期刊文献+
共找到6篇文章
< 1 >
每页显示 20 50 100
A novel diarylheptanoid bearing flavonol moiety from the rhizomes of Alpinia officinarum Hance 被引量:7
1
作者 Zhao, Ling Liang, Jing Yu +1 位作者 Zhang, Jing Yu Chen, Yun 《Chinese Chemical Letters》 SCIE CAS CSCD 2010年第2期194-196,共3页
A novel diarylheptanoid bearing flavonol moiety,named officinin A(1),along with two known compounds galangin and kaempferide were isolated from the rhizomes of Alpina officinarum Hance.The structure elucidation was ac... A novel diarylheptanoid bearing flavonol moiety,named officinin A(1),along with two known compounds galangin and kaempferide were isolated from the rhizomes of Alpina officinarum Hance.The structure elucidation was accomplished by HRESI -MS,1D and 2D NMR methods. 展开更多
关键词 alpinia officinarum hance DIARYLHEPTANOID Officinin A
下载PDF
The effect of characteristic Li-medicine Alpinia officinarum Hance on improving insulin resistance
2
作者 ZHENG Xiu-wen WEN Huan +6 位作者 ZHANG Jun-qing HUANG Yu-fang ZHANG Yu-xin LIU Ai-xia LI Xiang-yi GAO Ya-nan ZHANG Xu-guang 《Journal of Hainan Medical University》 2022年第19期1-5,共5页
Objective:To study the effects of characteristic Li-medicine Alpinia officinarum Hance on improving insulin resistance(IR),and provide scientific evidence for the adjuvant treatment T2DM.Methods:CCK8 kit was used to d... Objective:To study the effects of characteristic Li-medicine Alpinia officinarum Hance on improving insulin resistance(IR),and provide scientific evidence for the adjuvant treatment T2DM.Methods:CCK8 kit was used to detect the viability of HepG2 cells with 0-200μg/mL Alpinia officinarum Hance extract(AOE)and 0-100μmol/L galangin,and determine the administration concentration.The IR model was established by inducing HepG2 cells with high glucose for 48 hours,and rosiglitazone(ROSI)was used as the positive control drug.Furthermore,we detected intracellular and extracellular glucose contents in IR-HepG2 cells after dosing AOE and galangin by flow cytometry and glucose detection kit,and evaluated the effect of regulating glucose metabolism and IR.Western blot was used to detect the effects of AOE and galangin on the expression of glucose transporter-4(GLUT4)in IR-HepG2 cells.Results:CCK8 kit test result showed that 0-200μg/mL AOE and 0-50μmol/L galangin had no significant effect on HepG2 cell viability.The results of flow cytometry and glucose detection kit showed that the glucose uptake and consumption of the IR model group induced by high glucose was significantly lower than that of the blank group,and thus the IR model was successfully established.Both 50μg/mL AOE and 10,20μmol/L galangin significantly increased the glucose uptake and consumption of IR-HepG2 cells(P<0.05);Western blot experiment showed that AOE and galangin significantly increased GLUT4 level of IR-HepG2 cells(P<0.01).Conclusion:Alpinia officinarum Hance could promote the uptake and consumption of glucose in IR-HepG2 cells by up-regulating the expression of GLUT4 protein,thereby improving IR and enhancing insulin sensitivity. 展开更多
关键词 alpinia officinarum hance Insulin resistance HepG2 cells GLUT4
下载PDF
Chromatographic fingerprint analysis and quantitative evaluate the rhizomes of Alpinia officinarum Hance(lesser galangal) 被引量:3
3
作者 Haoyan Jiao Shengmei Xu +2 位作者 Chunlin Fan Qingwen Zhang Ying Wang 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2019年第10期728-738,共11页
The rhizome of Alpinia officinarum Hance is a well-known traditional Chinese medicine(TCM)and has been widely used for the remedy of gastrointestinal diseases.In the present study,a simple and rapid HPLC-DAD was devel... The rhizome of Alpinia officinarum Hance is a well-known traditional Chinese medicine(TCM)and has been widely used for the remedy of gastrointestinal diseases.In the present study,a simple and rapid HPLC-DAD was developed for the quality control of the rhizomes of A.officinarum.Its chemical fingerprint was established using raw material of 15 different origins in China.Similarity analysis(SA)and hierarchical clusting analysis(HCA)were applied to select the qualitative markers.Principal components analysis(PCA)was conducted to select the quantitative markers of the rhizomes of A.officinarum samples from different origins.The constituents were confirmed by(+)electrospray ionization LC-MS.12 constituents were selected as common peaks and 10 of them were confirmed by(+)electrospray ionization LC-MS.Six bioactive constituents including DPHA,galangin flavanone,galangin,galangin 3-methylether,DPHB and DPHC were simultaneous determination by using the HPLC-DAD analysis.The developed method was able to determine the bioactive components with excellent resolution,precision and recovery.The results indicated that chromatographic fingerprint combination with multi-components determination method is suitable for quality assessment of the rhizomes of A.officinarum. 展开更多
关键词 alpinia officinarum hance Simultaneous determination Chromatographic fingerprint Quality evaluation Traditional Chinese medicine
原文传递
Herb-drug interaction in the protective effect of Alpinia officinarum against gastric injury induced by indomethacin based on pharmacokinetic, tissue distribution and excretion studies in rats
4
作者 Xuguang Zhang Zhenrui Xie +5 位作者 Xun Chen Junqiang Qiu Yinfeng Tan Xiaoliang Li Hailong Li Junqing Zhang 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2021年第2期200-209,共10页
Alpinia officinarum Hance of the Chinese traditional herb for the treatment of emesis, abdominal pain and diarrhea has been used to counteract gastric disease induced by indomethacin in rats without obvious side effec... Alpinia officinarum Hance of the Chinese traditional herb for the treatment of emesis, abdominal pain and diarrhea has been used to counteract gastric disease induced by indomethacin in rats without obvious side effects. However, the role of herb-drug interaction between indomethacin and A. officinarum based on pharmacokinetic, tissue distribution and excretion still remains unknown. In this study, an ultra-fast liquid-tandem mass spectrometry(UFLC-MS/MS) method was developed for simultaneous determination of indomethacin and its three metabolites, O-desmethylindomethacin(ODI), deschlorobenzoylindomethacin(NDI) and indomethacin acyl-b-D-glucuronide(IDAbG) by oral administration of indomethacin solution with and without the ethanolic extract of A. officinarum and applied to comparative pharmacokinetic, tissue distribution and excretion studies. Our results clarified that oral administration of A. officinarum produced significant alterations in the pharmacokinetic parameters of indomethacin. And the pharmacokinetic interaction between indomethacin and A. officinarum reduced the systemic exposure of indomethacin and increased its elimination. Tissue distribution results demonstrated that co-administration of A. Officinarum could not reduce the accumulation of indomethacin in the target tissue of the stomach, but could accelerate the excretions of indomethacin and its three metabolites including ODI, NDI and IDAb G in the bile and feces of rats in the excretion study.Therefore, A. Officinarum might have a gastrointestinal protective effect through the interaction role with indomethacin based on the pharmacokinetics and excretion in rats. 展开更多
关键词 alpinia officinarum hance INDOMETHACIN Herb-drug interaction PHARMACOKINETICS Tissue distribution EXCRETION
下载PDF
A new dimeric diarylheptanoid from the rhizomes of Alpinia officinarum 被引量:4
5
作者 LIU Dan QU Wei +2 位作者 ZHAO Ling GUAN Fu-Qin LIANG Jing-Yu 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2014年第2期139-141,共3页
AIM: To study the chemical constituents of the rhizomes of Alpinia officinarum Hance. METHOD: Compounds were isolated by repeated column chromatography, and their structures were elucidated on the basis of spectral an... AIM: To study the chemical constituents of the rhizomes of Alpinia officinarum Hance. METHOD: Compounds were isolated by repeated column chromatography, and their structures were elucidated on the basis of spectral analysis. The cytotoxic activities of these compounds were evaluated with the T98G and B16F10 cell lines by the MTT assay. RESULTS: A dimeric diarylheptanoid, named alpinin B(1), along with three known diarylheptanoids were obtained, and their structures were identified as alpinin B(1), 1, 7-diphenyl-3,5-heptanedione(2),(4E)-1, 7-diphenylhept-4-en-3-one(3) and(4E)-7-(4-hydroxyphenyl)-1-phenylhept-4-en-3-one(4). CONCLUSION: Compound 1 is a new dimeric diarylheptanoid. The biosynthetic pathway of 1 was speculated to originate from a Michael reaction between compounds 2 and 3. Compound 3 showed cytotoxicity against the human glioblastoma T98G cell line with IC50 of 27 μmol L 1. 展开更多
关键词 alpinia officinarum hance DIARYLHEPTANOID alpinin B 1 7-diphenyl-3 5-heptanedione (4E)-l 7-diphenylhept-4-en -3-one
原文传递
A novel dimeric diarylheptanoid from the rhizomes of Alpinia officinarum 被引量:4
6
作者 Dan Liu Wei Qu +1 位作者 Ling Zhao Jing Yu Liang 《Chinese Chemical Letters》 SCIE CAS CSCD 2012年第2期189-192,共4页
A novel dimeric diarylheptanoid,named alpinin A(1),along with two known compounds,1,7-diphenyl-5-ol-3-heptanone and 7- (4'-hydroxy-3'-methoxyphenyl)-l-phenyl-4-heptene-3-one,were isolated from the rhizomes of Al... A novel dimeric diarylheptanoid,named alpinin A(1),along with two known compounds,1,7-diphenyl-5-ol-3-heptanone and 7- (4'-hydroxy-3'-methoxyphenyl)-l-phenyl-4-heptene-3-one,were isolated from the rhizomes of Alpinia officinarum Hance.The structure of compound 1 was elucidated on the basis of spectral analysis,including HR-IT-TOF-MS,1D and 2D NMR.And a possible biogenetic pathway had been proposed for 1. 展开更多
关键词 alpinia officinarum hance Diarylheptanoid Alpinin A
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部