Practice of Perioperative Rational Use of Antibacterial Drugs Based on Drug Pathway

[Objectives]To establish a new management model for rational use of perioperative antibacterial drugs in surgical departments.[Methods]Based on evidence-based medicine,the department s drug pathway was formulated,and the new mode of rational drug use control was established by using fine pharmaceutical technology intervention,and the intervention effect was evaluated by the intensity of antibacterial drug use,per capita drug costs and the proportion of drugs.[Results]After adopting drug pathway in departments,the intensity of antibacterial drug use,per capita drug costs and the proportion of drugs decreased significantly,and the effect of rational drug use control was remarkable.[Conclusions]The drug pathway provides a new management and control mode for the rational use of perioperative antibacterial drugs in surgical departments of hospitals.Thus,it is worthy of popularization and application.

An Analysis of Land Use and Land Cover Changes, and Implications for Conservation in Mukumbura (Ward 2), Mt Darwin, Zimbabwe, 2002-2022

Understanding trends of land use land cover (LULC) changes is important for biodiversity monitoring and conservation planning, and identifying the areas affected by change and designing sustainable solutions to reduce the changes. The study aims to evaluate and quantify the historical changes in land use and land cover in Mukumbura (Ward 2), Mt Darwin, Zimbabwe, from 2002 to 2022. The objective of the study was to analyse the LULC changes in Ward 2 (Mukumbura), Mt Darwin, Northern Zimbabwe, for a period of 20 years using geospatial techniques. Landsat satellite images were processed using Google Earth Engine (GEE) and the supervised classification with maximum likelihood algorithm was employed to generate LULC maps between 2002 and 2022 with a five (5) year interval, investigating the following variables, forest cover, barren land, water cover and the fields. Findings revealed a substantial reduction in forest cover by 38.8%, water bodies (wetlands, ponds, and rivers) declined by 55.6%, whilst fields (crop/agricultural fields) increased by 93.3% and the barren land cover increased by 26.3% from 2002 to 2022. These findings point to substantial changes in LULC over the observed years. LULC changes have resulted in habitat fragmentation, reduced biodiversity, and the disruption of ecosystem functions. The study concludes that if these deforestation trends, cultivation, and settlement land expansion continue, the ward will have limited indigenous fruit trees. Therefore, the causes for LULC changes must be controlled, sustainable forest resources use practiced, hence the need to domesticate the indigenous fruit trees in arborloo toilets.

Game Analysis of Regulation for Online Prescription Drugs under Customer Feedback Mechanism

Objective To study the way to better regulate the online sales of prescription drugs,and to provide reference for the adjustment of relevant policies since the online sales of prescription drugs has become an inevitable trend.Methods A game model was constructed for the strategy choice of pharmaceutical e-commerce platform,customers and government departments based on differential game theory and Nash equilibrium game model to analyze the pure strategy Nash equilibrium,Nash equilibrium dominant strategy of each subject and the mixed strategy Nash equilibrium under different conditions.Besides,Matlab was used to carry out simulation analysis.Results and Conclusion The study shows that:(1)Improving the credibility of the government and reducing the cost of government regulation can not only make the pharmaceutical e-commerce platform operate with high quality,but also give greater play to government functions;(2)The greater the influence of social evaluation on pharmaceutical e-commerce platforms,the lower the cost of high-quality operation of pharmaceutical e-commerce platform,and the greater the probability of customer choosing real evaluation strategy;(3)The greater the customers’perception of potential risk,the greater the compensation,and the lower the cost of reporting.Then,the greater the probability that government departments will choose strict regulation.Finally,the model solution and simulation analysis are combined to provide countermeasures and suggestions for the safety regulation of online sales of prescription drugs.

Analysis of the Current Situation of Drug Clinical Trial Institutions in Shaanxi Province

To understand the current situation of institutional registration in Shaanxi Province after the implementation ofregistration system management in drug clinical trial institutions.Relevant information was collected on the“Announcement on the Accreditation of Drug Clinical Trial Institutions”issued by the National Medical Products Administration from 2005 to August 2022,the record management information system of drug and medical device clinical trial institutions,and the drug clinical trial registration and information publicity platform.A retrospective analysis was carried out in terms of institutional development,regional distribution,registered majors,principal investigators,and the number of drug clinical trials.After the implementation of institution registration,the number of drug clinical trial institutions in Shaanxi Province increased by 47.4%,884 principal investigators were registered,the number of registered majors expanded from 58 qualified to 117,and the professional scope increased by 50.4%.The policy of institution registration is conducive to promoting the rational use of medical resources and the development of drug clinical trial institutions and improving the healthy development of the pharmaceutical industry in Shaanxi Province.

Identification of cell surface markers for acute myeloid leukemia prognosis based on multi-model analysis

Given the extremely high inter-patient heterogeneity of acute myeloid leukemia(AML),the identification of biomarkers for prognostic assessment and therapeutic guidance is critical.Cell surface markers(CSMs)have been shown to play an important role in AML leukemogenesis and progression.In the current study,we evaluated the prognostic potential of all human CSMs in 130 AML patients from The Cancer Genome Atlas(TCGA)based on differential gene expression analysis and univariable Cox proportional hazards regression analysis.By using multi-model analysis,including Adaptive LASSO regression,LASSO regression,and Elastic Net,we constructed a 9-CSMs prognostic model for risk stratification of the AML patients.The predictive value of the 9-CSMs risk score was further validated at the transcriptome and proteome levels.Multivariable Cox regression analysis showed that the risk score was an independent prognostic factor for the AML patients.The AML patients with high 9-CSMs risk scores had a shorter overall and event-free survival time than those with low scores.Notably,single-cell RNA-sequencing analysis indicated that patients with high 9-CSMs risk scores exhibited chemotherapy resistance.Furthermore,PI3K inhibitors were identified as potential treatments for these high-risk patients.In conclusion,we constructed a 9-CSMs prognostic model that served as an independent prognostic factor for the survival of AML patients and held the potential for guiding drug therapy.

Regulation effects of water and nitrogen on yield,water,and nitrogen use efficiency of wolfberry

Wolfberry(Lycium barbarum L.)is important for health care and ecological protection.However,it faces problems of low productivity and resource utilization during planting.Exploring reasonable models for water and nitrogen management is important for solving these problems.Based on field trials in 2021 and 2022,this study analyzed the effects of controlling soil water and nitrogen application levels on wolfberry height,stem diameter,crown width,yield,and water(WUE)and nitrogen use efficiency(NUE).The upper and lower limits of soil water were controlled by the percentage of soil water content to field water capacity(θ_(f)),and four water levels,i.e.,adequate irrigation(W0,75%-85%θ_(f)),mild water deficit(W1,65%-75%θ_(f)),moderate water deficit(W2,55%-65%θ_(f)),and severe water deficit(W3,45%-55%θ_(f))were used,and three nitrogen application levels,i.e.,no nitrogen(N0,0 kg/hm^(2)),low nitrogen(N1,150 kg/hm^(2)),medium nitrogen(N2,300 kg/hm^(2)),and high nitrogen(N3,450 kg/hm^(2))were implied.The results showed that irrigation and nitrogen application significantly affected plant height,stem diameter,and crown width of wolfberry at different growth stages(P<0.01),and their maximum values were observed in W1N2,W0N2,and W1N3 treatments.Dry weight per plant and yield of wolfberry first increased and then decreased with increasing nitrogen application under the same water treatment.Dry weight per hundred grains and dry weight percentage increased with increasing nitrogen application under W0 treatment.However,under other water treatments,the values first increased and then decreased with increasing nitrogen application.Yield and its component of wolfberry first increased and then decreased as water deficit increased under the same nitrogen treatment.Irrigation water use efficiency(IWUE,8.46 kg/(hm^(2)·mm)),WUE(6.83 kg/(hm^(2)·mm)),partial factor productivity of nitrogen(PFPN,2.56 kg/kg),and NUE(14.29 kg/kg)reached their highest values in W2N2,W1N2,W1N2,and W1N1 treatments.Results of principal component analysis(PCA)showed that yield,WUE,and NUE were better in W1N2 treatment,making it a suitable water and nitrogen management mode for the irrigation area of the Yellow River in the Gansu Province,China and similar planting areas.

Visualization analysis of research hotspots and trends on gastrointestinal tumor organoids

BACKGROUND Gastrointestinal tumor organoids serve as an effective model for simulating cancer in vitro and have been applied in basic biology and preclinical research.Despite over a decade of development and increasing research achievements in this field,a systematic and comprehensive analysis of the research hotspots and future trends is lacking.AIM To address this problem by employing bibliometric tools to explore the publication years,countries/regions,institutions,journals,authors,keywords,and references in this field.METHODS The literature was collected from Web of Science databases.CiteSpace-6.2R4,a widely used bibliometric analysis software package,was used for institutional analysis and reference burst analysis.VOSviewer 1.6.19 was used for journal cocitation analysis,author co-authorship and co-citation analysis.The‘online platform for bibliometric analysis(https://bibliometric.com/app)’was used to assess the total number of publications and the cooperation relationships between countries.Finally,we employed the bibliometric R software package(version R.4.3.1)in R-studio,for a comprehensive scientific analysis of the literature.RESULTS Our analysis included a total of 1466 publications,revealing a significant yearly increase in articles on the study of gastrointestinal tumor organoids.The United States(n=393)and Helmholtz Association(n=93)have emerged as the leading countries and institutions,respectively,in this field,with Hans Clevers and Toshiro Sato being the most contributing authors.The most influential journal in this field is Gastroenterology.The most impactful reference is"Long term expansion of epithelial organs from human colon,adenoma,adenocarcinoma,and Barrett's epithelium".Keywords analysis and citation burst analysis indicate that precision medicine,disease modeling,drug development and screening,and regenerative medicine are the most cutting-edge directions.These focal points were further detailed based on the literature.CONCLUSION This bibliometric study offers an objective and quantitative analysis of the research in this field,which can be considered as an important guide for next scientific research.

Mechanism of imipenem-induced mental disorder: A meta-analysis

BACKGROUND Imipenem is a highly effective carbapenem antibiotic,which is widely used in the treatment of many serious bacterial infections.At the same time,it can also cause some adverse reactions,mental abnormalities are the most concerned central nervous system adverse reactions.Different patients respond differently to imipenem,and the effect of imipenem on psychiatric disorders is unclear.Therefore,meta-analysis summarizing the results of multiple previous studies can provide stronger evidence support for clinical guidelines to guide clinical rational use of imipenem to minimize risks.After reviewing the literature published between 2003 and 2017,seven controlled trials with a total of 550 patients were included,with 273 and 277 patients in the control and experimental groups,respectively.The sample size of the study ranged from a minimum of 30 cases to a maximum of 61 cases.Patients in the experimental group were treated with imipenem while the control group was treated with conventional drugs.Meta-analysis showed that the incidence of mental disorders in the experimental group was higher than that in the control group(odds ratio=3.66,95%confidence interval:1.11-12.11,P=0.030);however,there was no significant difference in the incidence of adverse reactions between the two groups(odds ratio=0.05,95%confidence interval:0.00 to 0.10,P=0.060).Funnel diagrams showed that the scattered points of each study were symmetrical and distributed in an inverted funnel shape;therefore,there was no publication bias.CONCLUSION Imipenem can cause mental disorders in patients.However,the low quality of the included literature may have affected the final results.Therefore,it is necessary to conduct a high-quality randomized controlled study with multiple samples to further confirm the mechanism of imipenem-induced mental disorders and provide effective guidance for clinical treatment.

Spatiotemporal characteristics and driving mechanisms of land use/land cover(LULC)changes in the Jinghe River Basin,China

Understanding the trajectories and driving mechanisms behind land use/land cover(LULC)changes is essential for effective watershed planning and management.This study quantified the net change,exchange,total change,and transfer rate of LULC in the Jinghe River Basin(JRB),China using LULC data from 2000 to 2020.Through trajectory analysis,knowledge maps,chord diagrams,and standard deviation ellipse method,we examined the spatiotemporal characteristics of LULC changes.We further established an index system encompassing natural factors(digital elevation model(DEM),slope,aspect,and curvature),socio-economic factors(gross domestic product(GDP)and population),and accessibility factors(distance from railways,distance from highways,distance from water,and distance from residents)to investigate the driving mechanisms of LULC changes using factor detector and interaction detector in the geographical detector(Geodetector).The key findings indicate that from 2000 to 2020,the JRB experienced significant LULC changes,particularly for farmland,forest,and grassland.During the study period,LULC change trajectories were categorized into stable,early-stage,late-stage,repeated,and continuous change types.Besides the stable change type,the late-stage change type predominated the LULC change trajectories,comprising 83.31% of the total change area.The period 2010-2020 witnessed more active LULC changes compared to the period 2000-2010.The LULC changes exhibited a discrete spatial expansion trend during 2000-2020,predominantly extending from southeast to northwest of the JRB.Influential driving factors on LULC changes included slope,GDP,and distance from highways.The interaction detection results imply either bilinear or nonlinear enhancement for any two driving factors impacting the LULC changes from 2000 to 2020.This comprehensive understanding of the spatiotemporal characteristics and driving mechanisms of LULC changes offers valuable insights for the planning and sustainable management of LULC in the JRB.

Spatiotemporal dynamics of land use/land cover(LULC)changes and its impact on land surface temperature:A case study in New Town Kolkata,eastern India

Rapid urbanization creates complexity,results in dynamic changes in land and environment,and influences the land surface temperature(LST)in fast-developing cities.In this study,we examined the impact of land use/land cover(LULC)changes on LST and determined the intensity of urban heat island(UHI)in New Town Kolkata(a smart city),eastern India,from 1991 to 2021 at 10-a intervals using various series of Landsat multi-spectral and thermal bands.This study used the maximum likelihood algorithm for image classification and other methods like the correlation analysis and hotspot analysis(Getis–Ord Gi^(*) method)to examine the impact of LULC changes on urban thermal environment.This study noticed that the area percentage of built-up land increased rapidly from 21.91%to 45.63%during 1991–2021,with a maximum positive change in built-up land and a maximum negative change in sparse vegetation.The mean temperature significantly increased during the study period(1991–2021),from 16.31℃to 22.48℃in winter,29.18℃to 34.61℃in summer,and 19.18℃to 27.11℃in autumn.The result showed that impervious surfaces contribute to higher LST,whereas vegetation helps decrease it.Poor ecological status has been found in built-up land,and excellent ecological status has been found in vegetation and water body.The hot spot and cold spot areas shifted their locations every decade due to random LULC changes.Even after New Town Kolkata became a smart city,high LST has been observed.Overall,this study indicated that urbanization and changes in LULC patterns can influence the urban thermal environment,and appropriate planning is needed to reduce LST.This study can help policy-makers create sustainable smart cities.

Clinical Analysis of Common Irrational Gastroenterology Medication Problems in The Gastroenterology Department

Objective: To investigate and analyze the irrational problems of common gastroenterology medications applied to gastroenterology patients during treatment, and to develop and implement countermeasures. Methods: This study included 60 patients admitted to the Department of Gastroenterology from January 2021 to December 2023 who were randomly divided into a control group (conventional drug management) and an observation group (targeted drug treatment), of 30 cases each. After the implementation of different management methods, the occurrence of irrational drug use and the incidence of adverse reactions between both groups were compared and statistically analyzed. Results: The incidence of irrational medication in the observation group (13.33%) was lower than that in the control group (40.00%) (P < 0.05). The occurrence of adverse reactions in the observation group (10.00%) was lower than that of the control group (36.67%) after treatment (P < 0.05). The observation group had a higher level of satisfaction after treatment (90.00%) as compared to the control group (66.67%) (P < 0.05). Conclusion: Implementation of targeted drug treatment for gastroenterology patients reduced the incidence of irrational medication use, reduced adverse reactions, and improved patient satisfaction.

Present situation of rational drug use in plateau area

Plateau is characterized by low oxygen,low pressure,strong radiation,cold and dryness,among which low oxygen is the main factor that affects the normal life activities of human body.Altitude hypoxia leads to significant changes in the metabolic characteristics of drugs in vivo,which in turn affects the efficacy and adverse actions of drugs.This paper summarizes the present situation of rational drug use in plateau area and pinpoints the existing problems.Meanwhile,we posit the strategies and measures for realizing rational and precise pharmacotherapy of plateau residents.First,we need to acquire a panoramic view of differential and relative pharmacokinetics and pharmacodynamics in between plateau area and plain area by carrying out comparative studies on drug metabolisms and on comprehensive drug efficacies and mechanisms.Second,we must apply the findings from basic research to clinical practice and formulate guidelines and recommendations of drug use for plateau habitants.Finally,we should eventually achieve precise and individualized drug use for plateau habitants based on their characteristic etiology and pathogenesis.

The Level of Knowledge, Behaviors, and Attitudes on Rational Use of Drugs of Patients Who Applied to the Family Health Center in Istanbul, Türkiye: A Cross-Sectional Study

Background: This study, it was aimed to determine the level of knowledge, attitudes, and behaviors of patients who applied to a family health center about the rational use of drugs. Irrational use of drugs is a major problem worldwide. WHO reports that half of the patients do not use their drugs correctly. Methods: This cross-sectional study was conducted between 1 October 2017 and 30 November 2018 at Istanbul Fatih Family Health Center No 7. The sample size was determined as 301 people selected by systematic sampling method from patients aged 18 and older. Results: The mean age of the participants was 53.8% ± 16.8%, 59.8% were female, 62.5% were married, and 52.5% were primary school graduates. 63.9% of the participants knew the names of the drugs they used, and 79.9% of them knew the indication for use. 89% of individuals check the expiry date of the drugs before using them, and 83.1% read the drug prospectus. 84% of the participants support the prohibition of using over-the-counter drugs. Conclusion: The level of knowledge of the participants about the rational use of drugs is above the societal average. However, some issues need more awareness. The high level of rational use of drugs awareness of physicians and pharmacists will also strengthen the rational use of drugs and indirectly increase the awareness of the public.

Analysis of Land Use Change and Driving Factors in Mojiang County Based on PLUS Model

[Objectives]To explore the characteristics of land use change and its main influencing factors in Mojiang County from 2000 to 2020,and try to provide a scientific reference for alleviating the contradiction between man and land in Mojiang County and realizing the sustainable development of regional land resources.[Methods]Based on the land cover data and socio-economic data of Mojiang County from 2000 to 2020,the dynamic degree of land use,land use transfer matrix and center-of-gravity transfer model were calculated,and the temporal and spatial change characteristics and driving factors of various types of land use were calculated by PLUS model.[Results]From 2000 to 2020,the area and proportion of grassland,waters and construction land in Mojiang County showed an upward trend,while the area and proportion of cultivated land and forest land showed a downward trend.Among them,cultivated land was mainly converted into forest land and grassland,and some were converted into waters and construction land;forest land was mainly converted into cultivated land and grassland,and part of it was converted into waters and construction land.From 2000 to 2020,the center-of-gravity of cultivated land,forest land and construction land in Mojiang County moved to the southeast of the county,and the moving rates were 0.66,1.97 and 10.58 km/yr,respectively;the center-of-gravity of grassland and waters moved to the southwest of the county,and the moving rates were 1.30 and 20.20 km/yr,respectively.Distance from road,distance from government and distance from waters are the main driving forces affecting land use change in Mojiang County;the forecast shows that in 2040,the area of grassland and forest land in Mojiang County will continue to decrease,the area of cultivated land will turn to rise,and the area of waters and construction land will continue to rise.[Conclusions]Reasonable planning and optimizing the allocation of cultivated land and forest land structure and strict control of the expansion scale of construction land are necessary measures to ensure the coordinated development of regional land rational use and economic construction.

Combination Use of PFGE and Drug-resistant Analysis in the Epidemiological Investigation of Listeria Monocytogenes

Listeria monocytogenes is the pathogen of listeriosis and it causes severe infections like septicemia, encephalitis, and meningitis, especially in immunocompromised individuals, newborns, and pregnant women. Its wide distribution in the environment and ability to survive or even grow under adverse conditions has made L. monocytogenes an important public health concern and in food industry.

Analysis and Dynamics of Illicit Drug Use Described by Fractional Derivative with Mittag-Leffler Kernel

Illicit drug use is a significant problem that causes great material and moral losses and threatens the future of the society.For this reason,illicit drug use and related crimes are the most significant criminal cases examined by scientists.This paper aims at modeling the illegal drug use using the Atangana-Baleanu fractional derivative with Mittag-Leffler kernel.Also,in this work,the existence and uniqueness of solutions of the fractional-order Illicit drug use model are discussed via Picard-Lindelöf theorem which provides successive approximations using a convergent sequence.Then the stability analysis for both disease-free and endemic equilibrium states is conducted.A numerical scheme based on the known Adams-Bashforth method is designed in fractional form to approximate the novel Atangana-Baleanu fractional operator of order 0<a≤1.Finally,numerical simulation results based on different values of fractional order,which also serve as control parameter,are presented to justify the theoretical findings.

Analysis on the Problems of Rational Drug Use Carrying Out by Hospital Pharmacists in China

Pharmacists are the implementers of clinical drug management, and they play an irreplaceable role in promoting the improvement of rational drug use. However, the current role of pharmacists in the supervision and protection of rational drug use has not been fully exerted. This article is aimed to investigate the current situation of pharmacists’ work of rational drug use from the perspectives of pharmacists, physicians, and patients. It is found that the professional value of pharmacists in the rational drug use has not been valued by medical institutions, physicians, and patients. Pharmacists face problems such as workload, working conditions, and doctor-patient cooperation in the rational drug use. Suggestions are made for further exerting the professional value of pharmacists in promoting the level of rational drug use. Relevant managers should pay full attention to the professional value of pharmacists, and provide corresponding system and facility guarantees for pharmacists to carry out rational drug use.

Investigation and Analysis of Rational Drug Use of Residents in Changshou District of Chongqing, China

The objective of this study was to acquire the information about residents of Changshou District’s knowledge levels and their behaviors of drug use so that implementation strategies of rational drug use can be formulated accordingly to promote and spread health education of rational drug use.Online and offline surveys were randomly conducted about rational drug use conditions of residents in Changshou District by questionnaires.Online questionnaires were sent to residents of Changshou District by Wenjuanxing,a professional platform used for surveys.Offline questionnaires were mainly distributed to residents of communities in Changshou District.All the online and offline statistics were analyzed and counted.309 questionnaires were distributed(176 online questionnaires and 133 paper questionnaires),and the effective recovery rate was 75.4%.According to investigation and survey,conditions of resident’s rational drug use were optimistic.Only 8.15%of residents who participated in the survey(or research subjects)took paracetamol tablets and Vitamin C Yinqiao tablets(also known as VC Honeysuckle Pills)at the same time when they had a cold or fever.Among 8.15%of residents,5.15%frequently took paracetamol,caffeine,and aspirin powder(also known as headache powder),80.26%checked expiration date of drugs before taking medicine,and>50%knew that drinking after taking medicines such as cephalosporin is prohibited.Common irrational problems caused by drug use were as follows:40%of research subjects took dietary supplements as drugs and 28%of them failed to know the correct usage and dosage of drugs.Proportion of drugs that were taken with irrational usage and dosage was antibiotics(64%),antibacterial(52%),drugs for patients with diabetes mellitus(36%),drugs for patients with hyperlipidemia,hypertension,and hyperglycemia(32%),vitamins(24%),drugs for the treatment of common cold and cough(20%),and others.Publicity of rational drug use should not be restricted to specific population,and knowledge of safe drug use is supposed to be actively popularized.Contents of rational drug use are as follows:Guide the public to correctly understand the functions of vitamins and dietary supplements strengthen publicity of rational use of drugs such as antibiotics,antibacterial drugs,drugs for chronic diseases,cold,and cough.Focus should be given on usage and dosage of drugs,use of antibacterial drugs,and repeated and excessive use of drugs caused by joint use of drugs with same ingredients of OTC drugs for the treatment of common cold and cough.

Analysis of Drug Use in Outpatients with Hypertension Based on Real-World Study

Objective To explore the situation and trend of drug use in the treatment of hypertension in outpatient department of a hospital,and to provide reference for clinical rational drug use.Methods The data of 833 outpatients with hypertension in a hospital from July to December in 2020 were retrospectively analyzed.Results and Conclusion Among the 833 cases,calcium channel blocker(CCB)was the most frequently used drug(38.54%),followed by angiotensin receptor blocker(ARB)(13.81%),β-receptor blockers(β-RB)(10.44%),angiotensin-converting enzyme inhibitor(ACEI)(5.52%),and diuretics(0.72%).The combination rate was 37.09%(including single-pill combination,SPC).The highest rate was the combination of two drugs(28.21%),followed by the combination of three drugs(8.64%)and four drugs(1.20%).The DDDs and DDC of SPC were the highest among the six kinds of drugs.The use of antihypertensive drugs in outpatient department of the hospital is in line with the medication guidelines,but a small number of drugs are used irrationally,which needs further supervision and management.

Response of Ecosystem Service Value Based on Land Use Changes and Analysis of its Driving Factors in Typical Hilly Region with Red Soil

The contribution rate of ecosystem service value variation was used to analyze the effects of land use changes on the changes of ecosystem service value in Xingguo County during 1996-2005.Grey integrated correlation was employed to explore the contribution level of the indicators such as total population,urbanization level,proportion of primary industry and investment of social fixed assets on ecosystem service value,and the correlation analysis was also carried out.The results showed that the ecosystem service value in Xingguo County during 1996-2005 mainly was woodland,and the decrease of woodland area was the major reason for the sustained reduction of ecosystem service value.With the further increase of market demand and the incentives of local government,the garden area rapidly increased during 2001-2005,and the influence degree of garden towards the changes of ecosystem service value was only second to woodland,ranking No.2.Four socio-economic indicators had different correlation degree with ecosystem service value during the different research periods.Total population,urbanization level and proportion of primary industry had high correlation degree with ecosystem service value,whereas the influence degree of various socio-economic indicators on ecosystem service value was equal with each other day by day.Urbanization level,investment of social fixed assets and total population had significant negative correlation with ecosystem service value,while the proportion of primary industry had positive correlation with ecosystem service value.