BACKGROUND Dry eye syndrome(DES)after diabetic cataract surgery can seriously affect the patient’s quality of life.Therefore,effective alleviation of symptoms in patients with this disease has important clinical sign...BACKGROUND Dry eye syndrome(DES)after diabetic cataract surgery can seriously affect the patient’s quality of life.Therefore,effective alleviation of symptoms in patients with this disease has important clinical significance.AIM To explore the clinical effect of recombinant human epidermal growth factor(rhEGF)plus sodium hyaluronate(SH)eye drops on DES after cataract surgery in patients with diabetes.METHODS We retrospectively evaluated 82 patients with diabetes who experienced DES after cataract surgery at Tianjin Beichen Hospital,Affiliated Hospital of Nankai University between April 2021 and April 2023.They were classified into an observation group(42 cases,rhEGF+SH eye drops)and a control group(40 cases,SH eye drops alone),depending on the different treatment schemes.The therapeutic efficacy,dry eye symptom score,tear film breakup time(TFBUT),basic tear secretion score[assessed using Schirmer I test(SIt)],corneal fluorescein staining(FL)score,tear inflammatory markers,adverse reactions during treat-ment,and treatment satisfaction were compared between the two groups.RESULTS Therapeutic efficacy was higher in the observation group compared with the control group.Both groups showed improved TFBUT and dry eye,as well as improved SIt and FL scores after treatment,with a more pronounced improvement in the observation group.Although no marked differences in adverse reactions were observed between the two groups,treatment satisfaction was higher in the observation group.CONCLUSION rhEGF+SH eye drops rendered clinical benefits to patients by effectively ameliorating dry eye and visual impairment with favorable efficacy,fewer adverse reactions,and high safety levels.Thus,this treatment should be promoted in clinical practice.展开更多
目的:观察滋肾养肝润目汤治疗干眼症的临床疗效。方法:将127例肝肾阴虚型干眼症患者随机分为对照组62例和治疗组65例,对照组给予0.1%玻璃酸钠滴眼液滴双眼治疗,每日4次,治疗组给予滋肾养肝润目汤治疗,日1剂,两组均以7 d为1个疗程,治疗4...目的:观察滋肾养肝润目汤治疗干眼症的临床疗效。方法:将127例肝肾阴虚型干眼症患者随机分为对照组62例和治疗组65例,对照组给予0.1%玻璃酸钠滴眼液滴双眼治疗,每日4次,治疗组给予滋肾养肝润目汤治疗,日1剂,两组均以7 d为1个疗程,治疗4个疗程。观察两组患者治疗前后眼干、畏光、眼疲劳、头晕、视物模糊、异物感等主要临床症状的改善情况,比较患者主要证候积分变化情况、泪液分泌量、泪膜破裂时间及角膜荧光素染色情况,比较两组患者临床疗效。结果:两组患者的眼干、畏光、眼疲劳、头晕、视物模糊、异物感等主要临床症状均有所改善,证候积分有所下降,以治疗组的改善尤为明显,差异有统计学意义(P<0.05);两组患者经治疗后泪液分泌量(Schirmer I test,SIt)、泪膜破裂时间(BUT)均较治疗前有所升高,角膜荧光素染色(FL)则较治疗前有所降低,以治疗组的变化程度尤为明显,差异有统计学意义(P<0.05);对照组有效率为79%,治疗组有效率为90.7%,治疗组有效率明显高于对照组,差异有统计学意义(P<0.05)。结论:滋肾养肝润目汤是可滋阴填精、养肝明目,有效缓解干眼症患者眼干、畏光、眼疲劳、头晕、视物模糊、异物感等临床症状,促进泪液分泌,延长泪膜破裂时间,临床疗效显著。展开更多
基金Supported by Tianjin Health Research Project,No.TJWJ2023MS062。
文摘BACKGROUND Dry eye syndrome(DES)after diabetic cataract surgery can seriously affect the patient’s quality of life.Therefore,effective alleviation of symptoms in patients with this disease has important clinical significance.AIM To explore the clinical effect of recombinant human epidermal growth factor(rhEGF)plus sodium hyaluronate(SH)eye drops on DES after cataract surgery in patients with diabetes.METHODS We retrospectively evaluated 82 patients with diabetes who experienced DES after cataract surgery at Tianjin Beichen Hospital,Affiliated Hospital of Nankai University between April 2021 and April 2023.They were classified into an observation group(42 cases,rhEGF+SH eye drops)and a control group(40 cases,SH eye drops alone),depending on the different treatment schemes.The therapeutic efficacy,dry eye symptom score,tear film breakup time(TFBUT),basic tear secretion score[assessed using Schirmer I test(SIt)],corneal fluorescein staining(FL)score,tear inflammatory markers,adverse reactions during treat-ment,and treatment satisfaction were compared between the two groups.RESULTS Therapeutic efficacy was higher in the observation group compared with the control group.Both groups showed improved TFBUT and dry eye,as well as improved SIt and FL scores after treatment,with a more pronounced improvement in the observation group.Although no marked differences in adverse reactions were observed between the two groups,treatment satisfaction was higher in the observation group.CONCLUSION rhEGF+SH eye drops rendered clinical benefits to patients by effectively ameliorating dry eye and visual impairment with favorable efficacy,fewer adverse reactions,and high safety levels.Thus,this treatment should be promoted in clinical practice.
文摘目的:观察滋肾养肝润目汤治疗干眼症的临床疗效。方法:将127例肝肾阴虚型干眼症患者随机分为对照组62例和治疗组65例,对照组给予0.1%玻璃酸钠滴眼液滴双眼治疗,每日4次,治疗组给予滋肾养肝润目汤治疗,日1剂,两组均以7 d为1个疗程,治疗4个疗程。观察两组患者治疗前后眼干、畏光、眼疲劳、头晕、视物模糊、异物感等主要临床症状的改善情况,比较患者主要证候积分变化情况、泪液分泌量、泪膜破裂时间及角膜荧光素染色情况,比较两组患者临床疗效。结果:两组患者的眼干、畏光、眼疲劳、头晕、视物模糊、异物感等主要临床症状均有所改善,证候积分有所下降,以治疗组的改善尤为明显,差异有统计学意义(P<0.05);两组患者经治疗后泪液分泌量(Schirmer I test,SIt)、泪膜破裂时间(BUT)均较治疗前有所升高,角膜荧光素染色(FL)则较治疗前有所降低,以治疗组的变化程度尤为明显,差异有统计学意义(P<0.05);对照组有效率为79%,治疗组有效率为90.7%,治疗组有效率明显高于对照组,差异有统计学意义(P<0.05)。结论:滋肾养肝润目汤是可滋阴填精、养肝明目,有效缓解干眼症患者眼干、畏光、眼疲劳、头晕、视物模糊、异物感等临床症状,促进泪液分泌,延长泪膜破裂时间,临床疗效显著。
