Tau proteins accumulation and their spreading pattern were afected by gender in cognitive impairment patients,especially in the progression of Alzheimer’s disease(AD).However,it was unclear whether the gender efects ...Tau proteins accumulation and their spreading pattern were afected by gender in cognitive impairment patients,especially in the progression of Alzheimer’s disease(AD).However,it was unclear whether the gender efects for tau deposition infuenced by amyloid deposition.The aim of this study was to investigate gender diferences for tau depositions in Aβpositive(A^(+))subjects.In this study,tau and amyloid positron emission tomography images,structural magnetic resonance imaging images,and demographic information were collected from 179 subjects in Alzheimer’s Disease Neuroimaging Initiative(ADNI)database and 63 subjects from Huashan Hospital.Subjects were classifed as T^(+)or T^(-)according to the presence or absence of tau(T)biomarkers.We used two-sample t test and one-way analysis of variance test to analyze the efect of gender with adjusting for age,years of education,and Minimum Mental State Examination.In the ADNI cohort,we found diferences in Tau deposition in fusiform gyrus,inferior temporal gyrus,middle temporal gyrus and parahippocampal gyrus between the female T^(+)(FT^(+))and male T^(+)(MT^(+))groups(p<0.05).Tau deposition did not difer signifcantly between female T^(-)(FT^(-))and male T^(-)(MT^(-))subjects(p>0.05).In the Huashan Hospital cohort,there was no diference in Tau deposition between FT^(+)and MT^(+)(p>0.05).The results show that tau depositions signifcantly increased in females in above brain regions.Our fndings suggest that tau deposition is infuenced by gender in the A+subjects.This result has important clinical implications for the development of gender-guided early interventions for patients with both Tau and Amyloid depositions.展开更多
基金the National Natural Science Foundation of China(82020108013,81971641,82071200,82021002)the research project of Shanghai Health Commission(2020YJZX0111)+1 种基金the Shanghai Aging and Maternal and Child Health Research Special Project(Grant 2020YJZX0111)the Clinical Research Plan of Shanghai Hospital Development Center(Grants SHDC2020CR1038B and SHDC2020CR4007).
文摘Tau proteins accumulation and their spreading pattern were afected by gender in cognitive impairment patients,especially in the progression of Alzheimer’s disease(AD).However,it was unclear whether the gender efects for tau deposition infuenced by amyloid deposition.The aim of this study was to investigate gender diferences for tau depositions in Aβpositive(A^(+))subjects.In this study,tau and amyloid positron emission tomography images,structural magnetic resonance imaging images,and demographic information were collected from 179 subjects in Alzheimer’s Disease Neuroimaging Initiative(ADNI)database and 63 subjects from Huashan Hospital.Subjects were classifed as T^(+)or T^(-)according to the presence or absence of tau(T)biomarkers.We used two-sample t test and one-way analysis of variance test to analyze the efect of gender with adjusting for age,years of education,and Minimum Mental State Examination.In the ADNI cohort,we found diferences in Tau deposition in fusiform gyrus,inferior temporal gyrus,middle temporal gyrus and parahippocampal gyrus between the female T^(+)(FT^(+))and male T^(+)(MT^(+))groups(p<0.05).Tau deposition did not difer signifcantly between female T^(-)(FT^(-))and male T^(-)(MT^(-))subjects(p>0.05).In the Huashan Hospital cohort,there was no diference in Tau deposition between FT^(+)and MT^(+)(p>0.05).The results show that tau depositions signifcantly increased in females in above brain regions.Our fndings suggest that tau deposition is infuenced by gender in the A+subjects.This result has important clinical implications for the development of gender-guided early interventions for patients with both Tau and Amyloid depositions.
