture in recent years. [Method] We analyzed land area covered, area affected, and disaster rate arising from severe drought occurring in China in the period 1978-2008, in conjunction with the planting area of crops in China and forcing of drought on the planting area of crops. [Result] In recent years, a large portion of provinces and cities in China, especially the southern areas, the drought has not yet been eased, but tends to deteriorate; since 1978, the area affected in China occasioned by drought has been rapidly mounting, and total crop failure area caused by drought, on the whole, also assumes trend of rise. In the mean time, population explosion and economic development are responsible for dwindling of planting area of grain, and tardy rise in total grain yield. [Conclusion] Constructing harmonious valley and achieving concordant coexistence between human and water, is to regulate human behaviors and further strengthen related ecological protection work, on the basis of scientifically understanding and correctly harnessing natural law.展开更多
Fine-grained ZK60 magnesium alloy sheets of 2.0 mm in thickness were successfully joined by laser beam welding (LBW). The effects of welding parameters including laser power and welding speed on the microstructures ...Fine-grained ZK60 magnesium alloy sheets of 2.0 mm in thickness were successfully joined by laser beam welding (LBW). The effects of welding parameters including laser power and welding speed on the microstructures and mechanical properties of the joints were investigated. A sound bead, with the ultimate tensile strength (UTS) of 300 MPa and elongation of 12.0%, up to 92.5% and 65% of those of the base metal, respectively, is obtained with the optimized welding parameters. No liquation cracking is visible in the partially melted zone (PMZ) owing to the inhibitory action of the fine dispersed precipitates and the fine-grained microstructure in the as-rolled magnesium alloy sheets. The fusion zone (FZ) is featured with the equiaxed dendritic grains of the average grain size about 8 μm, which are similar to those in the heat affected zone (HAZ), and this contributes to the relatively high joint efficiency.展开更多
Based on the assay of the total content and available content of the trace nutrient elements and the soil pH and organic matter of the soil samples,the characteristic of the available content of the trace nutrient ele...Based on the assay of the total content and available content of the trace nutrient elements and the soil pH and organic matter of the soil samples,the characteristic of the available content of the trace nutrient elements and their affecting factors are studied. The results show that the available B in western Jilin is in a middle level,the content in Nong'an is higher than that in the others; the available Mn is extremely abundant; the available Cu in Nong'an is obviously higher than other areas,and the content in Da'an differs greatly; the available Zn is in a middle level; the severe shortage of available Mo differs between different areas; and the available Fe is extremely abundant. The available Mn,Cu and Fe have significantly positive correlation with their total content; the available B has significantly positive correlation with pH,and Zn has obviously negative correlation with pH; the available Mn and Fe had significantly positive correlation with soil organic matter.展开更多
Affective factors and cognitive factors are two important parts of English learning, However, English teaching in recent years have taken into special consideration the necessity of knowledge and intelligence and comp...Affective factors and cognitive factors are two important parts of English learning, However, English teaching in recent years have taken into special consideration the necessity of knowledge and intelligence and comparatively ignored the development of affection. It may greatly reduce students' English learning capacity and limit the whole development of students. This paper will discuss the definition and the importance of affection and some main affective factors, and illustrate some implications of how to implement practical affective activities.展开更多
Piezoelectric ceramic element (PCE) is a kind of actuator applied widely on the intelligent material & structure. Establishing the relationship between the transferring stress and the controlling signal, namely t...Piezoelectric ceramic element (PCE) is a kind of actuator applied widely on the intelligent material & structure. Establishing the relationship between the transferring stress and the controlling signal, namely the transferring and actuating equation, is a key step to analyze the actuating performance of the PCE. Based on the method of the shear lag theory, the procedure of the stress transferring is analyzed and the transferring and actuating model is established in this paper. Some measurements for PCE(PZT5) actuating the Glass Fiber/Epoxy laminate have been done to verify the model established. The experimental results show that the theoretical model agrees well with the practice. Finally, the effect of the main factors on PCE actuating the laminate is studied by using the experimental and theoretical results.展开更多
The quantitative analysis method was used to measure the tourism image of Nanjing waterfront to make clear its composition.An evaluation method was also adopted in terms of cognitive image,affective image and the whol...The quantitative analysis method was used to measure the tourism image of Nanjing waterfront to make clear its composition.An evaluation method was also adopted in terms of cognitive image,affective image and the whole image,which may offer some references for the evaluation of other tourism images in urban waterfront of the same kind.展开更多
文摘This paper develops two models to investigate the effect of team leader positive affectivity (PA) on team member turnover intention and team organizational citizenship behavior (OCB), at the individual and team levels, respectively. A two-wave longitudinal study was conducted involving a survey of 58 team leaders and 174 team members in a large Chinese telecom company across a three-month period. We found that team members' organization-based self-esteem (OBSE) at Time 1 mediates the relationship between team leader PA at Time 1 and team member turnover intention at Time 2, whereas team aggregated OBSE at Time 1 mediates the relationship between leader PA at Time1 and team OCB at Time 2.
文摘In this editorial we comment on the article by Zhang et al published in the recent issue of the World Journal of Psychiatry.We focus on identity diffusion,identity perturbations,their origin and developmental pathways.This is an upcoming problem in the society as not only school children are affected.Adolescents and young people suffer from uncertainty in gender identity,in self-image,migration effects due to chronic crises caused by war,pandemic disruptions or climate change.We show how such chronic uncertainty can be cared for,treated,and contained.The key is affective holding,reflection and to provide adequate affective mentalizing in a close concomitant way.These key features also depend on ambient conditions,such as psychotherapeutic care.In a qualitative interview study carried out in a cyclical research design with a comparative analysis on the basis of thematic coding using Grounded Theory Methodology we found institu-tionalized defenses in health policies.Professionals request better training and adequat academic knowledge as well as research into unresolved areas for improvement of the ambient conditions for adequat development of the self.Practice points for further clinical and scientific development are given and discussed.
基金supported by the Shenzhen Key Laboratory of Drug Addiction (ZDSYS20190902093601675)CAS Key Laboratory of Brain Connectome and Manipulation (2019DP173024)+2 种基金National Natural Science Foundation of China (82274358)Shenzhen-Hong Kong Institute of Brain ScienceGuangdong Basic and Applied Basic Research Foundation (2023B1515040009)
文摘Painful stimuli elicit first-line reflexive defensive reactions and,in many cases,also evoke second-line recuperative behaviors,the latter of which reflects the sensing of tissue damage and the alleviation of suffering.The lateral parabrachial nucleus(lPBN),composed of external-(elPBN),dorsal-(dlPBN),and central/superior-subnuclei(jointly referred to as slPBN),receives sensory inputs from spinal projection neurons and plays important roles in processing affective information from external threats and body integrity disruption.However,the organizational rules of lPBN neurons that provoke diverse behaviors in response to different painful stimuli from cutaneous and deep tissues remain unclear.In this study,we used region-specific neuronal depletion or silencing approaches combined with a battery of behavioral assays to show that slPBN neurons expressing substance P receptor(NK1R)(lPBNNK1R)are crucial for driving pain-associated self-care behaviors evoked by sustained noxious thermal and mechanical stimuli applied to skin or bone/muscle,while elPBN neurons are dispensable for driving such reactions.Notably,lPBNNK1R neurons are specifically required for forming sustained somatic pain-induced negative teaching signals and aversive memory but are not necessary for fear-learning or escape behaviors elicited by external threats.Lastly,both lPBNNK1R and elPBN neurons contribute to chemical irritant-induced nocifensive reactions.Our results reveal the functional organization of parabrachial substrates that drive distinct behavioral outcomes in response to sustained pain versus external danger under physiological conditions.
基金supported by the National Natural Science Foundation of China(No.U1960202).
文摘The mechanisms of oxide metallurgy include inducing the formation of intragranular acicular ferrite(IAF)using micron-sized inclusions and restricting the growth of prior austenite grains(PAGs)by nanosized particles during welding.The chaotically oriented IAF and refined PAGs inhibit crack initiation and propagation in the steel,resulting in high impact toughness.This work summarizes the com-bined effect of deoxidizers and alloying elements,with the aim to provide a new perspective for the research and practice related to im-proving the impact toughness of the heat affected zone(HAZ)during the high heat input welding.Ti complex deoxidation with other strong deoxidants,such as Mg,Ca,Zr,and rare earth metals(REMs),can improve the toughness of the heat-affected zone(HAZ)by re-fining PAGs or increasing IAF contents.However,it is difficult to identify the specific phase responsible for IAF nucleation because ef-fective inclusions formed by complex deoxidation are usually multiphase.Increasing alloying elements,such as C,Si,Al,Nb,or Cr,con-tents can impair HAZ toughness.A high C content typically increases the number of coarse carbides and decreases the potency of IAF formation.Si,Cr,or Al addition leads to the formation of undesirable microstructures.Nb reduces the high-temperature stability of the precipitates.Mo,V,and B can enhance HAZ toughness.Mo-containing precipitates present good thermal stability.VN or V(C,N)is ef-fective in promoting IAF nucleation due to its good coherent crystallographic relationship with ferrite.The formation of the B-depleted zone around the inclusion promotes IAF formation.The interactions between alloying elements are complex,and the effect of adding dif-ferent alloying elements remains to be evaluated.In the future,the interactions between various alloying elements and their effects on ox-ide metallurgy,as well as the calculation of the nucleation effects of effective inclusions using first principles calculations will become the focus of oxide metallurgy.
基金National Key Research and Development Plan of China, Grant/Award Number: 2021YFB3600503National Natural Science Foundation of China, Grant/Award Numbers: 62276065, U21A20472。
文摘Attention mechanism has been a successful method for multimodal affective analysis in recent years. Despite the advances, several significant challenges remain in fusing language and its nonverbal context information. One is to generate sparse attention coefficients associated with acoustic and visual modalities, which helps locate critical emotional se-mantics. The other is fusing complementary cross‐modal representation to construct optimal salient feature combinations of multiple modalities. A Conditional Transformer Fusion Network is proposed to handle these problems. Firstly, the authors equip the transformer module with CNN layers to enhance the detection of subtle signal patterns in nonverbal sequences. Secondly, sentiment words are utilised as context conditions to guide the computation of cross‐modal attention. As a result, the located nonverbal fea-tures are not only salient but also complementary to sentiment words directly. Experi-mental results show that the authors’ method achieves state‐of‐the‐art performance on several multimodal affective analysis datasets.
文摘BACKGROUND Affective disorders(AD)have been linked to inflammatory processes,although the underlying mechanisms of this relationship are still not fully elucidated.It is hypothesized that demographic,somatic,lifestyle,and personality variables predict inflammatory parameters in AD.AIM To identify biopsychosocial factors contributing to inflammation in AD measured with two parameters,C-reactive protein(CRP)and leukocytes.METHODS This observational study investigated 186 hospital inpatients diagnosed with AD using demographic parameters,serum inflammatory markers,somatic variables,psychological questionnaires,and lifestyle parameters.Hierarchical regression analyses were used to predict inflammatory markers from demographic,somatic,lifestyle,and personality variables.RESULTS Analyses showed that 33.8%of the variance of CRP was explained by body mass index and other somatic medication(e.g.anti-diabetics),age and education,and age of affective disorder diagnosis.For leukocytes,20.1%of the variance was explained by smoking,diet,metabolic syndrome(MetS),and anti-inflammatory medication(e.g.non-steroidal anti-inflammatory drugs).Other psychiatric or behavioural variables did not reach significance.CONCLUSION Metabolic components seem important,with mounting evidence for a metabolic affective disorder subtype.Lifestyle modifications and psychoeducation should be employed to prevent or treat MetS in AD.
基金Supported by The National Natural Science Foundation of China,No.81871080the Key R&D Program of Jining(Major Program),No.2023YXNS004+2 种基金the National Natural Science Foundation of China,No.81401486the Natural Science Foundation of Liaoning Province of China,No.20170540276the Medicine and Health Science Technology Development Program of Shandong Province,No.202003070713.
文摘BACKGROUND Panic disorder(PD)involves emotion dysregulation,but its underlying mechanisms remain poorly understood.Previous research suggests that implicit emotion regulation may play a central role in PD-related emotion dysregulation and symptom maintenance.However,there is a lack of studies exploring the neural mechanisms of implicit emotion regulation in PD using neurophysiological indicators.AIM To study the neural mechanisms of implicit emotion regulation in PD with eventrelated potentials(ERP).METHODS A total of 25 PD patients and 20 healthy controls(HC)underwent clinical evaluations.The study utilized a case-control design with random sampling,selecting participants for the case group from March to December 2018.Participants performed an affect labeling task,using affect labeling as the experimental condition and gender labeling as the control condition.ERP and behavioral data were recorded to compare the late positive potential(LPP)within and between the groups.RESULTS Both PD and HC groups showed longer reaction times and decreased accuracy under the affect labeling.In the HC group,late LPP amplitudes exhibited a dynamic pattern of initial increase followed by decrease.Importantly,a significant group×condition interaction effect was observed.Simple effect analysis revealed a reduction in the differences of late LPP amplitudes between the affect labeling and gender labeling conditions in the PD group compared to the HC group.Furthermore,among PD patients under the affect labeling,the late LPP was negatively correlated with disease severity,symptom frequency,and intensity.CONCLUSION PD patients demonstrate abnormalities in implicit emotion regulation,hampering their ability to mobilize cognitive resources for downregulating negative emotions.The late LPP amplitude in response to affect labeling may serve as a potentially valuable clinical indicator of PD severity.
文摘BACKGROUND The outcome of surgical treatment for colorectal cancer(CRC)remains unsatis-factory and warrants further exploration and optimization.AIM To clarify the impact of chemotherapy plus cellular immunotherapy[dendritic cell-cytokine-induced killer(DC-CIK)cell immunotherapy]on patients after CRC surgery and to explore the mediating variables.METHODS A total cohort of 121 patients who underwent CRC surgery between January 2019 and April 2022 were selected.The sample comprised a control group of 55 pa-tients who received the XELOX chemotherapy regimen and a research group of 66 patients who received XELOX+DC-CIK immunotherapy.We performed compa-rative analyses of the clinical and pathological data of the two groups,including efficacy(2-year disease-free survival[DFS]rate),the incidence of adverse events(diarrhea,myelosuppression,gastrointestinal reactions,and peripheral neuritis),serum levels of tumor markers[carcinoembryonic antigens and carbohydrate an-tigens(CA)19-9 and CA242],and T-cell subsets[cluster of differentiation(CD)3+,CD3+CD4+,CD3+CD8+,natural killer(NK),and NK T cells].We also conducted preliminary univariate and mul-tivariate analyses of the variables that affected the efficacy of the treatments.RESULTS We found a significantly higher 2-year DFS rate of treatment efficacy in the research group than in the control group,with a statistically lower incidence of adverse events.Both groups showed a reduction in serum tumor markers after treatment but there was no marked intergroup difference.After treatment,the various T-cell subgroup indicators in the control group were significantly lower than those in the research group.The indices of T-cell subsets in the research group showed no significant change from preoperative levels.Univariate analysis revealed a significant correlation between TNM staging,tumor differentiation,and the rates of nonresponse to treatment in CRC patients after surgery.Multivariate results indicated that the treatment approach significantly affected the efficacy of postoperative CRC treatment.CONCLUSION We concluded that XELOX+DC-CIK immunotherapy for postsurgical CRC patients offers reduced rates of treatment-induced adverse events,extended 2-year DFS,enhanced immunity,and increased physiological antitumor responses.
基金a phased achievement of the 2020 Youth Fund Project of the Ministry of Education in Humanities and Social Sciences of China,titled“Legislative Research on Collaborative Dispute Resolution Mechanisms for Medical Disputes in the Guangdong-Hong Kong-Macao Greater Bay Area”(Project Number 20YJC820023)。
文摘As the frontier of intelligent computing technology,affective computing has been used in border inspection,case investigation,crime assessment,public opinion management,traffic management and other scenarios of public governance.However,there are still public risks associated with its failure to meet the basic requirements of modern public governance,and these risks are rooted in its technical characteristics.The technical characteristics of turning emotions into signals can give rise to such problems as degrading the right to informed consent,de-governance,and undermining human dignity when applied in public governance,and consequently can lead to social rights anxiety.Additionally,the affective modeling characteristics of affective computing tend to incur the rights risks of insufficient algorithm accuracy,algorithmic discrimination,and algorithmic black boxes.To avoid these risks,it is necessary to adopt the dynamic consent model as the premise for applying affective computing in public governance,and to regulate the auxiliary application of affective computing in public governance in a hierarchical manner,to achieve a balance between the application of affective computing technology and the protection of citizens'rights and the maintenance of public ethics.
文摘Scars, when in good evolution, result in a smooth, thin and discreet tissue. Keloid scars, however, are a type of abnormal and exacerbated repair response to tissue injury, whether in surgical interventions or in various injuries, which present in a prominent and gross way. In this context, there is an excess of collagen deposition in the tissue repair process, which can lead to the formation of keloids. The diagnosis of the condition presented is made by the medical professional or by the patient himself after the surgical intervention or skin injury. Under this analysis, protruding, rough and bad-looking scars are identified. In addition, we highlight the existence of keloids similar to large tumors, described as Jorge Lobo disease. The treatment encompasses massages, compressions, corticosteroids, chemotherapy, collagenase and cryotherapy. At first, we used corticosteroid-based massages, and then we started using compressive dressings until we started intrakeloid infiltrations with injectable triamcinolone. Triamcinolone 10 mg injectable—1/10—in 0.9% saline, with syringe and fixed needle 0.3 mm × 8 mm, intralesional infiltrate, in this context, proved to be effective for its treatment when applied sequentially and linearly. In cases where the medication was applied, there was an improvement after 21 days of application and a definitive improvement 2 months after the injury. In comparison, on the other hand, patients who were not subjected to the application of the medication may improve after 4 months of the injury or worsen compared to the initial case. We have come to the conclusion that this procedure may be one of the chosen ones for the treatment of keloid scars, being one of the most recommended for cases of keloid already installed.
文摘In advanced otological surgeries, powered instruments form an indispensable part. The risk of deterioration to hearing in the operated ear is a commonly discussed issue, however, there remains a possibility of affecting the hearing in the contralateral ear due to transcranial vibration. So in this study we aimed to assess the possibility of the non-operated ear being affected by the noise generated during ear surgeries and whether it is temporary or permanent in nature. Methodology: This study included 63 patients diagnosed with unilateral disease who underwent mastoid surgery. Preoperatively all the patients were subjected to Pure tone audiometry (PTA), Transient evoked otoacoustic emission (TEOAE) and Distortion product otoacoustic emission (DPOAE). Patients were operated using both cutting and diamond burrs of ranging from sizes 1 - 6 mm. Total drilling time was recorded. Results: Post-operative hearing evaluation was done at 1 week, 4 weeks and 12 weeks. The sound emitted by various burrs was recorded by Sound Level Meter. Out of the total 58 patients that followed up, 46 showed change in at least one of the hearing parameters. Patients showing changes had a higher drilling time as compared to those with no changes. Of these, the changes associated with the total drilling time and with cutting burr time were found to be significant. The hearing changes seen on PTA, TEOAE and DPOAE were transient in nature with only one patient having a persistent decreased high frequency threshold at the end of 12 weeks. It was also found that cutting burrs produce more sound as compared to diamond burrs and a larger size burr of a type produces more sound than a smaller one of its type. Conclusion: The drilling of mastoid bone during ear surgeries can transiently impair the hearing in the contralateral ear which is of great significance in patients with only one hearing ear.
基金Supported by 973 Project of National Basic Research Program of China(2006CB403200 )Science and Technology Program of Guizhou Province (S2007-1021,2008-73,TZJF2008-17)National Scientific and Technological Support Project of China(2006BAD03-A0303)~~
文摘[Objective] The research was aimed to study the dynamics of slope runoff and soil erosion in different forest types in karst depression.[Method] Precipitation observation sites at the bottom of karst depression and runoff observation sites in different forest types were established to monitor regularly the main indices changes of runoff and soil erosion at fixed position in 4 years.[Result] The surface runoff of different forest types appeared singer peak from February to November,with lowest valley from June to July.The runoff coefficient appeared double peaks from February to May and from July to September.The changing coefficient of runoff appeared three peaks from March to April,from July to August and from September to November.The silt concentration appeared one peak from March to May and The erosion modulus appeared double peaks from March to May and from June to August.Runoff showed annually reduced trend with the growth of forests and the development of vegetation layer's structure.There was a positive correlation between the runoff and its silt concentration in different forest types.Precipitation and evaporation had notable positive correlation with the runoff,and similar correlation but not marked with silt concentration.The fitting analysis results of surface runoff and erosion modulus showed that rocky desertification intensified the unevenness of surface runoff and increased the surface runoff and erosion modulus.The penetrability of surface soil in new planted forest was lower than that in young forest,and that in surface soil of different forest types was higher than in bottom soil.[Conclusion] The research provided theoretical basis for the biological management technologies of water and soil conservation and the control of karst rocky desertification in karst regions.
基金Project(2011CB605503)supported by the National Basic Research Program of China
文摘The oxidation behavior of Ti?22Al?(27?x)Nb?xZr (x=0, 1, 6) alloys at 800 °C for exposure time up to 100 h was examined. It is shown that oxidation rate of experimental alloys obeys the parabolic kinetics. Ti?22Al?26Nb?1Zr alloy demonstrates more excellent oxidation resistance than the other two alloys. The main oxidation products are TiO2, Al2O3 and AlNbO4 phases for all these alloys. For the Ti?22Al?26Nb?1Zr alloy, Zr addition can modify the growth mechanism of oxide scale, which can effectively hinder the diffusion of oxygen. Whereas, reaction of Zr with oxygen leads to the formation of ZrO2 precipitates for the Ti?22Al?21Nb?6Zr alloy, which promotes the oxygen ingress into the substrate. Meanwhile, oxidation affected zones, including internal-oxidation layer and oxygen-enriched zone, are present beneath the outmost oxide scale. The difference in these zones is derived from the phase constitution in the starting Ti?22Al?(27?x)Nb?xZr (x=0, 1, 6) alloys.
基金Supported by Ministry of Water Resources Public Welfare Industry Research Program(200901026)Philosophical Social Sciences Foundation of Jiangsu Colleges(08SJD7900052)~~
文摘[Objective] To research the evolution of drought in China and its impact on agriculture in recent years. [Method] We analyzed land area covered, area affected, and disaster rate arising from severe drought occurring in China in the period 1978-2008, in conjunction with the planting area of crops in China and forcing of drought on the planting area of crops. [Result] In recent years, a large portion of provinces and cities in China, especially the southern areas, the drought has not yet been eased, but tends to deteriorate; since 1978, the area affected in China occasioned by drought has been rapidly mounting, and total crop failure area caused by drought, on the whole, also assumes trend of rise. In the mean time, population explosion and economic development are responsible for dwindling of planting area of grain, and tardy rise in total grain yield. [Conclusion] Constructing harmonious valley and achieving concordant coexistence between human and water, is to regulate human behaviors and further strengthen related ecological protection work, on the basis of scientifically understanding and correctly harnessing natural law.
基金Project(51274092)supported by the National Natural Science Foundation of ChinaProject(20120161110040)supported by the Doctoral Program of Higher Education of China
文摘Fine-grained ZK60 magnesium alloy sheets of 2.0 mm in thickness were successfully joined by laser beam welding (LBW). The effects of welding parameters including laser power and welding speed on the microstructures and mechanical properties of the joints were investigated. A sound bead, with the ultimate tensile strength (UTS) of 300 MPa and elongation of 12.0%, up to 92.5% and 65% of those of the base metal, respectively, is obtained with the optimized welding parameters. No liquation cracking is visible in the partially melted zone (PMZ) owing to the inhibitory action of the fine dispersed precipitates and the fine-grained microstructure in the as-rolled magnesium alloy sheets. The fusion zone (FZ) is featured with the equiaxed dendritic grains of the average grain size about 8 μm, which are similar to those in the heat affected zone (HAZ), and this contributes to the relatively high joint efficiency.
基金Supported by a Sub-project "Ecological Geochemical Survey of Oil Crop (sunflower) Producing Area in Western Jilin" of the Project of China Geological Survey and Jilin Provincial Government " Agricul-tural Geological Survey of Jilin Province"~~
文摘Based on the assay of the total content and available content of the trace nutrient elements and the soil pH and organic matter of the soil samples,the characteristic of the available content of the trace nutrient elements and their affecting factors are studied. The results show that the available B in western Jilin is in a middle level,the content in Nong'an is higher than that in the others; the available Mn is extremely abundant; the available Cu in Nong'an is obviously higher than other areas,and the content in Da'an differs greatly; the available Zn is in a middle level; the severe shortage of available Mo differs between different areas; and the available Fe is extremely abundant. The available Mn,Cu and Fe have significantly positive correlation with their total content; the available B has significantly positive correlation with pH,and Zn has obviously negative correlation with pH; the available Mn and Fe had significantly positive correlation with soil organic matter.
文摘Affective factors and cognitive factors are two important parts of English learning, However, English teaching in recent years have taken into special consideration the necessity of knowledge and intelligence and comparatively ignored the development of affection. It may greatly reduce students' English learning capacity and limit the whole development of students. This paper will discuss the definition and the importance of affection and some main affective factors, and illustrate some implications of how to implement practical affective activities.
文摘Piezoelectric ceramic element (PCE) is a kind of actuator applied widely on the intelligent material & structure. Establishing the relationship between the transferring stress and the controlling signal, namely the transferring and actuating equation, is a key step to analyze the actuating performance of the PCE. Based on the method of the shear lag theory, the procedure of the stress transferring is analyzed and the transferring and actuating model is established in this paper. Some measurements for PCE(PZT5) actuating the Glass Fiber/Epoxy laminate have been done to verify the model established. The experimental results show that the theoretical model agrees well with the practice. Finally, the effect of the main factors on PCE actuating the laminate is studied by using the experimental and theoretical results.
文摘The quantitative analysis method was used to measure the tourism image of Nanjing waterfront to make clear its composition.An evaluation method was also adopted in terms of cognitive image,affective image and the whole image,which may offer some references for the evaluation of other tourism images in urban waterfront of the same kind.