Effect of Body Mass Index on All-cause Mortality and Incidence of Cardiovascular Diseases─Report for Meta-Analysis of Prospective Studies on Optimal Cut-off Points of Body Mass Index in Chinese Adults

Objective To verify the optimal cut-off points for overweight and obesity in Chinese adults based on the relationship of baseline body mass index (BMI) to all-cause mortality, and incidence of cardiovascular diseases from pooled data of Chinese cohorts. Methods The prospective study data of existing cohort studies in China were collected, and the age-adjusted all-cause mortality stratified by BMI were estimated. The similar analysis was repeated after excluding deaths within the first three years of follow-up and after excluding smokers. The incidence of age-adjusted coronary heart disease (CHD) and stroke stratified by BMI were also analyzed. Multiple Cox regression coefficients of BMI for the incidence of CHD and stroke after controlling other risk factors were pooled utilizing the methods of weighting by inverse of variance to reveal whether BMI had independent effect and its strength on the incidence of CHD and stroke. Results The data of 4 cohorts including 76 227 persons, with 745 346 person-years of follow-up were collected and analyzed. The age-adjusted all-cause mortality stratified by BMI showed a U-shaped curve, even after excluding deaths within the first three years of follow-up and excluding smokers. Age-adjusted all-cause mortality increased when BMI was lower than 18.5 and higher than 28. The incidence of CHD and stroke, especially ishemic stroke increased with increasing BMI, this was consistent with parallel increasing of risk factors. Cox regression analysis showed that BMI was an independent risk factor for both CHD and stroke. Each amount of 2 kg/m2 increase in baseline BMI might cause 15.4%, 6.1% and 18.8 % increase in relative risk of CHD, total stroke and ischemic stroke. Reduction of BMI to under 24 might prevent the incidence of CHD by 11% and that of stroke by 15 % for men, and 22 % of both diseases for women. Conclusion BMI ≤18.5, 24-27.9 and ≥28 (kg/m2) is the appropriate cut-off points for underweight, overweight and obesity in Chinese adults.

BMI and BMI Changes to All-cause Mortality among the Elderly in Beijing： a 20-year Cohort Study

Objective To explore the association between body mass index （BMI） and all-cause mortality among the elderly in Beijing. Methods This analysis was based on the Beijing multidimensional longitudinal study of aging （BLSA）, which included 2,090 subjects over 55 years old and was followed-up from 1992 to 2012. BMI-mortality curves were drawn to find the optimal BMI range with the lowest mortality. Cox proportional hazard models were used to obtain the hazard ratios （HRs） for BMI and BMI changes in the overall population and in specific stratified populations. Results During follow-up, 2,264 deaths were recorded; BMI-mortality curve was U-shaped, with the lowest mortality at a BMI of approximately 25 kg/m2. After adjusting for gender, age, smoking, drinking and some pre-existing diseases, HRs for underweight, overweight and obesity compared with normal weight were 2.372 （95% C/： 2.254-2.632）, 0.767 （95% CI： 0.666-0.884） and 0.872 （95% CI： 0.830-1.246）, respectively. HR for BMI drop was 3.245 （95% CI： 0.824-22.772） in the underweight group and 1.892 （95% C/： 0.830-1.246） in the normal weight group, HR for BMI rise was 1.795 （95% CI： 1.243-2.591） in normal weight group and 2.962 （95% CI： 2.202-3.203） in the overweight group. Conclusion Keeping BMI in an overweight status and stable is related to a reduced mortality

Elevated serum uric acid level as a predictor for cardiovascu-lar and all-cause mortality in Chinese patients with high cardiovascular risk

Objective To assess the predictive value of serum uric acid levels for cardiovascular and all-cause mortality in a large prospective population based study.Methods The study was based on 3648 participants in Shanghai and Beijing,who were inpatients with high cardiovascular(CV) risk at baseLine (2004.7 to 2005.1),and blood was taken.Follow-up for death from cardiovascular disease and any cause was complete until January 1,2006.Results The mean follow-up was 1 years.There were 303 deaths during follow-up,of which 121 were cardiovascular.Crude mortality rates were 8.3 % for all patients,6.8% for female patients (116/1715),and 9.7% (187/1933) for male patients.Among men,patients in the lower and higher uric acid groups had increased cardiac and overall mortality risks compared with patients in the normal uric acid groups.Similar relation was found in women but not statistically significant.After adjusting for other conventional risk factors (age,diabetes,hypertension,diuretic use and smoking),baseline uric acid level was still associated with increased risk for death from cardiovascular disease (P=0.005),or death from all causes (P=0.014) Conclusion Our data suggest that abnormal serum uric acid levels are independently and significantly associated with risk of cardiovascular and all-cause mortality.(J Geriatr Cardiol 2008;5:15-20)

Influence of Underlying Diseases and Age on the Association between Obesity and All-Cause Mortality in Post-Middle Age

Background: Studies on the association between obesity and all-cause mortality have found that the degree of obesity is directly proportional to all-cause mortality. In contrast, there have been studies indicating that obese people with underlying diseases have a higher survival rate. We hypothesized that age and underlying diseases lead to such contrasting results. Therefore, we conducted a study to clarify the influence of post-middle age obesity and underlying diseases on all-cause mortality. Methods: This study used data from longitudinal studies in the United States, which conducted follow-up for 19 years on 33,708 participants in different age groups: ≥45, 45 - 64, and ≥65 years. Hazard ratio (HR) was determined using the Cox proportional hazards model to analyze a group consisting of all participants, a group of those with underlying diseases, and a group of those without underlying diseases, considering age, gender, education history, marital status, household income, smoking history, and BMI category as covariates. Results: In the group aged ≥65 without underlying diseases, HR was almost 1 in those with BMI 25 - 35 kg/m2. Further, HR was higher in the 45 - 64 age group without underlying diseases if BMI was >35 kg/m2. However, HR was approximately 1 in the ≥65 age group. Conclusions: The study revealed that among individuals aged ≥65 years without underlying diseases, there was no association between obesity and all-cause mortality. Among individuals without underlying diseases, HR was higher in the 45 - 64 age group with BMI > 35 kg/m2 but was approximately 1 among those aged ≥65 years. Therefore, an interaction based on age was detected. These findings may lead to recommendations regarding the need to modify the advice and education provided to obese individuals in different age groups.

Mortality from chronic liver disease:Recent trends and impact of the COVID-19 pandemic

Prepandemic time trends in mortality from chronic liver disease(CLD)differed according to specific cause of death(decreasing for liver cirrhosis,stable or increasing for liver cancer),etiology(increasing for nonalcoholic fatty liver disease,generally decreasing for other etiologies),and world region(decreasing in areas with the highest burden of hepatitis B virus,increasing in Eastern Europe and other countries).The coronavirus disease 2019(COVID-19)pandemic affected mortality of patients with CLD both directly,with a higher risk for severe illness and death depending on age,stage and etiology of the disease,and indirectly,through social isolation and loss of support,harmful drinking,and difficulties in access to care.Nevertheless,only sparse data are available on variations in CLD as a cause of death during the pandemic.In the USA,in 2020-2021 a growth in mortality was registered for all liver diseases,more marked for alcoholic liver disease,especially among young people aged 25-44 years and in selected ethnic groups.COVID-19 related deaths accounted only for a minor part of the excess.Further data from mortality registers of other countries are warranted,preferably adopting the so-called multiple cause-of-death approach,and extended to deaths attributed to viral hepatitis and liver cancer.

Study of Mortality and Causes of Death in the Service of Stomatology, Maxillofacial and Plastic Surgery of the Face at Cocody Teaching Hospital (RCI)

Introduction: The study of mortality is an indicator that allows a control and a review of the therapeutic measures in the hospital environment. The purpose of this work was to determine the epidemiological profile of the patients who died and analyse the circumstances of the death in a hospital service. Material and Methods: It is a retrospective descriptive study conducted in the service of Stomatology, maxillofacial and plastic surgery of the face over a period of 10 years (from January 1999 to December 2008). Seventy-two cases have been taken into account. Results: The crude death rate was 4.29%. Higher level of male has been noted with a sex ratio of 1.77. The most affected age groups were the 3rd and 2nd decades, respectively with 20.8% and 19.4% with an average age of 39 years. Cellulitis of the face and their complications were responsible for deaths in 58.33% of cases. The majority of deaths occurred between 6 p.m. and 6 a.m. (65.28%). These deaths were preventable in 5.6% of cases. Conclusion: Facing the lack of description of the ultimate circumstances of death in the medical records, the conclusion of this study has been the establishment of a regular medical audit in the service, which would track mortality in order to reduce its rate.

2016-2021年北京市5岁以下儿童死亡变化趋势及死因研究

目的 分析2016-2021年北京市5岁以下儿童死亡率(U5MR)变化趋势及主要死因,为制定、调整干预策略提供依据。方法 提取北京市妇幼保健网络信息系统中2016-2021年5岁以下儿童死亡监测数据,对北京市U5MR和不同年龄组死亡率变化趋势及主要死因进行回顾性分析。结果 2016-2021年北京市U5MR呈下降趋势,2021年下降至2.24‰,已达到国际领先水平。5岁以下儿童各年龄组中,新生儿死亡率(NMR)下降速度最快,年度变化百分比(APC)为-8.98%(95%CI:-13.14%~-5.59%),是2016-2021年北京市U5MR下降的主要原因;而1~<5岁儿童死亡率呈上升趋势(APC=13.50%,95%CI:1.06%~27.51%)。2016-2021年早产或低出生体重(APC=-14.00%,95%CI:-23.51%~-6.38%)和其他新生儿疾病死亡率(APC=-25.91%,95%CI:-44.69%~-12.43%),呈下降趋势;意外伤害死亡率呈上升趋势(APC=12.34%,95%CI:5.11%~19.72%)。2021年主要死因中,远郊地区先天异常、意外伤害、早产或低出生体重和出生窒息死亡率均高于城市地区。2016-2021年,城市地区和远郊地区早产或低出生体重死亡率均呈下降趋势,城市地区出生窒息和远郊地区其他新生儿病死亡率呈下降趋势;城市地区意外伤害和肺炎死亡率呈上升趋势。结论 北京市在降低NMR以及降低早产或低出生体重和其他新生儿病等疾病死亡率方面成果显著,但同时还应重视意外伤害、先天异常和出生窒息等主要死因防控,并加强对1~<5岁儿童群体的关注。

Population attributable risks of cigarette smoking for deaths of all causes, all cancers and other chronic diseases among adults aged 40-74 years in urban Shanghai, China

Objective： To evaluate the population attributable risks （PARs） between cigarette smoking and deaths of all causes, all cancers, lung cancer and other chronic diseases in urban Shanghai. Methods： In total, 61,480 men aged 40-74 years from 2002 to 2006 and 74,941 women aged 40-70 years from 1997 to 2000 were recruited to undergo baseline surveys in urban Shanghai, with response rates of 74.0% and 92.3%, respectively. A Cox proportional hazards regression model was used to estimate relative risks （RRs） and 95% confidence intervals （95% CIs） of deaths associated with cigarette smoking. PARs and 95 % CIs for deaths were estimated from smoking exposure rates and the estimated RRs. Results： Cigarette smoking was responsible for 23.9% （95% CI： 19.4-28.3%） and 2.4% （95% Ch 1.6- 3.2%） of all deaths in men and women, respectively, in our study population. Respiratory disease had the highest PAR in men [37.5% （95% CI： 21.5-51.6%）], followed by cancer [31.3% （95% Ch 24.6-37.7%）] and cardiovascular disease （CVD） [24.1% （95% CI： 16.7-31.2%）]. While the top three PARs were 12.7% （95% CI： 6.1-19.3%）, 4.0% （95% CI： 2.4-5.6%）, and 1.1% （95% CI： 0.0-2.3%）, for respiratory disease, CVD, and cancer, respectively in women. For deaths of lung cancer, the PAR of smoking was 68.4% （95% CI： 58.2- 76.5%） in men. Conclusions： In urban Shanghai, 23.9% and 2.4% of all deaths in men and women could have been prevented if no people had smoked in the area. Effective control programs against cigarette smoking should be strongly advocated to reduce the increasing smoking-related death burden.

Potential Toxicological and Cardiopulmonary Effects of PM2,5 Exposure and Related Mortality:Findings of Recent Studies Published during 2003-2013

Air pollution has environmental issue owing become a serious to its diverse harmful effects on the physical and biological environment. According to the Environmental Protection Agency （EPA） and the World Health Organization （WHO）, air pollution affects millions of people worldwide. Hundreds of thousands of deaths each year and a range of diseases, particularly among vulnerable groups （i.e., children, the elderly, and people with special medical conditions）, are attributed to air pollution. These effects are not always caused by single pollutant in the air; rather, they are considered consequences of the multi-pollutants to which people are simultaneously exposed.

Morbidity and Mortality of Inpatients in the Department of Infectious Diseases of the University Hospital of Bobo-Dioulasso, Burkina Faso

Background: Infectious Diseases are responsible for nearly 17 million annual deaths worldwide. Burkina Faso, like the majority of poor countries, remains vulnerable to infectious diseases. The objective of the present study was to analyze the profile of inpatients, including the mortality and causes of death, in the Infectious Diseases Department of Sour&#244;Sanou teaching hospital (Bobo-Dioulasso, Burkina Faso). Methods: We carried out a cross-sectional study based on medical records of all inpatients from 2011 to 2015. Results: We included 1169 patients. The gender ratio was 0.8. The age group 30 to 39 was more represented (30.2%) as well as housewives and farmers (73.7%). Over one-thirds of the patients (35.3%) were consulted within an average of 7 days. The most common reason for consultation was fever (65.1%). Around 62.0% of inpatients were infected by the Human Immunodeficiency Virus (HIV). Digestive diseases ranked first (21.8%) followed by nervous system disorders (19.4%) and tuberculosis (17.8%). Overall morbidity rate was 31.3%. About 42% were admitted to the emergency ward while 83.3% already arrived with poor health condition. And 82.1% of deaths occurred on pathological grounds of which 66.7% were related to HIV. Main causes of death included nervous system diseases (28.6%), tuberculosis (21.9%) and gastrointestinal diseases (18.3%). Conclusion: Infectious diseases remain a major public health issue. Further efforts are needed to improve their management in Burkina Faso.

老年人时间-空间步态特征和不良健康结局风险

背景:步态是衡量老年人功能状态的最佳指标之一。步态参数与老年人不良健康结局相关。目的:总结比较步态参数之间的实际应用价值,对老年人时间-空间参数与不良健康结局风险的研究进展进行综述。方法:以“gait speed,walking speed,step length,cadence,step frequency,step time,walking base,aged and elderly”为英文检索词,以“步速,步长,步频,步行时间,步宽,老年人”为中文检索词,检索PubMed、Web of Science、中国知网数据库2010年1月至2023年6月发表的相关文献,最终纳入52篇文献进行综述分析。结果与结论:(1)目前研究者多关注“步速、步长、步频”3项基础时间-空间参数,探索其与老年人不良健康结局的关联。(2)老年人步速降低可能会增加跌倒、全因死亡的风险,或是全因死亡的独立预测因子;慢步速老年人出现认知功能下降的风险更高,在评估老年人认知障碍时步速或许能作为首选的步态参数;慢步速老年人患衰弱或常见慢性疾病的比例更高,且有着更高住院和公共照料的风险。(3)步长与个体身高和下肢长度呈正相关,但年龄增长引起的步长缩短与身高和下肢长度无关,步长缩短反映出老年人身体功能的降低,步长缩短是老年人跌倒事件发生、认知功能下降的风险因素。(4)步频常作为衡量运动强度的指标,步频≥100步/min能够预测全因死亡率,步频减慢可能会导致老年人有更高的跌倒、住院和全因死亡风险。(5)步态参数的变化和老年人身体健康水平密切相关,并且两者可能存在双向关系。研究结果将为进一步提升临床人群风险筛查、完善老年人健康风险评估、提高老年人健康保障和促进主动健康提供理论依据。

Analysis of Cause of Death in Inner Mongolia of China, 2008-2014

Objective: The aim of our study was to analyze the character of cause of death in Inner Mongolia of China from 2008 to 2014. Methods: We collected data from monitoring points of the Death Registry System (DRS) in Inner Mongolia. We calculated the mortality rates by gender, year and age-specific. We calculated the proportion, the mortality rate and potential years of life lost (PYLL) of various system deaths. Results: During the period 2008-2014, the average crude mortality rate of all cause of death was 539.33/105. The mortality rate increased semilogarithm linearly with age. The top four system deaths were circulatory system, neoplasm, respiratory system and injury. In 2014, the mortality rates of circulatory system were increased and the mortality rates of certain infectious and parasitic diseases, neoplasms, respiratory system, genitourinary system and injury were decreased compared to those in 2008. Conclusion: Through analysis the indicators of proportion, the mortality rate and PYLL indicated that health status of a population in Inner Mongolia was at a better level.

Cancer mortality in Inner Mongolia of China, 2008-2010

Objective: The aim of our study was to determine the status of the common cancer in Inner Mongolia of China. Methods: We obtained data from the Centers for Disease Control in the Inner Mongolia from five monitoring points of DRS in Inner Mongolia from 2008 to 2010. We calculated the crude mortality, the proportion of all cause of death during the three years, further calculated cancer mortality, the proportion of cancer death and PYLL by genders. Results: During the period 2008-2010, the crude mortality of all cause of death is 518.02 per million in Inner Mongolia. As the second most common cause of death, the mortality dying from cancer is 127.11 per million, accounting for over one fifth of all deaths. Among all deaths from cancer, the lung cancer had the highest mortality rates (46.25 per million in males and 17.95 per million in females) and PYLL (0.72 in males and 0.41 in females), followed by the liver cancer (23.76 per million) and the gastric cancer (16.15 per million). The female breast cancer is the fourth leading cancer from mortality and PYLL for 7.65 per million and 0.17. Conclusion: Our analysis determined the severity of cancer death in Inner Mongolia of China from 2008 to 2010.Our study found that the cancer mortality in Inner Mongolia is lower than Chinese average level and most west countries, higher than some Africa countries. Our results will guide future cancer control strategies in Inner Mongolia of China.

Early Mortality (120 Days) amongst Incident Hemodialysis with End Stage Kidney Disease: A 5-Year Retrospective Study

Background: End stage kidney failure (ESKF) is a major public health problem worldwide. Haemodialysis is the principal method in its management, and is associated with high mortality mostly owing to cardiovascular disease (CVD). In Cameroon, data on its predictors is lacking. Objectives: This study aimed at determining the 120 day mortality, causes of death and its predictors and amongst incident haemodialysis patients with end stage kidney disease in Cameroon. Methods: We retrospectively reviewed medical records of patients admitted for ESKF who started haemodialysis between January 2016 and December 2020 (5 years) and who died within 120 days. For these patients, the variables collected were: age, gender, comorbidities, dialysis parameters, para-clinical parameters, cause of death. The causes of death were registered as stated by the attending physician. Data were analysed using SPSS 20. A p-value Results: Out of 1012 incident patients, 258 died giving a mortality rate of 25.5%. Of these, 59.7% were males. The mean age (SD) was 46.52 (15.6) years. The main causes of death included sepsis (45.61%), CVD (12.86%), and severe anaemia (9.94%);and were comparable between males and females except for anaemia which was more prevalent in females (p = 0.003). Catheters related infections (77.9%), and chest infections (9.0%) were the main sources of sepsis while sudden death (76.2%), myocardial infarction (9.5%), and heart failure (9.5%) were the main cardiovascular causes of death. Hypertension (65%), CVD (35.6%), and diabetes (9.19%) were the main comorbidities associated to death. The main vascular access was central venous catheter 96%. CVD (p = 0016, aOR;4.107), Albumin ≤ 3.5 g/dl (p = 0.015, aOR;23.083), and Creatinine > 20 mg/dl (p = 0.024, aOR;5.649) were independent predictors of mortality. Conclusion: One in four patients on haemodialysis died early. CVD, hypoalbuminemia and late initiation were predictors of mortality. Majority of patients die from preventable causes, with sepsis from catheter being the most frequent.

2002-2020年上海方松街道社区居民死亡情况及其趋势分析

目的:分析上海方松街道社区2002-2020年居民死亡情况及其趋势。方法:整理2002-2020年上海方松街道社区户籍居民全死因监测资料,采用死亡率、中国标化死亡率等指标分析居民死亡情况,采用Joinpoint回归模型计算平均年度变化百分比(AAPC),并分析其趋势。结果:上海方松街道社区2002-2020年合计死亡3293例,粗死亡率为354.63/10万,中国标化死亡率为352.29/10万。2002-2020年合计粗死亡率AAPC为-2.46%(95%CI为-4.29%,-0.61%,P=0.01),合计中国标化死亡率AAPC为-2.72%(95%CI为-4.01%,-1.42%,P<0.001)。前5位死因分别为恶性肿瘤(占32.71%),心血管疾病(占26.66%),呼吸系统疾病(占12.82%),消化系统疾病(占2.98%),内分泌、营养和代谢疾病(占2.7%)。男、女性死亡率和标化率均逐年下降(均P<0.05)。男性粗死亡率和标化死亡率均高于女性(均P<0.001)。65~79岁组死亡率年均下降7.85%(P<0.001)。2002-2020年60~69岁组死亡数占比AAPC(95%CI)为2.82%(0.23%,5.48%,P=0.034),80岁以上组死亡数占比AAPC(95%CI)为1.67%(0.48%,2.87%,P=0.009),均呈逐年上升;70~79岁死亡数占比AAPC(95%CI)为-3.53%(-5.04%,-2.00%,P<0.001),呈逐年下降。结论:上海方松街道社区居民的死亡存在性别、年龄和疾病差异,社区需加强65岁以下及男性居民的健康管理。

乳酸/白蛋白值对肝衰竭患者短期预后的预测价值——基于MIMIC-Ⅳ数据库的研究

目的探讨乳酸/白蛋白值(LAR)对肝衰竭患者短期预后的预测价值。方法在MIMIC⁃Ⅳ数据库中筛选在ICU治疗的842例肝衰竭患者。收集患者的人口基本信息、入院时的相关评分、合并症、入院后首次监测的生命体征和首次检测的实验室指标、治疗情况、预后情况。根据入院后28 d的死亡情况将患者分为死亡组(346例)和生存组(496例)。使用单因素和多因素COX回归模型分析肝衰竭患者入院后28 d全因死亡的影响因素。通过绘制受试者工作特征(ROC)曲线,比较LAR和其他评分对肝衰竭患者入院后28 d全因死亡的预测效能。将肝衰竭患者分为高LAR组(n=278)和低LAR组(n=564),比较两组的生存曲线。通过亚组分析评估LAR与肝衰竭患者入院后28 d全因死亡风险之间相关性的影响因素。结果COX回归分析结果显示,LAR是肝衰竭患者入院后28 d全因死亡的独立预测因子(P<0.05)。LAR预测肝衰竭患者入院后28 d全因死亡的曲线下面积(AUC)为0.669,与急性生理学评分Ⅲ、牛津急性疾病严重程度评分、序贯器官衰竭评估评分、简明急性生理学评分Ⅱ比较差异无统计学意义(P>0.05),但优于全身炎症反应综合征评分(P<0.05);各评分联合LAR后的AUC均优于未联合时的AUC(P<0.05)。高LAR组患者入院后28 d全因死亡率高于低LAR组患者(P<0.05)。亚组分析结果表明,心肌梗死合并情况和凝血酶原时间可影响LAR与肝衰竭患者入院后28 d全因死亡风险之间的关联程度(交互效应P值<0.05)。结论LAR可以作为肝衰竭患者入院后28 d全因死亡的独立预测指标,预测效能较为理想,且有助于提升现有评分的预测效能。

Maternal Mortality in the Gynecology-Obstetric Department at the Yalgado Ouedraogo University Hospital Center (CHUYO), Burkina Faso: About 181 Cases Collected from January 1^stto December 31^st2016

Objective: To study maternal mortality in the obstetrics and gynecology department at Yalgado Ouedraogo teaching Hospital Center. Patients and Methods: We conducted a cross-sectional retrospective and descriptive study of 181 cases of maternal deaths during study period. The parameters studied were sociodemographic characteristics, the causes of death, the clinical data and the contributing factors. Results: The maternal mortality ratio was 2624 per 100,000 live births. The mean age of death was 26.79 with extremes of 15 years to 40 years. Direct obstetric causes accounted for 58% dominated by hypertension and complications, hemorrhage during pregnancy and postpartum, and obstetric infections. The indirect obstetric causes were 42% dominated by non-obstetric infections and chronic anemias. In addition to the delay in consultation and delay in care, the lack of antenatal care was the contributing factor to maternal deaths. Conclusion: Maternal mortality remains a public health problem in view of its high ratio. The reduction of this scourge will inevitably go through a health insurance that will allow the supply of quality care.

2011-2021年无锡市梁溪区婴儿死亡因素分析

目的:研究无锡市梁溪区2011年至2021年婴儿死亡率变化趋势、主要死因构成情况,为制定干预政策以降低婴儿死亡率提供实践依据。方法:回顾性分析梁溪区2011年至2021年的婴儿死亡资料,通过线性拟合计算婴儿死亡率的年估计百分比(EAPC)变化,分析婴儿死亡率变化趋势,采用卡方检验分析其年龄、危险因素和死因等分布特征。结果:2011-2021年婴儿死亡率和新生儿死亡率的EAPC均无统计学差异,分别为-0.003%(95%CI为-4.78%~4.39%)和-1.784%(95%CI为-7.96%~4.71%);低出生体质量儿死亡发生率大于非低出生体质量儿(χ~2=1326.559,P<0.05);早产儿死亡发生率大于非早产儿(χ~2=909.733,P<0.05)。比较婴儿死亡7个死因在各年龄组别的死亡率,新生儿窒息(χ~2=45.094,P<0.05)、早产低出生体质量(χ~2=9.955,P<0.05)和RDS(χ~2=26.143,P<0.05)在0-6日龄死亡率最高;意外(χ~2=21.900,P<0.05)在28日-11月龄死亡率最高。结论:2011-2021年梁溪区婴儿死亡率稳定在较低水平,死亡率变化趋势平稳;不同年龄组婴儿死因死亡率存在差异。提示应借鉴发达地区或国家经验,结合中国国情,制定降低婴儿死亡的干预措施。