Transfer characteristics of dynamic biochemical signals in non-reversing pulsatile flows in a shallow Y-shaped microfluidic channel: signal filtering and nonlinear amplitude-frequency modulation

The transports of the dynamic biochemical signals in the non-reversing pulsatile flows in the mixing microchannel of a Y-shaped microfluidic device are ana- lyzed. The results show that the mixing micro-channel acts as a low-pass filter, and the biochemical signals are nonlinearly modulated by the pulsatile flows, which depend on the biochemical signal frequency, the flow signal frequency, and the biochemical signal transporting distance. It is concluded that, the transfer characteristics of the dynamic biochemical signals, which are transported in the time-varying flows, should be carefully considered for better loading biochemical signals on the cells cultured on the bottom of the microfluidic channel.

A fatigue damage model for rock salt considering the effects of loading frequency and amplitude

With the large-scale construction of underground gas storage in salt deposit, much more efforts have been made to assess the fatigue properties of rock salt. The fatigue damage processes the primary, steady,and accelerated phases, which is similar to the axial irrecoverable deformation compiled from the loci of the loading cycles of rock salt. The cumulative fatigue damage increases with a decrease in the loading frequency and with an increase in the stress amplitude within the range tested. To take into account the effects of loading frequency and amplitude on the fatigue behavior of rock salt subjected to cyclic loading, a low cycle fatigue damage model was exclusively established combined with the Manson–Coffin formula. The proposed damage evolution equation was validated with experimental results and proved to be efficient in the prediction of fatigue damage tendency of rock salt under different loading frequencies and amplitudes.

Target tracking based on frequency spectrum amplitude

The amplitude of frequency spectrum can he integrated with prohabilisfic data association （PDA） to distinguish the target with clutter echoes, especially in low SNR underwater environment. A new target-tracking algorithm is presented which adopts the amplitude of frequency spectrum to improve target tracking in clutter. The prohabilisfic density distribution of frequency spectrum amplitude is analyzed. By simulation, the results show that the algorithm is superior to PDA. This approach enhances stability for the association probability and increases the performance of target tracking.

Targeted treatment of cancer with radiofrequency electromagnetic fields amplitude-modulated at tumor-specific frequencies

In the past century, there have been many attempts to treat cancer with low levels of electric and magnetic fields. We have developed noninvasive biofeedback examination devices and techniques and discovered that patients with the same tumor type exhibit biofeedback responses to the same, precise frequencies. Intrabuccal administration of 27.12 MHz radiofrequency(RF) electromagnetic fields(EMF), which are amplitude-modulated at tumor-specific frequencies, results in long-term objective responses in patients with cancer and is not associated with any significant adverse effects. Intrabuccal administration allows for therapeutic delivery of very low and safe levels of EMF throughout the body as exemplified by responses observed in the femur, liver, adrenal glands, and lungs. In vitro studies have demonstrated that tumor-specific frequencies identified in patients with various forms of cancer are capable of blocking the growth of tumor cells in a tissue- and tumor-specific fashion. Current experimental evidence suggests that tumor-specific modulation frequencies regulate the expression of genes involved in migration and invasion and disrupt the mitotic spindle. This novel targeted treatment approach is emerging as an appealing therapeutic option for patients with advanced cancer given its excellent tolerability. Dissection of the molecular mechanisms accounting for the anti-cancer effects of tumor-specific modulation frequencies is likely to lead to the discovery of novel pathways in cancer.

Optimized analysis of ionospheric amplitude modulated heating parameters for excitation of very/extremely low frequency radiations

It is now well known that amplitude modulated(AM) high frequency(HF) radio wave transmissions into the ionosphere can be used to generate very/extremely low frequency(VLF/ELF) radio waves using the so-called ‘electrojet antenna’. Duty cycle and heating frequency are analyzed and discussed with the lower-ionosphere modulated heating model, so as to improve the radiation efficiency of VLF/ELF waves in AM ionospheric heating experiments. Based on numerical simulation, the ranges of parametric selectivity in optimal duty cycle and heating frequency( fHF) are derived. The International Reference Ionosphere 2015(IRI-2015) model and two-parameter model are used to predict background electron density profiles, and optimized ranges of duty cycle for different density profiles are analyzed and compared. The influences of wave polarizations on optimal duty cycle are also discussed. It is shown that intensity of the VLF/ELF equivalent radiation source(M) firstly rises and then falls with the increase of duty cycle. When using the IRI model, M peaks at a duty cycle of 50%, optimally ranging from 40%-70%. For the two-parameter model case, an optimal duty cycle is 40% and the optimized ranges vary from 30%-60%. Heating with an X-mode polarization is more efficient than with the O-mode case in VLF/ELF wave generation. Nevertheless, an optimal duty cycle is almost independent of HF wave polarizations. To obtain better VLF/ELF generation, optional fHFmay be 0.8-0.9 times of foE for the O-mode heating and 0.75-0.85 times for the X-mode polarization case. Finally, the variations of these two parameters in different latitudes are discussed.

Research on the Seismic Wave Characteristics of Low Frequency Signals before the Alxa Left Banner MS5.8 Earthquake in Inner Mongolia,China

In order to search for the seismic wave characteristics of low frequency signals in the Alxa Left Banner region,Inner Mongolia,the low frequency signals of seismic wave data are extracted from the earthquakes of MS5. 8 in 2015 and MS5. 0 in 2016 in this area. The results show that:① Before the MS5. 8 earthquake,the seismic stations located near the epicenter in Wuhai,Dongshengmiao,and Shizuishan recorded seismic waves that showed the phenomenon of spectrum shift from high to low frequency.② The low frequency signals recorded by different stations have obvious difference.③ According to the data recorded by the station closest to the epicenter,low-frequency signals were recorded about120 hours before the earthquake and had obvious anomalies. This may reflect slow slip before the earthquake.

MEASUREMENT OF AMPLITUDE AND DELAY OF STIMULUS FREQUENCY OTOACOUSTIC EMISSIONS

Although stimulus frequency otoacoustic emissions (SFOAEs) have been used as a non-invasive measure of cochlear mechanics, clinical and experimental application of SFOAEs has been limited by difficulties in accurately deriving quantitative information from sound pressure measured in the ear canal. In this study, a novel signal processing method for multicomponent analysis (MCA) was used to measure the amplitude and delay of the SFOAE. This report shows the delay-frequency distribution of the SFOAE measured from the human ear. A low level acoustical suppressor near the probe tone significantly suppressed the SFOAE, strongly indicating that the SFOAE was generated at characteristic frequency locations. Information derived from this method may reveal more details of cochlear mechanics in the human ear.

EXACT ANALYSIS OF SPURIOUS SIGNALS IN DIRECT DIGITAL FREQUENCY SYNTHESIZERS DUE TO AMPLITUDE QUANTIZATION

Amplitude quantization is one of the main sources of spurious noise frequencies in Direct Digital Frequency Synthesizers (DDFSs), which affect their application to many wireless telecommu- nication systems. In this paper, two different kinds of spurious signals due to amplitude quantization in DDFSs are exactly formulated in the time domain and detailedly compared in the frequency do- main, and the effects of the DDFS parameter variations on the spurious performance are thoroughly studied. Then the spectral properties and power levels of the amplitude-quantization spurs in the absence of phase-accumulator truncation are emphatically analyzed by waveform estimation and computer simulation, and several important conclusions are derived which can provide theoretical support for parameter choice and spurious performance evaluation in the application of DDFSs.

A Single Pattern Matching Algorithm Based on Character Frequency

Based on the study of single pattern matching, MBF algorithm is proposed by imitating the string searching procedure of human. The algorithm preprocesses the pattern by using the idea of Quick Search algorithm and the already-matched pattern psefix and suffix information. In searching phase, the algorithm makes use of the!character using frequency and the continue-skip idea. The experiment shows that MBF algorithm is more efficient than other algorithms.

Changes in the amplitude of low-frequency fluctuations in specific frequency bands in major depressive disorder after electroconvulsive therapy

BACKGROUND Major depressive disorder(MDD)tends to have a high incidence and high suicide risk.Electroconvulsive therapy(ECT)is currently a relatively effective treatment for MDD.However,the mechanism of efficacy of ECT is still unclear.AIM To investigate the changes in the amplitude of low-frequency fluctuations in specific frequency bands in patients with MDD after ECT.METHODS Twenty-two MDD patients and fifteen healthy controls(HCs)were recruited to this study.MDD patients received 8 ECT sessions with bitemporal placement.Resting-state functional magnetic resonance imaging was adopted to examine regional cerebellar blood flow in both the MDD patients and HCs.The MDD patients were scanned twice(before the first ECT session and after the eighth ECT session)to acquire data.Then,the amplitude of low-frequency fluctuations(ALFF)was computed to characterize the intrinsic neural oscillations in different bands(typical frequency,slow-5,and slow-4 bands).RESULTS Compared to before ECT(pre-ECT),we found that MDD patients after the eighth ECT(post-ECT)session had a higher ALFF in the typical band in the right middle frontal gyrus,posterior cingulate,right supramarginal gyrus,left superior frontal gyrus,and left angular gyrus.There was a lower ALFF in the right superior temporal gyrus.Compared to pre-ECT values,the ALFF in the slow-5 band was significantly increased in the right limbic lobe,cerebellum posterior lobe,right middle orbitofrontal gyrus,and frontal lobe in post-ECT patients,whereas the ALFF in the slow-5 band in the left sublobar region,right angular gyrus,and right frontal lobe was lower.In contrast,significantly higher ALFF in the slow-4 band was observed in the frontal lobe,superior frontal gyrus,parietal lobe,right inferior parietal lobule,and left angular gyrus.CONCLUSION Our results suggest that the abnormal ALFF in pre-and post-ECT MDD patients may be associated with specific frequency bands.

The dynamic characteristics of saturated remolded loess under cyclic load

Due to the joint development characteristic and macropore structure of loess,it is easy to cause structure collapse under earthquake or artificial vibration.The study on the loess disaster effect and its mechanism under earthquake action is insufficient due to its complexity.Hence,to study the deformation and mechanical properties more accurately,the dynamic characteristics of saturated remolded loess under cyclic dynamic load were tested using a GDS dynamic triaxial instrument in this paper.The test results show that strain and pore water pressure increase gradually at different rates with the development of vibration,and there is an obvious inflection point in the time-history curve of both.When the number of vibrations(N)exceeds this point,the strain increases rapidly,and pore water pressure tends to be stable.Under the action of large amplitude and low-frequency dynamic load,the strain and pore water pressure increase rapidly with fewer vibrations and the deviator stress(q)decreases rapidly,while the sample achieves damage faster with the increase of amplitude.During the application of a dynamic load,the effective stress(p)gradually decreases and its rate of change slows down.Finally,when the saturated remolded loess is subjected to a constant-amplitude dynamic load,the combination of large amplitude and low frequency leads to the failure of the sample in the shortest time.

Numerical study of flow and thermal characteristics of pulsed impinging jet on a dimpled surface

This research comprehensively investigates the flow and thermal characteristics of a pulsating impinging jet over a dimpled surface.It analyzes the impact of key parameters(e.g.,inlet velocity pulsation functions,pulsation frequency,amplitude,dimple pitch,dimple depth,Reynolds number)on flow patterns and heat transfer.Validated computational fluid dynamics and the Re-normalization group turbulence model are employed to accurately simulate complex turbulent flow behavior.Local and average heat transfer coefficients are calculated and compared to steady impingement cases,revealing the potential benefits of pulsation for heat transfer enhancement.The study also examines how pulsation-induced flow modulation and thermal mixing affect heat transfer mechanisms.Results indicate that combining fluctuating flow with a dimpled surface can improve heat transfer rates.In summary,increasing pulsation amplitude consistently enhances heat transfer,while the effect of frequency varies between impinging and wall jet zones.

A Three-Layers Plane Wall Exposed to Oscillating Temperatures with Different Amplitudes and Frequencies

A linear model of three layers plane wall exposed to oscillating temperatures with different amplitudes and frequencies was built by using a physical superposition. A physical superposition of two states was performed, one state is a wall which one surface is exposed to oscillating temperature and the other surface is exposed to zero relative temperature and a second state is a wall which one surface is exposed to relative zero temperature while the other surface is exposed to oscillating temperature with different amplitudes and frequencies. Temperature distributions were introduced for different amplitudes, frequencies and thermal conductivities. It was shown that increasing the frequency value decreases the temperature penetration length, high frequency value leads to extremum temperature values changes on the surface while low frequency value allows gradually temperature changes during the time period. Temperature distribution lines where there are at the same time heat flux entry and heat flux exit were not received for the same constraint frequencies.

Quantitative prediction of channel sand bodies based on seismic peak attributes in the frequency domain and its application

The boundary identification and quantitative thickness prediction of channel sand bodies are always difficult in seismic exploration.We present a new method for boundary identification and quantitative thickness prediction of channel sand bodies based on seismic peak attributes in the frequency domain.Using seismic forward modeling of a typical thin channel sand body,a new seismic attribute-the ratio of peak frequency to amplitude was constructed.Theoretical study demonstrated that seismic peak frequency is sensitive to the thickness of the channel sand bodies,while the amplitude attribute is sensitive to the strata lithology.The ratio of the two attributes can highlight the boundaries of the channel sand body.Moreover,the thickness of the thin channel sand bodies can be determined using the relationship between seismic peak frequency and thin layer thickness.Practical applications have demonstrated that the seismic peak frequency attribute can depict the horizontal distribution characteristics of channels very well.The ratio of peak frequency to amplitude attribute can improve the identification ability of channel sand body boundaries.Quantitative prediction and boundary identification of channel sand bodies with seismic peak attributes in the frequency domain are feasible.

Improvements of corner frequency and scaling factor for stochastic finite-fault modeling

In this paper, three existing source spectral models for stochastic finite-fault modeling of ground motion were reviewed. These three models were used to calculate the far-field received energy at a site from a vertical fault and the mean spectral ratio over 15 stations of the Northridge earthquake, and then compared. From the comparison, a necessary measure was observed to maintain the far-field received energy independent of subfault size and avoid overestimation of the long- period spectra/level. Two improvements were made to one of the three models （i.e., the model based on dynamic comer frequency） as follows： （i） a new method to compute the subfault comer frequency was proposed, where the subfault comer frequency is determined based on a basic value calculated from the total seismic moment of the entire fault and an increment depending on the seismic moment assigned to the subfault; and （ii） the difference of the radiation energy from each suhfault was considered into the scaling factor. The improved model was also compared with the unimproved model through the far-field received energy and the mean spectral ratio. The comparison proves that the improved model allows the received energy to be more independent of subfault size than the unimproved model, and decreases the overestimation degree of the long-period spectral amplitude.

Numerical simulation research on response characteristics of surrounding rock for deep super-large section chamber under dynamic and static combined loading condition

The stability control of surrounding rock for large or super-large section chamber is a difficult technical problem in deep mining condition.Based on the in-site geological conditions of Longgu coal mine,this paper used the dynamic module of FLAC3D to study the response characteristics of deep super-large section chamber under dynamic and static combined loading condition.Results showed that under the static loading condition,the maximum vertical stress,deformation and failure range are large,where the stress concentration coefficient is 1.64.The maximum roof-to-floor and two-sides deformations are 54.6 mm and 53.1 mm,respectively.Then,under the dynamic and static combined loading condition:(1)The influence of dynamic load frequency on the two-sides is more obvious;(2)The dynamic load amplitude has the greatest influence on the stress concentration degree,and the plastic failure tends to develop to the deeper;(3)With the dynamic load source distance increase,the response of surrounding rock is gradually attenuated.On this basis,empirical equations for each dynamic load conditions were obtained by using regression analysis method,and all correlation coefficients are greater than 0.99.This research provided reference for the supporting design of deep super-large section chamber under same or similar conditions.

Characteristics of the Function of Ice Force on Vertical Cylindrical Piles

A lot of tests on ice forces on vertical cylindrical piles are conducted in the ice basin of ice laboratory in Tianjin University to identify the characteristics of ice forces on fixed platforms in the Bohai Gulf. A function of ice forces is simplified on basis of test data, and the characteristics of the ice forces including the amplitude of the force and the breaking frequency of the ice sheet is detailed by use of the Fast-Fourier-Transform method, The results show that the ice breaking frequency presents a linear relationship with the ratio of ice moving velocity to ice thickness at low velocities. At high velocities, the frequency remains constant with the increase of the ratio of ice moving velocity to ice thickness. These conclusions are compared those published in literature.

A 532 nm molecular iodine optical frequency standard based on modulation transfer spectroscopy

We report construction of an iodine-stabilized laser frequency standard at 532 nm based on modulation transfer spectroscopy(MTS)technology with good reproducibility.A frequency stability of 2.5×10^(-14)at 1 s averaging time is achieved,and the frequency reproducibility has a relative uncertainty of 3.5×10^(-13),demonstrating the great stability of our setup.The systematic uncertainty of the iodine-stabilized laser frequency standard is evaluated,especially the contribution of the residual amplitude modulation(RAM).The contribution of the RAM in MTS cannot be evaluated directly.To solve this problem,we theoretically deduce the MTS signal with RAM under large modulation depth,and prove that the non-symmetric shape of the MTS signal is directly related to the MTS effect.The non-symmetric shape factor can be calibrated with a frequency comb,and in real experiments,this value can be obtained by least-squares fitting of the MTS signal,from which we can infer the RAMinduced frequency shift.The full frequency uncertainty is evaluated to be 5.3 kHz(corresponding to a relative frequency uncertainty of 9.4×10^(-12)).The corrected transition frequency has a difference from the BIPM-recommended value of 2 kHz,which is within 1σ uncertainty,proving the validity of our evaluation.

Rock fragmentation mechanisms and an experimental study of drilling tools during high-frequency harmonic vibration

Resonance drilling is a new technology, still at the laboratory stage. It has great potential to improve rock fragmentation efficiency. We analyzed the amplitude-frequency characteristics of steady- state mechanical vibration excited by harmonic vibration in rocks and an apparatus was built to achieve high fi＇equency vibration of rock. The influence of rock drillability, rotary speed, excitation frequency, and other parameters on the rate of penetration （ROP） in resonance drilling was analyzed. The results show that the rock drillability decreased with an increase in excitation frequency. When drilling with a large size drill bit, the ROP increased with excitation frequency. The ROP reached a maximum value at the resonant frequency of the rock. Tile ROP of the bit increased linearly with rotary speed when no vibration was applied on the rock and increased approximately exponentially when harmonic vibration was applied. In addition, the resonant frequency of the rock was changing during the process of rock fi＇agmentation, so in order to achieve tile desired resonance of the rock, it is necessary to detemaine an appropriate hamlonic vibration excitation frequency.

Extraction of internal wave amplitude from nautical X-Band radar observations

One of the most important parameters for oceanic internal waves (IWs) is their amplitude. We have developed a method to retrieve the IW amplitude from nautical X-Band radar images based on the KdV equation for continuous stratified finite depth system. We have also tested the method of measuring the amplitude of IWs from X-Band radar backscatter image sequences acquired on June 2009 in the northeastern South China Sea. The method was applied in several radar images. Experiments show that the retrieval amplitudes are consistent with the in-situ observational amplitudes of IWs by using the towed thermistor chain and conductivity-temperature-depth (CTD) profile. The uncertainty of the method is also discussed.