BACKGROUND: Aluminum phosphide(Al P) poisoning is common in the developing countries. There is no specifi c antidote for the treatment of acute Al P poisoning. Early diagnosis of poisoning and outcome predictors may f...BACKGROUND: Aluminum phosphide(Al P) poisoning is common in the developing countries. There is no specifi c antidote for the treatment of acute Al P poisoning. Early diagnosis of poisoning and outcome predictors may facilitate treatment decisions. The objective of this study was to determine the trend of blood lactate level in acute Al P poisoning to evaluate its role as a prognostic factor.METHODS: This was a prospective study on acute Al P intoxicated patients during one year. Demographic data, clinical and laboratory data on admission, and outcome were recorded in a selfmade questionnaire. Blood lactate levels were analyzed every two hours for 24 hours.RESULTS: Thirty-nine(27 male, 12 female) patients were included in the study. The mortality rate was 38.5%. The mean blood pressure, pulse rate, blood p H and serum bicarbonate level were significantly different between the survivors and non-survivors groups. Blood lactate level was signifi cantly higher in the non-survivors group during 8 to 16 hours post ingestion.CONCLUSION: Blood lactate level could be used as an index of severity of acute Al P poisoning.展开更多
Background:Aluminium phosphide is a usual ingredient of rodenticide and its poisoning is a common cause of suicide in India.Signs and symptoms of its toxicity are well-known.Its toxic effects are mainly due to liberat...Background:Aluminium phosphide is a usual ingredient of rodenticide and its poisoning is a common cause of suicide in India.Signs and symptoms of its toxicity are well-known.Its toxic effects are mainly due to liberation of phosphine gas which causes cell hypoxia due to inhibition of oxidative phosphorylation and results in circulatory failure.Aims and Objectives:Mortality with aluminium phosphide is high as there is no specific antidote available yet.And hence we need to explore holistic treatment approach to improve patient outcomes in aluminium phosphide poisoning.Materials and Methods:Present study discusses a holistic treatment approach to aluminium phosphide poisoning in this retrospective analysis of 100 cases from a tertiary care hospital in this study.Results:Around 65%patients survived due to the holistic treatment approach and correct treatment protocol with supportive therapy.Conclusions:The aggressive and appropriate management with continuous hemodynamic monitoring and holistic treatment approach can reduce the mortality significantly in aluminium phosphide poisoning.展开更多
基金supported by a grant from Toxicological Research Center of Shahid Beheshti University of Medical Sciences
文摘BACKGROUND: Aluminum phosphide(Al P) poisoning is common in the developing countries. There is no specifi c antidote for the treatment of acute Al P poisoning. Early diagnosis of poisoning and outcome predictors may facilitate treatment decisions. The objective of this study was to determine the trend of blood lactate level in acute Al P poisoning to evaluate its role as a prognostic factor.METHODS: This was a prospective study on acute Al P intoxicated patients during one year. Demographic data, clinical and laboratory data on admission, and outcome were recorded in a selfmade questionnaire. Blood lactate levels were analyzed every two hours for 24 hours.RESULTS: Thirty-nine(27 male, 12 female) patients were included in the study. The mortality rate was 38.5%. The mean blood pressure, pulse rate, blood p H and serum bicarbonate level were significantly different between the survivors and non-survivors groups. Blood lactate level was signifi cantly higher in the non-survivors group during 8 to 16 hours post ingestion.CONCLUSION: Blood lactate level could be used as an index of severity of acute Al P poisoning.
文摘Background:Aluminium phosphide is a usual ingredient of rodenticide and its poisoning is a common cause of suicide in India.Signs and symptoms of its toxicity are well-known.Its toxic effects are mainly due to liberation of phosphine gas which causes cell hypoxia due to inhibition of oxidative phosphorylation and results in circulatory failure.Aims and Objectives:Mortality with aluminium phosphide is high as there is no specific antidote available yet.And hence we need to explore holistic treatment approach to improve patient outcomes in aluminium phosphide poisoning.Materials and Methods:Present study discusses a holistic treatment approach to aluminium phosphide poisoning in this retrospective analysis of 100 cases from a tertiary care hospital in this study.Results:Around 65%patients survived due to the holistic treatment approach and correct treatment protocol with supportive therapy.Conclusions:The aggressive and appropriate management with continuous hemodynamic monitoring and holistic treatment approach can reduce the mortality significantly in aluminium phosphide poisoning.